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Items: 1 to 50 of 64

1.

Generation and testing of clinical-grade exosomes for pancreatic cancer.

Mendt M, Kamerkar S, Sugimoto H, McAndrews KM, Wu CC, Gagea M, Yang S, Blanko EVR, Peng Q, Ma X, Marszalek JR, Maitra A, Yee C, Rezvani K, Shpall E, LeBleu VS, Kalluri R.

JCI Insight. 2018 Apr 19;3(8). pii: 99263. doi: 10.1172/jci.insight.99263. [Epub ahead of print]

2.

Cancer-associated rs6983267 SNP and its accompanying long noncoding RNA CCAT2 induce myeloid malignancies via unique SNP-specific RNA mutations.

Shah MY, Ferracin M, Pileczki V, Chen B, Redis R, Fabris L, Zhang X, Ivan C, Shimizu M, Rodriguez-Aguayo C, Dragomir M, Van Roosbroeck K, Almeida MI, Ciccone M, Nedelcu D, Cortez MA, Manshouri T, Calin S, Muftuoglu M, Banerjee PP, Badiwi MH, Parker-Thornburg J, Multani A, Welsh JW, Estecio MR, Ling H, Tomuleasa C, Dima D, Yang H, Alvarez H, You MJ, Radovich M, Shpall E, Fabbri M, Rezvani K, Girnita L, Berindan-Neagoe I, Maitra A, Verstovsek S, Fodde R, Bueso-Ramos C, Gagea M, Manero GG, Calin GA.

Genome Res. 2018 Apr;28(4):432-447. doi: 10.1101/gr.225128.117. Epub 2018 Mar 22.

PMID:
29567676
3.

A spontaneous model of spondyloarthropathies that develops bone loss and pathological bone formation: A process regulated by IL27RA-/- and mutant-p53.

Dibra D, Xia X, Gagea M, Lozano G, Li S.

PLoS One. 2018 Mar 1;13(3):e0193485. doi: 10.1371/journal.pone.0193485. eCollection 2018.

4.

MLH1-rheMac hereditary nonpolyposis colorectal cancer syndrome in rhesus macaques.

Brammer DW, Gillespie PJ, Tian M, Young D, Raveendran M, Williams LE, Gagea M, Benavides FJ, Perez CJ, Broaddus RR, Bernacky BJ, Barnhart KF, Alauddin MM, Bhutani MS, Gibbs RA, Sidman RL, Pasqualini R, Arap W, Rogers J, Abee CR, Gelovani JG.

Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):2806-2811. doi: 10.1073/pnas.1722106115. Epub 2018 Feb 28.

5.

Single oral dose acute and subacute toxicity of a c-MET tyrosine kinase inhibitor and CDK 4/6 inhibitor combination drug therapy.

Smith B, Hsu YH, Flores R, Gagea M, Craig S, Hung MC.

Am J Cancer Res. 2018 Jan 1;8(1):183-191. eCollection 2018.

6.

Depletion of S100A4+ stromal cells does not prevent HCC development but reduces the stem cell-like phenotype of the tumors.

Jiao J, González Á, Stevenson HL, Gagea M, Sugimoto H, Kalluri R, Beretta L.

Exp Mol Med. 2018 Jan 5;50(1):e422. doi: 10.1038/emm.2017.175.

7.

YEATS2 links histone acetylation to tumorigenesis of non-small cell lung cancer.

Mi W, Guan H, Lyu J, Zhao D, Xi Y, Jiang S, Andrews FH, Wang X, Gagea M, Wen H, Tora L, Dent SYR, Kutateladze TG, Li W, Li H, Shi X.

Nat Commun. 2017 Oct 20;8(1):1088. doi: 10.1038/s41467-017-01173-4.

8.

Enhanced inflammation and attenuated tumor suppressor pathways are associated with oncogene-induced lung tumors in aged mice.

Parikh N, Shuck RL, Gagea M, Shen L, Donehower LA.

