Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 246

1.

Phosphorylation of the α-chain in the integrin LFA-1 enables β2-chain phosphorylation and α-actinin binding required for cell adhesion.

Jahan F, Madhavan S, Rolova T, Viazmina L, Grönholm M, Gahmberg CG.

J Biol Chem. 2018 Aug 10;293(32):12318-12330. doi: 10.1074/jbc.RA118.004318. Epub 2018 Jun 14.

2.

Neuronal ICAM-5 Inhibits Microglia Adhesion and Phagocytosis and Promotes an Anti-inflammatory Response in LPS Stimulated Microglia.

Paetau S, Rolova T, Ning L, Gahmberg CG.

Front Mol Neurosci. 2017 Dec 22;10:431. doi: 10.3389/fnmol.2017.00431. eCollection 2017.

3.

LFA-1 integrin antibodies inhibit leukocyte α4β1-mediated adhesion by intracellular signaling.

Grönholm M, Jahan F, Bryushkova EA, Madhavan S, Aglialoro F, Soto Hinojosa L, Uotila LM, Gahmberg CG.

Blood. 2016 Sep 1;128(9):1270-81. doi: 10.1182/blood-2016-03-705160. Epub 2016 Jul 21.

4.

Mitochondrial toxicity of triclosan on mammalian cells.

Ajao C, Andersson MA, Teplova VV, Nagy S, Gahmberg CG, Andersson LC, Hautaniemi M, Kakasi B, Roivainen M, Salkinoja-Salonen M.

Toxicol Rep. 2015 Apr 7;2:624-637. doi: 10.1016/j.toxrep.2015.03.012. eCollection 2015.

5.

RIFINs are adhesins implicated in severe Plasmodium falciparum malaria.

Goel S, Palmkvist M, Moll K, Joannin N, Lara P, Akhouri RR, Moradi N, Öjemalm K, Westman M, Angeletti D, Kjellin H, Lehtiö J, Blixt O, Ideström L, Gahmberg CG, Storry JR, Hult AK, Olsson ML, von Heijne G, Nilsson I, Wahlgren M.

Nat Med. 2015 Apr;21(4):314-7. doi: 10.1038/nm.3812. Epub 2015 Mar 9.

PMID:
25751816
6.

The peptide toxin amylosin of Bacillus amyloliquefaciens from moisture-damaged buildings is immunotoxic, induces potassium efflux from mammalian cells, and has antimicrobial activity.

Rasimus-Sahari S, Teplova VV, Andersson MA, Mikkola R, Kankkunen P, Matikainen S, Gahmberg CG, Andersson LC, Salkinoja-Salonen M.

Appl Environ Microbiol. 2015 Apr;81(8):2939-49. doi: 10.1128/AEM.03430-14. Epub 2015 Feb 13.

7.

ICAM-5 affects spine maturation by regulation of NMDA receptor binding to α-actinin.

Ning L, Paetau S, Nyman-Huttunen H, Tian L, Gahmberg CG.

Biol Open. 2015 Jan 8;4(2):125-36. doi: 10.1242/bio.201410439.

8.

ICAM-5: a neuronal dendritic adhesion molecule involved in immune and neuronal functions.

Gahmberg CG, Ning L, Paetau S.

Adv Neurobiol. 2014;8:117-32. Review.

PMID:
25300135
9.

Specific phosphorylations transmit signals from leukocyte β2 to β1 integrins and regulate adhesion.

Uotila LM, Jahan F, Soto Hinojosa L, Melandri E, Grönholm M, Gahmberg CG.

J Biol Chem. 2014 Nov 14;289(46):32230-42. doi: 10.1074/jbc.M114.588111. Epub 2014 Oct 2.

10.

Regulation of integrin activity by phosphorylation.

Gahmberg CG, Grönholm M, Uotila LM.

Adv Exp Med Biol. 2014;819:85-96. doi: 10.1007/978-94-017-9153-3_6. Review.

PMID:
25023169
11.

Crystal structures of an ICAM-5 ectodomain fragment show electrostatic-based homophilic adhesions.

Recacha R, Jiménez D, Tian L, Barredo R, Gahmberg CG, Casasnovas JM.

Acta Crystallogr D Biol Crystallogr. 2014 Jul;70(Pt 7):1934-43. doi: 10.1107/S1399004714009468. Epub 2014 Jun 29.

12.

Interactions between intercellular adhesion molecule-5 positive elements and their surroundings in the rodent visual cortex.

Kelly EA, Tremblay MÈ, Gahmberg CG, Tian L, Majewska AK.

