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Items: 1 to 50 of 779

1.

An epilepsy-associated KCNT1 mutation enhances excitability of human iPSC-derived neurons by increasing Slack KNa currents.

Quraishi IH, Stern S, Mangan KP, Zhang Y, Ali SR, Mercier MR, Marchetto MC, McLachlan MJ, Jones EM, Gage FH, Kaczmarek LK.

J Neurosci. 2019 Jul 26. pii: 1628-18. doi: 10.1523/JNEUROSCI.1628-18.2019. [Epub ahead of print]

PMID:
31350261
2.

Corrigendum: Patch-Seq Protocol to Analyze the Electrophysiology, Morphology and Transcriptome of Whole Single Neurons Derived From Human Pluripotent Stem Cells.

van den Hurk M, Erwin JA, Yeo GW, Gage FH, Bardy C.

Front Mol Neurosci. 2019 Jun 11;12:150. doi: 10.3389/fnmol.2019.00150. eCollection 2019.

3.

Th17 Lymphocytes Induce Neuronal Cell Death in a Human iPSC-Based Model of Parkinson's Disease.

Sommer A, Marxreiter F, Krach F, Fadler T, Grosch J, Maroni M, Graef D, Eberhardt E, Riemenschneider MJ, Yeo GW, Kohl Z, Xiang W, Gage FH, Winkler J, Prots I, Winner B.

Cell Stem Cell. 2019 Jun 6;24(6):1006. doi: 10.1016/j.stem.2019.04.019. No abstract available.

PMID:
31173705
4.

Adult neurogenesis in mammals.

Gage FH.

Science. 2019 May 31;364(6443):827-828. doi: 10.1126/science.aav6885. No abstract available.

PMID:
31147506
5.

Nerve cells from the brain invade prostate tumours.

Schafer ST, Gage FH.

Nature. 2019 May;569(7758):637-638. doi: 10.1038/d41586-019-01461-7. No abstract available.

PMID:
31138915
6.

Modeling neuropsychiatric disorders using human induced pluripotent stem cells.

Wang M, Zhang L, Gage FH.

Protein Cell. 2019 May 27. doi: 10.1007/s13238-019-0638-8. [Epub ahead of print] Review.

PMID:
31134525
7.

Studying treatment resistance in depression using patient derived neurons in vitro.

Vadodaria KC, Ji Y, Skime M, Paquola A, Nelson T, Hall-Flavin D, Fredlender C, Heard KJ, Deng Y, Le AT, Dave S, Fung L, Li X, Marchetto MC, Weinshilboum R, Gage FH.

Mol Psychiatry. 2019 Jun;24(6):775. doi: 10.1038/s41380-019-0424-2. No abstract available.

PMID:
31118486
8.

Chemical modulation of transcriptionally enriched signaling pathways to optimize the conversion of fibroblasts into neurons.

Herdy J, Schafer S, Kim Y, Ansari Z, Zangwill D, Ku M, Paquola A, Lee H, Mertens J, Gage FH.

Elife. 2019 May 17;8. pii: e41356. doi: 10.7554/eLife.41356.

9.

Altered serotonergic circuitry in SSRI-resistant major depressive disorder patient-derived neurons.

Vadodaria KC, Ji Y, Skime M, Paquola AC, Nelson T, Hall-Flavin D, Heard KJ, Fredlender C, Deng Y, Elkins J, Dani K, Le AT, Marchetto MC, Weinshilboum R, Gage FH.

Mol Psychiatry. 2019 Jun;24(6):808-818. doi: 10.1038/s41380-019-0377-5. Epub 2019 Mar 22.

PMID:
30903001
10.

Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3.

Farrelly LA, Thompson RE, Zhao S, Lepack AE, Lyu Y, Bhanu NV, Zhang B, Loh YE, Ramakrishnan A, Vadodaria KC, Heard KJ, Erikson G, Nakadai T, Bastle RM, Lukasak BJ, Zebroski H 3rd, Alenina N, Bader M, Berton O, Roeder RG, Molina H, Gage FH, Shen L, Garcia BA, Li H, Muir TW, Maze I.