Aging Cell. 2018 Feb;17(1). doi: 10.1111/acel.12691. Epub 2017 Oct 18.

9.

TRPA1-FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p.

Berrout J, Kyriakopoulou E, Moparthi L, Hogea AS, Berrout L, Ivan C, Lorger M, Boyle J, Peers C, Muench S, Gomez JE, Hu X, Hurst C, Hall T, Umamaheswaran S, Wesley L, Gagea M, Shires M, Manfield I, Knowles MA, Davies S, Suhling K, Gonzalez YT, Carragher N, Macleod K, Abbott NJ, Calin GA, Gamper N, Zygmunt PM, Timsah Z.

Nat Commun. 2017 Oct 16;8(1):947. doi: 10.1038/s41467-017-00983-w.

10.

Development of an Electroporation and Nanoparticle-based Therapeutic Platform for Bone Metastases.

Melancon MP, Appleton Figueira T, Fuentes DT, Tian L, Qiao Y, Gu J, Gagea M, Ensor JE, Muñoz NM, Maldonado KL, Dixon K, McWatters A, Mitchell J, McArthur M, Gupta S, Tam AL.

Radiology. 2018 Jan;286(1):149-157. doi: 10.1148/radiol.2017161721. Epub 2017 Aug 21.

PMID:
28825892
11.

Cord blood NK cells engineered to express IL-15 and a CD19-targeted CAR show long-term persistence and potent antitumor activity.

Liu E, Tong Y, Dotti G, Shaim H, Savoldo B, Mukherjee M, Orange J, Wan X, Lu X, Reynolds A, Gagea M, Banerjee P, Cai R, Bdaiwi MH, Basar R, Muftuoglu M, Li L, Marin D, Wierda W, Keating M, Champlin R, Shpall E, Rezvani K.

Leukemia. 2018 Feb;32(2):520-531. doi: 10.1038/leu.2017.226. Epub 2017 Jul 20.

PMID:
28725044
12.

Multifunctional Effects of a Small-Molecule STAT3 Inhibitor on NASH and Hepatocellular Carcinoma in Mice.

Jung KH, Yoo W, Stevenson HL, Deshpande D, Shen H, Gagea M, Yoo SY, Wang J, Eckols TK, Bharadwaj U, Tweardy DJ, Beretta L.

Clin Cancer Res. 2017 Sep 15;23(18):5537-5546. doi: 10.1158/1078-0432.CCR-16-2253. Epub 2017 May 22.

PMID:
28533225
13.

A murine preclinical syngeneic transplantation model for breast cancer precision medicine.

Federico L, Chong Z, Zhang D, McGrail DJ, Zhao W, Jeong KJ, Vellano CP, Ju Z, Gagea M, Liu S, Mitra S, Dennison JB, Lorenzi PL, Cardnell R, Diao L, Wang J, Lu Y, Byers LA, Perou CM, Lin SY, Mills GB.

Sci Adv. 2017 Apr 19;3(4):e1600957. doi: 10.1126/sciadv.1600957. eCollection 2017 Apr.

14.

YAP/TAZ-Mediated Upregulation of GAB2 Leads to Increased Sensitivity to Growth Factor-Induced Activation of the PI3K Pathway.

Wang C, Gu C, Jeong KJ, Zhang D, Guo W, Lu Y, Ju Z, Panupinthu N, Yang JY, Gagea MM, Ng PK, Zhang F, Mills GB.

Cancer Res. 2017 Apr 1;77(7):1637-1648. doi: 10.1158/0008-5472.CAN-15-3084. Epub 2017 Feb 15.

15.

Metastasis regulation by PPARD expression in cancer cells.

Zuo X, Xu W, Xu M, Tian R, Moussalli MJ, Mao F, Zheng X, Wang J, Morris JS, Gagea M, Eng C, Kopetz S, Maru DM, Rashid A, Broaddus R, Wei D, Hung MC, Sood AK, Shureiqi I.

JCI Insight. 2017 Jan 12;2(1):e91419. doi: 10.1172/jci.insight.91419.

