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Developmental Expression of the Cytosolic Sulfotransferases in Human Liver.

Dubaisi S, Caruso JA, Gaedigk R, Vyhlidal CA, Smith PC, Hines RN, Kocarek TA, Runge-Morris M.

Drug Metab Dispos. 2019 Jun;47(6):592-600. doi: 10.1124/dmd.119.086363. Epub 2019 Mar 18.


Impact of Genetic Variation on Pravastatin Systemic Exposure in Pediatric Hypercholesterolemia.

Wagner JB, Abdel-Rahman S, Gaedigk R, Gaedigk A, Raghuveer G, Staggs VS, Kauffman R, Van Haandel L, Leeder JS.

Clin Pharmacol Ther. 2019 Jun;105(6):1501-1512. doi: 10.1002/cpt.1330. Epub 2019 Feb 25.


Proteomics of human liver membrane transporters: a focus on fetuses and newborn infants.

van Groen BD, van de Steeg E, Mooij MG, van Lipzig MMH, de Koning BAE, Verdijk RM, Wortelboer HM, Gaedigk R, Bi C, Leeder JS, van Schaik RHN, van Rosmalen J, Tibboel D, Vaes WH, de Wildt SN.

Eur J Pharm Sci. 2018 Nov 1;124:217-227. doi: 10.1016/j.ejps.2018.08.042. Epub 2018 Aug 30.


Age- and Genotype-Dependent Variability in the Protein Abundance and Activity of Six Major Uridine Diphosphate-Glucuronosyltransferases in Human Liver.

Bhatt DK, Mehrotra A, Gaedigk A, Chapa R, Basit A, Zhang H, Choudhari P, Boberg M, Pearce RE, Gaedigk R, Broeckel U, Leeder JS, Prasad B.

Clin Pharmacol Ther. 2019 Jan;105(1):131-141. doi: 10.1002/cpt.1109. Epub 2018 Jul 12.


Polymorphic Expression of UGT1A9 is Associated with Variable Acetaminophen Glucuronidation in Neonates: A Population Pharmacokinetic and Pharmacogenetic Study.

Linakis MW, Cook SF, Kumar SS, Liu X, Wilkins DG, Gaedigk R, Gaedigk A, Sherwin CMT, van den Anker JN.

Clin Pharmacokinet. 2018 Oct;57(10):1325-1336. doi: 10.1007/s40262-018-0634-9.


Hepatic Abundance and Activity of Androgen- and Drug-Metabolizing Enzyme UGT2B17 Are Associated with Genotype, Age, and Sex.

Bhatt DK, Basit A, Zhang H, Gaedigk A, Lee SB, Claw KG, Mehrotra A, Chaudhry AS, Pearce RE, Gaedigk R, Broeckel U, Thornton TA, Nickerson DA, Schuetz EG, Amory JK, Leeder JS, Prasad B.

Drug Metab Dispos. 2018 Jun;46(6):888-896. doi: 10.1124/dmd.118.080952. Epub 2018 Mar 30.


Impact of SLCO1B1 Genotype on Pediatric Simvastatin Acid Pharmacokinetics.

Wagner JB, Abdel-Rahman S, Van Haandel L, Gaedigk A, Gaedigk R, Raghuveer G, Kauffman R, Leeder JS.

J Clin Pharmacol. 2018 Jun;58(6):823-833. doi: 10.1002/jcph.1080. Epub 2018 Feb 22.


Ontogeny-related pharmacogene changes in the pediatric liver transcriptome.

Meier R, Bi C, Gaedigk R, Heruth DP, Ye SQ, Leeder JS, Fridley BL.

Pharmacogenet Genomics. 2018 Mar;28(3):86-94. doi: 10.1097/FPC.0000000000000326.


Variants in the CYP2B6 3'UTR Alter In Vitro and In Vivo CYP2B6 Activity: Potential Role of MicroRNAs.

