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Post-Transcriptional Modulation of aENaC mRNA in Alveolar Epithelial Cells: Involvement of its 3' Untranslated Region.

Migneault F, Gagnon F, Pascariu M, Laperle J, Roy A, Dagenais A, Berthiaume Y.

Cell Physiol Biochem. 2019;52(5):984-1002. doi: 10.33594/000000068.


A catalog of annotated high-confidence SNPs from exome capture and sequencing reveals highly polymorphic genes in Norway spruce (Picea abies).

Azaiez A, Pavy N, Gérardi S, Laroche J, Boyle B, Gagnon F, Mottet MJ, Beaulieu J, Bousquet J.

BMC Genomics. 2018 Dec 17;19(1):942. doi: 10.1186/s12864-018-5247-z.


Analysis and Experimental Validation of Efficient Coded OFDM for an Impulsive Noise Environment.

Sarr NB, Agba BL, Gagnon F, Boeglen H, Vauzelle R.

Sensors (Basel). 2018 Oct 29;18(11). pii: E3667. doi: 10.3390/s18113667.


Spatial Distribution of Parkinson's Disease Prevalence in Québec by Hydrographic Region.

Susser SR, Gagnon F.

Can J Neurol Sci. 2018 Jul;45(4):478-480. doi: 10.1017/cjn.2018.24.


DNA methylation age is associated with an altered hemostatic profile in a multiethnic meta-analysis.

Ward-Caviness CK, Huffman JE, Everett K, Germain M, van Dongen J, Hill WD, Jhun MA, Brody JA, Ghanbari M, Du L, Roetker NS, de Vries PS, Waldenberger M, Gieger C, Wolf P, Prokisch H, Koenig W, O'Donnell CJ, Levy D, Liu C, Truong V, Wells PS, Trégouët DA, Tang W, Morrison AC, Boerwinkle E, Wiggins KL, McKnight B, Guo X, Psaty BM, Sotoodenia N, Boomsma DI, Willemsen G, Ligthart L, Deary IJ, Zhao W, Ware EB, Kardia SLR, Van Meurs JBJ, Uitterlinden AG, Franco OH, Eriksson P, Franco-Cereceda A, Pankow JS, Johnson AD, Gagnon F, Morange PE, de Geus EJC, Starr JM, Smith JA, Dehghan A, Björck HM, Smith NL, Peters A.

Blood. 2018 Oct 25;132(17):1842-1850. doi: 10.1182/blood-2018-02-831347. Epub 2018 Jul 24.


Validation of the evaluation capacity in organizations questionnaire.

Gagnon F, Aubry T, Cousins JB, Goh SC, Elliott C.

Eval Program Plann. 2018 Jun;68:166-175. doi: 10.1016/j.evalprogplan.2018.01.002. Epub 2018 Jan 2.


Genetically defined elevated homocysteine levels do not result in widespread changes of DNA methylation in leukocytes.

Mandaviya PR, Joehanes R, Aïssi D, Kühnel B, Marioni RE, Truong V, Stolk L, Beekman M, Bonder MJ, Franke L, Gieger C, Huan T, Ikram MA, Kunze S, Liang L, Lindemans J, Liu C, McRae AF, Mendelson MM, Müller-Nurasyid M, Peters A, Slagboom PE, Starr JM, Trégouët DA, Uitterlinden AG, van Greevenbroek MMJ, van Heemst D, van Iterson M, Wells PS, Yao C, Deary IJ, Gagnon F, Heijmans BT, Levy D, Morange PE, Waldenberger M, Heil SG, van Meurs JBJ; CHARGE Consortium Epigenetics group and BIOS Consortium.

PLoS One. 2017 Oct 30;12(10):e0182472. doi: 10.1371/journal.pone.0182472. eCollection 2017.


Homocysteine levels associate with subtle changes in leukocyte DNA methylation: an epigenome-wide analysis.