16.

Heterogeneous perivascular cell coverage affects breast cancer metastasis and response to chemotherapy.

Kim J, de Sampaio PC, Lundy DM, Peng Q, Evans KW, Sugimoto H, Gagea M, Kienast Y, do Amaral NS, Rocha RM, Eikesdal HP, Lønning PE, Meric-Bernstam F, LeBleu VS.

JCI Insight. 2016 Dec 22;1(21):e90733. doi: 10.1172/jci.insight.90733.

17.

Diaphragmatic Hernia of the Stomach with Gastric Rupture in a Domestic Pig.

Hill LR, Huang SY, Gagea M.

Comp Med. 2016;66(5):399-404.

18.

Aurora kinase-A overexpression in mouse mammary epithelium induces mammary adenocarcinomas harboring genetic alterations shared with human breast cancer.

Treekitkarnmongkol W, Katayama H, Kai K, Sasai K, Jones JC, Wang J, Shen L, Sahin AA, Gagea M, Ueno NT, Creighton CJ, Sen S.

Carcinogenesis. 2016 Dec;37(12):1180-1189. Epub 2016 Sep 13.

19.

NHERF1/EBP50 Suppresses Wnt-β-Catenin Pathway-Driven Intestinal Neoplasia.

Georgescu MM, Gagea M, Cote G.

Neoplasia. 2016 Aug;18(8):512-23. doi: 10.1016/j.neo.2016.07.003.

20.

Native and engineered tropism of vectors derived from a rare species D adenovirus serotype 43.

Belousova N, Mikheeva G, Xiong C, Stagg LJ, Gagea M, Fox PS, Bassett RL, Ladbury JE, Braun MB, Stehle T, Li C, Krasnykh V.

Oncotarget. 2016 Aug 16;7(33):53414-53429. doi: 10.18632/oncotarget.10800.

21.

Irreversible Electroporation in the Epidural Space of the Porcine Spine: Effects on Adjacent Structures.

Tam AL, Figueira TA, Gagea M, Ensor JE, Dixon K, McWatters A, Gupta S, Fuentes DT.

Radiology. 2016 Dec;281(3):763-771. Epub 2016 Jun 7.

22.

Corrigendum to "Interleukin-30 (IL27p28) alleviates experimental sepsis by modulating cytokine profile in NKT cells".

Yan J, Mitra A, Hu J, Cutrera JJ, Xia X, Doetschman T, Gagea M, Mishra L, Li S.

J Hepatol. 2016 May 27. pii: S0168-8278(16)30180-5. doi: 10.1016/j.jhep.2016.04.028. [Epub ahead of print] No abstract available.

PMID:
27241198
23.

Activity of 8F4, a T-cell receptor-like anti-PR1/HLA-A2 antibody, against primary human AML in vivo.

Sergeeva A, He H, Ruisaard K, St John L, Alatrash G, Clise-Dwyer K, Li D, Patenia R, Hong R, Sukhumalchandra P, You MJ, Gagea M, Ma Q, Molldrem JJ.

Leukemia. 2016 Jul;30(7):1475-84. doi: 10.1038/leu.2016.57. Epub 2016 Mar 8.

24.

Lack of Immunomodulatory Interleukin-27 Enhances Oncogenic Properties of Mutant p53 In Vivo.

Dibra D, Mitra A, Newman M, Xia X, Cutrera JJ, Gagea M, Kleinerman ES, Lozano G, Li S.

Clin Cancer Res. 2016 Aug 1;22(15):3876-83. doi: 10.1158/1078-0432.CCR-15-2052. Epub 2016 Mar 15.

25.

KLF4 Is Essential for Induction of Cellular Identity Change and Acinar-to-Ductal Reprogramming during Early Pancreatic Carcinogenesis.

Wei D, Wang L, Yan Y, Jia Z, Gagea M, Li Z, Zuo X, Kong X, Huang S, Xie K.

Cancer Cell. 2016 Mar 14;29(3):324-338. doi: 10.1016/j.ccell.2016.02.005.

