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Items: 1 to 50 of 166

1.

Structural variation at the CYP2C locus: Characterization of deletion and duplication alleles.

Botton MR, Lu X, Zhao G, Repnikova E, Seki Y, Gaedigk A, Schadt EE, Edelmann L, Scott SA.

Hum Mutat. 2019 Jul 1. doi: 10.1002/humu.23855. [Epub ahead of print]

PMID:
31260137
2.

Ontogeny of Hepatic Sulfotransferases and Prediction of Age-Dependent Fractional Contribution of Sulfation in Acetaminophen Metabolism.

Ladumor MK, Bhatt DK, Gaedigk A, Sharma S, Thakur A, Pearce RE, Leeder JS, Bolger MB, Singh S, Prasad B.

Drug Metab Dispos. 2019 Aug;47(8):818-831. doi: 10.1124/dmd.119.086462. Epub 2019 May 17.

PMID:
31101678
3.

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2B6 and Efavirenz-Containing Antiretroviral Therapy.

Desta Z, Gammal RS, Gong L, Whirl-Carrillo M, Gaur AH, Sukasem C, Hockings J, Myers A, Swart M, Tyndale RF, Masimirembwa C, Iwuchukwu OF, Chirwa S, Lennox J, Gaedigk A, Klein TE, Haas DW.

Clin Pharmacol Ther. 2019 Apr 21. doi: 10.1002/cpt.1477. [Epub ahead of print]

PMID:
31006110
4.

Clinical Pharmacogenetics Implementation Consortium Guideline for Cytochrome P450 (CYP)2D6 Genotype and Atomoxetine Therapy.

Brown JT, Bishop JR, Sangkuhl K, Nurmi EL, Mueller DJ, Dinh JC, Gaedigk A, Klein TE, Caudle KE, McCracken JT, de Leon J, Leeder JS.

Clin Pharmacol Ther. 2019 Jul;106(1):94-102. doi: 10.1002/cpt.1409. Epub 2019 Apr 13. Review.

PMID:
30801677
5.

Integrated CYP2D6 interrogation for multiethnic copy number and tandem allele detection.

Qiao W, Martis S, Mendiratta G, Shi L, Botton MR, Yang Y, Gaedigk A, Vijzelaar R, Edelmann L, Kornreich R, Desnick RJ, Scott SA.

Pharmacogenomics. 2019 Jan;20(1):9-20. doi: 10.2217/pgs-2018-0135. Epub 2018 Dec 6.

PMID:
30730286
6.

Impact of Genetic Variation on Pravastatin Systemic Exposure in Pediatric Hypercholesterolemia.

Wagner JB, Abdel-Rahman S, Gaedigk R, Gaedigk A, Raghuveer G, Staggs VS, Kauffman R, Van Haandel L, Leeder JS.

Clin Pharmacol Ther. 2019 Jun;105(6):1501-1512. doi: 10.1002/cpt.1330. Epub 2019 Feb 25.

PMID:
30549267
7.

The Evolution of PharmVar.

Gaedigk A, Sangkuhl K, Whirl-Carrillo M, Twist GP, Klein TE, Miller NA; PharmVar Steering Committee.

Clin Pharmacol Ther. 2019 Jan;105(1):29-32. doi: 10.1002/cpt.1275. Epub 2018 Dec 7. No abstract available.

8.

CYP2C9*61, a rare missense variant identified in a Puerto Rican patient with low warfarin dose requirements.

Claudio-Campos KI, González-Santiago P, Renta JY, Rodríguez J, Carrasquillo K, Gaedigk A, Roche A, Ducongé J.

Pharmacogenomics. 2019 Jan;20(1):3-8. doi: 10.2217/pgs-2018-0143. Epub 2018 Dec 6.

PMID:
30518301
9.

Pharmacogene Variation Consortium Gene Introduction: NUDT15.

Yang JJ, Whirl-Carrillo M, Scott SA, Turner AJ, Schwab M, Tanaka Y, Suarez-Kurtz G, Schaeffeler E, Klein TE, Miller NA, Gaedigk A.

Clin Pharmacol Ther. 2019 May;105(5):1091-1094. doi: 10.1002/cpt.1268. Epub 2018 Dec 4. No abstract available.

10.

The Case for Pharmacogenetics-Guided Prescribing of Codeine in Children.

Gammal RS, Caudle KE, Quinn CT, Wang WC, Gaedigk A, Prows CA, Haidar CE, Taylor AK, Klein TE, Sangkuhl K, Hankins JS, Crews KR.

