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Items: 1 to 50 of 79

1.

Effector TH17 Cells Give Rise to Long-Lived TRM Cells that Are Essential for an Immediate Response against Bacterial Infection.

Amezcua Vesely MC, Pallis P, Bielecki P, Low JS, Zhao J, Harman CCD, Kroehling L, Jackson R, Bailis W, Licona-Limón P, Xu H, Iijima N, Pillai PS, Kaplan DH, Weaver CT, Kluger Y, Kowalczyk MS, Iwasaki A, Pereira JP, Esplugues E, Gagliani N, Flavell RA.

Cell. 2019 Aug 22;178(5):1176-1188.e15. doi: 10.1016/j.cell.2019.07.032.

PMID:
31442406
2.

Conserved transcriptomic profile between mouse and human colitis allows unsupervised patient stratification.

Czarnewski P, Parigi SM, Sorini C, Diaz OE, Das S, Gagliani N, Villablanca EJ.

Nat Commun. 2019 Jun 28;10(1):2892. doi: 10.1038/s41467-019-10769-x.

3.

Role of IL-10 Receptor Signaling in the Function of CD4+ T-Regulatory Type 1 cells: T-Cell Therapy in Patients with Inflammatory Bowel Disease.

Soukou S, Brockmann L, Bedke T, Gagliani N, Flavell RA, Huber S.

Crit Rev Immunol. 2018;38(5):415-431. doi: 10.1615/CritRevImmunol.2018026850.

PMID:
30806217
4.

Human Fetal TNF-α-Cytokine-Producing CD4+ Effector Memory T Cells Promote Intestinal Development and Mediate Inflammation Early in Life.

Schreurs RRCE, Baumdick ME, Sagebiel AF, Kaufmann M, Mokry M, Klarenbeek PL, Schaltenberg N, Steinert FL, van Rijn JM, Drewniak A, The SML, Bakx R, Derikx JPM, de Vries N, Corpeleijn WE, Pals ST, Gagliani N, Friese MA, Middendorp S, Nieuwenhuis EES, Reinshagen K, Geijtenbeek TBH, van Goudoever JB, Bunders MJ.

Immunity. 2019 Feb 19;50(2):462-476.e8. doi: 10.1016/j.immuni.2018.12.010. Epub 2019 Feb 12.

PMID:
30770246
5.

Dietary Habits and Intestinal Immunity: From Food Intake to CD4+ T H Cells.

Siracusa F, Schaltenberg N, Villablanca EJ, Huber S, Gagliani N.

Front Immunol. 2019 Jan 15;9:3177. doi: 10.3389/fimmu.2018.03177. eCollection 2018. Review.

6.

Molecular and functional heterogeneity of IL-10-producing CD4+ T cells.

Brockmann L, Soukou S, Steglich B, Czarnewski P, Zhao L, Wende S, Bedke T, Ergen C, Manthey C, Agalioti T, Geffken M, Seiz O, Parigi SM, Sorini C, Geginat J, Fujio K, Jacobs T, Roesch T, Izbicki JR, Lohse AW, Flavell RA, Krebs C, Gustafsson JA, Antonson P, Roncarolo MG, Villablanca EJ, Gagliani N, Huber S.

Nat Commun. 2018 Dec 21;9(1):5457. doi: 10.1038/s41467-018-07581-4.

7.

The Biology of T Regulatory Type 1 Cells and Their Therapeutic Application in Immune-Mediated Diseases.

Roncarolo MG, Gregori S, Bacchetta R, Battaglia M, Gagliani N.

Immunity. 2018 Dec 18;49(6):1004-1019. doi: 10.1016/j.immuni.2018.12.001. Review.

PMID:
30566879
8.

Commensal Bacteria-Specific CD4+ T Cell Responses in Health and Disease.

Sorini C, Cardoso RF, Gagliani N, Villablanca EJ.

Front Immunol. 2018 Nov 20;9:2667. doi: 10.3389/fimmu.2018.02667. eCollection 2018. Review.

9.

Author Correction: Differential expression pattern of co-inhibitory molecules on CD4+ T cells in uncomplicated versus complicated malaria.

Abel A, Steeg C, Aminkiah F, Addai-Mensah O, Addo M, Gagliani N, Casar C, Yar DD, Owusu-Dabo E, Jacobs T, Mackroth MS.

Sci Rep. 2018 Nov 29;8(1):17587. doi: 10.1038/s41598-018-36410-3.