Commun Integr Biol. 2013 Nov 1;6(6):e27315. doi: 10.4161/cib.27315. Epub 2013 Dec 10.

13.

Developmental endothelial locus-1 attenuates complement-dependent phagocytosis through inhibition of Mac-1-integrin.

Mitroulis I, Kang YY, Gahmberg CG, Siegert G, Hajishengallis G, Chavakis T, Choi EY.

Thromb Haemost. 2014 May 5;111(5):1004-6. doi: 10.1160/TH13-09-0794. Epub 2013 Dec 19. No abstract available.

14.

SHARPIN regulates uropod detachment in migrating lymphocytes.

Pouwels J, De Franceschi N, Rantakari P, Auvinen K, Karikoski M, Mattila E, Potter C, Sundberg JP, Hogg N, Gahmberg CG, Salmi M, Ivaska J.

Cell Rep. 2013 Nov 14;5(3):619-28. doi: 10.1016/j.celrep.2013.10.011. Epub 2013 Nov 7.

15.

Integrin CD11c/CD18 α-chain phosphorylation is functionally important.

Uotila LM, Aatonen M, Gahmberg CG.

J Biol Chem. 2013 Nov 15;288(46):33494-9. doi: 10.1074/jbc.C113.497446. Epub 2013 Oct 15.

16.

In vivo targeting of activated leukocytes by a β2-integrin binding peptide.

Ranta TM, Suojanen J, Peñate-Medina O, Will O, Tower RJ, Glüer C, Kairemo K, Gahmberg CG, Koivunen E, Sorsa T, Saris PE, Reunanen J.

Mol Diagn Ther. 2014 Feb;18(1):39-44. doi: 10.1007/s40291-013-0052-5.

PMID:
23982749
17.
18.

Potato crop as a source of emetic Bacillus cereus and cereulide-induced mammalian cell toxicity.

Hoornstra D, Andersson MA, Teplova VV, Mikkola R, Uotila LM, Andersson LC, Roivainen M, Gahmberg CG, Salkinoja-Salonen MS.

Appl Environ Microbiol. 2013 Jun;79(12):3534-43. doi: 10.1128/AEM.00201-13. Epub 2013 Mar 22.

19.

Pilus adhesin RrgA interacts with complement receptor 3, thereby affecting macrophage function and systemic pneumococcal disease.

Orrskog S, Rounioja S, Spadafina T, Gallotta M, Norman M, Hentrich K, Fälker S, Ygberg-Eriksson S, Hasenberg M, Johansson B, Uotila LM, Gahmberg CG, Barocchi M, Gunzer M, Normark S, Henriques-Normark B.

MBio. 2012 Dec 26;4(1):e00535-12. doi: 10.1128/mBio.00535-12.

20.

Interactions between ICAM-5 and β1 integrins regulate neuronal synapse formation.

Ning L, Tian L, Smirnov S, Vihinen H, Llano O, Vick K, Davis RL, Rivera C, Gahmberg CG.

J Cell Sci. 2013 Jan 1;126(Pt 1):77-89. doi: 10.1242/jcs.106674. Epub 2012 Sep 26.

21.

Transendothelial migration of lymphocytes mediated by intraendothelial vesicle stores rather than by extracellular chemokine depots.

Shulman Z, Cohen SJ, Roediger B, Kalchenko V, Jain R, Grabovsky V, Klein E, Shinder V, Stoler-Barak L, Feigelson SW, Meshel T, Nurmi SM, Goldstein I, Hartley O, Gahmberg CG, Etzioni A, Weninger W, Ben-Baruch A, Alon R.

Nat Immunol. 2011 Dec 4;13(1):67-76. doi: 10.1038/ni.2173.

PMID:
22138716
22.

TCR-induced activation of LFA-1 involves signaling through Tiam1.

Grönholm M, Jahan F, Marchesan S, Karvonen U, Aatonen M, Narumanchi S, Gahmberg CG.

J Immunol. 2011 Oct 1;187(7):3613-9. doi: 10.4049/jimmunol.1100704. Epub 2011 Aug 29.

23.

Hydrophobic interaction between the SH2 domain and the kinase domain is required for the activation of Csk.

Mikkola ET, Gahmberg CG.

J Mol Biol. 2010 Jun 18;399(4):618-27. doi: 10.1016/j.jmb.2010.04.045. Epub 2010 Apr 29.

PMID:
20434462
24.

Role of leukemia cell invadosome in extramedullary infiltration.

Stefanidakis M, Karjalainen K, Jaalouk DE, Gahmberg CG, O'Brien S, Pasqualini R, Arap W, Koivunen E.

Blood. 2009 Oct 1;114(14):3008-17. doi: 10.1182/blood-2008-04-148643. Epub 2009 Jul 27.