Nature. 2019 Mar;567(7749):535-539. doi: 10.1038/s41586-019-1024-7. Epub 2019 Mar 13.

PMID:
30867594
11.

Microglia, complement and schizophrenia.

Wang M, Zhang L, Gage FH.

Nat Neurosci. 2019 Mar;22(3):333-334. doi: 10.1038/s41593-019-0343-1. No abstract available.

PMID:
30796420
12.

Species-specific maturation profiles of human, chimpanzee and bonobo neural cells.

Marchetto MC, Hrvoj-Mihic B, Kerman BE, Yu DX, Vadodaria KC, Linker SB, Narvaiza I, Santos R, Denli AM, Mendes AP, Oefner R, Cook J, McHenry L, Grasmick JM, Heard K, Fredlender C, Randolph-Moore L, Kshirsagar R, Xenitopoulos R, Chou G, Hah N, Muotri AR, Padmanabhan K, Semendeferi K, Gage FH.

Elife. 2019 Feb 7;8. pii: e37527. doi: 10.7554/eLife.37527.

13.

Serotonin-induced hyperactivity in SSRI-resistant major depressive disorder patient-derived neurons.

Vadodaria KC, Ji Y, Skime M, Paquola A, Nelson T, Hall-Flavin D, Fredlender C, Heard KJ, Deng Y, Le AT, Dave S, Fung L, Li X, Marchetto MC, Weinshilboum R, Gage FH.

Mol Psychiatry. 2019 Jun;24(6):795-807. doi: 10.1038/s41380-019-0363-y. Epub 2019 Jan 30.

PMID:
30700803
14.

Centrifugal Inputs to the Main Olfactory Bulb Revealed Through Whole Brain Circuit-Mapping.

Padmanabhan K, Osakada F, Tarabrina A, Kizer E, Callaway EM, Gage FH, Sejnowski TJ.

Front Neuroanat. 2019 Jan 7;12:115. doi: 10.3389/fnana.2018.00115. eCollection 2018.

15.

Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease.

Eftekharzadeh B, Daigle JG, Kapinos LE, Coyne A, Schiantarelli J, Carlomagno Y, Cook C, Miller SJ, Dujardin S, Amaral AS, Grima JC, Bennett RE, Tepper K, DeTure M, Vanderburg CR, Corjuc BT, DeVos SL, Gonzalez JA, Chew J, Vidensky S, Gage FH, Mertens J, Troncoso J, Mandelkow E, Salvatella X, Lim RYH, Petrucelli L, Wegmann S, Rothstein JD, Hyman BT.

Neuron. 2019 Jan 16;101(2):349. doi: 10.1016/j.neuron.2018.12.031. No abstract available.

16.

Limits to human neurogenesis-really?

Lucassen PJ, Toni N, Kempermann G, Frisen J, Gage FH, Swaab DF.

Mol Psychiatry. 2019 Jan 7. doi: 10.1038/s41380-018-0337-5. [Epub ahead of print] No abstract available.

PMID:
30617274
17.

Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons.

Schafer ST, Paquola ACM, Stern S, Gosselin D, Ku M, Pena M, Kuret TJM, Liyanage M, Mansour AA, Jaeger BN, Marchetto MC, Glass CK, Mertens J, Gage FH.

Nat Neurosci. 2019 Feb;22(2):243-255. doi: 10.1038/s41593-018-0295-x. Epub 2019 Jan 7.

18.

Mitochondria, Metabolism, and Redox Mechanisms in Psychiatric Disorders.

Kim Y, Vadodaria KC, Lenkei Z, Kato T, Gage FH, Marchetto MC, Santos R.

Antioxid Redox Signal. 2019 Aug 1;31(4):275-317. doi: 10.1089/ars.2018.7606. Epub 2019 Feb 1.