10.

Colitis Promotes a Pathological Condition of the Liver in the Absence of Foxp3+ Regulatory T Cells.

Mathies F, Steffens N, Kleinschmidt D, Stuhlmann F, Huber FJ, Roy U, Meyer T, Luetgehetmann M, von Petersdorff M, Seiz O, Herkel J, Schramm C, Flavell RA, Gagliani N, Krebs C, Panzer U, Abdullah Z, Strowig T, Bedke T, Huber S.

J Immunol. 2018 Dec 15;201(12):3558-3568. doi: 10.4049/jimmunol.1800711. Epub 2018 Nov 16.

PMID:
30446566
11.

Loss of complex O-glycosylation impairs exocrine pancreatic function and induces MODY8-like diabetes in mice.

Wolters-Eisfeld G, Mercanoglu B, Hofmann BT, Wolpers T, Schnabel C, Harder S, Steffen P, Bachmann K, Steglich B, Schrader J, Gagliani N, Schlüter H, Güngör C, Izbicki JR, Wagener C, Bockhorn M.

Exp Mol Med. 2018 Oct 10;50(10):133. doi: 10.1038/s12276-018-0157-3.

12.

Differential expression pattern of co-inhibitory molecules on CD4+ T cells in uncomplicated versus complicated malaria.

Abel A, Steeg C, Aminkiah F, Addai-Mensah O, Addo M, Gagliani N, Casar C, Yar DD, Owusu-Dabo E, Jacobs T, Mackroth MS.

Sci Rep. 2018 Mar 19;8(1):4789. doi: 10.1038/s41598-018-22659-1. Erratum in: Sci Rep. 2018 Nov 29;8(1):17587.

13.

TH17 cell plasticity: The role of dendritic cells and molecular mechanisms.

Agalioti T, Villablanca EJ, Huber S, Gagliani N.

J Autoimmun. 2018 Feb;87:50-60. doi: 10.1016/j.jaut.2017.12.003. Epub 2018 Jan 19. Review.

14.

Intestinal IFN-γ-producing type 1 regulatory T cells coexpress CCR5 and programmed cell death protein 1 and downregulate IL-10 in the inflamed guts of patients with inflammatory bowel disease.

Alfen JS, Larghi P, Facciotti F, Gagliani N, Bosotti R, Paroni M, Maglie S, Gruarin P, Vasco CM, Ranzani V, Frusteri C, Iseppon A, Moro M, Crosti MC, Gatti S, Pagani M, Caprioli F, Abrignani S, Flavell RA, Geginat J.

J Allergy Clin Immunol. 2018 Nov;142(5):1537-1547.e8. doi: 10.1016/j.jaci.2017.12.984. Epub 2018 Jan 31.

15.

Recipe for IBD: can we use food to control inflammatory bowel disease?

Witkowski M, Witkowski M, Gagliani N, Huber S.

Semin Immunopathol. 2018 Feb;40(2):145-156. doi: 10.1007/s00281-017-0658-5. Epub 2017 Nov 9. Review.

16.

TH17 Cell and Epithelial Cell Crosstalk during Inflammatory Bowel Disease and Carcinogenesis.

Kempski J, Brockmann L, Gagliani N, Huber S.

Front Immunol. 2017 Oct 25;8:1373. doi: 10.3389/fimmu.2017.01373. eCollection 2017. Review.

17.

A Protective Function of IL-22BP in Ischemia Reperfusion and Acetaminophen-Induced Liver Injury.

Kleinschmidt D, Giannou AD, McGee HM, Kempski J, Steglich B, Huber FJ, Ernst TM, Shiri AM, Wegscheid C, Tasika E, Hübener P, Huber P, Bedke T, Steffens N, Agalioti T, Fuchs T, Noll J, Lotter H, Tiegs G, Lohse AW, Axelrod JH, Galun E, Flavell RA, Gagliani N, Huber S.

J Immunol. 2017 Dec 15;199(12):4078-4090. doi: 10.4049/jimmunol.1700587. Epub 2017 Nov 6.

18.

Intestinal type 1 regulatory T cells migrate to periphery to suppress diabetogenic T cells and prevent diabetes development.

Yu H, Gagliani N, Ishigame H, Huber S, Zhu S, Esplugues E, Herold KC, Wen L, Flavell RA.

Proc Natl Acad Sci U S A. 2017 Sep 26;114(39):10443-10448. doi: 10.1073/pnas.1705599114. Epub 2017 Sep 11.