Clin Pharmacol Ther. 2019 Jun;105(6):1300-1302. doi: 10.1002/cpt.1260. Epub 2018 Nov 22. No abstract available.

PMID:
30467830
11.

Lean body weight dosing avoids excessive systemic exposure to proton pump inhibitors for children with obesity.

Shakhnovich V, Abdel-Rahman S, Friesen CA, Weigel J, Pearce RE, Gaedigk A, Leeder JS, Kearns GL.

Pediatr Obes. 2019 Jan;14(1). doi: 10.1111/ijpo.12459. Epub 2018 Sep 26.

PMID:
30257076
12.

CYP2D6 genotype analysis of a Thai population: platform comparison.

Chamnanphon M, Gaedigk A, Vanwong N, Nuntamool N, Hongkaew Y, Puangpetch A, Sukasem C.

Pharmacogenomics. 2018 Aug 1;19(12):947-960. doi: 10.2217/pgs-2018-0075. Epub 2018 Jul 11.

PMID:
29992861
13.

PASSPORT-seq: A Novel High-Throughput Bioassay to Functionally Test Polymorphisms in Micro-RNA Target Sites.

Ipe J, Collins KS, Hao Y, Gao H, Bhatia P, Gaedigk A, Liu Y, Skaar TC.

Front Genet. 2018 Jun 15;9:219. doi: 10.3389/fgene.2018.00219. eCollection 2018.

14.

Stargazer: a software tool for calling star alleles from next-generation sequencing data using CYP2D6 as a model.

Lee SB, Wheeler MM, Patterson K, McGee S, Dalton R, Woodahl EL, Gaedigk A, Thummel KE, Nickerson DA.

Genet Med. 2019 Feb;21(2):361-372. doi: 10.1038/s41436-018-0054-0. Epub 2018 Jun 6.

15.

Age- and Genotype-Dependent Variability in the Protein Abundance and Activity of Six Major Uridine Diphosphate-Glucuronosyltransferases in Human Liver.

Bhatt DK, Mehrotra A, Gaedigk A, Chapa R, Basit A, Zhang H, Choudhari P, Boberg M, Pearce RE, Gaedigk R, Broeckel U, Leeder JS, Prasad B.

Clin Pharmacol Ther. 2019 Jan;105(1):131-141. doi: 10.1002/cpt.1109. Epub 2018 Jul 12.

PMID:
29737521
16.

Ten Years' Experience with the CYP2D6 Activity Score: A Perspective on Future Investigations to Improve Clinical Predictions for Precision Therapeutics.

Gaedigk A, Dinh JC, Jeong H, Prasad B, Leeder JS.

J Pers Med. 2018 Apr 17;8(2). pii: E15. doi: 10.3390/jpm8020015. Review.

17.

Polymorphic Expression of UGT1A9 is Associated with Variable Acetaminophen Glucuronidation in Neonates: A Population Pharmacokinetic and Pharmacogenetic Study.

Linakis MW, Cook SF, Kumar SS, Liu X, Wilkins DG, Gaedigk R, Gaedigk A, Sherwin CMT, van den Anker JN.

Clin Pharmacokinet. 2018 Oct;57(10):1325-1336. doi: 10.1007/s40262-018-0634-9.

PMID:
29654492
18.

Hepatic Abundance and Activity of Androgen- and Drug-Metabolizing Enzyme UGT2B17 Are Associated with Genotype, Age, and Sex.

Bhatt DK, Basit A, Zhang H, Gaedigk A, Lee SB, Claw KG, Mehrotra A, Chaudhry AS, Pearce RE, Gaedigk R, Broeckel U, Thornton TA, Nickerson DA, Schuetz EG, Amory JK, Leeder JS, Prasad B.

Drug Metab Dispos. 2018 Jun;46(6):888-896. doi: 10.1124/dmd.118.080952. Epub 2018 Mar 30.

19.

Impact of SLCO1B1 Genotype on Pediatric Simvastatin Acid Pharmacokinetics.

Wagner JB, Abdel-Rahman S, Van Haandel L, Gaedigk A, Gaedigk R, Raghuveer G, Kauffman R, Leeder JS.

J Clin Pharmacol. 2018 Jun;58(6):823-833. doi: 10.1002/jcph.1080. Epub 2018 Feb 22.

PMID:
29469964
20.

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and Tamoxifen Therapy.

Goetz MP, Sangkuhl K, Guchelaar HJ, Schwab M, Province M, Whirl-Carrillo M, Symmans WF, McLeod HL, Ratain MJ, Zembutsu H, Gaedigk A, van Schaik RH, Ingle JN, Caudle KE, Klein TE.