PMID:
30585734
19.

Long-Term Labeling of Hippocampal Neural Stem Cells by a Lentiviral Vector.

Suh H, Zhou QG, Fernandez-Carasa I, Clemenson GD Jr, Pons-Espinal M, Ro EJ, Marti M, Raya A, Gage FH, Consiglio A.

Front Mol Neurosci. 2018 Nov 15;11:415. doi: 10.3389/fnmol.2018.00415. eCollection 2018.

20.

Chronotype and cellular circadian rhythms predict the clinical response to lithium maintenance treatment in patients with bipolar disorder.

McCarthy MJ, Wei H, Nievergelt CM, Stautland A, Maihofer AX, Welsh DK, Shilling P, Alda M, Alliey-Rodriguez N, Anand A, Andreasson OA, Balaraman Y, Berrettini WH, Bertram H, Brennand KJ, Calabrese JR, Calkin CV, Claasen A, Conroy C, Coryell WH, Craig DW, D'Arcangelo N, Demodena A, Djurovic S, Feeder S, Fisher C, Frazier N, Frye MA, Gage FH, Gao K, Garnham J, Gershon ES, Glazer K, Goes F, Goto T, Harrington G, Jakobsen P, Kamali M, Karberg E, Kelly M, Leckband SG, Lohoff F, McInnis MG, Mondimore F, Morken G, Nurnberger JI, Obral S, Oedegaard KJ, Ortiz A, Ritchey M, Ryan K, Schinagle M, Schoeyen H, Schwebel C, Shaw M, Shekhtman T, Slaney C, Stapp E, Szelinger S, Tarwater B, Zandi PP, Kelsoe JR.

Neuropsychopharmacology. 2019 Feb;44(3):620-628. doi: 10.1038/s41386-018-0273-8. Epub 2018 Nov 16.

21.

Adult Hippocampal Neurogenesis: A Coming-of-Age Story.

Kuhn HG, Toda T, Gage FH.

J Neurosci. 2018 Dec 5;38(49):10401-10410. doi: 10.1523/JNEUROSCI.2144-18.2018. Epub 2018 Oct 31.

22.

Aging in a Dish: iPSC-Derived and Directly Induced Neurons for Studying Brain Aging and Age-Related Neurodegenerative Diseases.

Mertens J, Reid D, Lau S, Kim Y, Gage FH.

Annu Rev Genet. 2018 Nov 23;52:271-293. doi: 10.1146/annurev-genet-120417-031534. Epub 2018 Sep 12. Review.

23.

Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer's mouse model.

Choi SH, Bylykbashi E, Chatila ZK, Lee SW, Pulli B, Clemenson GD, Kim E, Rompala A, Oram MK, Asselin C, Aronson J, Zhang C, Miller SJ, Lesinski A, Chen JW, Kim DY, van Praag H, Spiegelman BM, Gage FH, Tanzi RE.

Science. 2018 Sep 7;361(6406). pii: eaan8821. doi: 10.1126/science.aan8821.

24.

Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease.

Eftekharzadeh B, Daigle JG, Kapinos LE, Coyne A, Schiantarelli J, Carlomagno Y, Cook C, Miller SJ, Dujardin S, Amaral AS, Grima JC, Bennett RE, Tepper K, DeTure M, Vanderburg CR, Corjuc BT, DeVos SL, Gonzalez JA, Chew J, Vidensky S, Gage FH, Mertens J, Troncoso J, Mandelkow E, Salvatella X, Lim RYH, Petrucelli L, Wegmann S, Rothstein JD, Hyman BT.

Neuron. 2018 Sep 5;99(5):925-940.e7. doi: 10.1016/j.neuron.2018.07.039. Erratum in: Neuron. 2019 Jan 16;101(2):349.

PMID:
30189209
25.