19.

Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells.

Bosurgi L, Cao YG, Cabeza-Cabrerizo M, Tucci A, Hughes LD, Kong Y, Weinstein JS, Licona-Limon P, Schmid ET, Pelorosso F, Gagliani N, Craft JE, Flavell RA, Ghosh S, Rothlin CV.

Science. 2017 Jun 9;356(6342):1072-1076. doi: 10.1126/science.aai8132. Epub 2017 May 11.

20.

Regulation of TH17 Cells and Associated Cytokines in Wound Healing, Tissue Regeneration, and Carcinogenesis.

Brockmann L, Giannou AD, Gagliani N, Huber S.

Int J Mol Sci. 2017 May 11;18(5). pii: E1033. doi: 10.3390/ijms18051033. Review.

21.

CD4+ T Helper Cell Plasticity in Infection, Inflammation, and Autoimmunity.

Huber S, Gagliani N, O'Connor W Jr, Geginat J, Caprioli F.

Mediators Inflamm. 2017;2017:7083153. doi: 10.1155/2017/7083153. Epub 2017 Jan 29. No abstract available.

22.

IL-10 Receptor Signaling Is Essential for TR1 Cell Function In Vivo.

Brockmann L, Gagliani N, Steglich B, Giannou AD, Kempski J, Pelczar P, Geffken M, Mfarrej B, Huber F, Herkel J, Wan YY, Esplugues E, Battaglia M, Krebs CF, Flavell RA, Huber S.

J Immunol. 2017 Feb 1;198(3):1130-1141. doi: 10.4049/jimmunol.1601045. Epub 2016 Dec 21.

23.

HRG/HER2/HER3 signaling promotes AhR-mediated Memo-1 expression and migration in colorectal cancer.

Bogoevska V, Wolters-Eisfeld G, Hofmann BT, El Gammal AT, Mercanoglu B, Gebauer F, Vashist YK, Bogoevski D, Perez D, Gagliani N, Izbicki JR, Bockhorn M, Güngör C.

Oncogene. 2017 Apr 27;36(17):2394-2404. doi: 10.1038/onc.2016.390. Epub 2016 Dec 12.

PMID:
27941874
24.

Autoimmune Renal Disease Is Exacerbated by S1P-Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney.

Krebs CF, Paust HJ, Krohn S, Koyro T, Brix SR, Riedel JH, Bartsch P, Wiech T, Meyer-Schwesinger C, Huang J, Fischer N, Busch P, Mittrücker HW, Steinhoff U, Stockinger B, Perez LG, Wenzel UO, Janneck M, Steinmetz OM, Gagliani N, Stahl RAK, Huber S, Turner JE, Panzer U.

Immunity. 2016 Nov 15;45(5):1078-1092. doi: 10.1016/j.immuni.2016.10.020.

25.

A pathogenic role for T cell-derived IL-22BP in inflammatory bowel disease.

Pelczar P, Witkowski M, Perez LG, Kempski J, Hammel AG, Brockmann L, Kleinschmidt D, Wende S, Haueis C, Bedke T, Witkowski M, Krasemann S, Steurer S, Booth CJ, Busch P, König A, Rauch U, Benten D, Izbicki JR, Rösch T, Lohse AW, Strowig T, Gagliani N, Flavell RA, Huber S.

Science. 2016 Oct 21;354(6310):358-362.

PMID:
27846573
26.

Basic Aspects of T Helper Cell Differentiation.

Gagliani N, Huber S.

Methods Mol Biol. 2017;1514:19-30. Review.

PMID:
27787789
27.

The light and the dark sides of Interleukin-10 in immune-mediated diseases and cancer.

Geginat J, Larghi P, Paroni M, Nizzoli G, Penatti A, Pagani M, Gagliani N, Meroni P, Abrignani S, Flavell RA.

Cytokine Growth Factor Rev. 2016 Aug;30:87-93. doi: 10.1016/j.cytogfr.2016.02.003. Epub 2016 Mar 8. Review.

PMID:
26980675
28.

Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis.

Nowarski R, Jackson R, Gagliani N, de Zoete MR, Palm NW, Bailis W, Low JS, Harman CC, Graham M, Elinav E, Flavell RA.

Cell. 2015 Dec 3;163(6):1444-56. doi: 10.1016/j.cell.2015.10.072.

29.

Immune Depletion in Combination with Allogeneic Islets Permanently Restores Tolerance to Self-Antigens in Diabetic NOD Mice.