26.

An Advanced Histologic Method for Evaluation of Intestinal Adenomas in Mice Using Digital Slides.

Davis JS, Gupta V, Gagea M, Wu X.

PLoS One. 2016 Mar 14;11(3):e0151463. doi: 10.1371/journal.pone.0151463. eCollection 2016.

27.

Correction: Ability to Generate Patient-Derived Breast Cancer Xenografts Is Enhanced in Chemoresistant Disease and Predicts Poor Patient Outcomes.

McAuliffe PF, Evans KW, Akcakanat A, Chen K, Zheng X, Zhao H, Eterovic AK, Sangai T, Holder AM, Sharma C, Chen H, Do KA, Tarco E, Gagea M, Naff KA, Sahin A, Multani AS, Black DM, Mittendorf EA, Bedrosian I, Mills GB, Gonzalez-Angulo AM, Meric-Bernstam F.

PLoS One. 2016 Mar 8;11(3):e0151121. doi: 10.1371/journal.pone.0151121. eCollection 2016. No abstract available.

28.

KLF4-Mediated Suppression of CD44 Signaling Negatively Impacts Pancreatic Cancer Stemness and Metastasis.

Yan Y, Li Z, Kong X, Jia Z, Zuo X, Gagea M, Huang S, Wei D, Xie K.

Cancer Res. 2016 Apr 15;76(8):2419-31. doi: 10.1158/0008-5472.CAN-15-1691. Epub 2016 Feb 15.

29.

A new HIF-1α/RANTES-driven pathway to hepatocellular carcinoma mediated by germline haploinsufficiency of SART1/HAF in mice.

Koh MY, Gagea M, Sargis T, Lemos R Jr, Grandjean G, Charbono A, Bekiaris V, Sedy J, Kiriakova G, Liu X, Roberts LR, Ware C, Powis G.

Hepatology. 2016 May;63(5):1576-91. doi: 10.1002/hep.28468. Epub 2016 Mar 7.

30.

Interleukin-30 (IL27p28) alleviates experimental sepsis by modulating cytokine profile in NKT cells.

Yan J, Mitra A, Hu J, Cutrera JJ, Xia X, Doetschman T, Gagea M, Mishra L, Li S.

J Hepatol. 2016 May;64(5):1128-1136. doi: 10.1016/j.jhep.2015.12.020. Epub 2016 Jan 6.

31.

A Sucrose-Enriched Diet Promotes Tumorigenesis in Mammary Gland in Part through the 12-Lipoxygenase Pathway.

Jiang Y, Pan Y, Rhea PR, Tan L, Gagea M, Cohen L, Fischer SM, Yang P.

Cancer Res. 2016 Jan 1;76(1):24-9. doi: 10.1158/0008-5472.CAN-14-3432.

32.

Expression pattern of FGFR2, Grb2 and Plcγ1 acts as a novel prognostic marker of recurrence recurrence-free survival in lung adenocarcinoma.

Timsah Z, Berrout J, Suraokar M, Behrens C, Song J, Lee JJ, Ivan C, Gagea M, Shires M, Hu X, Vallien C, Kingsley CV, Wistuba I, Ladbury JE.

Am J Cancer Res. 2015 Sep 15;5(10):3135-48. eCollection 2015.

33.

Differentiation therapy for hepatocellular carcinoma: Multifaceted effects of miR-148a on tumor growth and phenotype and liver fibrosis.

Jung KH, Zhang J, Zhou C, Shen H, Gagea M, Rodriguez-Aguayo C, Lopez-Berestein G, Sood AK, Beretta L.

Hepatology. 2016 Mar;63(3):864-79. doi: 10.1002/hep.28367. Epub 2016 Jan 14.

34.

Deletion of cyclooxygenase-2 inhibits K-ras-induced lung carcinogenesis.

Pan Y, Jiang Y, Tan L, Ravoori MK, Gagea M, Kundra V, Fischer SM, Yang P.