Burgess KS, Ipe J, Swart M, Metzger IF, Lu J, Gufford BT, Thong N, Desta Z, Gaedigk R, Pearce RE, Gaedigk A, Liu Y, Skaar TC.

Clin Pharmacol Ther. 2018 Jul;104(1):130-138. doi: 10.1002/cpt.892. Epub 2017 Oct 25.


Early pregnancy intrauterine fetal exposure to maternal smoking and impact on fetal telomere length.

Mirzakhani H, De Vivo I, Leeder JS, Gaedigk R, Vyhlidal CA, Weiss ST, Tantisira K.

Eur J Obstet Gynecol Reprod Biol. 2017 Nov;218:27-32. doi: 10.1016/j.ejogrb.2017.09.013. Epub 2017 Sep 14.


Genetic and Nongenetic Factors Associated with Protein Abundance of Flavin-Containing Monooxygenase 3 in Human Liver.

Xu M, Bhatt DK, Yeung CK, Claw KG, Chaudhry AS, Gaedigk A, Pearce RE, Broeckel U, Gaedigk R, Nickerson DA, Schuetz E, Rettie AE, Leeder JS, Thummel KE, Prasad B.

J Pharmacol Exp Ther. 2017 Nov;363(2):265-274. doi: 10.1124/jpet.117.243113. Epub 2017 Aug 17.


Metabolic and molecular insights into an essential role of nicotinamide phosphoribosyltransferase.

Zhang LQ, Van Haandel L, Xiong M, Huang P, Heruth DP, Bi C, Gaedigk R, Jiang X, Li DY, Wyckoff G, Grigoryev DN, Gao L, Li L, Wu M, Leeder JS, Ye SQ.

Cell Death Dis. 2017 Mar 23;8(3):e2705. doi: 10.1038/cddis.2017.132.


Ontogeny of Hepatic Drug Transporters as Quantified by LC-MS/MS Proteomics.

Prasad B, Gaedigk A, Vrana M, Gaedigk R, Leeder JS, Salphati L, Chu X, Xiao G, Hop C, Evers R, Gan L, Unadkat JD.

Clin Pharmacol Ther. 2016 Oct;100(4):362-70. doi: 10.1002/cpt.409. Epub 2016 Aug 13.


Developmental Expression of CYP2B6: A Comprehensive Analysis of mRNA Expression, Protein Content and Bupropion Hydroxylase Activity and the Impact of Genetic Variation.

Pearce RE, Gaedigk R, Twist GP, Dai H, Riffel AK, Leeder JS, Gaedigk A.

Drug Metab Dispos. 2016 Jul;44(7):948-58. doi: 10.1124/dmd.115.067546. Epub 2015 Nov 25.


Age, Sexual Dimorphism, and Disease Associations in the Developing Human Fetal Lung Transcriptome.

Kho AT, Chhabra D, Sharma S, Qiu W, Carey VJ, Gaedigk R, Vyhlidal CA, Leeder JS, Tantisira KG, Weiss ST.

Am J Respir Cell Mol Biol. 2016 Jun;54(6):814-21. doi: 10.1165/rcmb.2015-0326OC.


Variability in Expression of CYP3A5 in Human Fetal Liver.

Vyhlidal CA, Pearce RE, Gaedigk R, Calamia JC, Shuster DL, Thummel KE, Leeder JS.

Drug Metab Dispos. 2015 Aug;43(8):1286-93. doi: 10.1124/dmd.115.064998. Epub 2015 May 15. Erratum in: Drug Metab Dispos. 2016 Sep;44(9):1459.


Age-Related Changes in MicroRNA Expression and Pharmacogenes in Human Liver.

Burgess KS, Philips S, Benson EA, Desta Z, Gaedigk A, Gaedigk R, Segar MW, Liu Y, Skaar TC.

Clin Pharmacol Ther. 2015 Aug;98(2):205-15. doi: 10.1002/cpt.145.


Effect of CYP3A5*3 on asthma control among children treated with inhaled beclomethasone.