Patch-Seq Protocol to Analyze the Electrophysiology, Morphology and Transcriptome of Whole Single Neurons Derived From Human Pluripotent Stem Cells.

van den Hurk M, Erwin JA, Yeo GW, Gage FH, Bardy C.

Front Mol Neurosci. 2018 Aug 10;11:261. doi: 10.3389/fnmol.2018.00261. eCollection 2018. Erratum in: Front Mol Neurosci. 2019 Jun 11;12:150.

26.

A novel environment-evoked transcriptional signature predicts reactivity in single dentate granule neurons.

Jaeger BN, Linker SB, Parylak SL, Barron JJ, Gallina IS, Saavedra CD, Fitzpatrick C, Lim CK, Schafer ST, Lacar B, Jessberger S, Gage FH.

Nat Commun. 2018 Aug 6;9(1):3084. doi: 10.1038/s41467-018-05418-8.

27.

Erratum: An in vivo model of functional and vascularized human brain organoids.

Mansour AA, Gonçalves JT, Bloyd CW, Li H, Fernandes S, Quang D, Johnston S, Parylak SL, Jin X, Gage FH.

Nat Biotechnol. 2018 Aug 6;36(8):772. doi: 10.1038/nbt0818-772e. No abstract available.

PMID:
30080830
28.

BrainImageR: spatiotemporal gene set analysis referencing the human brain.

Linker SB, Hsu JY, Pfaff A, Amatya D, Ko SM, Voter S, Wong Q, Gage FH.

Bioinformatics. 2019 Jan 15;35(2):343-345. doi: 10.1093/bioinformatics/bty618.

PMID:
30010719
29.

Th17 Lymphocytes Induce Neuronal Cell Death in a Human iPSC-Based Model of Parkinson's Disease.

Sommer A, Marxreiter F, Krach F, Fadler T, Grosch J, Maroni M, Graef D, Eberhardt E, Riemenschneider MJ, Yeo GW, Kohl Z, Xiang W, Gage FH, Winkler J, Prots I, Winner B.

Cell Stem Cell. 2018 Jul 5;23(1):123-131.e6. doi: 10.1016/j.stem.2018.06.015. Erratum in: Cell Stem Cell. 2019 Jun 6;24(6):1006.

30.

High-resolution comparative analysis of great ape genomes.

Kronenberg ZN, Fiddes IT, Gordon D, Murali S, Cantsilieris S, Meyerson OS, Underwood JG, Nelson BJ, Chaisson MJP, Dougherty ML, Munson KM, Hastie AR, Diekhans M, Hormozdiari F, Lorusso N, Hoekzema K, Qiu R, Clark K, Raja A, Welch AE, Sorensen M, Baker C, Fulton RS, Armstrong J, Graves-Lindsay TA, Denli AM, Hoppe ER, Hsieh P, Hill CM, Pang AWC, Lee J, Lam ET, Dutcher SK, Gage FH, Warren WC, Shendure J, Haussler D, Schneider VA, Cao H, Ventura M, Wilson RK, Paten B, Pollen A, Eichler EE.

Science. 2018 Jun 8;360(6393). pii: eaar6343. doi: 10.1126/science.aar6343.

31.

Mitochondrial Aging Defects Emerge in Directly Reprogrammed Human Neurons due to Their Metabolic Profile.

Kim Y, Zheng X, Ansari Z, Bunnell MC, Herdy JR, Traxler L, Lee H, Paquola ACM, Blithikioti C, Ku M, Schlachetzki JCM, Winkler J, Edenhofer F, Glass CK, Paucar AA, Jaeger BN, Pham S, Boyer L, Campbell BC, Hunter T, Mertens J, Gage FH.

Cell Rep. 2018 May 29;23(9):2550-2558. doi: 10.1016/j.celrep.2018.04.105.

32.

Prediction of response to drug therapy in psychiatric disorders.

Stern S, Linker S, Vadodaria KC, Marchetto MC, Gage FH.

Open Biol. 2018 May;8(5). pii: 180031. doi: 10.1098/rsob.180031. Review.

