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Dermatophyte Immune Memory Is Only Skin-Deep.

Verma AH, Gaffen SL.

J Invest Dermatol. 2019 Mar;139(3):517-519. doi: 10.1016/j.jid.2018.10.022.


Combined Blockade of TNF-α and IL-17A Alleviates Progression of Collagen-Induced Arthritis without Causing Serious Infections in Mice.

Shen F, Verma AH, Volk A, Jones B, Coleman BM, Loza MJ, Malaviya R, Moore B, Weinstock D, Elloso MM, Gaffen SL, Ort T.

J Immunol. 2019 Apr 1;202(7):2017-2026. doi: 10.4049/jimmunol.1801436. Epub 2019 Feb 11.


IL-17 integrates multiple self-reinforcing, feed-forward mechanisms through the RNA binding protein Arid5a.

Amatya N, Childs EE, Cruz JA, Aggor FEY, Garg AV, Berman AJ, Gudjonsson JE, Atasoy U, Gaffen SL.

Sci Signal. 2018 Oct 9;11(551). pii: eaat4617. doi: 10.1126/scisignal.aat4617.


T Cell Receptor-Independent, CD31/IL-17A-Driven Inflammatory Axis Shapes Synovitis in Juvenile Idiopathic Arthritis.

Ferguson ID, Griffin P, Michel JJ, Yano H, Gaffen SL, Mueller RG, Dvergsten JA, Piganelli JD, Rosenkranz ME, Kietz DA, Vallejo AN.

Front Immunol. 2018 Aug 6;9:1802. doi: 10.3389/fimmu.2018.01802. eCollection 2018.


IL-36 and IL-1/IL-17 Drive Immunity to Oral Candidiasis via Parallel Mechanisms.

Verma AH, Zafar H, Ponde NO, Hepworth OW, Sihra D, Aggor FEY, Ainscough JS, Ho J, Richardson JP, Coleman BM, Hube B, Stacey M, McGeachy MJ, Naglik JR, Gaffen SL, Moyes DL.

J Immunol. 2018 Jul 15;201(2):627-634. doi: 10.4049/jimmunol.1800515. Epub 2018 Jun 11.


Innate Immunity to Mucosal Candida Infections.

Verma A, Gaffen SL, Swidergall M.

J Fungi (Basel). 2017 Oct 31;3(4). pii: E60. doi: 10.3390/jof3040060. Review.


Processing of Candida albicans Ece1p Is Critical for Candidalysin Maturation and Fungal Virulence.

Richardson JP, Mogavero S, Moyes DL, Blagojevic M, Krüger T, Verma AH, Coleman BM, De La Cruz Diaz J, Schulz D, Ponde NO, Carrano G, Kniemeyer O, Wilson D, Bader O, Enoiu SI, Ho J, Kichik N, Gaffen SL, Hube B, Naglik JR.

MBio. 2018 Jan 23;9(1). pii: e02178-17. doi: 10.1128/mBio.02178-17.


Candida albicans-epithelial interactions and induction of mucosal innate immunity.

Naglik JR, König A, Hube B, Gaffen SL.

Curr Opin Microbiol. 2017 Dec;40:104-112. doi: 10.1016/j.mib.2017.10.030. Epub 2017 Nov 17. Review.


IL-22 neutralizing autoantibodies impair fungal clearance in murine oropharyngeal candidiasis model.

Bichele R, Kärner J, Truusalu K, Smidt I, Mändar R, Conti HR, Gaffen SL, Peterson P, Laan M, Kisand K.

Eur J Immunol. 2018 Mar;48(3):464-470. doi: 10.1002/eji.201747209. Epub 2017 Dec 11.


Oral epithelial cells orchestrate innate type 17 responses to Candida albicans through the virulence factor candidalysin.

Verma AH, Richardson JP, Zhou C, Coleman BM, Moyes DL, Ho J, Huppler AR, Ramani K, McGeachy MJ, Mufazalov IA, Waisman A, Kane LP, Biswas PS, Hube B, Naglik JR, Gaffen SL.

Sci Immunol. 2017 Nov 3;2(17). pii: eaam8834. doi: 10.1126/sciimmunol.aam8834.


Interleukin-17 signaling triggers degradation of the constitutive NF-κB inhibitor ABIN-1.

Cruz JA, Childs EE, Amatya N, Garg AV, Beyaert R, Kane LP, Aneskievich BJ, Ma A, Gaffen SL.

Immunohorizons. 2017 Sep;1(7):133-141. doi: 10.4049/immunohorizons.1700035.


Interleukin 17 Family Cytokines: Signaling Mechanisms, Biological Activities, and Therapeutic Implications.

Monin L, Gaffen SL.