Oncotarget. 2015 Nov 17;6(36):38816-26. doi: 10.18632/oncotarget.5558.

35.

Ability to Generate Patient-Derived Breast Cancer Xenografts Is Enhanced in Chemoresistant Disease and Predicts Poor Patient Outcomes.

McAuliffe PF, Evans KW, Akcakanat A, Chen K, Zheng X, Zhao H, Eterovic AK, Sangai T, Holder AM, Sharma C, Chen H, Do KA, Tarco E, Gagea M, Naff KA, Sahin A, Multani AS, Black DM, Mittendorf EA, Bedrosian I, Mills GB, Gonzalez-Angulo AM, Meric-Bernstam F.

PLoS One. 2015 Sep 1;10(9):e0136851. doi: 10.1371/journal.pone.0136851. eCollection 2015. Erratum in: PLoS One. 2016;11(3):e0151121.

36.

Corrigendum: Grb2 monomer-dimer equilibrium determines normal versus oncogenic function.

Ahmed Z, Timsah Z, Suen KM, Cook NP, Lee Iv GR, Lin CC, Gagea M, Marti AA, Ladbury JE.

Nat Commun. 2015 Aug 3;6:8007. doi: 10.1038/ncomms9007. No abstract available.

37.

Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer.

Timsah Z, Ahmed Z, Ivan C, Berrout J, Gagea M, Zhou Y, Pena GN, Hu X, Vallien C, Kingsley CV, Lu Y, Hancock JF, Liu J, Gladden AB, Mills GB, Lopez-Berestein G, Hung MC, Sood AK, Bogdanov M, Ladbury JE.

Oncogene. 2016 Apr 28;35(17):2186-96. doi: 10.1038/onc.2015.279. Epub 2015 Jul 27.

38.

Grb2 monomer-dimer equilibrium determines normal versus oncogenic function.

Ahmed Z, Timsah Z, Suen KM, Cook NP, Lee GR 4th, Lin CC, Gagea M, Marti AA, Ladbury JE.

Nat Commun. 2015 Jun 24;6:7354. doi: 10.1038/ncomms8354. Erratum in: Nat Commun. 2015;6:8007.

39.

miR-21 Inhibition Reduces Liver Fibrosis and Prevents Tumor Development by Inducing Apoptosis of CD24+ Progenitor Cells.

Zhang J, Jiao J, Cermelli S, Muir K, Jung KH, Zou R, Rashid A, Gagea M, Zabludoff S, Kalluri R, Beretta L.

Cancer Res. 2015 May 1;75(9):1859-67. doi: 10.1158/0008-5472.CAN-14-1254. Epub 2015 Mar 13.

40.

Functional consequence of the MET-T1010I polymorphism in breast cancer.

Liu S, Meric-Bernstam F, Parinyanitikul N, Wang B, Eterovic AK, Zheng X, Gagea M, Chavez-MacGregor M, Ueno NT, Lei X, Zhou W, Nair L, Tripathy D, Brown PH, Hortobagyi GN, Chen K, Mendelsohn J, Mills GB, Gonzalez-Angulo AM.

Oncotarget. 2015 Feb 20;6(5):2604-14.

41.

Copy number gain of hsa-miR-569 at 3q26.2 leads to loss of TP53INP1 and aggressiveness of epithelial cancers.

Chaluvally-Raghavan P, Zhang F, Pradeep S, Hamilton MP, Zhao X, Rupaimoole R, Moss T, Lu Y, Yu S, Pecot CV, Aure MR, Peuget S, Rodriguez-Aguayo C, Han HD, Zhang D, Venkatanarayan A, Krohn M, Kristensen VN, Gagea M, Ram P, Liu W, Lopez-Berestein G, Lorenzi PL, Børresen-Dale AL, Chin K, Gray J, Dusetti NJ, McGuire SE, Flores ER, Sood AK, Mills GB.

Cancer Cell. 2014 Dec 8;26(6):863-879. doi: 10.1016/j.ccell.2014.10.010.