Clin Pharmacol Ther. 2018 May;103(5):770-777. doi: 10.1002/cpt.1007. Epub 2018 Jan 31.

21.

Impact of CYP2D6 on venlafaxine metabolism in Trinidadian patients with major depressive disorder.

Montané Jaime LK, Paul J, Lalla A, Legall G, Gaedigk A.

Pharmacogenomics. 2018 Feb;19(3):197-212. doi: 10.2217/pgs-2017-0142. Epub 2018 Jan 12.

PMID:
29327975
22.

Precision medicine: does ethnicity information complement genotype-based prescribing decisions?

Shah RR, Gaedigk A.

Ther Adv Drug Saf. 2018 Jan;9(1):45-62. doi: 10.1177/2042098617743393. Epub 2017 Dec 1. Review.

23.

Erratum: Constellation: a tool for rapid, automated phenotype assignment of a highly polymorphic pharmacogene, CYP2D6, from whole-genome sequences.

Twist GP, Gaedigk A, Miller NA, Farrow EG, Willig LK, Dinwiddie DL, Petrikin JE, Soden SE, Herd S, Gibson M, Cakici JA, Riffel AK, Leeder JS, Dinakarpandian D, Kingsmore SF.

NPJ Genom Med. 2017 Jan 11;2:16039. doi: 10.1038/npjgenmed.2016.39. eCollection 2017.

24.

The Pharmacogene Variation (PharmVar) Consortium: Incorporation of the Human Cytochrome P450 (CYP) Allele Nomenclature Database.

Gaedigk A, Ingelman-Sundberg M, Miller NA, Leeder JS, Whirl-Carrillo M, Klein TE; PharmVar Steering Committee.

Clin Pharmacol Ther. 2018 Mar;103(3):399-401. doi: 10.1002/cpt.910. Epub 2017 Nov 14.

25.

Variants in the CYP2B6 3'UTR Alter In Vitro and In Vivo CYP2B6 Activity: Potential Role of MicroRNAs.

Burgess KS, Ipe J, Swart M, Metzger IF, Lu J, Gufford BT, Thong N, Desta Z, Gaedigk R, Pearce RE, Gaedigk A, Liu Y, Skaar TC.

Clin Pharmacol Ther. 2018 Jul;104(1):130-138. doi: 10.1002/cpt.892. Epub 2017 Oct 25.

26.

Pharmacogenomic Variability of Oral Baclofen Clearance and Clinical Response in Children With Cerebral Palsy.

McLaughlin MJ, He Y, Brunstrom-Hernandez J, Thio LL, Carleton BC, Ross CJD, Gaedigk A, Lewandowski A, Dai H, Jusko WJ, Leeder JS.

PM R. 2018 Mar;10(3):235-243. doi: 10.1016/j.pmrj.2017.08.441. Epub 2017 Sep 1.

27.

Genetic and Nongenetic Factors Associated with Protein Abundance of Flavin-Containing Monooxygenase 3 in Human Liver.

Xu M, Bhatt DK, Yeung CK, Claw KG, Chaudhry AS, Gaedigk A, Pearce RE, Broeckel U, Gaedigk R, Nickerson DA, Schuetz E, Rettie AE, Leeder JS, Thummel KE, Prasad B.

J Pharmacol Exp Ther. 2017 Nov;363(2):265-274. doi: 10.1124/jpet.117.243113. Epub 2017 Aug 17.

28.

Association between CYP2D6 Genotypes and the Risk of Antidepressant Discontinuation, Dosage Modification and the Occurrence of Maternal Depression during Pregnancy.

Bérard A, Gaedigk A, Sheehy O, Chambers C, Roth M, Bozzo P, Johnson D, Kao K, Lavigne S, Wolfe L, Quinn D, Dieter K, Zhao JP; OTIS (MotherToBaby) Collaborative Research Committee.

Front Pharmacol. 2017 Jul 17;8:402. doi: 10.3389/fphar.2017.00402. eCollection 2017.

29.

Pharmacogenetic comparison of CYP2D6 predictive and measured phenotypes in a South African cohort.

Dodgen TM, De J Labuschagne C, van Schalkwyk A, Steffens FE, Gaedigk A, Cromarty AD, Alessandrini M, Pepper MS.

Pharmacogenomics J. 2017 Jul;17(4):393. doi: 10.1038/tpj.2017.20.

PMID:
28729716
30.

