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Items: 1 to 50 of 102

1.

Applications of mechanistic modelling to clinical and experimental immunology: an emerging technology to accelerate immunotherapeutic discovery and development.

Brown LV, Gaffney EA, Wagg J, Coles MC.

Clin Exp Immunol. 2018 Sep;193(3):284-292. doi: 10.1111/cei.13182. Review.

PMID:
30240512
2.

Osmotic and electroosmotic fluid transport across the retinal pigment epithelium: A mathematical model.

Dvoriashyna M, Foss AJE, Gaffney EA, Jensen OE, Repetto R.

J Theor Biol. 2018 Nov 7;456:233-248. doi: 10.1016/j.jtbi.2018.08.009. Epub 2018 Aug 7.

PMID:
30096403
3.

Heterogeneity induces spatiotemporal oscillations in reaction-diffusion systems.

Krause AL, Klika V, Woolley TE, Gaffney EA.

Phys Rev E. 2018 May;97(5-1):052206. doi: 10.1103/PhysRevE.97.052206.

PMID:
29906857
4.

Theoretical Insights into the Retinal Dynamics of Vascular Endothelial Growth Factor in Patients Treated with Ranibizumab, Based on an Ocular Pharmacokinetic/Pharmacodynamic Model.

Hutton-Smith LA, Gaffney EA, Byrne HM, Caruso A, Maini PK, Mazer NA.

Mol Pharm. 2018 Jul 2;15(7):2770-2784. doi: 10.1021/acs.molpharmaceut.8b00280. Epub 2018 May 29.

PMID:
29734810
5.

Predictive Mathematical Models for the Spread and Treatment of Hyperoxia-induced Photoreceptor Degeneration in Retinitis Pigmentosa.

Roberts PA, Gaffney EA, Whiteley JP, Luthert PJ, Foss AJE, Byrne HM.

Invest Ophthalmol Vis Sci. 2018 Mar 1;59(3):1238-1249. doi: 10.1167/iovs.17-23177.

PMID:
29625444
6.

Changes in the retreatment radiation tolerance of the spinal cord with time after the initial treatment.

Woolley TE, Belmonte-Beitia J, Calvo GF, Hopewell JW, Gaffney EA, Jones B.

Int J Radiat Biol. 2018 Jun;94(6):515-531. doi: 10.1080/09553002.2018.1430911. Epub 2018 Apr 23.

PMID:
29620431
7.

An in silico model of cytotoxic T-lymphocyte activation in the lymph node following short peptide vaccination.

Brown LV, Gaffney EA, Wagg J, Coles MC.

J R Soc Interface. 2018 Mar;15(140). pii: 20180041. doi: 10.1098/rsif.2018.0041.

PMID:
29540543
8.

Basal Tear Osmolarity as a metric to estimate body hydration and dry eye severity.

Willshire C, Bron AJ, Gaffney EA, Pearce EI.

Prog Retin Eye Res. 2018 May;64:56-64. doi: 10.1016/j.preteyeres.2018.02.001. Epub 2018 Feb 21. Review.

PMID:
29476817
9.

Human sperm swimming in a high viscosity mucus analogue.

Ishimoto K, Gadêlha H, Gaffney EA, Smith DJ, Kirkman-Brown J.

J Theor Biol. 2018 Jun 7;446:1-10. doi: 10.1016/j.jtbi.2018.02.013. Epub 2018 Feb 17.

10.

Random blebbing motion: A simple model linking cell structural properties to migration characteristics.

Woolley TE, Gaffney EA, Goriely A.

Phys Rev E. 2017 Jul;96(1-1):012409. doi: 10.1103/PhysRevE.96.012409. Epub 2017 Jul 18.

PMID:
29347096
11.

Ocular Pharmacokinetics of Therapeutic Antibodies Given by Intravitreal Injection: Estimation of Retinal Permeabilities Using a 3-Compartment Semi-Mechanistic Model.

Hutton-Smith LA, Gaffney EA, Byrne HM, Maini PK, Gadkar K, Mazer NA.

Mol Pharm. 2017 Aug 7;14(8):2690-2696. doi: 10.1021/acs.molpharmaceut.7b00164. Epub 2017 Jul 3.

PMID:
28631484
12.

