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Items: 30

1.

Angiotensin (1-7) does not interact directly with MAS1, but can potently antagonize signaling from the AT1 receptor.

Gaidarov I, Adams J, Frazer J, Anthony T, Chen X, Gatlin J, Semple G, Unett DJ.

Cell Signal. 2018 Oct;50:9-24. doi: 10.1016/j.cellsig.2018.06.007. Epub 2018 Jun 19.

PMID:
29928987
2.

Embelin and its derivatives unravel the signaling, proinflammatory and antiatherogenic properties of GPR84 receptor.

Gaidarov I, Anthony T, Gatlin J, Chen X, Mills D, Solomon M, Han S, Semple G, Unett DJ.

Pharmacol Res. 2018 May;131:185-198. doi: 10.1016/j.phrs.2018.02.021. Epub 2018 Feb 19.

PMID:
29471103
3.

Discovery of APD371: Identification of a Highly Potent and Selective CB2 Agonist for the Treatment of Chronic Pain.

Han S, Thoresen L, Jung JK, Zhu X, Thatte J, Solomon M, Gaidarov I, Unett DJ, Yoon WH, Barden J, Sadeque A, Usmani A, Chen C, Semple G, Grottick AJ, Al-Shamma H, Christopher R, Jones RM.

ACS Med Chem Lett. 2017 Nov 30;8(12):1309-1313. doi: 10.1021/acsmedchemlett.7b00396. eCollection 2017 Dec 14.

4.

Discovery of 2-(((1r,4r)-4-(((4-Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension.

Tran TA, Kramer B, Shin YJ, Vallar P, Boatman PD, Zou N, Sage CR, Gharbaoui T, Krishnan A, Pal B, Shakya SR, Garrido Montalban A, Adams JW, Ramirez J, Behan DP, Shifrina A, Blackburn A, Leakakos T, Shi Y, Morgan M, Sadeque A, Chen W, Unett DJ, Gaidarov I, Chen X, Chang S, Shu HH, Tung SF, Semple G.

J Med Chem. 2017 Feb 9;60(3):913-927. doi: 10.1021/acs.jmedchem.6b00871. Epub 2017 Jan 19.

PMID:
28072531
5.

(7-Benzyloxy-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic Acids as S1P1 Functional Antagonists.

Buzard DJ, Lopez L, Moody J, Kawasaki A, Schrader TO, Kasem M, Johnson B, Zhu X, Thoresen L, Kim SH, Gharbaoui T, Sengupta D, Calvano L, Krishnan A, Gao Y, Semple G, Edwards J, Barden J, Morgan M, Usmani K, Chen C, Sadeque A, Chen W, Christopher RJ, Thatte J, Fu L, Solomon M, Whelan K, Al-Shamma H, Gatlin J, Gaidarov I, Anthony T, Le M, Unett DJ, Stirn S, Blackburn A, Behan DP, Jones RM.

ACS Med Chem Lett. 2014 Nov 25;5(12):1334-9. doi: 10.1021/ml500422m. eCollection 2014 Dec 11.

6.

Discovery of APD334: Design of a Clinical Stage Functional Antagonist of the Sphingosine-1-phosphate-1 Receptor.

Buzard DJ, Kim SH, Lopez L, Kawasaki A, Zhu X, Moody J, Thoresen L, Calderon I, Ullman B, Han S, Lehmann J, Gharbaoui T, Sengupta D, Calvano L, Montalban AG, Ma YA, Sage C, Gao Y, Semple G, Edwards J, Barden J, Morgan M, Chen W, Usmani K, Chen C, Sadeque A, Christopher RJ, Thatte J, Fu L, Solomon M, Mills D, Whelan K, Al-Shamma H, Gatlin J, Le M, Gaidarov I, Anthony T, Unett DJ, Blackburn A, Rueter J, Stirn S, Behan DP, Jones RM.

ACS Med Chem Lett. 2014 Nov 4;5(12):1313-7. doi: 10.1021/ml500389m. eCollection 2014 Dec 11.

7.

Discovery of 1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalen-4-carboxamides as potent and selective CB2 receptor agonists.

Han S, Thoresen L, Zhu X, Narayanan S, Jung JK, Strah-Pleynet S, Decaire M, Choi K, Xiong Y, Yue D, Semple G, Thatte J, Solomon M, Fu L, Whelan K, Al-Shamma H, Gatlin J, Chen R, Dang H, Pride C, Gaidarov I, Unett DJ, Behan DP, Sadeque A, Usmani KA, Chen C, Edwards J, Morgan M, Jones RM.

Bioorg Med Chem Lett. 2015 Jan 15;25(2):322-6. doi: 10.1016/j.bmcl.2014.11.040. Epub 2014 Nov 26.

PMID:
25488844
8.

Kinetics of 5-HT2B receptor signaling: profound agonist-dependent effects on signaling onset and duration.

Unett DJ, Gatlin J, Anthony TL, Buzard DJ, Chang S, Chen C, Chen X, Dang HT, Frazer J, Le MK, Sadeque AJ, Xing C, Gaidarov I.

J Pharmacol Exp Ther. 2013 Dec;347(3):645-59. doi: 10.1124/jpet.113.207670. Epub 2013 Sep 18.

PMID:
24049061
9.

Differential tissue and ligand-dependent signaling of GPR109A receptor: implications for anti-atherosclerotic therapeutic potential.