Mandaviya PR, Aïssi D, Dekkers KF, Joehanes R, Kasela S, Truong V, Stolk L, Heemst DV, Ikram MA, Lindemans J, Slagboom PE, Trégouët DA, Uitterlinden AG, Wei C, Wells P, Gagnon F, van Greevenbroek MM, Heijmans BT, Milani L, Morange PE, van Meurs JB, Heil SG; BIOS Consortium.

Epigenomics. 2017 Nov;9(11):1403-1422. doi: 10.2217/epi-2017-0038. Epub 2017 Oct 9.


Why and How Political Science Can Contribute to Public Health? Proposals for Collaborative Research Avenues.

Gagnon F, Bergeron P, Clavier C, Fafard P, Martin E, Blouin C.

Int J Health Policy Manag. 2017 Apr 5;6(9):495-499. doi: 10.15171/ijhpm.2017.38.


Peripheral human CD4+CD8+ T lymphocytes exhibit a memory phenotype and enhanced responses to IL-2, IL-7 and IL-15.

Clénet ML, Gagnon F, Moratalla AC, Viel EC, Arbour N.

Sci Rep. 2017 Sep 14;7(1):11612. doi: 10.1038/s41598-017-11926-2.


Blood triglyceride levels are associated with DNA methylation at the serine metabolism gene PHGDH.

Truong V, Huang S, Dennis J, Lemire M, Zwingerman N, Aïssi D, Kassam I, Perret C, Wells P, Morange PE, Wilson M, Trégouët DA, Gagnon F.

Sci Rep. 2017 Sep 11;7(1):11207. doi: 10.1038/s41598-017-09552-z.


Association between consumption of private well water contaminated by low levels of arsenic and dysglycemia in a rural region of Quebec, Canada.

Lampron-Goulet É, Gagnon F, Langlois MF.

Environ Res. 2017 Nov;159:232-238. doi: 10.1016/j.envres.2017.07.049. Epub 2017 Aug 14.


Sex-specific effect of CPB2 Ala147Thr but not Thr325Ile variants on the risk of venous thrombosis: A comprehensive meta-analysis.

Zwingerman N, Medina-Rivera A, Kassam I, Wilson MD, Morange PE, Trégouët DA, Gagnon F.

PLoS One. 2017 May 26;12(5):e0177768. doi: 10.1371/journal.pone.0177768. eCollection 2017.


Leveraging cell type specific regulatory regions to detect SNPs associated with tissue factor pathway inhibitor plasma levels.

Dennis J, Medina-Rivera A, Truong V, Antounians L, Zwingerman N, Carrasco G, Strug L, Wells P, Trégouët DA, Morange PE, Wilson MD, Gagnon F.

Genet Epidemiol. 2017 Jul;41(5):455-466. doi: 10.1002/gepi.22049. Epub 2017 Apr 18.


A high-resolution reference genetic map positioning 8.8 K genes for the conifer white spruce: structural genomics implications and correspondence with physical distance.

Pavy N, Lamothe M, Pelgas B, Gagnon F, Birol I, Bohlmann J, Mackay J, Isabel N, Bousquet J.

Plant J. 2017 Apr;90(1):189-203. doi: 10.1111/tpj.13478. Epub 2017 Mar 6.


Genome-wide association study with additional genetic and post-transcriptional analyses reveals novel regulators of plasma factor XI levels.

Sennblad B, Basu S, Mazur J, Suchon P, Martinez-Perez A, van Hylckama Vlieg A, Truong V, Li Y, Gådin JR, Tang W, Grossman V, de Haan HG, Handin N, Silveira A, Souto JC, Franco-Cereceda A, Morange PE, Gagnon F, Soria JM, Eriksson P, Hamsten A, Maegdefessel L, Rosendaal FR, Wild P, Folsom AR, Trégouët DA, Sabater-Lleal M.

Hum Mol Genet. 2017 Feb 1;26(3):637-649. doi: 10.1093/hmg/ddw401.


Single nucleotide polymorphisms in an intergenic chromosome 2q region associated with tissue factor pathway inhibitor plasma levels and venous thromboembolism.

Dennis J, Truong V, Aïssi D, Medina-Rivera A, Blankenberg S, Germain M, Lemire M, Antounians L, Civelek M, Schnabel R, Wells P, Wilson MD, Morange PE, Trégouët DA, Gagnon F.