42.

PBI-05204, a supercritical CO₂ extract of Nerium oleander, inhibits growth of human pancreatic cancer via targeting the PI3K/mTOR pathway.

Pan Y, Rhea P, Tan L, Cartwright C, Lee HJ, Ravoori MK, Addington C, Gagea M, Kundra V, Kim SJ, Newman RA, Yang P.

Invest New Drugs. 2015 Apr;33(2):271-9. doi: 10.1007/s10637-014-0190-6. Epub 2014 Dec 6.

43.

Development and characterization of six new human papillary thyroid carcinoma cell lines.

Henderson YC, Ahn SH, Ryu J, Chen Y, Williams MD, El-Naggar AK, Gagea M, Schweppe RE, Haugen BR, Lai SY, Clayman GL.

J Clin Endocrinol Metab. 2015 Feb;100(2):E243-52. doi: 10.1210/jc.2014-2624. Epub 2014 Nov 26.

44.

Generation of a mouse model of T-cell lymphoma based on chronic LPS challenge and TGF-β signaling disruption.

Muñoz NM, Katz LH, Shina JH, Gi YJ, Menon VK, Gagea M, Rashid A, Chen J, Mishra L.

Genes Cancer. 2014 Sep;5(9-10):348-352.

45.

IL-30 (IL27p28) attenuates liver fibrosis through inducing NKG2D-rae1 interaction between NKT and activated hepatic stellate cells in mice.

Mitra A, Satelli A, Yan J, Xueqing X, Gagea M, Hunter CA, Mishra L, Li S.

Hepatology. 2014 Dec;60(6):2027-39. doi: 10.1002/hep.27392. Epub 2014 Oct 28.

46.

TRIM24 suppresses development of spontaneous hepatic lipid accumulation and hepatocellular carcinoma in mice.

Jiang S, Minter LC, Stratton SA, Yang P, Abbas HA, Akdemir ZC, Pant V, Post S, Gagea M, Lee RG, Lozano G, Barton MC.

J Hepatol. 2015 Feb;62(2):371-9. doi: 10.1016/j.jhep.2014.09.026. Epub 2014 Oct 2.

47.

TRIM24 links glucose metabolism with transformation of human mammary epithelial cells.

Pathiraja TN, Thakkar KN, Jiang S, Stratton S, Liu Z, Gagea M, Shi X, Shah PK, Phan L, Lee MH, Andersen J, Stampfer M, Barton MC.

Oncogene. 2015 May 28;34(22):2836-45. doi: 10.1038/onc.2014.220. Epub 2014 Jul 28.

48.

Targeting tyrosine-kinases and estrogen receptor abrogates resistance to endocrine therapy in breast cancer.

Liu S, Meng X, Chen H, Liu W, Miller T, Murph M, Lu Y, Zhang F, Gagea M, Arteaga CL, Mills GB, Meric-Bernstam F, González-Angulo AM.

Oncotarget. 2014 Oct 15;5(19):9049-64.

49.

Irreversible electroporation of the lumbar vertebrae in a porcine model: is there clinical-pathologic evidence of neural toxicity?

Tam AL, Abdelsalam ME, Gagea M, Ensor JE, Moussa M, Ahmed M, Goldberg SN, Dixon K, McWatters A, Miller JJ, Srimathveeravalli G, Solomon SB, Avritscher R, Wallace MJ, Gupta S.

Radiology. 2014 Sep;272(3):709-19. doi: 10.1148/radiol.14132560. Epub 2014 Apr 25.

PMID:
24766034
50.

Potentiation of colon cancer susceptibility in mice by colonic epithelial PPAR-δ/β overexpression.

Zuo X, Xu M, Yu J, Wu Y, Moussalli MJ, Manyam GC, Lee SI, Liang S, Gagea M, Morris JS, Broaddus RR, Shureiqi I.

J Natl Cancer Inst. 2014 Apr;106(4):dju052. doi: 10.1093/jnci/dju052. Epub 2014 Mar 28.

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