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Items: 1 to 50 of 765

1.

Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease.

Eftekharzadeh B, Daigle JG, Kapinos LE, Coyne A, Schiantarelli J, Carlomagno Y, Cook C, Miller SJ, Dujardin S, Amaral AS, Grima JC, Bennett RE, Tepper K, DeTure M, Vanderburg CR, Corjuc BT, DeVos SL, Gonzalez JA, Chew J, Vidensky S, Gage FH, Mertens J, Troncoso J, Mandelkow E, Salvatella X, Lim RYH, Petrucelli L, Wegmann S, Rothstein JD, Hyman BT.

Neuron. 2019 Jan 16;101(2):349. doi: 10.1016/j.neuron.2018.12.031. No abstract available.

PMID:
30653936
2.

Limits to human neurogenesis-really?

Lucassen PJ, Toni N, Kempermann G, Frisen J, Gage FH, Swaab DF.

Mol Psychiatry. 2019 Jan 7. doi: 10.1038/s41380-018-0337-5. [Epub ahead of print] No abstract available.

PMID:
30617274
3.

Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons.

Schafer ST, Paquola ACM, Stern S, Gosselin D, Ku M, Pena M, Kuret TJM, Liyanage M, Mansour AA, Jaeger BN, Marchetto MC, Glass CK, Mertens J, Gage FH.

Nat Neurosci. 2019 Jan 7. doi: 10.1038/s41593-018-0295-x. [Epub ahead of print]

PMID:
30617258
4.

MITOCHONDRIA, METABOLISM AND REDOX MECHANISMS IN PSYCHIATRIC DISORDERS.

Kim Y, Vadodaria KC, Lenkei Z, Kato T, Gage FH, Marchetto MC, Santos R.

Antioxid Redox Signal. 2018 Dec 26. doi: 10.1089/ars.2018.7606. [Epub ahead of print]

PMID:
30585734
5.

Long-Term Labeling of Hippocampal Neural Stem Cells by a Lentiviral Vector.

Suh H, Zhou QG, Fernandez-Carasa I, Clemenson GD Jr, Pons-Espinal M, Ro EJ, Marti M, Raya A, Gage FH, Consiglio A.

Front Mol Neurosci. 2018 Nov 15;11:415. doi: 10.3389/fnmol.2018.00415. eCollection 2018.

6.

Chronotype and cellular circadian rhythms predict the clinical response to lithium maintenance treatment in patients with bipolar disorder.

McCarthy MJ, Wei H, Nievergelt CM, Stautland A, Maihofer AX, Welsh DK, Shilling P, Alda M, Alliey-Rodriguez N, Anand A, Andreasson OA, Balaraman Y, Berrettini WH, Bertram H, Brennand KJ, Calabrese JR, Calkin CV, Claasen A, Conroy C, Coryell WH, Craig DW, D'Arcangelo N, Demodena A, Djurovic S, Feeder S, Fisher C, Frazier N, Frye MA, Gage FH, Gao K, Garnham J, Gershon ES, Glazer K, Goes F, Goto T, Harrington G, Jakobsen P, Kamali M, Karberg E, Kelly M, Leckband SG, Lohoff F, McInnis MG, Mondimore F, Morken G, Nurnberger JI, Obral S, Oedegaard KJ, Ortiz A, Ritchey M, Ryan K, Schinagle M, Schoeyen H, Schwebel C, Shaw M, Shekhtman T, Slaney C, Stapp E, Szelinger S, Tarwater B, Zandi PP, Kelsoe JR.

Neuropsychopharmacology. 2019 Feb;44(3):620-628. doi: 10.1038/s41386-018-0273-8. Epub 2018 Nov 16.

PMID:
30487653
7.

Adult Hippocampal Neurogenesis: A Coming-of-Age Story.

Kuhn HG, Toda T, Gage FH.

J Neurosci. 2018 Dec 5;38(49):10401-10410. doi: 10.1523/JNEUROSCI.2144-18.2018. Epub 2018 Oct 31.

