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Simvastatin induces autophagic flux to restore cerulein-impaired phagosome-lysosome fusion in acute pancreatitis.

Piplani H, Marek-Iannucci S, Sin J, Hou J, Takahashi T, Sharma A, de Freitas Germano J, Waldron RT, Saadaeijahromi H, Song Y, Gulla A, Wu B, Lugea A, Andres AM, Gaisano HY, Gottlieb RA, Pandol SJ.

Biochim Biophys Acta Mol Basis Dis. 2019 Nov 1;1865(11):165530. doi: 10.1016/j.bbadis.2019.08.006. Epub 2019 Aug 6.


A glucose-dependent spatial patterning of exocytosis in human β-cells is disrupted in type 2 diabetes.

Fu J, Githaka JM, Dai X, Plummer G, Suzuki K, Spigelman AF, Bautista A, Kim R, Greitzer-Antes D, Fox JEM, Gaisano HY, MacDonald PE.

JCI Insight. 2019 May 14;5. pii: 127896. doi: 10.1172/jci.insight.127896.


Association Between Age at Natural Menopause and Risk of Type 2 Diabetes in Postmenopausal Women With and Without Obesity.

Jiang J, Cui J, Wang A, Mu Y, Yan Y, Liu F, Pan Y, Li D, Li W, Liu G, Gaisano HY, Dou J, He Y.

J Clin Endocrinol Metab. 2019 Jul 1;104(7):3039-3048. doi: 10.1210/jc.2018-02310.


Association Between Triglyceride Level and Glycemic Control Among Insulin-Treated Patients With Type 2 Diabetes.

Zheng D, Dou J, Liu G, Pan Y, Yan Y, Liu F, Gaisano HY, Lu J, He Y.

J Clin Endocrinol Metab. 2019 Apr 1;104(4):1211-1220. doi: 10.1210/jc.2018-01656.


C2 Domains of Munc13-4 Are Crucial for Ca2+-Dependent Degranulation and Cytotoxicity in NK Cells.

Bin NR, Ma K, Tien CW, Wang S, Zhu D, Park S, Turlova E, Sugita K, Shirakawa R, van der Sluijs P, Horiuchi H, Sun HS, Monnier PP, Gaisano HY, Sugita S.

J Immunol. 2018 Jul 15;201(2):700-713. doi: 10.4049/jimmunol.1800426. Epub 2018 Jun 8.


Kv2.1 clusters on β-cell plasma membrane act as reservoirs that replenish pools of newcomer insulin granule through their interaction with syntaxin-3.

Greitzer-Antes D, Xie L, Qin T, Xie H, Zhu D, Dolai S, Liang T, Kang F, Hardy AB, He Y, Kang Y, Gaisano HY.

J Biol Chem. 2018 May 4;293(18):6893-6904. doi: 10.1074/jbc.RA118.002703. Epub 2018 Mar 16.


Pancreatitis-Induced Depletion of Syntaxin 2 Promotes Autophagy and Increases Basolateral Exocytosis.

Dolai S, Liang T, Orabi AI, Holmyard D, Xie L, Greitzer-Antes D, Kang Y, Xie H, Javed TA, Lam PP, Rubin DC, Thorn P, Gaisano HY.

Gastroenterology. 2018 May;154(6):1805-1821.e5. doi: 10.1053/j.gastro.2018.01.025. Epub 2018 Jan 31.


Depletion of the membrane-fusion regulator Munc18c attenuates caerulein hyperstimulation-induced pancreatitis.

Dolai S, Liang T, Orabi AI, Xie L, Holmyard D, Javed TA, Fernandez NA, Xie H, Cattral MS, Thurmond DC, Thorn P, Gaisano HY.

J Biol Chem. 2018 Feb 16;293(7):2510-2522. doi: 10.1074/jbc.RA117.000792. Epub 2017 Dec 28.


VAMP8 mucin exocytosis attenuates intestinal pathogenesis by Entamoeba histolytica.

Cornick S, Moreau F, Gaisano HY, Chadee K.

Microb Cell. 2017 Nov 27;4(12):426-427. doi: 10.15698/mic2017.12.605.