J Thromb Haemost. 2016 Oct;14(10):1960-1970. doi: 10.1111/jth.13431. Epub 2016 Sep 17.


Implementation of a radon measurement protocol and its communication plan by child care centre managers in Québec.

Gagnon F, Poulin P, Leclerc JM, Dessau JC, Abab A, Arsenault P, El-Turaby F, Lachance-Paquette G, Vézina FA.

Can J Public Health. 2016 Oct 20;107(3):e319-e325. doi: 10.17269/cjph.107.5339.


Explaining the Serological Characteristics of Streptococcus suis Serotypes 1 and 1/2 from Their Capsular Polysaccharide Structure and Biosynthesis.

Van Calsteren MR, Goyette-Desjardins G, Gagnon F, Okura M, Takamatsu D, Roy R, Gottschalk M, Segura M.

J Biol Chem. 2016 Apr 15;291(16):8387-98. doi: 10.1074/jbc.M115.700716. Epub 2016 Feb 24.


An epidemiological paradox.

Gagnon F.

CMAJ. 2015 Oct 6;187(14):1077-1078. doi: 10.1503/cmaj.1150064. No abstract available.


Development of highly reliable in silico SNP resource and genotyping assay from exome capture and sequencing: an example from black spruce (Picea mariana).

Pavy N, Gagnon F, Deschênes A, Boyle B, Beaulieu J, Bousquet J.

Mol Ecol Resour. 2016 Mar;16(2):588-98. doi: 10.1111/1755-0998.12468. Epub 2015 Oct 18.


Structure determination of the neutral exopolysaccharide produced by Lactobacillus delbrueckii subsp. bulgaricus OLL1073R-1.

Van Calsteren MR, Gagnon F, Nishimura J, Makino S.

Carbohydr Res. 2015 Sep 2;413:115-22. doi: 10.1016/j.carres.2015.05.015. Epub 2015 Jun 9.


[Water, the source of life! And sometimes disease...].

Provost-Dubois R, Michaud C, Gagnon F.

Perspect Infirm. 2015 May-Jun;12(3):35-41. French. No abstract available.


Association of the APOE-ε4 allele with outcome of traumatic brain injury in children and youth: a meta-analysis and meta-regression.

Kassam I, Gagnon F, Cusimano MD.

J Neurol Neurosurg Psychiatry. 2016 Apr;87(4):433-40. doi: 10.1136/jnnp-2015-310500. Epub 2015 Apr 22. Review.


Genetic determinants of tissue factor pathway inhibitor plasma levels.

Dennis J, Kassam I, Morange PE, Trégouët DA, Gagnon F.

Thromb Haemost. 2015 Aug;114(2):245-57. doi: 10.1160/TH14-12-1043. Epub 2015 Apr 16. Review.


Meta-analysis of 65,734 individuals identifies TSPAN15 and SLC44A2 as two susceptibility loci for venous thromboembolism.

Germain M, Chasman DI, de Haan H, Tang W, Lindström S, Weng LC, de Andrade M, de Visser MC, Wiggins KL, Suchon P, Saut N, Smadja DM, Le Gal G, van Hylckama Vlieg A, Di Narzo A, Hao K, Nelson CP, Rocanin-Arjo A, Folkersen L, Monajemi R, Rose LM, Brody JA, Slagboom E, Aïssi D, Gagnon F, Deleuze JF, Deloukas P, Tzourio C, Dartigues JF, Berr C, Taylor KD, Civelek M, Eriksson P; Cardiogenics Consortium, Psaty BM, Houwing-Duitermaat J, Goodall AH, Cambien F, Kraft P, Amouyel P, Samani NJ, Basu S, Ridker PM, Rosendaal FR, Kabrhel C, Folsom AR, Heit J, Reitsma PH, Trégouët DA, Smith NL, Morange PE.

Am J Hum Genet. 2015 Apr 2;96(4):532-42. doi: 10.1016/j.ajhg.2015.01.019. Epub 2015 Mar 12.