Mathematical models of retinitis pigmentosa: The oxygen toxicity hypothesis.

Roberts PA, Gaffney EA, Luthert PJ, Foss AJE, Byrne HM.

J Theor Biol. 2017 Jul 21;425:53-71. doi: 10.1016/j.jtbi.2017.05.006. Epub 2017 May 6.

PMID:
28483568
13.

History dependence and the continuum approximation breakdown: the impact of domain growth on Turing's instability.

Klika V, Gaffney EA.

Proc Math Phys Eng Sci. 2017 Mar;473(2199):20160744. doi: 10.1098/rspa.2016.0744. Epub 2017 Mar 15.

14.

Coarse-Graining the Fluid Flow around a Human Sperm.

Ishimoto K, Gadêlha H, Gaffney EA, Smith DJ, Kirkman-Brown J.

Phys Rev Lett. 2017 Mar 24;118(12):124501. doi: 10.1103/PhysRevLett.118.124501. Epub 2017 Mar 23.

PMID:
28388208
15.

Reply to Baveye and Darnault: Useful models are simple and extendable.

Coyte KZ, Tabuteau H, Gaffney EA, Foster KR, Durham WM.

Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):E2804-E2805. doi: 10.1073/pnas.1702303114. Epub 2017 Mar 24. No abstract available.

16.

Mechanical Cell-Cell Communication in Fibrous Networks: The Importance of Network Geometry.

Humphries DL, Grogan JA, Gaffney EA.

Bull Math Biol. 2017 Mar;79(3):498-524. doi: 10.1007/s11538-016-0242-5. Epub 2017 Jan 27.

17.

Microbial competition in porous environments can select against rapid biofilm growth.

Coyte KZ, Tabuteau H, Gaffney EA, Foster KR, Durham WM.

Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):E161-E170. doi: 10.1073/pnas.1525228113. Epub 2016 Dec 22.

18.

Effect of crosslinking in cartilage-like collagen microstructures.

Chen YC, Chen M, Gaffney EA, Brown CP.

J Mech Behav Biomed Mater. 2017 Feb;66:138-143. doi: 10.1016/j.jmbbm.2016.10.006. Epub 2016 Oct 15.

PMID:
27866057
19.

Modeling Longitudinal Preclinical Tumor Size Data to Identify Transient Dynamics in Tumor Response to Antiangiogenic Drugs.

Hutchinson LG, Mueller HJ, Gaffney EA, Maini PK, Wagg J, Phipps A, Boetsch C, Byrne HM, Ribba B.

CPT Pharmacometrics Syst Pharmacol. 2016 Nov;5(11):636-645. doi: 10.1002/psp4.12142. Epub 2016 Nov 14.

20.
21.

An overview of multiphase cartilage mechanical modelling and its role in understanding function and pathology.

Klika V, Gaffney EA, Chen YC, Brown CP.

J Mech Behav Biomed Mater. 2016 Sep;62:139-157. doi: 10.1016/j.jmbbm.2016.04.032. Epub 2016 May 11. Review.

22.

Mathematical and computational models of the retina in health, development and disease.

Roberts PA, Gaffney EA, Luthert PJ, Foss AJE, Byrne HM.

Prog Retin Eye Res. 2016 Jul;53:48-69. doi: 10.1016/j.preteyeres.2016.04.001. Epub 2016 Apr 7. Review.

PMID:
27063291
23.

Vascular phenotype identification and anti-angiogenic treatment recommendation: A pseudo-multiscale mathematical model of angiogenesis.

Hutchinson LG, Gaffney EA, Maini PK, Wagg J, Phipps A, Byrne HM.

J Theor Biol. 2016 Jun 7;398:162-80. doi: 10.1016/j.jtbi.2016.03.002. Epub 2016 Mar 14.

PMID:
26987523
24.

Hydrodynamic analysis of flagellated bacteria swimming in corners of rectangular channels.

Shum H, Gaffney EA.

Phys Rev E Stat Nonlin Soft Matter Phys. 2015 Dec;92(6):063016. doi: 10.1103/PhysRevE.92.063016. Epub 2015 Dec 16.

PMID:
26764813
25.

Fock space, symbolic algebra, and analytical solutions for small stochastic systems.

Santos FA, Gadêlha H, Gaffney EA.