Entamoeba histolytica-Induced Mucin Exocytosis Is Mediated by VAMP8 and Is Critical in Mucosal Innate Host Defense.

Cornick S, Moreau F, Gaisano HY, Chadee K.

MBio. 2017 Oct 3;8(5). pii: e01323-17. doi: 10.1128/mBio.01323-17.


Recent new insights into the role of SNARE and associated proteins in insulin granule exocytosis.

Gaisano HY.

Diabetes Obes Metab. 2017 Sep;19 Suppl 1:115-123. doi: 10.1111/dom.13001. Review.


Kv2.1 Clustering Contributes to Insulin Exocytosis and Rescues Human β-Cell Dysfunction.

Fu J, Dai X, Plummer G, Suzuki K, Bautista A, Githaka JM, Senior L, Jensen M, Greitzer-Antes D, Manning Fox JE, Gaisano HY, Newgard CB, Touret N, MacDonald PE.

Diabetes. 2017 Jul;66(7):1890-1900. doi: 10.2337/db16-1170. Epub 2017 Jun 12.


The SNARE Protein Syntaxin-1a Plays an Essential Role in Biphasic Exocytosis of the Incretin Hormone Glucagon-Like Peptide 1.

Wheeler SE, Stacey HM, Nahaei Y, Hale SJ, Hardy AB, Reimann F, Gribble FM, Larraufie P, Gaisano HY, Brubaker PL.

Diabetes. 2017 Sep;66(9):2327-2338. doi: 10.2337/db16-1403. Epub 2017 Jun 8.


Ex vivo human pancreatic slice preparations offer a valuable model for studying pancreatic exocrine biology.

Liang T, Dolai S, Xie L, Winter E, Orabi AI, Karimian N, Cosen-Binker LI, Huang YC, Thorn P, Cattral MS, Gaisano HY.

J Biol Chem. 2017 Apr 7;292(14):5957-5969. doi: 10.1074/jbc.M117.777433. Epub 2017 Feb 27.


Munc18b Increases Insulin Granule Fusion, Restoring Deficient Insulin Secretion in Type-2 Diabetes Human and Goto-Kakizaki Rat Islets with Improvement in Glucose Homeostasis.

Qin T, Liang T, Zhu D, Kang Y, Xie L, Dolai S, Sugita S, Takahashi N, Ostenson CG, Banks K, Gaisano HY.

EBioMedicine. 2017 Feb;16:262-274. doi: 10.1016/j.ebiom.2017.01.030. Epub 2017 Jan 22.


Syntaxin 2 Acts as Inhibitory SNARE for Insulin Granule Exocytosis.

Zhu D, Xie L, Kang Y, Dolai S, Bondo Hansen J, Qin T, Xie H, Liang T, Rubin DC, Osborne L, Gaisano HY.

Diabetes. 2017 Apr;66(4):948-959. doi: 10.2337/db16-0636. Epub 2017 Jan 23.


Post-Glucose Load Measures of Insulin Resistance and Prognosis of Nondiabetic Patients With Ischemic Stroke.

Pan Y, Jing J, Chen W, Zheng H, Jia Q, Mi D, Li H, Zhao X, Liu L, Wang C, Gaisano HY, He Y, Wang Y, Wang Y.

J Am Heart Assoc. 2017 Jan 20;6(1). pii: e004990. doi: 10.1161/JAHA.116.004990.


Palmitic acid increases invasiveness of pancreatic cancer cells AsPC-1 through TLR4/ROS/NF-κB/MMP-9 signaling pathway.

Binker-Cosen MJ, Richards D, Oliver B, Gaisano HY, Binker MG, Cosen-Binker LI.

Biochem Biophys Res Commun. 2017 Feb 26;484(1):152-158. doi: 10.1016/j.bbrc.2017.01.051. Epub 2017 Jan 12.


New Roles of Syntaxin-1A in Insulin Granule Exocytosis and Replenishment.

Liang T, Qin T, Xie L, Dolai S, Zhu D, Prentice KJ, Wheeler M, Kang Y, Osborne L, Gaisano HY.