33.

Survival of syngeneic and allogeneic iPSC-derived neural precursors after spinal grafting in minipigs.

Strnadel J, Carromeu C, Bardy C, Navarro M, Platoshyn O, Glud AN, Marsala S, Kafka J, Miyanohara A, Kato T Jr, Tadokoro T, Hefferan MP, Kamizato K, Yoshizumi T, Juhas S, Juhasova J, Ho CS, Kheradmand T, Chen P, Bohaciakova D, Hruska-Plochan M, Todd AJ, Driscoll SP, Glenn TD, Pfaff SL, Klima J, Ciacci J, Curtis E, Gage FH, Bui J, Yamada K, Muotri AR, Marsala M.

Sci Transl Med. 2018 May 9;10(440). pii: eaam6651. doi: 10.1126/scitranslmed.aam6651.

PMID:
29743351
34.

Efficient Generation of CA3 Neurons from Human Pluripotent Stem Cells Enables Modeling of Hippocampal Connectivity In Vitro.

Sarkar A, Mei A, Paquola ACM, Stern S, Bardy C, Klug JR, Kim S, Neshat N, Kim HJ, Ku M, Shokhirev MN, Adamowicz DH, Marchetto MC, Jappelli R, Erwin JA, Padmanabhan K, Shtrahman M, Jin X, Gage FH.

Cell Stem Cell. 2018 May 3;22(5):684-697.e9. doi: 10.1016/j.stem.2018.04.009.

35.

Author Correction: L1-associated genomic regions are deleted in somatic cells of the healthy human brain.

Erwin JA, Paquola ACM, Singer T, Gallina I, Novotny M, Quayle C, Bedrosian TA, Alves FIA, Butcher CR, Herdy JR, Sarkar A, Lasken RS, Muotri AR, Gage FH.

Nat Neurosci. 2018 Jul;21(7):1016. doi: 10.1038/s41593-018-0131-3.

PMID:
29703932
36.

Human Adult Neurogenesis: Evidence and Remaining Questions.

Kempermann G, Gage FH, Aigner L, Song H, Curtis MA, Thuret S, Kuhn HG, Jessberger S, Frankland PW, Cameron HA, Gould E, Hen R, Abrous DN, Toni N, Schinder AF, Zhao X, Lucassen PJ, Frisén J.

Cell Stem Cell. 2018 Jul 5;23(1):25-30. doi: 10.1016/j.stem.2018.04.004. Epub 2018 Apr 19. Review.

37.

The role of adult hippocampal neurogenesis in brain health and disease.

Toda T, Parylak SL, Linker SB, Gage FH.

Mol Psychiatry. 2019 Jan;24(1):67-87. doi: 10.1038/s41380-018-0036-2. Epub 2018 Apr 20. Review.

38.

An in vivo model of functional and vascularized human brain organoids.

Mansour AA, Gonçalves JT, Bloyd CW, Li H, Fernandes S, Quang D, Johnston S, Parylak SL, Jin X, Gage FH.

Nat Biotechnol. 2018 Jun;36(5):432-441. doi: 10.1038/nbt.4127. Epub 2018 Apr 16.

39.

Early life experience drives structural variation of neural genomes in mice.

Bedrosian TA, Quayle C, Novaresi N, Gage FH.

Science. 2018 Mar 23;359(6382):1395-1399. doi: 10.1126/science.aah3378.

PMID:
29567711
40.

Author Correction: CRISPR interference-based specific and efficient gene inactivation in the brain.

Zheng Y, Shen W, Zhang J, Yang B, Liu YN, Qi H, Yu X, Lu SY, Chen Y, Xu YZ, Li Y, Gage FH, Mi S, Yao J.

Nat Neurosci. 2018 Jun;21(6):894. doi: 10.1038/s41593-018-0125-1.

PMID:
29545585
41.

CRISPR interference-based specific and efficient gene inactivation in the brain.

