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Items: 1 to 50 of 197

1.

The Structural Dynamics of Engineered β-Lactamases Vary Broadly on Three Timescales yet Sustain Native Function.

Gobeil SMC, Ebert MCCJC, Park J, Gagné D, Doucet N, Berghuis AM, Pleiss J, Pelletier JN.

Sci Rep. 2019 Apr 30;9(1):6656. doi: 10.1038/s41598-019-42866-8.

2.

Temporal trends of legacy and emerging persistent organic pollutants in inuit preschoolers from Northern Quebec (Canada).

Turgeon O'Brien H, Gagné D, Lauzière J, Blanchet R, Vézina C, Ayotte P.

Int J Environ Health Res. 2019 Dec;29(6):643-656. doi: 10.1080/09603123.2018.1560396. Epub 2019 Jan 14.

PMID:
30636437
3.

Correction to: Sequence-specific backbone resonance assignments and microsecond timescale molecular dynamics simulation of human eosinophil-derived neurotoxin.

Gagné D, Narayanan C, Bafna K, Charest LA, Agarwal PK, Doucet N.

Biomol NMR Assign. 2018 Oct;12(2):365-367. doi: 10.1007/s12104-018-9833-4.

PMID:
30083869
4.

Ligand-Induced Variations in Structural and Dynamical Properties Within an Enzyme Superfamily.

Narayanan C, Bernard DN, Bafna K, Gagné D, Agarwal PK, Doucet N.

Front Mol Biosci. 2018 Jun 12;5:54. doi: 10.3389/fmolb.2018.00054. eCollection 2018.

5.

Intragenic sequences in the trophectoderm harbour the greatest proportion of methylation errors in day 17 bovine conceptuses generated using assisted reproductive technologies.

O'Doherty AM, McGettigan P, Irwin RE, Magee DA, Gagne D, Fournier E, Al-Naib A, Sirard MA, Walsh CP, Robert C, Fair T.

BMC Genomics. 2018 Jun 5;19(1):438. doi: 10.1186/s12864-018-4818-3.

6.

Genome-wide DNA methylation patterns of bovine blastocysts derived from in vivo embryos subjected to in vitro culture before, during or after embryonic genome activation.

Salilew-Wondim D, Saeed-Zidane M, Hoelker M, Gebremedhn S, Poirier M, Pandey HO, Tholen E, Neuhoff C, Held E, Besenfelder U, Havlicek V, Rings F, Fournier E, Gagné D, Sirard MA, Robert C, Gad A, Schellander K, Tesfaye D.

BMC Genomics. 2018 Jun 1;19(1):424. doi: 10.1186/s12864-018-4826-3.

7.

GHSR-D2R heteromerization modulates dopamine signaling through an effect on G protein conformation.

Damian M, Pons V, Renault P, M'Kadmi C, Delort B, Hartmann L, Kaya AI, Louet M, Gagne D, Ben Haj Salah K, Denoyelle S, Ferry G, Boutin JA, Wagner R, Fehrentz JA, Martinez J, Marie J, Floquet N, Galès C, Mary S, Hamm HE, Banères JL.

Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):4501-4506. doi: 10.1073/pnas.1712725115. Epub 2018 Apr 9.

8.

Conservation of Dynamics Associated with Biological Function in an Enzyme Superfamily.

Narayanan C, Bernard DN, Bafna K, Gagné D, Chennubhotla CS, Doucet N, Agarwal PK.

Structure. 2018 Mar 6;26(3):426-436.e3. doi: 10.1016/j.str.2018.01.015. Epub 2018 Feb 22.

9.

Application of Carnobacterium maltaromaticum as a feed additive for weaned rabbits to improve meat microbial quality and safety.

Koné AP, Zea JMV, Gagné D, Cinq-Mars D, Guay F, Saucier L.

Meat Sci. 2018 Jan;135:174-188. doi: 10.1016/j.meatsci.2017.09.017. Epub 2017 Oct 2.

10.
11.

Conserved amino acid networks modulate discrete functional properties in an enzyme superfamily.

Narayanan C, Gagné D, Reynolds KA, Doucet N.

Sci Rep. 2017 Jun 9;7(1):3207. doi: 10.1038/s41598-017-03298-4.

12.

Sequence-specific backbone resonance assignments and microsecond timescale molecular dynamics simulation of human eosinophil-derived neurotoxin.

Gagné D, Narayanan C, Bafna K, Charest LA, Agarwal PK, Doucet N.

Biomol NMR Assign. 2017 Oct;11(2):143-149. doi: 10.1007/s12104-017-9736-9. Epub 2017 Mar 7. Erratum in: Biomol NMR Assign. 2018 Oct;12(2):365-367.

13.

Exposure of bovine oocytes and embryos to elevated non-esterified fatty acid concentrations: integration of epigenetic and transcriptomic signatures in resultant blastocysts.