Warfarin Anticoagulation Therapy in Caribbean Hispanics of Puerto Rico: A Candidate Gene Association Study.

Claudio-Campos K, Labastida A, Ramos A, Gaedigk A, Renta-Torres J, Padilla D, Rivera-Miranda G, Scott SA, Ruaño G, Cadilla CL, Duconge-Soler J.

Front Pharmacol. 2017 Jun 7;8:347. doi: 10.3389/fphar.2017.00347. eCollection 2017.

31.

Age-dependent Protein Abundance of Cytosolic Alcohol and Aldehyde Dehydrogenases in Human Liver.

Bhatt DK, Gaedigk A, Pearce RE, Leeder JS, Prasad B.

Drug Metab Dispos. 2017 Sep;45(9):1044-1048. doi: 10.1124/dmd.117.076463. Epub 2017 Jun 12.

32.

Impact of CYP2D6 genotype on amitriptyline efficacy for the treatment of diabetic peripheral neuropathy: a pilot study.

Chaudhry M, Alessandrini M, Rademan J, Dodgen TM, Steffens FE, van Zyl DG, Gaedigk A, Pepper MS.

Pharmacogenomics. 2017 Apr;18(5):433-443. doi: 10.2217/pgs-2016-0185. Epub 2017 Mar 28.

33.

In vivo characterization of CYP2D6*12, *29 and *84 using dextromethorphan as a probe drug: a case report.

Gaedigk A, Twist GP, Farrow EG, Lowry JA, Soden SE, Miller NA.

Pharmacogenomics. 2017 Apr;18(5):427-431. doi: 10.2217/pgs-2016-0192. Epub 2017 Mar 14.

34.

Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for CYP2D6 genotype and use of ondansetron and tropisetron.

Bell GC, Caudle KE, Whirl-Carrillo M, Gordon RJ, Hikino K, Prows CA, Gaedigk A, Agundez J, Sadhasivam S, Klein TE, Schwab M.

Clin Pharmacol Ther. 2017 Aug;102(2):213-218. doi: 10.1002/cpt.598. Epub 2017 Apr 6. Review. No abstract available.

35.

Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants: 2016 update.

Hicks JK, Sangkuhl K, Swen JJ, Ellingrod VL, Müller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC.

Clin Pharmacol Ther. 2017 Jul;102(1):37-44. doi: 10.1002/cpt.597. Epub 2017 Feb 13. No abstract available.

36.

Age-Dependent Absolute Abundance of Hepatic Carboxylesterases (CES1 and CES2) by LC-MS/MS Proteomics: Application to PBPK Modeling of Oseltamivir In Vivo Pharmacokinetics in Infants.

Boberg M, Vrana M, Mehrotra A, Pearce RE, Gaedigk A, Bhatt DK, Leeder JS, Prasad B.

Drug Metab Dispos. 2017 Feb;45(2):216-223. doi: 10.1124/dmd.116.072652. Epub 2016 Nov 28.

37.

Pharmacogenetics to prevent maniac affective switching with treatment for bipolar disorder: CYP2D6.

Sánchez-Martín A, Sánchez-Iglesias S, García-Berrocal B, Lorenzo C, Gaedigk A, Isidoro-García M.

Pharmacogenomics. 2016 Aug;17(12):1291-3. doi: 10.2217/pgs-2016-0105. Epub 2016 Jul 29. Review. No abstract available.

38.

Prediction of Warfarin Dose in Pediatric Patients: An Evaluation of the Predictive Performance of Several Models.

Marek E, Momper JD, Hines RN, Takao CM, Gill JC, Pravica V, Gaedigk A, Burckart GJ, Neville KA.

J Pediatr Pharmacol Ther. 2016 May-Jun;21(3):224-32. doi: 10.5863/1551-6776-21.3.224.

39.

Prediction of CYP2D6 phenotype from genotype across world populations.

Gaedigk A, Sangkuhl K, Whirl-Carrillo M, Klein T, Leeder JS.

Genet Med. 2017 Jan;19(1):69-76. doi: 10.1038/gim.2016.80. Epub 2016 Jul 7. Erratum in: Genet Med. 2016 Nov;18(11):1167.

40.

Ontogeny of Hepatic Drug Transporters as Quantified by LC-MS/MS Proteomics.

Prasad B, Gaedigk A, Vrana M, Gaedigk R, Leeder JS, Salphati L, Chu X, Xiao G, Hop C, Evers R, Gan L, Unadkat JD.

Clin Pharmacol Ther. 2016 Oct;100(4):362-70. doi: 10.1002/cpt.409. Epub 2016 Aug 13.