Phys Rev E Stat Nonlin Soft Matter Phys. 2015 Dec;92(6):062714. doi: 10.1103/PhysRevE.92.062714. Epub 2015 Dec 28.

PMID:
26764734
26.

A Mechanistic Model of the Intravitreal Pharmacokinetics of Large Molecules and the Pharmacodynamic Suppression of Ocular Vascular Endothelial Growth Factor Levels by Ranibizumab in Patients with Neovascular Age-Related Macular Degeneration.

Hutton-Smith LA, Gaffney EA, Byrne HM, Maini PK, Schwab D, Mazer NA.

Mol Pharm. 2016 Sep 6;13(9):2941-50. doi: 10.1021/acs.molpharmaceut.5b00849. Epub 2016 Jan 14.

PMID:
26726925
27.

Membrane shrinkage and cortex remodelling are predicted to work in harmony to retract blebs.

Woolley TE, Gaffney EA, Goriely A.

R Soc Open Sci. 2015 Jul 29;2(7):150184. doi: 10.1098/rsos.150184. eCollection 2015 Jul.

28.

A simulation study of sperm motility hydrodynamics near fish eggs and spheres.

Ishimoto K, Cosson J, Gaffney EA.

J Theor Biol. 2016 Jan 21;389:187-97. doi: 10.1016/j.jtbi.2015.10.013. Epub 2015 Nov 2.

PMID:
26542943
29.

Retinal oxygen distribution and the role of neuroglobin.

Roberts PA, Gaffney EA, Luthert PJ, Foss AJ, Byrne HM.

J Math Biol. 2016 Jul;73(1):1-38. doi: 10.1007/s00285-015-0931-y. Epub 2015 Sep 14.

PMID:
26370669
30.

Glyph-Based Video Visualization for Semen Analysis.

Duffy B, Thiyagalingam J, Walton S, Smith DJ, Trefethen A, Kirkman-Brown JC, Gaffney EA, Min Chen.

IEEE Trans Vis Comput Graph. 2015 Aug;21(8):980-93. doi: 10.1109/TVCG.2013.265.

PMID:
26357260
31.

The mechanics of hyperactivation in adhered human sperm.

Ooi EH, Smith DJ, Gadêlha H, Gaffney EA, Kirkman-Brown J.

R Soc Open Sci. 2014 Oct 1;1(2):140230. doi: 10.1098/rsos.140230. eCollection 2014 Oct.

32.

Maternal hypoxia decreases capillary supply and increases metabolic inefficiency leading to divergence in myocardial oxygen supply and demand.

Hauton D, Al-Shammari A, Gaffney EA, Egginton S.

PLoS One. 2015 Jun 1;10(6):e0127424. doi: 10.1371/journal.pone.0127424. eCollection 2015.

33.

Global contraction or local growth, bleb shape depends on more than just cell structure.

Woolley TE, Gaffney EA, Oliver JM, Waters SL, Baker RE, Goriely A.

J Theor Biol. 2015 Sep 7;380:83-97. doi: 10.1016/j.jtbi.2015.04.023. Epub 2015 Apr 29.

PMID:
25934350
34.

Fluid flow and sperm guidance: a simulation study of hydrodynamic sperm rheotaxis.

Ishimoto K, Gaffney EA.

J R Soc Interface. 2015 May 6;12(106). pii: 20150172. doi: 10.1098/rsif.2015.0172.

35.

Hydrodynamic analysis of flagellated bacteria swimming near one and between two no-slip plane boundaries.

Shum H, Gaffney EA.

Phys Rev E Stat Nonlin Soft Matter Phys. 2015 Mar;91(3):033012. Epub 2015 Mar 20.

PMID:
25871207
36.

Changes to both cardiac metabolism and performance accompany acute reductions in functional capillary supply.

Hauton D, Winter J, Al-Shammari AA, Gaffney EA, Evans RD, Egginton S.

Biochim Biophys Acta. 2015 Apr;1850(4):681-90. doi: 10.1016/j.bbagen.2014.12.014. Epub 2014 Dec 18.

37.

Investigating the Turing conditions for diffusion-driven instability in the presence of a binding immobile substrate.

Korvasová K, Gaffney EA, Maini PK, Ferreira MA, Klika V.