PMID:
30381404
8.

Aging in a Dish: iPSC-Derived and Directly Induced Neurons for Studying Brain Aging and Age-Related Neurodegenerative Diseases.

Mertens J, Reid D, Lau S, Kim Y, Gage FH.

Annu Rev Genet. 2018 Nov 23;52:271-293. doi: 10.1146/annurev-genet-120417-031534. Epub 2018 Sep 12.

PMID:
30208291
9.

Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer's mouse model.

Choi SH, Bylykbashi E, Chatila ZK, Lee SW, Pulli B, Clemenson GD, Kim E, Rompala A, Oram MK, Asselin C, Aronson J, Zhang C, Miller SJ, Lesinski A, Chen JW, Kim DY, van Praag H, Spiegelman BM, Gage FH, Tanzi RE.

Science. 2018 Sep 7;361(6406). pii: eaan8821. doi: 10.1126/science.aan8821.

PMID:
30190379
10.

Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease.

Eftekharzadeh B, Daigle JG, Kapinos LE, Coyne A, Schiantarelli J, Carlomagno Y, Cook C, Miller SJ, Dujardin S, Amaral AS, Grima JC, Bennett RE, Tepper K, DeTure M, Vanderburg CR, Corjuc BT, DeVos SL, Gonzalez JA, Chew J, Vidensky S, Gage FH, Mertens J, Troncoso J, Mandelkow E, Salvatella X, Lim RYH, Petrucelli L, Wegmann S, Rothstein JD, Hyman BT.

Neuron. 2018 Sep 5;99(5):925-940.e7. doi: 10.1016/j.neuron.2018.07.039. Erratum in: Neuron. 2019 Jan 16;101(2):349.

PMID:
30189209
11.

Patch-Seq Protocol to Analyze the Electrophysiology, Morphology and Transcriptome of Whole Single Neurons Derived From Human Pluripotent Stem Cells.

van den Hurk M, Erwin JA, Yeo GW, Gage FH, Bardy C.

Front Mol Neurosci. 2018 Aug 10;11:261. doi: 10.3389/fnmol.2018.00261. eCollection 2018.

12.

A novel environment-evoked transcriptional signature predicts reactivity in single dentate granule neurons.

Jaeger BN, Linker SB, Parylak SL, Barron JJ, Gallina IS, Saavedra CD, Fitzpatrick C, Lim CK, Schafer ST, Lacar B, Jessberger S, Gage FH.

Nat Commun. 2018 Aug 6;9(1):3084. doi: 10.1038/s41467-018-05418-8.

13.

Erratum: An in vivo model of functional and vascularized human brain organoids.

Mansour AA, Gonçalves JT, Bloyd CW, Li H, Fernandes S, Quang D, Johnston S, Parylak SL, Jin X, Gage FH.

Nat Biotechnol. 2018 Aug 6;36(8):772. doi: 10.1038/nbt0818-772e. No abstract available.

PMID:
30080830
14.

BrainImageR: spatiotemporal gene set analysis referencing the human brain.

Linker SB, Hsu JY, Pfaff A, Amatya D, Ko SM, Voter S, Wong Q, Gage FH.

Bioinformatics. 2019 Jan 15;35(2):343-345. doi: 10.1093/bioinformatics/bty618.

PMID:
30010719
15.

Th17 Lymphocytes Induce Neuronal Cell Death in a Human iPSC-Based Model of Parkinson's Disease.

Sommer A, Maxreiter F, Krach F, Fadler T, Grosch J, Maroni M, Graef D, Eberhardt E, Riemenschneider MJ, Yeo GW, Kohl Z, Xiang W, Gage FH, Winkler J, Prots I, Winner B.

Cell Stem Cell. 2018 Jul 5;23(1):123-131.e6. doi: 10.1016/j.stem.2018.06.015.

PMID:
29979986
16.

High-resolution comparative analysis of great ape genomes.