J Biol Chem. 2017 Feb 10;292(6):2203-2216. doi: 10.1074/jbc.M116.769885. Epub 2016 Dec 28.


Synaptotagmin-7 Functions to Replenish Insulin Granules for Exocytosis in Human Islet β-Cells.

Dolai S, Xie L, Zhu D, Liang T, Qin T, Xie H, Kang Y, Chapman ER, Gaisano HY.

Diabetes. 2016 Jul;65(7):1962-76. doi: 10.2337/db15-1436. Epub 2016 Apr 26.


Association of Diabetes and Prognosis of Minor Stroke and Its Subtypes: A Prospective Observational Study.

Pan Y, Wang Y, Li H, Gaisano HY, Wang Y, He Y.

PLoS One. 2016 Apr 12;11(4):e0153178. doi: 10.1371/journal.pone.0153178. eCollection 2016.


Changes in beta cell function occur in prediabetes and early disease in the Lepr (db) mouse model of diabetes.

Do OH, Gunton JE, Gaisano HY, Thorn P.

Diabetologia. 2016 Jun;59(6):1222-30. doi: 10.1007/s00125-016-3942-3. Epub 2016 Apr 5.


Cell polarity defines three distinct domains in pancreatic β-cells.

Gan WJ, Zavortink M, Ludick C, Templin R, Webb R, Webb R, Ma W, Poronnik P, Parton RG, Gaisano HY, Shewan AM, Thorn P.

J Cell Sci. 2017 Jan 1;130(1):143-151. doi: 10.1242/jcs.185116. Epub 2016 Feb 26.


Syntaxin-3 Binds and Regulates Both R- and L-Type Calcium Channels in Insulin-Secreting INS-1 832/13 Cells.

Xie L, Dolai S, Kang Y, Liang T, Xie H, Qin T, Yang L, Chen L, Gaisano HY.

PLoS One. 2016 Feb 5;11(2):e0147862. doi: 10.1371/journal.pone.0147862. eCollection 2016.


Erratum to: Association of KCNB1 polymorphisms with lipid metabolisms and insulin resistance: a case-control design of population-based cross-sectional study in Chinese Han population.

Yu Y, Wang J, Kang R, Dong J, Zhang Y, Liu F, Yan Y, Zhu R, Xia L, Peng X, Zhang L, He D, Gaisano HY, Chen Z, He Y.

Lipids Health Dis. 2015 Nov 6;14(1):144. doi: 10.1186/s12944-015-0144-9. No abstract available.


Cell-to-Cell Communication and the Regulation of Pancreatic Function.

Thorn P, Gaisano HY.

Pancreas. 2015 Nov;44(8):1174-5. doi: 10.1097/MPA.0000000000000401. No abstract available.


Association of KCNB1 polymorphisms with lipid metabolisms and insulin resistance: a case-control design of population-based cross-sectional study in Chinese Han population.

Yu Y, Wang J, Kang R, Dong J, Zhang Y, Liu F, Yan Y, Zhu R, Xia L, Peng X, Zhang L, He D, Gaisano HY, Chen Z, He Y.

Lipids Health Dis. 2015 Sep 17;14:112. doi: 10.1186/s12944-015-0115-1. Erratum in: Lipids Health Dis. 2015;14(1):144. Herbert, Gaisano [corrected to Gaisano, Herbert Y].


Spatial and temporal coordination of insulin granule exocytosis in intact human pancreatic islets.

Almaça J, Liang T, Gaisano HY, Nam HG, Berggren PO, Caicedo A.

Diabetologia. 2015 Dec;58(12):2810-8. doi: 10.1007/s00125-015-3747-9. Epub 2015 Sep 16.


ER stress-associated CTRC mutants decrease stimulated pancreatic zymogen secretion through SIRT2-mediated microtubule dysregulation.

Binker MG, Richards D, Gaisano HY, Cosen-Binker LI.

Biochem Biophys Res Commun. 2015 Jul 31;463(3):329-35. doi: 10.1016/j.bbrc.2015.05.064. Epub 2015 May 28.


Munc18c mediates exocytosis of pre-docked and newcomer insulin granules underlying biphasic glucose stimulated insulin secretion in human pancreatic beta-cells.