41.

Rifampin Regulation of Drug Transporters Gene Expression and the Association of MicroRNAs in Human Hepatocytes.

Benson EA, Eadon MT, Desta Z, Liu Y, Lin H, Burgess KS, Segar MW, Gaedigk A, Skaar TC.

Front Pharmacol. 2016 Apr 26;7:111. doi: 10.3389/fphar.2016.00111. eCollection 2016.

42.

Characterization of Atomoxetine Biotransformation and Implications for Development of PBPK Models for Dose Individualization in Children.

Dinh JC, Pearce RE, Van Haandel L, Gaedigk A, Leeder JS.

Drug Metab Dispos. 2016 Jul;44(7):1070-9. doi: 10.1124/dmd.116.069518. Epub 2016 Apr 6.

43.

Role of Pharmacogenetics in Improving the Safety of Psychiatric Care by Predicting the Potential Risks of Mania in CYP2D6 Poor Metabolizers Diagnosed With Bipolar Disorder.

Sánchez-Iglesias S, García-Solaesa V, García-Berrocal B, Sanchez-Martín A, Lorenzo-Romo C, Martín-Pinto T, Gaedigk A, González-Buitrago JM, Isidoro-García M.

Medicine (Baltimore). 2016 Feb;95(6):e2473. doi: 10.1097/MD.0000000000002473.

44.

CYP2D7 Sequence Variation Interferes with TaqMan CYP2D6 (*) 15 and (*) 35 Genotyping.

Riffel AK, Dehghani M, Hartshorne T, Floyd KC, Leeder JS, Rosenblatt KP, Gaedigk A.

Front Pharmacol. 2016 Jan 12;6:312. doi: 10.3389/fphar.2015.00312. eCollection 2015.

45.

CYP450 genotype and pharmacogenetic association studies: a critical appraisal.

Shah RR, Gaedigk A, LLerena A, Eichelbaum M, Stingl J, Smith RL.

Pharmacogenomics. 2016 Feb;17(3):259-75. doi: 10.2217/pgs.15.172. Epub 2016 Jan 18.

PMID:
26780308
46.

Constellation: a tool for rapid, automated phenotype assignment of a highly polymorphic pharmacogene, CYP2D6, from whole-genome sequences.

Twist GP, Gaedigk A, Miller NA, Farrow EG, Willig LK, Dinwiddie DL, Petrikin JE, Soden SE, Herd S, Gibson M, Cakici JA, Riffel AK, Leeder JS, Dinakarpandian D, Kingsmore SF.

NPJ Genom Med. 2016 Jan 13;1:15007. doi: 10.1038/npjgenmed.2015.7. eCollection 2016. Erratum in: NPJ Genom Med. 2017 Jan 11;2:16039.

47.

Single dose, CYP2D6 genotype-stratified pharmacokinetic study of atomoxetine in children with ADHD.

Brown JT, Abdel-Rahman SM, van Haandel L, Gaedigk A, Lin YS, Leeder JS.

Clin Pharmacol Ther. 2016 Jun;99(6):642-50. doi: 10.1002/cpt.319. Epub 2016 Jan 12.

48.

Developmental Expression of CYP2B6: A Comprehensive Analysis of mRNA Expression, Protein Content and Bupropion Hydroxylase Activity and the Impact of Genetic Variation.

Pearce RE, Gaedigk R, Twist GP, Dai H, Riffel AK, Leeder JS, Gaedigk A.

Drug Metab Dispos. 2016 Jul;44(7):948-58. doi: 10.1124/dmd.115.067546. Epub 2015 Nov 25.

49.

Long-Read Single Molecule Real-Time Full Gene Sequencing of Cytochrome P450-2D6.

Qiao W, Yang Y, Sebra R, Mendiratta G, Gaedigk A, Desnick RJ, Scott SA.

Hum Mutat. 2016 Mar;37(3):315-23. doi: 10.1002/humu.22936. Epub 2015 Dec 18.

50.

Pharmacogenetic comparison of CYP2D6 predictive and measured phenotypes in a South African cohort.

Dodgen TM, Labuschagne CJ, van Schalkwyk A, Steffens FE, Gaedigk A, Cromarty AD, Alessandrini M, Pepper MS.

Pharmacogenomics J. 2016 Nov;16(6):566-572. doi: 10.1038/tpj.2015.76. Epub 2015 Oct 27. Erratum in: Pharmacogenomics J. 2017 Jul;17 (4):393.

PMID:
26503815

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