Stockmann C, Reilly CA, Fassl B, Gaedigk R, Nkoy F, Stone B, Roberts JK, Uchida DA, Leeder JS, Sherwin CM, Spigarelli MG, Yost GS, Ward RM.

J Allergy Clin Immunol. 2015 Aug;136(2):505-7. doi: 10.1016/j.jaci.2015.02.009. Epub 2015 Mar 29. No abstract available.


Fetal lung and placental methylation is associated with in utero nicotine exposure.

Chhabra D, Sharma S, Kho AT, Gaedigk R, Vyhlidal CA, Leeder JS, Morrow J, Carey VJ, Weiss ST, Tantisira KG, DeMeo DL.

Epigenetics. 2014 Nov;9(11):1473-84. doi: 10.4161/15592294.2014.971593.


Glucocorticoid genes and the developmental origins of asthma susceptibility and treatment response.

Sharma S, Kho AT, Chhabra D, Qiu W, Gaedigk R, Vyhlidal CA, Leeder JS, Barraza-Villarreal A, London SJ, Gilliland F, Raby BA, Weiss ST, Tantisira KG.

Am J Respir Cell Mol Biol. 2015 May;52(5):543-53. doi: 10.1165/rcmb.2014-0109OC.


Ontogeny of human hepatic and intestinal transporter gene expression during childhood: age matters.

Mooij MG, Schwarz UI, de Koning BA, Leeder JS, Gaedigk R, Samsom JN, Spaans E, van Goudoever JB, Tibboel D, Kim RB, de Wildt SN.

Drug Metab Dispos. 2014 Aug;42(8):1268-74. doi: 10.1124/dmd.114.056929. Epub 2014 May 14.


Vitamin D related genes in lung development and asthma pathogenesis.

Kho AT, Sharma S, Qiu W, Gaedigk R, Klanderman B, Niu S, Anderson C, Leeder JS, Weiss ST, Tantisira KG.

BMC Med Genomics. 2013 Nov 5;6:47. doi: 10.1186/1755-8794-6-47.


High-resolution melt analysis to detect sequence variations in highly homologous gene regions: application to CYP2B6.

Twist GP, Gaedigk R, Leeder JS, Gaedigk A.

Pharmacogenomics. 2013 Jun;14(8):913-22. doi: 10.2217/pgs.13.66.


Fluticasone propionate pharmacogenetics: CYP3A4*22 polymorphism and pediatric asthma control.

Stockmann C, Fassl B, Gaedigk R, Nkoy F, Uchida DA, Monson S, Reilly CA, Leeder JS, Yost GS, Ward RM.

J Pediatr. 2013 Jun;162(6):1222-7, 1227.e1-2. doi: 10.1016/j.jpeds.2012.11.031. Epub 2013 Jan 3.


Global tests of P-values for multifactor dimensionality reduction models in selection of optimal number of target genes.

Dai H, Bhandary M, Becker M, Leeder JS, Gaedigk R, Motsinger-Reif AA.

BioData Min. 2012 May 22;5(1):3. doi: 10.1186/1756-0381-5-3.


Red blood cell folate concentrations and polyglutamate distribution in juvenile arthritis: predictors of folate variability.

Becker ML, van Haandel L, Gaedigk R, Thomas B, Hoeltzel MF, Lasky A, Dai H, Stobaugh J, Leeder JS.

Pharmacogenet Genomics. 2012 Apr;22(4):236-46. doi: 10.1097/FPC.0b013e3283500202.


The role of CYP3A4 mRNA transcript with shortened 3'-untranslated region in hepatocyte differentiation, liver development, and response to drug induction.

Li D, Gaedigk R, Hart SN, Leeder JS, Zhong XB.

Mol Pharmacol. 2012 Jan;81(1):86-96. doi: 10.1124/mol.111.074393. Epub 2011 Oct 13.


Expression analysis of asthma candidate genes during human and murine lung development.

Melén E, Kho AT, Sharma S, Gaedigk R, Leeder JS, Mariani TJ, Carey VJ, Weiss ST, Tantisira KG.