J Theor Biol. 2015 Feb 21;367:286-295. doi: 10.1016/j.jtbi.2014.11.024. Epub 2014 Dec 4.

PMID:
25484005
38.

Glucose-lactate metabolic cooperation in cancer: insights from a spatial mathematical model and implications for targeted therapy.

McGillen JB, Kelly CJ, Martínez-González A, Martin NK, Gaffney EA, Maini PK, Pérez-García VM.

J Theor Biol. 2014 Nov 21;361:190-203. doi: 10.1016/j.jtbi.2014.09.018. Epub 2014 Sep 28.

PMID:
25264268
39.

Spreading speeds for plant populations in landscapes with low environmental variation.

Gilbert MA, Gaffney EA, Bullock JM, White SM.

J Theor Biol. 2014 Dec 21;363:436-52. doi: 10.1016/j.jtbi.2014.08.022. Epub 2014 Aug 21.

PMID:
25152218
40.

Swimming efficiency of spherical squirmers: beyond the Lighthill theory.

Ishimoto K, Gaffney EA.

Phys Rev E Stat Nonlin Soft Matter Phys. 2014 Jul;90(1):012704. Epub 2014 Jul 17.

PMID:
25122332
41.

A study of spermatozoan swimming stability near a surface.

Ishimoto K, Gaffney EA.

J Theor Biol. 2014 Nov 7;360:187-199. doi: 10.1016/j.jtbi.2014.06.034. Epub 2014 Jul 8.

PMID:
25014474
42.

Cartilage dysfunction in ALS patients as side effect of motion loss: 3D mechano-electrochemical computational model.

Manzano S, Gaffney EA, Doblaré M, Hamdy Doweidar M.

Biomed Res Int. 2014;2014:179070. doi: 10.1155/2014/179070. Epub 2014 Jun 3.

43.

Is pigment cell pattern formation in zebrafish a game of cops and robbers?

Woolley TE, Maini PK, Gaffney EA.

Pigment Cell Melanoma Res. 2014 Sep;27(5):686-7. doi: 10.1111/pcmr.12276. Epub 2014 Jun 27. No abstract available.

PMID:
24903209
44.

Modelling capillary oxygen supply capacity in mixed muscles: capillary domains revisited.

Al-Shammari AA, Gaffney EA, Egginton S.

J Theor Biol. 2014 Sep 7;356:47-61. doi: 10.1016/j.jtbi.2014.04.016. Epub 2014 Apr 24.

45.

Comparing methods for modelling spreading cell fronts.

Markham DC, Simpson MJ, Maini PK, Gaffney EA, Baker RE.

J Theor Biol. 2014 Jul 21;353:95-103. doi: 10.1016/j.jtbi.2014.02.023. Epub 2014 Mar 12.

PMID:
24613725
46.

Spreading speeds for stage structured plant populations in fragmented landscapes.

Gilbert MA, White SM, Bullock JM, Gaffney EA.

J Theor Biol. 2014 May 21;349:135-49. doi: 10.1016/j.jtbi.2014.01.024. Epub 2014 Jan 30.

PMID:
24486654
47.

Squirmer dynamics near a boundary.

Ishimoto K, Gaffney EA.

Phys Rev E Stat Nonlin Soft Matter Phys. 2013 Dec;88(6):062702. Epub 2013 Dec 2.

PMID:
24483481
48.

Incorporating spatial correlations into multispecies mean-field models.

Markham DC, Simpson MJ, Maini PK, Gaffney EA, Baker RE.

Phys Rev E Stat Nonlin Soft Matter Phys. 2013 Nov;88(5):052713. Epub 2013 Nov 20.

PMID:
24329302
49.

The sensitivity of Turing self-organization to biological feedback delays: 2D models of fish pigmentation.

Gaffney EA, Lee SS.

Math Med Biol. 2015 Mar;32(1):56-78. doi: 10.1093/imammb/dqt017. Epub 2013 Oct 1.

PMID:
24087834
50.

Turing's model for biological pattern formation and the robustness problem.

Maini PK, Woolley TE, Baker RE, Gaffney EA, Lee SS.

Interface Focus. 2012 Aug 6;2(4):487-96. doi: 10.1098/rsfs.2011.0113. Epub 2012 Feb 8.

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