Long-range epigenetic regulation is conferred by genetic variation located at thousands of independent loci.

Lemire M, Zaidi SH, Ban M, Ge B, Aïssi D, Germain M, Kassam I, Wang M, Zanke BW, Gagnon F, Morange PE, Trégouët DA, Wells PS, Sawcer S, Gallinger S, Pastinen T, Hudson TJ.

Nat Commun. 2015 Feb 26;6:6326. doi: 10.1038/ncomms7326.


Thrombin generation potential and whole-blood DNA methylation.

Rocañín-Arjó A, Dennis J, Suchon P, Aïssi D, Truong V, Trégouët DA, Gagnon F, Morange PE.

Thromb Res. 2015 Mar;135(3):561-4. doi: 10.1016/j.thromres.2014.12.010. Epub 2014 Dec 12. No abstract available.


Cautious enthusiasm about GWAS findings.

Gagnon F.

Blood. 2014 Nov 13;124(20):3041-2. doi: 10.1182/blood-2014-10-601518.


Genome-wide investigation of DNA methylation marks associated with FV Leiden mutation.

Aïssi D, Dennis J, Ladouceur M, Truong V, Zwingerman N, Rocanin-Arjo A, Germain M, Paton TA, Morange PE, Gagnon F, Trégouët DA.

PLoS One. 2014 Sep 29;9(9):e108087. doi: 10.1371/journal.pone.0108087. eCollection 2014.


Robust validation of methylation levels association at CPT1A locus with lipid plasma levels.

Gagnon F, Aïssi D, Carrié A, Morange PE, Trégouët DA.

J Lipid Res. 2014 Jul;55(7):1189-91. doi: 10.1194/jlr.E051276. Epub 2014 May 21. No abstract available.


RFC1 80G>A is a genetic determinant of methotrexate efficacy in rheumatoid arthritis: a human genome epidemiologic review and meta-analysis of observational studies.

Kung TN, Dennis J, Ma Y, Xie G, Bykerk V, Pope J, Thorne C, Keystone E, Siminovitch KA, Gagnon F.

Arthritis Rheumatol. 2014 May;66(5):1111-20. doi: 10.1002/art.38331. Review.


DNA methylation and body-mass index: a genome-wide analysis.

Dick KJ, Nelson CP, Tsaprouni L, Sandling JK, Aïssi D, Wahl S, Meduri E, Morange PE, Gagnon F, Grallert H, Waldenberger M, Peters A, Erdmann J, Hengstenberg C, Cambien F, Goodall AH, Ouwehand WH, Schunkert H, Thompson JR, Spector TD, Gieger C, Trégouët DA, Deloukas P, Samani NJ.

Lancet. 2014 Jun 7;383(9933):1990-8. doi: 10.1016/S0140-6736(13)62674-4. Epub 2014 Mar 13.


Informatics and genetic epidemiology.

Ziegler A, Wilson AF, Gagnon F.

Methods Inf Med. 2014;53(1):1-2. No abstract available.


Influencing public policies: Two (very good) reasons to look toward scientific knowledge in public policy.

Gagnon F, Bellefleur O.

Can J Public Health. 2014 Jul 11;106(1 Suppl 1):eS9-11. doi: 10.17269/cjph.106.3839.


A randomized, single-blind, controlled, parallel assignment study of exercise versus education as adjuvant in the treatment of peripheral neuropathic pain.

Toth C, Brady S, Gagnon F, Wigglesworth K.

Clin J Pain. 2014 Feb;30(2):111-8. doi: 10.1097/AJP.0b013e31828ccd0f.


Group B Streptococcus and Streptococcus suis capsular polysaccharides induce chemokine production by dendritic cells via Toll-like receptor 2- and MyD88-dependent and -independent pathways.

Calzas C, Goyette-Desjardins G, Lemire P, Gagnon F, Lachance C, Van Calsteren MR, Segura M.

Infect Immun. 2013 Sep;81(9):3106-18. doi: 10.1128/IAI.00113-13. Epub 2013 Jun 17.