Respir Res. 2011 Jun 23;12:86. doi: 10.1186/1465-9921-12-86.


PharmGKB summary: methotrexate pathway.

Mikkelsen TS, Thorn CF, Yang JJ, Ulrich CM, French D, Zaza G, Dunnenberger HM, Marsh S, McLeod HL, Giacomini K, Becker ML, Gaedigk R, Leeder JS, Kager L, Relling MV, Evans W, Klein TE, Altman RB.

Pharmacogenet Genomics. 2011 Oct;21(10):679-86. doi: 10.1097/FPC.0b013e328343dd93. No abstract available.


The effect of genotype on methotrexate polyglutamate variability in juvenile idiopathic arthritis and association with drug response.

Becker ML, Gaedigk R, van Haandel L, Thomas B, Lasky A, Hoeltzel M, Dai H, Stobaugh J, Leeder JS.

Arthritis Rheum. 2011 Jan;63(1):276-85. doi: 10.1002/art.30080.


Selective Toll--like receptor expression in human fetal lung.

Petrikin JE, Gaedigk R, Leeder JS, Truog WE.

Pediatr Res. 2010 Oct;68(4):335-8. doi: 10.1203/00006450-201011001-00656.


UGT2B17 and SULT1A1 gene copy number variation (CNV) detection by LabChip microfluidic technology.

Gaedigk A, Gaedigk R, Leeder JS.

Clin Chem Lab Med. 2010 May;48(5):627-33. doi: 10.1515/CCLM.2010.128.


Analysis of intracellular methotrexate polyglutamates in patients with juvenile idiopathic arthritis: effect of route of administration on variability in intracellular methotrexate polyglutamate concentrations.

Becker ML, van Haandel L, Gaedigk R, Lasky A, Hoeltzel M, Stobaugh J, Leeder JS.

Arthritis Rheum. 2010 Jun;62(6):1803-12. doi: 10.1002/art.27434.


A role for Wnt signaling genes in the pathogenesis of impaired lung function in asthma.

Sharma S, Tantisira K, Carey V, Murphy AJ, Lasky-Su J, Celedón JC, Lazarus R, Klanderman B, Rogers A, Soto-Quirós M, Avila L, Mariani T, Gaedigk R, Leeder S, Torday J, Warburton D, Raby B, Weiss ST.

Am J Respir Crit Care Med. 2010 Feb 15;181(4):328-36. doi: 10.1164/rccm.200907-1009OC. Epub 2009 Nov 19.


Transcriptomic analysis of human lung development.

Kho AT, Bhattacharya S, Tantisira KG, Carey VJ, Gaedigk R, Leeder JS, Kohane IS, Weiss ST, Mariani TJ.

Am J Respir Crit Care Med. 2010 Jan 1;181(1):54-63. doi: 10.1164/rccm.200907-1063OC. Epub 2009 Oct 8.


Platform dependence of inference on gene-wise and gene-set involvement in human lung development.

Du R, Tantisira K, Carey V, Bhattacharya S, Metje S, Kho AT, Klanderman BJ, Gaedigk R, Lazarus R, Mariani TJ, Leeder JS, Weiss ST.

BMC Bioinformatics. 2009 Jun 19;10:189. doi: 10.1186/1471-2105-10-189.


Human carboxylesterases HCE1 and HCE2: ontogenic expression, inter-individual variability and differential hydrolysis of oseltamivir, aspirin, deltamethrin and permethrin.

Yang D, Pearce RE, Wang X, Gaedigk R, Wan YJ, Yan B.

Biochem Pharmacol. 2009 Jan 15;77(2):238-47. doi: 10.1016/j.bcp.2008.10.005. Epub 2008 Oct 15.


Variability of CYP2J2 expression in human fetal tissues.

Gaedigk A, Baker DW, Totah RA, Gaedigk R, Pearce RE, Vyhlidal CA, Zeldin DC, Leeder JS.