Desmet KL, Van Hoeck V, Gagné D, Fournier E, Thakur A, O'Doherty AM, Walsh CP, Sirard MA, Bols PE, Leroy JL.

BMC Genomics. 2016 Dec 8;17(1):1004.

14.

Quantitative MALDI-MS Binding Assays: An Alternative to Radiolabeling.

Rossato M, Miralles G, M'Kadmi C, Maingot M, Amblard M, Mouillac B, Gagne D, Martinez J, Subra G, Enjalbal C, Cantel S.

ChemMedChem. 2016 Dec 6;11(23):2582-2587. doi: 10.1002/cmdc.201600447. Epub 2016 Nov 16.

PMID:
27922213
15.

Selenazolidine: a selenium containing proline surrogate in peptide science.

Cordeau E, Cantel S, Gagne D, Lebrun A, Martinez J, Subra G, Enjalbal C.

Org Biomol Chem. 2016 Sep 14;14(34):8101-8. doi: 10.1039/c6ob01450j. Epub 2016 Aug 10.

PMID:
27506250
16.

Responses of bovine early embryos to S-adenosyl methionine supplementation in culture.

Shojaei Saadi HA, Gagné D, Fournier É, Baldoceda Baldeon LM, Sirard MA, Robert C.

Epigenomics. 2016 Aug;8(8):1039-60. doi: 10.2217/epi-2016-0022. Epub 2016 Jul 15.

PMID:
27419740
17.

Body image, aging, and identity in women over 50: The Gender and Body Image (GABI) study.

Hofmeier SM, Runfola CD, Sala M, Gagne DA, Brownley KA, Bulik CM.

J Women Aging. 2017 Jan-Feb;29(1):3-14. doi: 10.1080/08952841.2015.1065140. Epub 2016 Jul 11.

18.

Ligand Binding Enhances Millisecond Conformational Exchange in Xylanase B2 from Streptomyces lividans.

Gagné D, Narayanan C, Nguyen-Thi N, Roux LD, Bernard DN, Brunzelle JS, Couture JF, Agarwal PK, Doucet N.

Biochemistry. 2016 Aug 2;55(30):4184-96. doi: 10.1021/acs.biochem.6b00130. Epub 2016 Jul 21.

19.
20.

New ligands of the ghrelin receptor based on the 1,2,4-triazole scaffold by introduction of a second chiral center.

Maingot M, Blayo AL, Denoyelle S, M'Kadmi C, Damian M, Mary S, Gagne D, Sanchez P, Aicher B, Schmidt P, Müller G, Teifel M, Günther E, Marie J, Banères JL, Martinez J, Fehrentz JA.

Bioorg Med Chem Lett. 2016 May 15;26(10):2408-2412. doi: 10.1016/j.bmcl.2016.04.003. Epub 2016 Apr 4.

PMID:
27072910
21.

The novel nonapeptide acein targets angiotensin converting enzyme in the brain and induces dopamine release.

Neasta J, Valmalle C, Coyne AC, Carnazzi E, Subra G, Galleyrand JC, Gagne D, M'Kadmi C, Bernad N, Bergé G, Cantel S, Marin P, Marie J, Banères JL, Kemel ML, Daugé V, Puget K, Martinez J.

Br J Pharmacol. 2016 Apr;173(8):1314-28. doi: 10.1111/bph.13424. Epub 2016 Mar 8.

22.

Breed-specific factors influence embryonic lipid composition: comparison between Jersey and Holstein.

Baldoceda L, Gilbert I, Gagné D, Vigneault C, Blondin P, Ferreira CR, Robert C.

Reprod Fertil Dev. 2015 Jan 15. doi: 10.1071/RD14211. [Epub ahead of print]

23.

Perturbation of the Conformational Dynamics of an Active-Site Loop Alters Enzyme Activity.

Gagné D, French RL, Narayanan C, Simonović M, Agarwal PK, Doucet N.

Structure. 2015 Dec 1;23(12):2256-2266. doi: 10.1016/j.str.2015.10.011. Epub 2015 Nov 19.

24.

Cumulus Cell Transcripts Transit to the Bovine Oocyte in Preparation for Maturation.

Macaulay AD, Gilbert I, Scantland S, Fournier E, Ashkar F, Bastien A, Saadi HA, Gagné D, Sirard MA, Khandjian ÉW, Richard FJ, Hyttel P, Robert C.

Biol Reprod. 2016 Jan;94(1):16. doi: 10.1095/biolreprod.114.127571. Epub 2015 Nov 19.

25.

The human decapping scavenger enzyme DcpS modulates microRNA turnover.

Meziane O, Piquet S, Bossé GD, Gagné D, Paquet E, Robert C, Tones MA, Simard MJ.