Gagliani N, Jofra T, Posgai AL, Atkinson MA, Battaglia M.

PLoS One. 2015 Nov 18;10(11):e0142318. doi: 10.1371/journal.pone.0142318. eCollection 2015.

30.

All in (IL-) 1?

Gagliani N, Battaglia M.

Transplantation. 2015 Nov;99(11):2235-6. doi: 10.1097/TP.0000000000000966. No abstract available.

PMID:
26492049
31.

IL-10-producing forkhead box protein 3-negative regulatory T cells inhibit B-cell responses and are involved in systemic lupus erythematosus.

Facciotti F, Gagliani N, Häringer B, Alfen JS, Penatti A, Maglie S, Paroni M, Iseppon A, Moro M, Crosti MC, Stölzel K, Romagnani C, Moroni G, Ingegnoli F, Torretta S, Pignataro L, Annoni A, Russo F, Pagani M, Abrignani S, Meroni P, Flavell R, Geginat J.

J Allergy Clin Immunol. 2016 Jan;137(1):318-321.e5. doi: 10.1016/j.jaci.2015.06.044. Epub 2015 Aug 25. No abstract available.

PMID:
26318071
32.

MiR-125a targets effector programs to stabilize Treg-mediated immune homeostasis.

Pan W, Zhu S, Dai D, Liu Z, Li D, Li B, Gagliani N, Zheng Y, Tang Y, Weirauch MT, Chen X, Zhu W, Wang Y, Chen B, Qian Y, Chen Y, Fang J, Herbst R, Richman L, Jallal B, Harley JB, Flavell RA, Yao Y, Shen N.

Nat Commun. 2015 May 12;6:7096. doi: 10.1038/ncomms8096.

PMID:
25963922
33.

Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation.

Gagliani N, Amezcua Vesely MC, Iseppon A, Brockmann L, Xu H, Palm NW, de Zoete MR, Licona-Limón P, Paiva RS, Ching T, Weaver C, Zi X, Pan X, Fan R, Garmire LX, Cotton MJ, Drier Y, Bernstein B, Geginat J, Stockinger B, Esplugues E, Huber S, Flavell RA.

Nature. 2015 Jul 9;523(7559):221-5. doi: 10.1038/nature14452. Epub 2015 Apr 29.

34.

Lack of the protein tyrosine phosphatase PTPN22 strengthens transplant tolerance to pancreatic islets in mice.

Fousteri G, Jofra T, Di Fonte R, Gagliani N, Morsiani C, Stabilini A, Battaglia M.

Diabetologia. 2015 Jun;58(6):1319-28. doi: 10.1007/s00125-015-3540-9. Epub 2015 Mar 7.

PMID:
25748328
35.

Heterogeneous CD3 expression levels in differing T cell subsets correlate with the in vivo anti-CD3-mediated T cell modulation.

Valle A, Barbagiovanni G, Jofra T, Stabilini A, Perol L, Baeyens A, Anand S, Cagnard N, Gagliani N, Piaggio E, Battaglia M.

J Immunol. 2015 Mar 1;194(5):2117-27. doi: 10.4049/jimmunol.1401551. Epub 2015 Feb 2.

36.

FLUshing in the bathroom.

Amezcua C, Gagliani N, Flavell R.

J Exp Med. 2014 Nov 17;211(12):2328-9. doi: 10.1084/jem.21112insight4. No abstract available.

37.

Inflammasomes and intestinal homeostasis: regulating and connecting infection, inflammation and the microbiota.

Gagliani N, Palm NW, de Zoete MR, Flavell RA.

Int Immunol. 2014 Sep;26(9):495-9. doi: 10.1093/intimm/dxu066. Epub 2014 Jun 19. Review.

38.

The fire within: microbes inflame tumors.

Gagliani N, Hu B, Huber S, Elinav E, Flavell RA.

Cell. 2014 May 8;157(4):776-83. doi: 10.1016/j.cell.2014.03.006. Review.

39.

Innate immune cells in inflammation and cancer.

Nowarski R, Gagliani N, Huber S, Flavell RA.

Cancer Immunol Res. 2013 Aug;1(2):77-84. doi: 10.1158/2326-6066.CIR-13-0081. Review.

40.

Th9 Cells Drive Host Immunity against Gastrointestinal Worm Infection.