Cold Spring Harb Perspect Biol. 2018 Apr 2;10(4). pii: a028522. doi: 10.1101/cshperspect.a028522. Review.


Follistatin-like protein 1 modulates IL-17 signaling via IL-17RC regulation in stromal cells.

Campfield BT, Eddens T, Henkel M, Majewski M, Horne W, Chaly Y, Gaffen SL, Hirsch R, Kolls JK.

Immunol Cell Biol. 2017 Sep;95(8):656-665. doi: 10.1038/icb.2017.26. Epub 2017 Apr 5.


The Aryl Hydrocarbon Receptor Governs Epithelial Cell Invasion during Oropharyngeal Candidiasis.

Solis NV, Swidergall M, Bruno VM, Gaffen SL, Filler SG.

MBio. 2017 Mar 21;8(2). pii: e00025-17. doi: 10.1128/mBio.00025-17.


IL-17 Signaling: The Yin and the Yang.

Amatya N, Garg AV, Gaffen SL.

Trends Immunol. 2017 May;38(5):310-322. doi: 10.1016/ Epub 2017 Feb 20. Review.


CCAAT/Enhancer-binding protein β promotes pathogenesis of EAE.

Simpson-Abelson MR, Hernandez-Mir G, Childs EE, Cruz JA, Poholek AC, Chattopadhyay A, Gaffen SL, McGeachy MJ.

Cytokine. 2017 Apr;92:24-32. doi: 10.1016/j.cyto.2017.01.005. Epub 2017 Jan 12.


IL-17 Receptor Signaling in Oral Epithelial Cells Is Critical for Protection against Oropharyngeal Candidiasis.

Conti HR, Bruno VM, Childs EE, Daugherty S, Hunter JP, Mengesha BG, Saevig DL, Hendricks MR, Coleman BM, Brane L, Solis N, Cruz JA, Verma AH, Garg AV, Hise AG, Richardson JP, Naglik JR, Filler SG, Kolls JK, Sinha S, Gaffen SL.

Cell Host Microbe. 2016 Nov 9;20(5):606-617. doi: 10.1016/j.chom.2016.10.001. Epub 2016 Oct 27.


IL-17 Receptor Signaling in the Lung Epithelium Is Required for Mucosal Chemokine Gradients and Pulmonary Host Defense against K. pneumoniae.

Chen K, Eddens T, Trevejo-Nunez G, Way EE, Elsegeiny W, Ricks DM, Garg AV, Erb CJ, Bo M, Wang T, Chen W, Lee JS, Gaffen SL, Kolls JK.

Cell Host Microbe. 2016 Nov 9;20(5):596-605. doi: 10.1016/j.chom.2016.10.003. Epub 2016 Oct 27.


MCPIP1/Regnase-1 Restricts IL-17A- and IL-17C-Dependent Skin Inflammation.

Monin L, Gudjonsson JE, Childs EE, Amatya N, Xing X, Verma AH, Coleman BM, Garg AV, Killeen M, Mathers A, Ward NL, Gaffen SL.

J Immunol. 2017 Jan 15;198(2):767-775. doi: 10.4049/jimmunol.1601551. Epub 2016 Dec 5.


The Kallikrein-Kinin System: A Novel Mediator of IL-17-Driven Anti-Candida Immunity in the Kidney.

Ramani K, Garg AV, Jawale CV, Conti HR, Whibley N, Jackson EK, Shiva SS, Horne W, Kolls JK, Gaffen SL, Biswas PS.

PLoS Pathog. 2016 Nov 4;12(11):e1005952. doi: 10.1371/journal.ppat.1005952. eCollection 2016 Nov.


Update on Gender Equity in Immunology, 2001 to 2016.

Shapiro VS, Kovats S, Parent MA, Gaffen SL, Hedrick CC, Jain P, Denzin LK, Raghavan M, Stephens R.

J Immunol. 2016 Nov 15;197(10):3751-3753. Epub 2016 Oct 17.


Editorial: Fake it 'til you make it: mast cells acquire IL-17 exogenously.

Huppler AR, Gaffen SL.

J Leukoc Biol. 2016 Sep;100(3):445-6. doi: 10.1189/jlb.3CE0216-071R. No abstract available.


Antibody blockade of IL-17 family cytokines in immunity to acute murine oral mucosal candidiasis.

Whibley N, Tritto E, Traggiai E, Kolbinger F, Moulin P, Brees D, Coleman BM, Mamo AJ, Garg AV, Jaycox JR, Siebenlist U, Kammüller M, Gaffen SL.

J Leukoc Biol. 2016 Jun;99(6):1153-64. doi: 10.1189/jlb.4A0915-428R. Epub 2016 Jan 4. Erratum in: J Leukoc Biol. 2017 Apr;101(4):1065.