Sci Rep. 2015 Nov 20;5:16688. doi: 10.1038/srep16688.

26.

Design of a peptidic inhibitor that targets the dimer interface of a prototypic galectin.

Vladoiu MC, Labrie M, Létourneau M, Egesborg P, Gagné D, Billard É, Grosset AA, Doucet N, Chatenet D, St-Pierre Y.

Oncotarget. 2015 Dec 1;6(38):40970-80. doi: 10.18632/oncotarget.5403.

27.

Genome-Wide DNA Methylation Patterns of Bovine Blastocysts Developed In Vivo from Embryos Completed Different Stages of Development In Vitro.

Salilew-Wondim D, Fournier E, Hoelker M, Saeed-Zidane M, Tholen E, Looft C, Neuhoff C, Besenfelder U, Havlicek V, Rings F, Gagné D, Sirard MA, Robert C, Shojaei Saadi HA, Gad A, Schellander K, Tesfaye D.

PLoS One. 2015 Nov 4;10(11):e0140467. doi: 10.1371/journal.pone.0140467. eCollection 2015.

28.

15N, 13C and 1H backbone resonance assignments of an artificially engineered TEM-1/PSE-4 class A β-lactamase chimera and its deconvoluted mutant.

Gobeil SM, Gagné D, Doucet N, Pelletier JN.

Biomol NMR Assign. 2016 Apr;10(1):93-9. doi: 10.1007/s12104-015-9645-8. Epub 2015 Sep 19.

29.

Agonism, Antagonism, and Inverse Agonism Bias at the Ghrelin Receptor Signaling.

M'Kadmi C, Leyris JP, Onfroy L, Galés C, Saulière A, Gagne D, Damian M, Mary S, Maingot M, Denoyelle S, Verdié P, Fehrentz JA, Martinez J, Banères JL, Marie J.

J Biol Chem. 2015 Nov 6;290(45):27021-39. doi: 10.1074/jbc.M115.659250. Epub 2015 Sep 11.

30.

Education, progressive muscle relaxation therapy, and exercise for the treatment of night eating syndrome. A pilot study.

Vander Wal JS, Maraldo TM, Vercellone AC, Gagne DA.

Appetite. 2015 Jun;89:136-44. doi: 10.1016/j.appet.2015.01.024. Epub 2015 Feb 4.

PMID:
25660340
31.

Ghrelin receptor conformational dynamics regulate the transition from a preassembled to an active receptor:Gq complex.

Damian M, Mary S, Maingot M, M'Kadmi C, Gagne D, Leyris JP, Denoyelle S, Gaibelet G, Gavara L, Garcia de Souza Costa M, Perahia D, Trinquet E, Mouillac B, Galandrin S, Galès C, Fehrentz JA, Floquet N, Martinez J, Marie J, Banères JL.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1601-6. doi: 10.1073/pnas.1414618112. Epub 2015 Jan 20.

32.

Genetic influence on the reduction in bovine embryo lipid content by l-carnitine.

Baldoceda L, Gagné D, Ferreira CR, Robert C.

Reprod Fertil Dev. 2015 Jan 9. doi: 10.1071/RD14215. [Epub ahead of print]

33.

Exploring the function of long non-coding RNA in the development of bovine early embryos.

Caballero J, Gilbert I, Fournier E, Gagné D, Scantland S, Macaulay A, Robert C.

Reprod Fertil Dev. 2014 Dec;27(1):40-52. doi: 10.1071/RD14338.

PMID:
25472043
34.

Network of long-range concerted chemical shift displacements upon ligand binding to human angiogenin.

Gagné D, Narayanan C, Doucet N.

Protein Sci. 2015 Apr;24(4):525-33. doi: 10.1002/pro.2613. Epub 2014 Dec 26.

35.

New trisubstituted 1,2,4-triazoles as ghrelin receptor antagonists.

Blayo AL, Maingot M, Aicher B, M'Kadmi C, Schmidt P, Müller G, Teifel M, Günther E, Gagne D, Denoyelle S, Martinez J, Fehrentz JA.

Bioorg Med Chem Lett. 2015 Jan 1;25(1):20-4. doi: 10.1016/j.bmcl.2014.11.031. Epub 2014 Nov 15.

PMID:
25435152
36.

Cytosolic galectin-7 impairs p53 functions and induces chemoresistance in breast cancer cells.

Grosset AA, Labrie M, Gagné D, Vladoiu MC, Gaboury L, Doucet N, St-Pierre Y.

BMC Cancer. 2014 Nov 3;14:801. doi: 10.1186/1471-2407-14-801.

37.

Impact of whole-genome amplification on the reliability of pre-transfer cattle embryo breeding value estimates.

Shojaei Saadi HA, Vigneault C, Sargolzaei M, Gagné D, Fournier É, de Montera B, Chesnais J, Blondin P, Robert C.

