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Items: 20


Cisplatin facilitates radiation-induced abscopal effects in conjunction with PD-1 checkpoint blockade through CXCR3/CXCL10-mediated T cell recruitment.

Luo R, Firat E, Gaedicke S, Guffart E, Watanabe T, Niedermann G.

Clin Cancer Res. 2019 Sep 10. pii: clincanres.1344.2019. doi: 10.1158/1078-0432.CCR-19-1344. [Epub ahead of print]


Combination treatment with hypofractionated radiotherapy plus IL-2/anti-IL-2 complexes and its theranostic evaluation.

Jing H, Hettich M, Gaedicke S, Firat E, Bartholomä M, Niedermann G.

J Immunother Cancer. 2019 Feb 26;7(1):55. doi: 10.1186/s40425-019-0537-9.


Imaging and Selective Elimination of Glioblastoma Stem Cells with Theranostic Near-Infrared-Labeled CD133-Specific Antibodies.

Jing H, Weidensteiner C, Reichardt W, Gaedicke S, Zhu X, Grosu AL, Kobayashi H, Niedermann G.

Theranostics. 2016 Apr 12;6(6):862-74. doi: 10.7150/thno.12890. eCollection 2016.


Decrease of VEGF-A in myeloid cells attenuates glioma progression and prolongs survival in an experimental glioma model.

Osterberg N, Ferrara N, Vacher J, Gaedicke S, Niedermann G, Weyerbrock A, Doostkam S, Schaefer HE, Plate KH, Machein MR.

Neuro Oncol. 2016 Jul;18(7):939-49. doi: 10.1093/neuonc/now005. Epub 2016 Mar 6.


Effective Eradication of Glioblastoma Stem Cells by Local Application of an AC133/CD133-Specific T-cell-Engaging Antibody and CD8 T Cells.

Prasad S, Gaedicke S, Machein M, Mittler G, Braun F, Hettich M, Firat E, Klingner K, Schüler J, Wider D, Wäsch RM, Herold-Mende C, Elsässer-Beile U, Niedermann G.

Cancer Res. 2015 Jun 1;75(11):2166-76. doi: 10.1158/0008-5472.CAN-14-2415. Epub 2015 Apr 3.


Patient-derived glioblastoma stem cells are killed by CD133-specific CAR T cells but induce the T cell aging marker CD57.

Zhu X, Prasad S, Gaedicke S, Hettich M, Firat E, Niedermann G.

Oncotarget. 2015 Jan 1;6(1):171-84.


Noninvasive positron emission tomography and fluorescence imaging of CD133+ tumor stem cells.

Gaedicke S, Braun F, Prasad S, Machein M, Firat E, Hettich M, Gudihal R, Zhu X, Klingner K, Schüler J, Herold-Mende CC, Grosu AL, Behe M, Weber W, Mäcke H, Niedermann G.

Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):E692-701. doi: 10.1073/pnas.1314189111. Epub 2014 Jan 27.


Chloroquine or chloroquine-PI3K/Akt pathway inhibitor combinations strongly promote γ-irradiation-induced cell death in primary stem-like glioma cells.

Firat E, Weyerbrock A, Gaedicke S, Grosu AL, Niedermann G.

PLoS One. 2012;7(10):e47357. doi: 10.1371/journal.pone.0047357. Epub 2012 Oct 16.


Delayed cell death associated with mitotic catastrophe in γ-irradiated stem-like glioma cells.

Firat E, Gaedicke S, Tsurumi C, Esser N, Weyerbrock A, Niedermann G.

Radiat Oncol. 2011 Jun 10;6:71. doi: 10.1186/1748-717X-6-71.


Non-invasive in vivo imaging of tumor-associated CD133/prominin.

Tsurumi C, Esser N, Firat E, Gaedicke S, Follo M, Behe M, Elsässer-Beile U, Grosu AL, Graeser R, Niedermann G.

PLoS One. 2010 Dec 20;5(12):e15605. doi: 10.1371/journal.pone.0015605.


Dietary vitamin E deficiency does not affect global and specific DNA methylation patterns in rat liver.

Fischer A, Gaedicke S, Frank J, Döring F, Rimbach G.

Br J Nutr. 2010 Oct;104(7):935-40. doi: 10.1017/S0007114510001649. Epub 2010 May 7.


Viability and DNA damage responses of TPPII-deficient Myc- and Ras-transformed fibroblasts.

Tsurumi C, Firat E, Gaedicke S, Huai J, Mandal PK, Niedermann G.

Biochem Biophys Res Commun. 2009 Sep 4;386(4):563-8. doi: 10.1016/j.bbrc.2009.06.068. Epub 2009 Jun 17.


Tripeptidyl peptidase II plays a role in the radiation response of selected primary cell types but not based on nuclear translocation and p53 stabilization.

Firat E, Tsurumi C, Gaedicke S, Huai J, Niedermann G.

Cancer Res. 2009 Apr 15;69(8):3325-31. doi: 10.1158/0008-5472.CAN-08-3269. Epub 2009 Apr 7.


Dietary vitamin E, brain redox status and expression of Alzheimer's disease-relevant genes in rats.

Gaedicke S, Zhang X, Huebbe P, Boesch-Saadatmandi C, Lou Y, Wiswedel I, Gardemann A, Frank J, Rimbach G.

Br J Nutr. 2009 Aug;102(3):398-406. doi: 10.1017/S000711450819122X. Epub 2009 Jan 28.


Vitamin E dependent microRNA regulation in rat liver.

Gaedicke S, Zhang X, Schmelzer C, Lou Y, Doering F, Frank J, Rimbach G.

FEBS Lett. 2008 Oct 15;582(23-24):3542-6. doi: 10.1016/j.febslet.2008.09.032. Epub 2008 Sep 24.


Activation of cellular death programs associated with immunosenescence-like phenotype in TPPII knockout mice.

Huai J, Firat E, Nil A, Million D, Gaedicke S, Kanzler B, Freudenberg M, van Endert P, Kohler G, Pahl HL, Aichele P, Eichmann K, Niedermann G.

Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5177-82. doi: 10.1073/pnas.0801413105. Epub 2008 Mar 24.


Analysis of direct and cross-presentation of antigens in TPPII knockout mice.

Firat E, Huai J, Saveanu L, Gaedicke S, Aichele P, Eichmann K, van Endert P, Niedermann G.

J Immunol. 2007 Dec 15;179(12):8137-45.


The role of endoplasmic reticulum-associated aminopeptidase 1 in immunity to infection and in cross-presentation.

Firat E, Saveanu L, Aichele P, Staeheli P, Huai J, Gaedicke S, Nil A, Besin G, Kanzler B, van Endert P, Niedermann G.

J Immunol. 2007 Feb 15;178(4):2241-8.


Differential proteasomal processing of hydrophobic and hydrophilic protein regions: contribution to cytotoxic T lymphocyte epitope clustering in HIV-1-Nef.

Lucchiari-Hartz M, Lindo V, Hitziger N, Gaedicke S, Saveanu L, van Endert PM, Greer F, Eichmann K, Niedermann G.

Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7755-60. Epub 2003 Jun 16.


Antitumor effect of the human immunodeficiency virus protease inhibitor ritonavir: induction of tumor-cell apoptosis associated with perturbation of proteasomal proteolysis.

Gaedicke S, Firat-Geier E, Constantiniu O, Lucchiari-Hartz M, Freudenberg M, Galanos C, Niedermann G.

Cancer Res. 2002 Dec 1;62(23):6901-8.

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