Gut-Busters: IL-17 Ain't Afraid of No IL-23.

Whibley N, Gaffen SL.

Immunity. 2015 Oct 20;43(4):620-2. doi: 10.1016/j.immuni.2015.10.001.


Delinking CARD9 and IL-17: CARD9 Protects against Candida tropicalis Infection through a TNF-α-Dependent, IL-17-Independent Mechanism.

Whibley N, Jaycox JR, Reid D, Garg AV, Taylor JA, Clancy CJ, Nguyen MH, Biswas PS, McGeachy MJ, Brown GD, Gaffen SL.

J Immunol. 2015 Oct 15;195(8):3781-92. doi: 10.4049/jimmunol.1500870. Epub 2015 Sep 2.


MCPIP1 Endoribonuclease Activity Negatively Regulates Interleukin-17-Mediated Signaling and Inflammation.

Garg AV, Amatya N, Chen K, Cruz JA, Grover P, Whibley N, Conti HR, Hernandez Mir G, Sirakova T, Childs EC, Smithgall TE, Biswas PS, Kolls JK, McGeachy MJ, Kolattukudy PE, Gaffen SL.

Immunity. 2015 Sep 15;43(3):475-87. doi: 10.1016/j.immuni.2015.07.021. Epub 2015 Aug 25.


C/EBPβ Promotes Immunity to Oral Candidiasis through Regulation of β-Defensins.

Simpson-Abelson MR, Childs EE, Ferreira MC, Bishu S, Conti HR, Gaffen SL.

PLoS One. 2015 Aug 28;10(8):e0136538. doi: 10.1371/journal.pone.0136538. eCollection 2015.


Beyond Candida albicans: Mechanisms of immunity to non-albicans Candida species.

Whibley N, Gaffen SL.

Cytokine. 2015 Nov;76(1):42-52. doi: 10.1016/j.cyto.2015.07.025. Epub 2015 Aug 11. Review.


Neutrophils Do Not Express IL-17A in the Context of Acute Oropharyngeal Candidiasis.

Huppler AR, Verma AH, Conti HR, Gaffen SL.

Pathogens. 2015 Jul 24;4(3):559-72. doi: 10.3390/pathogens4030559.


IL-17-Mediated Immunity to the Opportunistic Fungal Pathogen Candida albicans.

Conti HR, Gaffen SL.

J Immunol. 2015 Aug 1;195(3):780-8. doi: 10.4049/jimmunol.1500909. Review.


A Candida albicans Strain Expressing Mammalian Interleukin-17A Results in Early Control of Fungal Growth during Disseminated Infection.

Huppler AR, Whibley N, Woolford CA, Childs EE, He J, Biswas PS, McGeachy MJ, Mitchell AP, Gaffen SL.

Infect Immun. 2015 Sep;83(9):3684-92. doi: 10.1128/IAI.03057-14. Epub 2015 Jul 6.


Signaling through IL-17C/IL-17RE is dispensable for immunity to systemic, oral and cutaneous candidiasis.

Conti HR, Whibley N, Coleman BM, Garg AV, Jaycox JR, Gaffen SL.

PLoS One. 2015 Apr 7;10(4):e0122807. doi: 10.1371/journal.pone.0122807. eCollection 2015.


Integrating p38α MAPK immune signals in nonimmune cells.

Gaffen SL, McGeachy MJ.

Sci Signal. 2015 Mar 3;8(366):fs5. doi: 10.1126/scisignal.aaa8398. Review.


Correction: Role of Neutrophils in IL-17-Dependent Immunity to Mucosal Candidiasis.

Huppler AR, Conti HR, Hernández-Santos N, Darville T, Biswas PS, Gaffen SL.

J Immunol. 2015 Feb 1;194(3):1382. doi: 10.4049/jimmunol.1490053. No abstract available.


Brothers in arms: Th17 and Treg responses in Candida albicans immunity.

Whibley N, Gaffen SL.

PLoS Pathog. 2014 Dec 4;10(12):e1004456. doi: 10.1371/journal.ppat.1004456. eCollection 2014 Dec. Review. No abstract available.


Innate Defense against Fungal Pathogens.

Drummond RA, Gaffen SL, Hise AG, Brown GD.

Cold Spring Harb Perspect Med. 2014 Nov 10;5(6). pii: a019620. doi: 10.1101/cshperspect.a019620. Review.


Oral-resident natural Th17 cells and γδ T cells control opportunistic Candida albicans infections.