The genomic architecture and association genetics of adaptive characters using a candidate SNP approach in boreal black spruce.

Prunier J, Pelgas B, Gagnon F, Desponts M, Isabel N, Beaulieu J, Bousquet J.

BMC Genomics. 2013 Jun 1;14:368. doi: 10.1186/1471-2164-14-368.


Structure determination of Streptococcus suis serotype 14 capsular polysaccharide.

Van Calsteren MR, Gagnon F, Calzas C, Goyette-Desjardins G, Okura M, Takamatsu D, Gottschalk M, Segura M.

Biochem Cell Biol. 2013 Apr;91(2):49-58. doi: 10.1139/bcb-2012-0036. Epub 2012 Dec 3.


Development of high-density SNP genotyping arrays for white spruce (Picea glauca) and transferability to subtropical and nordic congeners.

Pavy N, Gagnon F, Rigault P, Blais S, Deschênes A, Boyle B, Pelgas B, Deslauriers M, Clément S, Lavigne P, Lamothe M, Cooke JE, Jaramillo-Correa JP, Beaulieu J, Isabel N, Mackay J, Bousquet J.

Mol Ecol Resour. 2013 Mar;13(2):324-36. doi: 10.1111/1755-0998.12062. Epub 2013 Jan 25.


A family-based association analysis and meta-analysis of the reading disabilities candidate gene DYX1C1.

Tran C, Gagnon F, Wigg KG, Feng Y, Gomez L, Cate-Carter TD, Kerr EN, Field LL, Kaplan BJ, Lovett MW, Barr CL.

Am J Med Genet B Neuropsychiatr Genet. 2013 Mar;162B(2):146-56. doi: 10.1002/ajmg.b.32123. Epub 2013 Jan 22.


A family of Nyquist pulses for coherent optical communications.

Châtelain B, Laperle C, Roberts K, Chagnon M, Xu X, Borowiec A, Gagnon F, Plant DV.

Opt Express. 2012 Apr 9;20(8):8397-416. doi: 10.1364/OE.20.008397.


Successful identification of rare variants using oligogenic segregation analysis as a prioritizing tool for whole-exome sequencing studies.

Gagnon F, Roslin NM, Lemire M.

BMC Proc. 2011 Nov 29;5 Suppl 9:S11. doi: 10.1186/1753-6561-5-S9-S11.


Health promoting schools provide community-based learning opportunities conducive to careers in rural practice.

Macnab A, Kasangaki A, Gagnon F.

Int J Family Med. 2011;2011:892518. doi: 10.1155/2011/892518. Epub 2011 Apr 7.


Radon measurement in schools located in three priority investigation areas in the province of Quebec, Canada.

Poulin P, Leclerc JM, Dessau JC, Deck W, Gagnon F.

Radiat Prot Dosimetry. 2012 Aug;151(2):278-89. doi: 10.1093/rpd/ncr483. Epub 2012 Jan 24.


The endothelial protein C receptor (PROCR) Ser219Gly variant and risk of common thrombotic disorders: a HuGE review and meta-analysis of evidence from observational studies.

Dennis J, Johnson CY, Adediran AS, de Andrade M, Heit JA, Morange PE, Trégouët DA, Gagnon F.

Blood. 2012 Mar 8;119(10):2392-400. doi: 10.1182/blood-2011-10-383448. Epub 2012 Jan 17. Review.


Streptococcus suis capsular polysaccharide inhibits phagocytosis through destabilization of lipid microdomains and prevents lactosylceramide-dependent recognition.

Houde M, Gottschalk M, Gagnon F, Van Calsteren MR, Segura M.

Infect Immun. 2012 Feb;80(2):506-17. doi: 10.1128/IAI.05734-11. Epub 2011 Nov 28.


A weight of evidence approach for the assessment of the ototoxic potential of industrial chemicals.

Vyskocil A, Truchon G, Leroux T, Lemay F, Gendron M, Gagnon F, Majidi NE, Boudjerida A, Lim S, Emond C, Viau C.

Toxicol Ind Health. 2012 Oct;28(9):796-819. Epub 2011 Nov 7. Review.


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