Kronenberg ZN, Fiddes IT, Gordon D, Murali S, Cantsilieris S, Meyerson OS, Underwood JG, Nelson BJ, Chaisson MJP, Dougherty ML, Munson KM, Hastie AR, Diekhans M, Hormozdiari F, Lorusso N, Hoekzema K, Qiu R, Clark K, Raja A, Welch AE, Sorensen M, Baker C, Fulton RS, Armstrong J, Graves-Lindsay TA, Denli AM, Hoppe ER, Hsieh P, Hill CM, Pang AWC, Lee J, Lam ET, Dutcher SK, Gage FH, Warren WC, Shendure J, Haussler D, Schneider VA, Cao H, Ventura M, Wilson RK, Paten B, Pollen A, Eichler EE.

Science. 2018 Jun 8;360(6393). pii: eaar6343. doi: 10.1126/science.aar6343.

17.

Mitochondrial Aging Defects Emerge in Directly Reprogrammed Human Neurons due to Their Metabolic Profile.

Kim Y, Zheng X, Ansari Z, Bunnell MC, Herdy JR, Traxler L, Lee H, Paquola ACM, Blithikioti C, Ku M, Schlachetzki JCM, Winkler J, Edenhofer F, Glass CK, Paucar AA, Jaeger BN, Pham S, Boyer L, Campbell BC, Hunter T, Mertens J, Gage FH.

Cell Rep. 2018 May 29;23(9):2550-2558. doi: 10.1016/j.celrep.2018.04.105.

18.

Prediction of response to drug therapy in psychiatric disorders.

Stern S, Linker S, Vadodaria KC, Marchetto MC, Gage FH.

Open Biol. 2018 May;8(5). pii: 180031. doi: 10.1098/rsob.180031. Review.

19.

Survival of syngeneic and allogeneic iPSC-derived neural precursors after spinal grafting in minipigs.

Strnadel J, Carromeu C, Bardy C, Navarro M, Platoshyn O, Glud AN, Marsala S, Kafka J, Miyanohara A, Kato T Jr, Tadokoro T, Hefferan MP, Kamizato K, Yoshizumi T, Juhas S, Juhasova J, Ho CS, Kheradmand T, Chen P, Bohaciakova D, Hruska-Plochan M, Todd AJ, Driscoll SP, Glenn TD, Pfaff SL, Klima J, Ciacci J, Curtis E, Gage FH, Bui J, Yamada K, Muotri AR, Marsala M.

Sci Transl Med. 2018 May 9;10(440). pii: eaam6651. doi: 10.1126/scitranslmed.aam6651.

PMID:
29743351
20.

Efficient Generation of CA3 Neurons from Human Pluripotent Stem Cells Enables Modeling of Hippocampal Connectivity In Vitro.

Sarkar A, Mei A, Paquola ACM, Stern S, Bardy C, Klug JR, Kim S, Neshat N, Kim HJ, Ku M, Shokhirev MN, Adamowicz DH, Marchetto MC, Jappelli R, Erwin JA, Padmanabhan K, Shtrahman M, Jin X, Gage FH.

Cell Stem Cell. 2018 May 3;22(5):684-697.e9. doi: 10.1016/j.stem.2018.04.009.

PMID:
29727680
21.

Author Correction: L1-associated genomic regions are deleted in somatic cells of the healthy human brain.

Erwin JA, Paquola ACM, Singer T, Gallina I, Novotny M, Quayle C, Bedrosian TA, Alves FIA, Butcher CR, Herdy JR, Sarkar A, Lasken RS, Muotri AR, Gage FH.

Nat Neurosci. 2018 Jul;21(7):1016. doi: 10.1038/s41593-018-0131-3.

PMID:
29703932
22.

Human Adult Neurogenesis: Evidence and Remaining Questions.

Kempermann G, Gage FH, Aigner L, Song H, Curtis MA, Thuret S, Kuhn HG, Jessberger S, Frankland PW, Cameron HA, Gould E, Hen R, Abrous DN, Toni N, Schinder AF, Zhao X, Lucassen PJ, Frisén J.