Conti HR, Peterson AC, Brane L, Huppler AR, Hernández-Santos N, Whibley N, Garg AV, Simpson-Abelson MR, Gibson GA, Mamo AJ, Osborne LC, Bishu S, Ghilardi N, Siebenlist U, Watkins SC, Artis D, McGeachy MJ, Gaffen SL.

J Exp Med. 2014 Sep 22;211(10):2075-84. doi: 10.1084/jem.20130877. Epub 2014 Sep 8.


The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing.

Gaffen SL, Jain R, Garg AV, Cua DJ.

Nat Rev Immunol. 2014 Sep;14(9):585-600. doi: 10.1038/nri3707. Review.


An essential role of interleukin-17 receptor signaling in the development of autoimmune glomerulonephritis.

Ramani K, Pawaria S, Maers K, Huppler AR, Gaffen SL, Biswas PS.

J Leukoc Biol. 2014 Sep;96(3):463-72. doi: 10.1189/jlb.3A0414-184R. Epub 2014 Jun 16.


Recent advances in host defense mechanisms/therapies against oral infectious diseases and consequences for systemic disease.

Gaffen SL, Herzberg MC, Taubman MA, Van Dyke TE.

Adv Dent Res. 2014 May;26(1):30-7. doi: 10.1177/0022034514525778. Review.


Animal models for candidiasis.

Conti HR, Huppler AR, Whibley N, Gaffen SL.

Curr Protoc Immunol. 2014 Apr 2;105:19.6.1-17. doi: 10.1002/0471142735.im1906s105. Review.


Rheumatoid arthritis patients exhibit impaired Candida albicans-specific Th17 responses.

Bishu S, Su EW, Wilkerson ER, Reckley KA, Jones DM, McGeachy MJ, Gaffen SL, Levesque MC.

Arthritis Res Ther. 2014 Feb 11;16(1):R50. doi: 10.1186/ar4480.


Role of neutrophils in IL-17-dependent immunity to mucosal candidiasis.

Huppler AR, Conti HR, Hernández-Santos N, Darville T, Biswas PS, Gaffen SL.

J Immunol. 2014 Feb 15;192(4):1745-52. doi: 10.4049/jimmunol.1302265. Epub 2014 Jan 17. Erratum in: J Immunol. 2015 Feb 1;194(3):1382.


Expansion of Foxp3(+) T-cell populations by Candida albicans enhances both Th17-cell responses and fungal dissemination after intravenous challenge.

Whibley N, Maccallum DM, Vickers MA, Zafreen S, Waldmann H, Hori S, Gaffen SL, Gow NA, Barker RN, Hall AM.

Eur J Immunol. 2014 Apr;44(4):1069-83. doi: 10.1002/eji.201343604. Epub 2014 Feb 13.


The adaptor CARD9 is required for adaptive but not innate immunity to oral mucosal Candida albicans infections.

Bishu S, Hernández-Santos N, Simpson-Abelson MR, Huppler AR, Conti HR, Ghilardi N, Mamo AJ, Gaffen SL.

Infect Immun. 2014 Mar;82(3):1173-80. doi: 10.1128/IAI.01335-13. Epub 2013 Dec 30.


Interleukin-17-induced protein lipocalin 2 is dispensable for immunity to oral candidiasis.

Ferreira MC, Whibley N, Mamo AJ, Siebenlist U, Chan YR, Gaffen SL.

Infect Immun. 2014 Mar;82(3):1030-5. doi: 10.1128/IAI.01389-13. Epub 2013 Dec 16.


IL-17 signaling and A20: a balancing act.

Garg AV, Gaffen SL.

Cell Cycle. 2013 Nov 15;12(22):3459-60. doi: 10.4161/cc.26699. Epub 2013 Oct 8. No abstract available.


The anaphase-promoting complex protein 5 (AnapC5) associates with A20 and inhibits IL-17-mediated signal transduction.

Ho AW, Garg AV, Monin L, Simpson-Abelson MR, Kinner L, Gaffen SL.

PLoS One. 2013 Jul 29;8(7):e70168. doi: 10.1371/journal.pone.0070168. Print 2013.


The deubiquitinase A20 mediates feedback inhibition of interleukin-17 receptor signaling.

Garg AV, Ahmed M, Vallejo AN, Ma A, Gaffen SL.

Sci Signal. 2013 Jun 4;6(278):ra44. doi: 10.1126/scisignal.2003699.


A competitive infection model of hematogenously disseminated candidiasis in mice redefines the role of Candida albicans IRS4 in pathogenesis.

Raman SB, Nguyen MH, Cheng S, Badrane H, Iczkowski KA, Wegener M, Gaffen SL, Mitchell AP, Clancy CJ.

Infect Immun. 2013 May;81(5):1430-8. doi: 10.1128/IAI.00743-12. Epub 2013 Feb 19.

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