Zhu D, Xie L, Karimian N, Liang T, Kang Y, Huang YC, Gaisano HY.

Mol Metab. 2015 Feb 16;4(5):418-26. doi: 10.1016/j.molmet.2015.02.004. eCollection 2015 May.


Chaperoning of closed syntaxin-3 through Lys46 and Glu59 in domain 1 of Munc18 proteins is indispensable for mast cell exocytosis.

Bin NR, Jung CH, Kim B, Chandrasegram P, Turlova E, Zhu D, Gaisano HY, Sun HS, Sugita S.

J Cell Sci. 2015 May 15;128(10):1946-60. doi: 10.1242/jcs.165662. Epub 2015 Mar 20.


Syntaxin-4 mediates exocytosis of pre-docked and newcomer insulin granules underlying biphasic glucose-stimulated insulin secretion in human pancreatic beta cells.

Xie L, Zhu D, Dolai S, Liang T, Qin T, Kang Y, Xie H, Huang YC, Gaisano HY.

Diabetologia. 2015 Jun;58(6):1250-9. doi: 10.1007/s00125-015-3545-4. Epub 2015 Mar 13.


Vesicle associated membrane protein 8 (VAMP8)-mediated zymogen granule exocytosis is dependent on endosomal trafficking via the constitutive-like secretory pathway.

Messenger SW, Falkowski MA, Thomas DD, Jones EK, Hong W, Gaisano HY, Boulis NM, Groblewski GE.

J Biol Chem. 2014 Oct 3;289(40):28040-53. doi: 10.1074/jbc.M114.593913. Epub 2014 Aug 19. Erratum in: J Biol Chem. 2014 Dec 19;289(51):35264. Giasano, Herbert Y [Corrected to Gaisano, Herbert Y].


PTEN deletion in pancreatic α-cells protects against high-fat diet-induced hyperglucagonemia and insulin resistance.

Wang L, Luk CT, Cai EP, Schroer SA, Allister EM, Shi SY, Wheeler MB, Gaisano HY, Woo M.

Diabetes. 2015 Jan;64(1):147-57. doi: 10.2337/db13-1715. Epub 2014 Aug 4.


Phosphatidylinositol 4,5-biphosphate (PIP2) modulates syntaxin-1A binding to sulfonylurea receptor 2A to regulate cardiac ATP-sensitive potassium (KATP) channels.

Xie L, Liang T, Kang Y, Lin X, Sobbi R, Xie H, Chao C, Backx P, Feng ZP, Shyng SL, Gaisano HY.

J Mol Cell Cardiol. 2014 Oct;75:100-10. doi: 10.1016/j.yjmcc.2014.07.012. Epub 2014 Jul 26.


Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic β cells.

Zhang M, Robitaille M, Showalter AD, Huang X, Liu Y, Bhattacharjee A, Willard FS, Han J, Froese S, Wei L, Gaisano HY, Angers S, Sloop KW, Dai FF, Wheeler MB.

Mol Cell Proteomics. 2014 Nov;13(11):3049-62. doi: 10.1074/mcp.M114.040196. Epub 2014 Jul 20.


Insulin secretion from beta cells in intact mouse islets is targeted towards the vasculature.

Low JT, Zavortink M, Mitchell JM, Gan WJ, Do OH, Schwiening CJ, Gaisano HY, Thorn P.

Diabetologia. 2014 Aug;57(8):1655-63. doi: 10.1007/s00125-014-3252-6. Epub 2014 May 5.


Here come the newcomer granules, better late than never.

Gaisano HY.

Trends Endocrinol Metab. 2014 Aug;25(8):381-8. doi: 10.1016/j.tem.2014.03.005. Epub 2014 Apr 16. Review.


The secretory deficit in islets from db/db mice is mainly due to a loss of responding beta cells.

Do OH, Low JT, Gaisano HY, Thorn P.

Diabetologia. 2014 Jul;57(7):1400-9. doi: 10.1007/s00125-014-3226-8. Epub 2014 Apr 6.


Biliopancreatic route for effective viral transduction of pancreatic islets.

Banks K, Qin T, Liang T, Wang AJ, Gaisano HY.