Cell Stem Cell. 2018 Jul 5;23(1):25-30. doi: 10.1016/j.stem.2018.04.004. Epub 2018 Apr 19. Review.

PMID:
29681514
23.

The role of adult hippocampal neurogenesis in brain health and disease.

Toda T, Parylak SL, Linker SB, Gage FH.

Mol Psychiatry. 2019 Jan;24(1):67-87. doi: 10.1038/s41380-018-0036-2. Epub 2018 Apr 20. Review.

24.

An in vivo model of functional and vascularized human brain organoids.

Mansour AA, Gonçalves JT, Bloyd CW, Li H, Fernandes S, Quang D, Johnston S, Parylak SL, Jin X, Gage FH.

Nat Biotechnol. 2018 Jun;36(5):432-441. doi: 10.1038/nbt.4127. Epub 2018 Apr 16.

25.

Early life experience drives structural variation of neural genomes in mice.

Bedrosian TA, Quayle C, Novaresi N, Gage FH.

Science. 2018 Mar 23;359(6382):1395-1399. doi: 10.1126/science.aah3378.

PMID:
29567711
26.

Author Correction: CRISPR interference-based specific and efficient gene inactivation in the brain.

Zheng Y, Shen W, Zhang J, Yang B, Liu YN, Qi H, Yu X, Lu SY, Chen Y, Xu YZ, Li Y, Gage FH, Mi S, Yao J.

Nat Neurosci. 2018 Jun;21(6):894. doi: 10.1038/s41593-018-0125-1.

PMID:
29545585
27.

CRISPR interference-based specific and efficient gene inactivation in the brain.

Zheng Y, Shen W, Zhang J, Yang B, Liu YN, Qi H, Yu X, Lu SY, Chen Y, Xu YZ, Li Y, Gage FH, Mi S, Yao J.

Nat Neurosci. 2018 Mar;21(3):447-454. doi: 10.1038/s41593-018-0077-5. Epub 2018 Feb 5. Erratum in: Nat Neurosci. 2018 Mar 15;:.

PMID:
29403034
28.

Modeling psychiatric disorders using patient stem cell-derived neurons: a way forward.

Vadodaria KC, Amatya DN, Marchetto MC, Gage FH.

Genome Med. 2018 Jan 4;10(1):1. doi: 10.1186/s13073-017-0512-3.

29.

Insights into the role of somatic mosaicism in the brain.

Paquola ACM, Erwin JA, Gage FH.

Curr Opin Syst Biol. 2017 Feb;1:90-94. doi: 10.1016/j.coisb.2016.12.004. Epub 2016 Dec 9.

30.

Review: adult neurogenesis contributes to hippocampal plasticity.

Toda T, Gage FH.

Cell Tissue Res. 2018 Sep;373(3):693-709. doi: 10.1007/s00441-017-2735-4. Epub 2017 Nov 29. Review.

PMID:
29185071
31.

Mechanisms of dietary flavonoid action in neuronal function and neuroinflammation.

Jaeger BN, Parylak SL, Gage FH.

Mol Aspects Med. 2018 Jun;61:50-62. doi: 10.1016/j.mam.2017.11.003. Epub 2017 Nov 9. Review.

PMID:
29117513
32.

MicroRNAs in Post-traumatic Stress Disorder.

Snijders C, de Nijs L, Baker DG, Hauger RL, van den Hove D, Kenis G, Nievergelt CM, Boks MP, Vermetten E, Gage FH, Rutten BPF.

Curr Top Behav Neurosci. 2018;38:23-46. doi: 10.1007/7854_2017_32.

PMID:
29063484
33.

Corrigendum: L1-associated genomic regions are deleted in somatic cells of the healthy human brain.

Erwin JA, Paquola ACM, Singer T, Gallina I, Novotny M, Quayle C, Bedrosian TA, Alves FIA, Butcher CR, Herdy JR, Sarkar A, Lasken RS, Muotri AR, Gage FH.