25.

PKCepsilon regulation of an alpha5 integrin-ZO-1 complex controls lamellae formation in migrating cancer cells.

Tuomi S, Mai A, Nevo J, Laine JO, Vilkki V, Ohman TJ, Gahmberg CG, Parker PJ, Ivaska J.

Sci Signal. 2009 Jun 30;2(77):ra32. doi: 10.1126/scisignal.2000135.

26.

Introduction to recent advances in biochemistry, biophysics and molecular and cell biology.

Gahmberg CG.

Biochim Biophys Acta. 2009 Jun;1790(6):403. doi: 10.1016/j.bbagen.2009.05.003. No abstract available.

PMID:
19497433
27.

Regulation of integrin activity and signalling.

Gahmberg CG, Fagerholm SC, Nurmi SM, Chavakis T, Marchesan S, Grönholm M.

Biochim Biophys Acta. 2009 Jun;1790(6):431-44. doi: 10.1016/j.bbagen.2009.03.007. Epub 2009 Mar 14. Review.

28.

Neuronal regulation of immune responses in the central nervous system.

Tian L, Rauvala H, Gahmberg CG.

Trends Immunol. 2009 Feb;30(2):91-9. doi: 10.1016/j.it.2008.11.002. Epub 2009 Jan 12. Review.

PMID:
19144568
29.

Del-1, an endogenous leukocyte-endothelial adhesion inhibitor, limits inflammatory cell recruitment.

Choi EY, Chavakis E, Czabanka MA, Langer HF, Fraemohs L, Economopoulou M, Kundu RK, Orlandi A, Zheng YY, Prieto DA, Ballantyne CM, Constant SL, Aird WC, Papayannopoulou T, Gahmberg CG, Udey MC, Vajkoczy P, Quertermous T, Dimmeler S, Weber C, Chavakis T.

Science. 2008 Nov 14;322(5904):1101-4. doi: 10.1126/science.1165218. Erratum in: Science. 2009 Aug 21;325(5943):946.

30.

An unusual allosteric mobility of the C-terminal helix of a high-affinity alphaL integrin I domain variant bound to ICAM-5.

Zhang H, Casasnovas JM, Jin M, Liu JH, Gahmberg CG, Springer TA, Wang JH.

Mol Cell. 2008 Aug 8;31(3):432-7. doi: 10.1016/j.molcel.2008.06.022.

31.

Beta2 integrin phosphorylation on Thr758 acts as a molecular switch to regulate 14-3-3 and filamin binding.

Takala H, Nurminen E, Nurmi SM, Aatonen M, Strandin T, Takatalo M, Kiema T, Gahmberg CG, Ylänne J, Fagerholm SC.

Blood. 2008 Sep 1;112(5):1853-62. doi: 10.1182/blood-2007-12-127795. Epub 2008 Jun 12.

32.

ICAM-5--a novel two-facetted adhesion molecule in the mammalian brain.

Gahmberg CG, Tian L, Ning L, Nyman-Huttunen H.

Immunol Lett. 2008 May 15;117(2):131-5. doi: 10.1016/j.imlet.2008.02.004. Epub 2008 Mar 10. Review.

PMID:
18367254
33.

Regulation of LFA-1-dependent inflammatory cell recruitment by Cbl-b and 14-3-3 proteins.

Choi EY, Orlova VV, Fagerholm SC, Nurmi SM, Zhang L, Ballantyne CM, Gahmberg CG, Chavakis T.

Blood. 2008 Apr 1;111(7):3607-14. doi: 10.1182/blood-2007-07-103077. Epub 2008 Jan 31.

34.

Shedded neuronal ICAM-5 suppresses T-cell activation.

Tian L, Lappalainen J, Autero M, Hänninen S, Rauvala H, Gahmberg CG.

Blood. 2008 Apr 1;111(7):3615-25. doi: 10.1182/blood-2007-09-111179. Epub 2008 Jan 25.

35.

Importance of molecular studies on major blood groups--intercellular adhesion molecule-4, a blood group antigen involved in multiple cellular interactions.

Toivanen A, Ihanus E, Mattila M, Lutz HU, Gahmberg CG.

Biochim Biophys Acta. 2008 Mar;1780(3):456-66. Epub 2007 Sep 15. Review.

PMID:
17997044
36.

Activation of NMDA receptors promotes dendritic spine development through MMP-mediated ICAM-5 cleavage.

Tian L, Stefanidakis M, Ning L, Van Lint P, Nyman-Huttunen H, Libert C, Itohara S, Mishina M, Rauvala H, Gahmberg CG.