Gaidarov I, Chen X, Anthony T, Maciejewski-Lenoir D, Liaw C, Unett DJ.

Cell Signal. 2013 Oct;25(10):2003-16. doi: 10.1016/j.cellsig.2013.06.008. Epub 2013 Jun 14.

PMID:
23770183
10.

Myocardial expression, signaling, and function of GPR22: a protective role for an orphan G protein-coupled receptor.

Adams JW, Wang J, Davis JR, Liaw C, Gaidarov I, Gatlin J, Dalton ND, Gu Y, Ross J Jr, Behan D, Chien K, Connolly D.

Am J Physiol Heart Circ Physiol. 2008 Aug;295(2):H509-21. doi: 10.1152/ajpheart.00368.2008. Epub 2008 Jun 6.

11.

Nicotinic acid receptor agonists differentially activate downstream effectors.

Richman JG, Kanemitsu-Parks M, Gaidarov I, Cameron JS, Griffin P, Zheng H, Guerra NC, Cham L, Maciejewski-Lenoir D, Behan DP, Boatman D, Chen R, Skinner P, Ornelas P, Waters MG, Wright SD, Semple G, Connolly DT.

J Biol Chem. 2007 Jun 22;282(25):18028-36. Epub 2007 Apr 23.

12.

Phosphoinositide 3-kinase C2alpha links clathrin to microtubule-dependent movement.

Zhao Y, Gaidarov I, Keen JH.

J Biol Chem. 2007 Jan 12;282(2):1249-56. Epub 2006 Nov 15.

13.

Langerhans cells release prostaglandin D2 in response to nicotinic acid.

Maciejewski-Lenoir D, Richman JG, Hakak Y, Gaidarov I, Behan DP, Connolly DT.

J Invest Dermatol. 2006 Dec;126(12):2637-46. Epub 2006 Sep 28.

14.

Individual phosphoinositide 3-kinase C2alpha domain activities independently regulate clathrin function.

Gaidarov I, Zhao Y, Keen JH.

J Biol Chem. 2005 Dec 9;280(49):40766-72. Epub 2005 Oct 7.

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G protein-coupled receptor/arrestin3 modulation of the endocytic machinery.

Santini F, Gaidarov I, Keen JH.

J Cell Biol. 2002 Feb 18;156(4):665-76. Epub 2002 Feb 11.

18.
19.

The class II phosphoinositide 3-kinase PI3K-C2alpha is concentrated in the trans-Golgi network and present in clathrin-coated vesicles.

Domin J, Gaidarov I, Smith ME, Keen JH, Waterfield MD.

J Biol Chem. 2000 Apr 21;275(16):11943-50.

20.

[Biochemical characteristics of bovine retina nucleoside diphosphate kinase].

Karashchuk GN, Kakuev DL, Popov VI, Gań≠darov IO, Abdulaev NG.

Bioorg Khim. 1999 Jul;25(7):513-9. Russian.

PMID:
10563204
21.

Spatial control of coated-pit dynamics in living cells.

Gaidarov I, Santini F, Warren RA, Keen JH.

Nat Cell Biol. 1999 May;1(1):1-7.

PMID:
10559856
22.
23.

Acute cholesterol depletion inhibits clathrin-coated pit budding.

Subtil A, Gaidarov I, Kobylarz K, Lampson MA, Keen JH, McGraw TE.

Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):6775-80.

24.

Arrestin function in G protein-coupled receptor endocytosis requires phosphoinositide binding.

Gaidarov I, Krupnick JG, Falck JR, Benovic JL, Keen JH.

EMBO J. 1999 Feb 15;18(4):871-81.

25.

Nucleoside diphosphate kinase from bovine retina: purification, subcellular localization, molecular cloning, and three-dimensional structure.

Abdulaev NG, Karaschuk GN, Ladner JE, Kakuev DL, Yakhyaev AV, Tordova M, Gaidarov IO, Popov VI, Fujiwara JH, Chinchilla D, Eisenstein E, Gilliland GL, Ridge KD.

Biochemistry. 1998 Oct 6;37(40):13958-67.

PMID:
9760230
26.

Mapping of the molecular determinants involved in the interaction between eps15 and AP-2.

Iannolo G, Salcini AE, Gaidarov I, Goodman OB Jr, Baulida J, Carpenter G, Pelicci PG, Di Fiore PP, Keen JH.

Cancer Res. 1997 Jan 15;57(2):240-5.

27.

A functional phosphatidylinositol 3,4,5-trisphosphate/phosphoinositide binding domain in the clathrin adaptor AP-2 alpha subunit. Implications for the endocytic pathway.

Gaidarov I, Chen Q, Falck JR, Reddy KK, Keen JH.

J Biol Chem. 1996 Aug 23;271(34):20922-9. Erratum in: J Biol Chem 1996 Oct 25;271(43):27188.

28.

[Guanylate kinase from bovine retina: isolation, primary structure, and expression in E. coli].

Gań≠darov IO, Suslov ON, Ovchinnikova TV, Abdulaev NG.

Bioorg Khim. 1994 Apr;20(4):367-81. Russian.

PMID:
7911663
29.

Tactics of sparing activity during the acute period of severe burns.

Troshev K, Gaidarov I.

Acta Chir Plast. 1994;36(3):71-3.

PMID:
7618408
30.

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