J Pharmacol Exp Ther. 2006 Nov;319(2):523-32. Epub 2006 Jul 25.


Improvement in survival and muscle function in an mdx/utrn(-/-) double mutant mouse using a human retinal dystrophin transgene.

Gaedigk R, Law DJ, Fitzgerald-Gustafson KM, McNulty SG, Nsumu NN, Modrcin AC, Rinaldi RJ, Pinson D, Fowler SC, Bilgen M, Burns J, Hauschka SD, White RA.

Neuromuscul Disord. 2006 Mar;16(3):192-203. Epub 2006 Feb 17.


Characterization of the ALP1 gene locus of Trichophyton tonsurans.

Bhathena A, Gaedigk R, Abdel-Rahman SM.

Mycopathologia. 2005 Nov;160(4):265-72.


Nuclear receptor expression in fetal and pediatric liver: correlation with CYP3A expression.

Vyhlidal CA, Gaedigk R, Leeder JS.

Drug Metab Dispos. 2006 Jan;34(1):131-7. Epub 2005 Oct 21.


CYP2D7 splice variants in human liver and brain: does CYP2D7 encode functional protein?

Gaedigk A, Gaedigk R, Leeder JS.

Biochem Biophys Res Commun. 2005 Nov 4;336(4):1241-50.


Variability of CYP3A7 expression in human fetal liver.

Leeder JS, Gaedigk R, Marcucci KA, Gaedigk A, Vyhlidal CA, Schindel BP, Pearce RE.

J Pharmacol Exp Ther. 2005 Aug;314(2):626-35. Epub 2005 Apr 21.


Chromosomal localization, hematologic characterization, and iron metabolism of the hereditary erythroblastic anemia (hea) mutant mouse.

White RA, McNulty SG, Roman S, Garg U, Wirtz E, Kohlbrecher D, Nsumu NN, Pinson D, Gaedigk R, Blackmore K, Copple A, Rasul S, Watanabe M, Shimizu K.

Blood. 2004 Sep 1;104(5):1511-8. Epub 2004 May 20.


Genetic Heterogeneity in the rRNA Gene Locus of Trichophyton tonsurans.

Gaedigk A, Gaedigk R, Abdel-Rahman SM.

J Clin Microbiol. 2003 Dec;41(12):5478-87.


Discovery of a novel nonfunctional cytochrome P450 2D6 allele, CYP2D642, in African American subjects.

Gaedigk A, Ndjountché L, Gaedigk R, Leeder JS, Bradford LD.

Clin Pharmacol Ther. 2003 Jun;73(6):575-6. No abstract available.


Primary Sjögren's syndrome and deficiency of ICA69.

Winer S, Astsaturov I, Cheung R, Tsui H, Song A, Gaedigk R, Winer D, Sampson A, McKerlie C, Bookman A, Dosch HM.

Lancet. 2002 Oct 5;360(9339):1063-9.


ICA69(null) nonobese diabetic mice develop diabetes, but resist disease acceleration by cyclophosphamide.

Winer S, Astsaturov I, Gaedigk R, Hammond-McKibben D, Pilon M, Song A, Kubiak V, Karges W, Arpaia E, McKerlie C, Zucker P, Singh B, Dosch HM.

J Immunol. 2002 Jan 1;168(1):475-82.


Peptide dose, MHC affinity, and target self-antigen expression are critical for effective immunotherapy of nonobese diabetic mouse prediabetes.

Winer S, Gunaratnam L, Astsatourov I, Cheung RK, Kubiak V, Karges W, Hammond-McKibben D, Gaedigk R, Graziano D, Trucco M, Becker DJ, Dosch HM.

J Immunol. 2000 Oct 1;165(7):4086-94.


Chromosomal localization of CCS, the copper chaperone for Cu/Zn superoxide dismutase.

Bartnikas TB, Waggoner DJ, Casareno RL, Gaedigk R, White RA, Gitlin JD.

Mamm Genome. 2000 May;11(5):409-11. No abstract available.


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