Zheng Y, Shen W, Zhang J, Yang B, Liu YN, Qi H, Yu X, Lu SY, Chen Y, Xu YZ, Li Y, Gage FH, Mi S, Yao J.

Nat Neurosci. 2018 Mar;21(3):447-454. doi: 10.1038/s41593-018-0077-5. Epub 2018 Feb 5. Erratum in: Nat Neurosci. 2018 Mar 15;:.

PMID:
29403034
42.

Modeling psychiatric disorders using patient stem cell-derived neurons: a way forward.

Vadodaria KC, Amatya DN, Marchetto MC, Gage FH.

Genome Med. 2018 Jan 4;10(1):1. doi: 10.1186/s13073-017-0512-3.

43.

Insights into the role of somatic mosaicism in the brain.

Paquola ACM, Erwin JA, Gage FH.

Curr Opin Syst Biol. 2017 Feb;1:90-94. doi: 10.1016/j.coisb.2016.12.004. Epub 2016 Dec 9.

44.

Review: adult neurogenesis contributes to hippocampal plasticity.

Toda T, Gage FH.

Cell Tissue Res. 2018 Sep;373(3):693-709. doi: 10.1007/s00441-017-2735-4. Epub 2017 Nov 29. Review.

PMID:
29185071
45.

Mechanisms of dietary flavonoid action in neuronal function and neuroinflammation.

Jaeger BN, Parylak SL, Gage FH.

Mol Aspects Med. 2018 Jun;61:50-62. doi: 10.1016/j.mam.2017.11.003. Epub 2017 Nov 9. Review.

PMID:
29117513
46.

MicroRNAs in Post-traumatic Stress Disorder.

Snijders C, de Nijs L, Baker DG, Hauger RL, van den Hove D, Kenis G, Nievergelt CM, Boks MP, Vermetten E, Gage FH, Rutten BPF.

Curr Top Behav Neurosci. 2018;38:23-46. doi: 10.1007/7854_2017_32. Review.

PMID:
29063484
47.

Corrigendum: L1-associated genomic regions are deleted in somatic cells of the healthy human brain.

Erwin JA, Paquola ACM, Singer T, Gallina I, Novotny M, Quayle C, Bedrosian TA, Alves FIA, Butcher CR, Herdy JR, Sarkar A, Lasken RS, Muotri AR, Gage FH.

Nat Neurosci. 2017 Sep 28;20(10):1427. doi: 10.1038/nn1017-1427a. No abstract available.

PMID:
28949329
48.

An in vitro model of lissencephaly: expanding the role of DCX during neurogenesis.

Shahsavani M, Pronk RJ, Falk R, Lam M, Moslem M, Linker SB, Salma J, Day K, Schuster J, Anderlid BM, Dahl N, Gage FH, Falk A.

Mol Psychiatry. 2018 Jul;23(7):1674-1684. doi: 10.1038/mp.2017.175. Epub 2017 Sep 19.

PMID:
28924182
49.

Nup153 Interacts with Sox2 to Enable Bimodal Gene Regulation and Maintenance of Neural Progenitor Cells.

Toda T, Hsu JY, Linker SB, Hu L, Schafer ST, Mertens J, Jacinto FV, Hetzer MW, Gage FH.

Cell Stem Cell. 2017 Nov 2;21(5):618-634.e7. doi: 10.1016/j.stem.2017.08.012. Epub 2017 Sep 14.

50.

Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells.

Topol A, Zhu S, Hartley BJ, English J, Hauberg ME, Tran N, Rittenhouse CA, Simone A, Ruderfer DM, Johnson J, Readhead B, Hadas Y, Gochman PA, Wang YC, Shah H, Cagney G, Rapoport J, Gage FH, Dudley JT, Sklar P, Mattheisen M, Cotter D, Fang G, Brennand KJ.

Cell Rep. 2017 Sep 5;20(10):2525. doi: 10.1016/j.celrep.2017.08.073. No abstract available.

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