BMC Genomics. 2014 Oct 12;15:889. doi: 10.1186/1471-2164-15-889.

38.

Maintenance of native-like protein dynamics may not be required for engineering functional proteins.

Gobeil SMC, Clouthier CM, Park J, Gagné D, Berghuis AM, Doucet N, Pelletier JN.

Chem Biol. 2014 Oct 23;21(10):1330-1340. doi: 10.1016/j.chembiol.2014.07.016. Epub 2014 Sep 4.

39.

Improvement of bovine in vitro embryo production by vitamin K₂ supplementation.

Baldoceda-Baldeon LM, Gagné D, Vigneault C, Blondin P, Robert C.

Reproduction. 2014 Nov;148(5):489-97. doi: 10.1530/REP-14-0324. Epub 2014 Aug 26.

PMID:
25161289
40.

Sexual dimorphism in developmental programming of the bovine preimplantation embryo caused by colony-stimulating factor 2.

Dobbs KB, Gagné D, Fournier E, Dufort I, Robert C, Block J, Sirard MA, Bonilla L, Ealy AD, Loureiro B, Hansen PJ.

Biol Reprod. 2014 Sep;91(3):80. doi: 10.1095/biolreprod.114.121087. Epub 2014 Jul 30.

PMID:
25078682
41.

Sequence-specific backbone (1)H, (13)C, and (15)N resonance assignments of human ribonuclease 4.

Gagné D, Doucet N.

Biomol NMR Assign. 2015 Apr;9(1):181-5. doi: 10.1007/s12104-014-9570-2. Epub 2014 Jul 17.

42.

Histologic characterization of acellular dermal matrices in a porcine model of tissue expander breast reconstruction.

Carruthers CA, Dearth CL, Reing JE, Kramer CR, Gagne DH, Crapo PM, Garcia O Jr, Badhwar A, Scott JR, Badylak SF.

Tissue Eng Part A. 2015 Jan;21(1-2):35-44. doi: 10.1089/ten.TEA.2014.0095. Epub 2014 Sep 29.

43.

An integrated platform for bovine DNA methylome analysis suitable for small samples.

Shojaei Saadi HA, O'Doherty AM, Gagné D, Fournier É, Grant JR, Sirard MA, Robert C.

BMC Genomics. 2014 Jun 9;15:451. doi: 10.1186/1471-2164-15-451.

44.

Usual dietary fatty acid intakes and red-blood-cell membrane fatty acid composition in Inuit children attending child-care centres in Nunavik, northern Québec, Canada.

Blanchet R, Lauzière J, Gagné D, Vézina C, Ayotte P, O'Brien HT.

Public Health Nutr. 2014 Dec;17(12):2844-52. doi: 10.1017/S1368980013003182. Epub 2013 Dec 3.

PMID:
24476681
45.

Effect of dietary calcium intake on lead exposure in Inuit children attending childcare centres in Nunavik.

Turgeon O'Brien H, Gagné D, Vaissière E, Blanchet R, Lauzière J, Vézina C, Ayotte P.

Int J Environ Health Res. 2014;24(5):482-95. doi: 10.1080/09603123.2013.865714. Epub 2014 Jan 2.

PMID:
24382151
46.

Enhancing understanding and improving prediction of severe weather through spatiotemporal relational learning.

McGovern A, Gagne DJ 2nd, Williams JK, Brown RA, Basara JB.

Mach Learn. 2014;95(1):27-50. Epub 2013 Apr 13.

47.

Characteristics of women with body size satisfaction at midlife: results of the Gender and Body Image (GABI) Study.

Runfola CD, Von Holle A, Peat CM, Gagne DA, Brownley KA, Hofmeier SM, Bulik CM.

J Women Aging. 2013;25(4):287-304. doi: 10.1080/08952841.2013.816215.

48.

Combined methylation mapping of 5mC and 5hmC during early embryonic stages in bovine.

de Montera B, Fournier E, Shojaei Saadi HA, Gagné D, Laflamme I, Blondin P, Sirard MA, Robert C.

BMC Genomics. 2013 Jun 18;14:406. doi: 10.1186/1471-2164-14-406.

49.

Structural and functional importance of local and global conformational fluctuations in the RNase A superfamily.

Gagné D, Doucet N.

FEBS J. 2013 Nov;280(22):5596-607. doi: 10.1111/febs.12371. Epub 2013 Jun 24. Review.

50.

Evaluation of ECHO PS Positioning System in a Porcine Model of Simulated Laparoscopic Ventral Hernia Repair.

Hanna EM, Voeller GR, Roth JS, Scott JR, Gagne DH, Iannitti DA.

ISRN Surg. 2013 May 23;2013:862549. doi: 10.1155/2013/862549. Print 2013.

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