Nat Neurosci. 2017 Sep 28;20(10):1427. doi: 10.1038/nn1017-1427a. No abstract available.

PMID:
28949329
34.

An in vitro model of lissencephaly: expanding the role of DCX during neurogenesis.

Shahsavani M, Pronk RJ, Falk R, Lam M, Moslem M, Linker SB, Salma J, Day K, Schuster J, Anderlid BM, Dahl N, Gage FH, Falk A.

Mol Psychiatry. 2018 Jul;23(7):1674-1684. doi: 10.1038/mp.2017.175. Epub 2017 Sep 19.

PMID:
28924182
35.

Nup153 Interacts with Sox2 to Enable Bimodal Gene Regulation and Maintenance of Neural Progenitor Cells.

Toda T, Hsu JY, Linker SB, Hu L, Schafer ST, Mertens J, Jacinto FV, Hetzer MW, Gage FH.

Cell Stem Cell. 2017 Nov 2;21(5):618-634.e7. doi: 10.1016/j.stem.2017.08.012. Epub 2017 Sep 14.

36.

Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells.

Topol A, Zhu S, Hartley BJ, English J, Hauberg ME, Tran N, Rittenhouse CA, Simone A, Ruderfer DM, Johnson J, Readhead B, Hadas Y, Gochman PA, Wang YC, Shah H, Cagney G, Rapoport J, Gage FH, Dudley JT, Sklar P, Mattheisen M, Cotter D, Fang G, Brennand KJ.

Cell Rep. 2017 Sep 5;20(10):2525. doi: 10.1016/j.celrep.2017.08.073. No abstract available.

37.

Serotonin in psychiatry: in vitro disease modeling using patient-derived neurons.

Vadodaria KC, Stern S, Marchetto MC, Gage FH.

Cell Tissue Res. 2018 Jan;371(1):161-170. doi: 10.1007/s00441-017-2670-4. Epub 2017 Aug 15. Review.

PMID:
28812143
38.

Examining non-LTR retrotransposons in the context of the evolving primate brain.

Linker SB, Marchetto MC, Narvaiza I, Denli AM, Gage FH.

BMC Biol. 2017 Aug 11;15(1):68. doi: 10.1186/s12915-017-0409-z. Review.

39.

Intact piRNA pathway prevents L1 mobilization in male meiosis.

Newkirk SJ, Lee S, Grandi FC, Gaysinskaya V, Rosser JM, Vanden Berg N, Hogarth CA, Marchetto MCN, Muotri AR, Griswold MD, Ye P, Bortvin A, Gage FH, Boeke JD, An W.

Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):E5635-E5644. doi: 10.1073/pnas.1701069114. Epub 2017 Jun 19.

40.

Differentiation of Inflammation-Responsive Astrocytes from Glial Progenitors Generated from Human Induced Pluripotent Stem Cells.

Santos R, Vadodaria KC, Jaeger BN, Mei A, Lefcochilos-Fogelquist S, Mendes APD, Erikson G, Shokhirev M, Randolph-Moore L, Fredlender C, Dave S, Oefner R, Fitzpatrick C, Pena M, Barron JJ, Ku M, Denli AM, Kerman BE, Charnay P, Kelsoe JR, Marchetto MC, Gage FH.

Stem Cell Reports. 2017 Jun 6;8(6):1757-1769. doi: 10.1016/j.stemcr.2017.05.011.

41.

An environment-dependent transcriptional network specifies human microglia identity.

Gosselin D, Skola D, Coufal NG, Holtman IR, Schlachetzki JCM, Sajti E, Jaeger BN, O'Connor C, Fitzpatrick C, Pasillas MP, Pena M, Adair A, Gonda DD, Levy ML, Ransohoff RM, Gage FH, Glass CK.

Science. 2017 Jun 23;356(6344). pii: eaal3222. doi: 10.1126/science.aal3222. Epub 2017 May 25.

42.

Corrigendum: Evolution of a transcriptional regulator from a transmembrane nucleoporin.