Pancreas. 2014 Mar;43(2):240-4. doi: 10.1097/MPA.0000000000000096.


Phosphatidylinositol 4,5-biphosphate (PIP2) modulates interaction of syntaxin-1A with sulfonylurea receptor 1 to regulate pancreatic β-cell ATP-sensitive potassium channels.

Liang T, Xie L, Chao C, Kang Y, Lin X, Qin T, Xie H, Feng ZP, Gaisano HY.

J Biol Chem. 2014 Feb 28;289(9):6028-40. doi: 10.1074/jbc.M113.511808. Epub 2014 Jan 15.


Role of vesicle-associated membrane protein 2 in exocytosis of glucagon-like peptide-1 from the murine intestinal L cell.

Li SK, Zhu D, Gaisano HY, Brubaker PL.

Diabetologia. 2014 Apr;57(4):809-18. doi: 10.1007/s00125-013-3143-2. Epub 2013 Dec 20.


Glucose principally regulates insulin secretion in mouse islets by controlling the numbers of granule fusion events per cell.

Low JT, Mitchell JM, Do OH, Bax J, Rawlings A, Zavortink M, Morgan G, Parton RG, Gaisano HY, Thorn P.

Diabetologia. 2013 Dec;56(12):2629-37. doi: 10.1007/s00125-013-3019-5. Epub 2013 Sep 1.


Exocyst sec5 regulates exocytosis of newcomer insulin granules underlying biphasic insulin secretion.

Xie L, Zhu D, Kang Y, Liang T, He Y, Gaisano HY.

PLoS One. 2013 Jul 2;8(7):e67561. doi: 10.1371/journal.pone.0067561. Print 2013.


Somatostatin receptor type 2 antagonism improves glucagon counterregulation in biobreeding diabetic rats.

Karimian N, Qin T, Liang T, Osundiji M, Huang Y, Teich T, Riddell MC, Cattral MS, Coy DH, Vranic M, Gaisano HY.

Diabetes. 2013 Aug;62(8):2968-77. doi: 10.2337/db13-0164. Epub 2013 Apr 29.


UCP2 regulates the glucagon response to fasting and starvation.

Allister EM, Robson-Doucette CA, Prentice KJ, Hardy AB, Sultan S, Gaisano HY, Kong D, Gilon P, Herrera PL, Lowell BB, Wheeler MB.

Diabetes. 2013 May;62(5):1623-33. doi: 10.2337/db12-0981. Epub 2013 Feb 22.


Munc18b is a major mediator of insulin exocytosis in rat pancreatic β-cells.

Lam PP, Ohno M, Dolai S, He Y, Qin T, Liang T, Zhu D, Kang Y, Liu Y, Kauppi M, Xie L, Wan WC, Bin NR, Sugita S, Olkkonen VM, Takahashi N, Kasai H, Gaisano HY.

Diabetes. 2013 Jul;62(7):2416-28. doi: 10.2337/db12-1380. Epub 2013 Feb 19.


RalA GTPase tethers insulin granules to L- and R-type calcium channels through binding α2 δ-1 subunit.

Xie L, Kang Y, Liang T, Dolai S, Xie H, Parsaud L, Lopez JA, He Y, Chidambaram S, Lam PP, James DE, Sugita S, Gaisano HY.

Traffic. 2013 Apr;14(4):428-39. doi: 10.1111/tra.12047. Epub 2013 Feb 14.


Role of the SNARE protein SNAP23 on cAMP-stimulated renin release in mouse juxtaglomerular cells.

Mendez M, Gaisano HY.

Am J Physiol Renal Physiol. 2013 Mar 1;304(5):F498-504. doi: 10.1152/ajprenal.00556.2012. Epub 2012 Dec 26.


Syntaxin-3 regulates newcomer insulin granule exocytosis and compound fusion in pancreatic beta cells.

Zhu D, Koo E, Kwan E, Kang Y, Park S, Xie H, Sugita S, Gaisano HY.

Diabetologia. 2013 Feb;56(2):359-69. doi: 10.1007/s00125-012-2757-0. Epub 2012 Nov 7.


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