J Cell Biol. 2007 Aug 13;178(4):687-700. Epub 2007 Aug 6.

37.

14-3-3 proteins bind both filamin and alphaLbeta2 integrin in activated T cells.

Nurmi SM, Gahmberg CG, Fagerholm SC.

Ann N Y Acad Sci. 2006 Dec;1090:318-25.

PMID:
17384276
38.

A novel pathway of HMGB1-mediated inflammatory cell recruitment that requires Mac-1-integrin.

Orlova VV, Choi EY, Xie C, Chavakis E, Bierhaus A, Ihanus E, Ballantyne CM, Gahmberg CG, Bianchi ME, Nawroth PP, Chavakis T.

EMBO J. 2007 Feb 21;26(4):1129-39. Epub 2007 Feb 1.

39.

DC-SIGN binds ICAM-3 isolated from peripheral human leukocytes through Lewis x residues.

Bogoevska V, Nollau P, Lucka L, Grunow D, Klampe B, Uotila LM, Samsen A, Gahmberg CG, Wagener C.

Glycobiology. 2007 Mar;17(3):324-33. Epub 2006 Dec 4.

PMID:
17145745
40.

Phosphorylation of the LFA-1 integrin beta2-chain on Thr-758 leads to adhesion, Rac-1/Cdc42 activation, and stimulation of CD69 expression in human T cells.

Nurmi SM, Autero M, Raunio AK, Gahmberg CG, Fagerholm SC.

J Biol Chem. 2007 Jan 12;282(2):968-75. Epub 2006 Nov 15.

41.

Interfering with leukocyte integrin activation--a novel concept in the development of anti-inflammatory drugs.

Hilden TJ, Nurmi SM, Fagerholm SC, Gahmberg CG.

Ann Med. 2006;38(7):503-11. Review.

PMID:
17101541
42.

Red-cell ICAM-4 is a ligand for the monocyte/macrophage integrin CD11c/CD18: characterization of the binding sites on ICAM-4.

Ihanus E, Uotila LM, Toivanen A, Varis M, Gahmberg CG.

Blood. 2007 Jan 15;109(2):802-10. Epub 2006 Sep 19.

43.

P-selectin glycoprotein ligand 1 and beta2-integrins cooperate in the adhesion of leukocytes to von Willebrand factor.

Pendu R, Terraube V, Christophe OD, Gahmberg CG, de Groot PG, Lenting PJ, Denis CV.

Blood. 2006 Dec 1;108(12):3746-52. Epub 2006 Aug 22.

44.

alpha-Chain phosphorylation of the human leukocyte CD11b/CD18 (Mac-1) integrin is pivotal for integrin activation to bind ICAMs and leukocyte extravasation.

Fagerholm SC, Varis M, Stefanidakis M, Hilden TJ, Gahmberg CG.

Blood. 2006 Nov 15;108(10):3379-86. Epub 2006 Jul 20.

45.

alpha-Actinin-dependent cytoskeletal anchorage is important for ICAM-5-mediated neuritic outgrowth.

Nyman-Huttunen H, Tian L, Ning L, Gahmberg CG.

J Cell Sci. 2006 Aug 1;119(Pt 15):3057-66. Epub 2006 Jul 4.

46.

Lipoprotein(a) in atherosclerotic plaques recruits inflammatory cells through interaction with Mac-1 integrin.

Sotiriou SN, Orlova VV, Al-Fakhri N, Ihanus E, Economopoulou M, Isermann B, Bdeir K, Nawroth PP, Preissner KT, Gahmberg CG, Koschinsky ML, Chavakis T.

FASEB J. 2006 Mar;20(3):559-61. Epub 2006 Jan 10.

PMID:
16403785
47.
48.

A tripeptide mimetic of von Willebrand factor residues 981-983 enhances platelet adhesion to fibrinogen by signaling through integrin alpha(IIb)beta3.

Litjens PE, Van Willigen G, Weeterings C, Ijsseldijk MJ, Van Lier M, Koivunen E, Gahmberg CG, Akkerman JW.

J Thromb Haemost. 2005 Jun;3(6):1274-83.

49.

[Targeted anticancer drugs and their development].

Kervinen J, Gahmberg CG.

Duodecim. 2004;120(19):2323-30. Review. Finnish. No abstract available.

PMID:
15565985
50.

P marks the spot: site-specific integrin phosphorylation regulates molecular interactions.

Fagerholm SC, Hilden TJ, Gahmberg CG.

Trends Biochem Sci. 2004 Sep;29(9):504-12. Review.

PMID:
15337124

Supplemental Content

Loading ...
Support Center