Licona-Limón P, Henao-Mejia J, Temann AU, Gagliani N, Licona-Limón I, Ishigame H, Hao L, Herbert DR, Flavell RA.

Immunity. 2013 Oct 17;39(4):744-57. doi: 10.1016/j.immuni.2013.07.020.

41.

Paradoxical role of the proto-oncogene Axl and Mer receptor tyrosine kinases in colon cancer.

Bosurgi L, Bernink JH, Delgado Cuevas V, Gagliani N, Joannas L, Schmid ET, Booth CJ, Ghosh S, Rothlin CV.

Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):13091-6. doi: 10.1073/pnas.1302507110. Epub 2013 Jul 22.

42.

T cell-derived protein S engages TAM receptor signaling in dendritic cells to control the magnitude of the immune response.

Carrera Silva EA, Chan PY, Joannas L, Errasti AE, Gagliani N, Bosurgi L, Jabbour M, Perry A, Smith-Chakmakova F, Mucida D, Cheroutre H, Burstyn-Cohen T, Leighton JA, Lemke G, Ghosh S, Rothlin CV.

Immunity. 2013 Jul 25;39(1):160-70. doi: 10.1016/j.immuni.2013.06.010. Epub 2013 Jul 11.

43.

Transplant tolerance to pancreatic islets is initiated in the graft and sustained in the spleen.

Gagliani N, Jofra T, Valle A, Stabilini A, Morsiani C, Gregori S, Deng S, Rothstein DM, Atkinson M, Kamanaka M, Flavell RA, Roncarolo MG, Battaglia M.

Am J Transplant. 2013 Aug;13(8):1963-75. doi: 10.1111/ajt.12333. Epub 2013 Jul 8.

44.

Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells.

Gagliani N, Magnani CF, Huber S, Gianolini ME, Pala M, Licona-Limon P, Guo B, Herbert DR, Bulfone A, Trentini F, Di Serio C, Bacchetta R, Andreani M, Brockmann L, Gregori S, Flavell RA, Roncarolo MG.

Nat Med. 2013 Jun;19(6):739-46. doi: 10.1038/nm.3179. Epub 2013 Apr 28. Erratum in: Nat Med. 2014 Oct;20(10):1217.

PMID:
23624599
45.

IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine.

Huber S, Gagliani N, Zenewicz LA, Huber FJ, Bosurgi L, Hu B, Hedl M, Zhang W, O'Connor W Jr, Murphy AJ, Valenzuela DM, Yancopoulos GD, Booth CJ, Cho JH, Ouyang W, Abraham C, Flavell RA.

Nature. 2012 Nov 8;491(7423):259-63. doi: 10.1038/nature11535. Epub 2012 Oct 17.

46.

MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice.

Hoshi N, Schenten D, Nish SA, Walther Z, Gagliani N, Flavell RA, Reizis B, Shen Z, Fox JG, Iwasaki A, Medzhitov R.

Nat Commun. 2012;3:1120. doi: 10.1038/ncomms2113.

47.

Life, death, and miracles: Th17 cells in the intestine.

Huber S, Gagliani N, Flavell RA.

Eur J Immunol. 2012 Sep;42(9):2238-45. doi: 10.1002/eji.201242619. Review.

48.

Alterations in the adenosine metabolism and CD39/CD73 adenosinergic machinery cause loss of Treg cell function and autoimmunity in ADA-deficient SCID.

Sauer AV, Brigida I, Carriglio N, Hernandez RJ, Scaramuzza S, Clavenna D, Sanvito F, Poliani PL, Gagliani N, Carlucci F, Tabucchi A, Roncarolo MG, Traggiai E, Villa A, Aiuti A.

Blood. 2012 Feb 9;119(6):1428-39. doi: 10.1182/blood-2011-07-366781. Epub 2011 Dec 19.

49.

The Intestine: where amazing things happen.

Gagliani N, Huber S, Flavell RA.

Cell Res. 2012 Feb;22(2):277-9. doi: 10.1038/cr.2011.204. Epub 2011 Dec 20. No abstract available.

50.

Rapamycin combined with anti-CD45RB mAb and IL-10 or with G-CSF induces tolerance in a stringent mouse model of islet transplantation.

Gagliani N, Gregori S, Jofra T, Valle A, Stabilini A, Rothstein DM, Atkinson M, Roncarolo MG, Battaglia M.

PLoS One. 2011;6(12):e28434. doi: 10.1371/journal.pone.0028434. Epub 2011 Dec 9.

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