Franks TM, Benner C, Narvaiza I, Marchetto MCN, Young JM, Malik HS, Gage FH, Hetzer MW.

Genes Dev. 2017 Apr 15;31(8):845. doi: 10.1101/gad.300699.117. No abstract available.

43.

Variations in brain defects result from cellular mosaicism in the activation of heat shock signalling.

Ishii S, Torii M, Son AI, Rajendraprasad M, Morozov YM, Kawasawa YI, Salzberg AC, Fujimoto M, Brennand K, Nakai A, Mezger V, Gage FH, Rakic P, Hashimoto-Torii K.

Nat Commun. 2017 May 2;8:15157. doi: 10.1038/ncomms15157.

44.

Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network.

McConnell MJ, Moran JV, Abyzov A, Akbarian S, Bae T, Cortes-Ciriano I, Erwin JA, Fasching L, Flasch DA, Freed D, Ganz J, Jaffe AE, Kwan KY, Kwon M, Lodato MA, Mills RE, Paquola ACM, Rodin RE, Rosenbluh C, Sestan N, Sherman MA, Shin JH, Song S, Straub RE, Thorpe J, Weinberger DR, Urban AE, Zhou B, Gage FH, Lehner T, Senthil G, Walsh CA, Chess A, Courchesne E, Gleeson JG, Kidd JM, Park PJ, Pevsner J, Vaccarino FM; Brain Somatic Mosaicism Network.

Science. 2017 Apr 28;356(6336). pii: eaal1641. doi: 10.1126/science.aal1641. Epub 2017 Apr 27. Review.

45.

A role for miR-19 in the migration of adult-born neurons and schizophrenia.

Han J, Gage FH.

Neurogenesis (Austin). 2016 Dec 5;3(1):e1251873. doi: 10.1080/23262133.2016.1251873. eCollection 2016.

46.

Corrigendum: Nuclear RNA-seq of single neurons reveals molecular signatures of activation.

Lacar B, Linker SB, Jaeger BN, Krishnaswami SR, Barron JJ, Kelder MJ, Parylak SL, Paquola AC, Venepally P, Novotny M, O'Connor C, Fitzpatrick C, Erwin JA, Hsu JY, Husband D, McConnell MJ, Lasken R, Gage FH.

Nat Commun. 2017 Mar 17;8:15047. doi: 10.1038/ncomms15047. No abstract available.

47.

Molecular Mechanisms of Bipolar Disorder: Progress Made and Future Challenges.

Kim Y, Santos R, Gage FH, Marchetto MC.

Front Cell Neurosci. 2017 Feb 14;11:30. doi: 10.3389/fncel.2017.00030. eCollection 2017. Review.

48.

Conserved expression of transposon-derived non-coding transcripts in primate stem cells.

Ramsay L, Marchetto MC, Caron M, Chen SH, Busche S, Kwan T, Pastinen T, Gage FH, Bourque G.

BMC Genomics. 2017 Feb 28;18(1):214. doi: 10.1186/s12864-017-3568-y.

49.

Neurons derived from patients with bipolar disorder divide into intrinsically different sub-populations of neurons, predicting the patients' responsiveness to lithium.

Stern S, Santos R, Marchetto MC, Mendes APD, Rouleau GA, Biesmans S, Wang QW, Yao J, Charnay P, Bang AG, Alda M, Gage FH.

Mol Psychiatry. 2018 Jun;23(6):1453-1465. doi: 10.1038/mp.2016.260. Epub 2017 Feb 28.

50.

Hippocampal α-Synuclein in Dementia with Lewy Bodies Contributes to Memory Impairment and Is Consistent with Spread of Pathology.

Adamowicz DH, Roy S, Salmon DP, Galasko DR, Hansen LA, Masliah E, Gage FH.

J Neurosci. 2017 Feb 15;37(7):1675-1684. doi: 10.1523/JNEUROSCI.3047-16.2016. Epub 2016 Dec 30.

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