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Items: 1 to 50 of 64

1.

Generation of Spinocerebellar Ataxia Type 2 induced pluripotent stem cell lines, CHOPi002-A and CHOPi003-A, from patients with abnormal CAG repeats in the coding region of the ATXN2 gene.

Maguire JA, Gagne AL, Gonzalez-Alegre P, Davidson BL, Shakkottai V, Gadue P, French DL.

Stem Cell Res. 2019 Jan;34:101361. doi: 10.1016/j.scr.2018.101361. Epub 2018 Dec 10.

2.

Highly Efficient CRISPR-Cas9-Mediated Genome Editing in Human Pluripotent Stem Cells.

Maguire JA, Cardenas-Diaz FL, Gadue P, French DL.

Curr Protoc Stem Cell Biol. 2019 Feb;48(1):e64. doi: 10.1002/cpsc.64. Epub 2018 Oct 24.

PMID:
30358158
3.

Generation of a human Juvenile myelomonocytic leukemia iPSC line, CHOPi001-A, with a mutation in CBL.

Gagne AL, Maguire JA, Gandre-Babbe S, Chou ST, Tasian SK, Loh ML, Weiss MJ, Gadue P, French DL.

Stem Cell Res. 2018 Aug;31:157-160. doi: 10.1016/j.scr.2018.07.001. Epub 2018 Jul 5.

4.

GATA6 suppression enhances lung specification from human pluripotent stem cells.

Liao CM, Mukherjee S, Tiyaboonchai A, Maguire JA, Cardenas-Diaz FL, French DL, Gadue P.

J Clin Invest. 2018 Jul 2;128(7):2944-2950. doi: 10.1172/JCI96539. Epub 2018 Jun 11.

5.

Exploring the Interaction Between eIF2α Dysregulation, Acute Endoplasmic Reticulum Stress and DYT1 Dystonia in the Mammalian Brain.

Beauvais G, Rodriguez-Losada N, Ying L, Zakirova Z, Watson JL, Readhead B, Gadue P, French DL, Ehrlich ME, Gonzalez-Alegre P.

Neuroscience. 2018 Feb 10;371:455-468. doi: 10.1016/j.neuroscience.2017.12.033. Epub 2017 Dec 28.

PMID:
29289717
6.

Induced Pluripotent Stem Cell-Derived Megakaryocytes and Platelets for Disease Modeling and Future Clinical Applications.

Borst S, Sim X, Poncz M, French DL, Gadue P.

Arterioscler Thromb Vasc Biol. 2017 Nov;37(11):2007-2013. doi: 10.1161/ATVBAHA.117.309197. Epub 2017 Oct 5. Review.

7.

Identifying and enriching platelet-producing human stem cell-derived megakaryocytes using factor V uptake.

Sim X, Jarocha D, Hayes V, Hanby HA, Marks MS, Camire RM, French DL, Poncz M, Gadue P.

Blood. 2017 Jul 13;130(2):192-204. doi: 10.1182/blood-2017-01-761049. Epub 2017 Apr 28.

8.

GATA6 Plays an Important Role in the Induction of Human Definitive Endoderm, Development of the Pancreas, and Functionality of Pancreatic β Cells.

Tiyaboonchai A, Cardenas-Diaz FL, Ying L, Maguire JA, Sim X, Jobaliya C, Gagne AL, Kishore S, Stanescu DE, Hughes N, De Leon DD, French DL, Gadue P.

Stem Cell Reports. 2017 Mar 14;8(3):589-604. doi: 10.1016/j.stemcr.2016.12.026. Epub 2017 Feb 9.

9.

Generation of human control iPS cell line CHOPWT10 from healthy adult peripheral blood mononuclear cells.

Maguire JA, Gagne AL, Jobaliya CD, Gandre-Babbe S, Gadue P, French DL.

Stem Cell Res. 2016 Mar;16(2):338-41. doi: 10.1016/j.scr.2016.02.017. Epub 2016 Feb 3.

10.

Generation of Hermansky Pudlak syndrome type 2 (HPS2) induced pluripotent stem cells (iPSCs).

Maguire JA, Lu L, Mills JA, Sullivan LM, Gadue P, French DL.

Stem Cell Res. 2016 Mar;16(2):287-9. doi: 10.1016/j.scr.2016.01.015. Epub 2016 Jan 14.

11.

Generation of Hermansky-Pudlak Syndrome Type 1 (HPS1) induced pluripotent stem cells (iPSCs).

Maguire JA, Lu L, Mills JA, Sullivan LM, Gagne A, Gadue P, French DL.

Stem Cell Res. 2016 Mar;16(2):233-5. doi: 10.1016/j.scr.2016.01.014. Epub 2016 Jan 14.

12.

Generation of human control iPS cell line CHOPWT9 from healthy adult peripheral blood mononuclear cells.

Maguire JA, Gagne A, Mills JA, Gadue P, French DL.

Stem Cell Res. 2016 Jan;16(1):14-6. doi: 10.1016/j.scr.2015.11.005. Epub 2015 Nov 19.

13.

Generation of poikiloderma with neutropenia (PN) induced pluripotent stem cells (iPSCs).

Mills JA, Hudock KM, Sullivan SK, Herrera P, Sullivan LM, Gadue P, French DL.

Stem Cell Res. 2015 Nov;15(3):595-7. doi: 10.1016/j.scr.2015.10.006. Epub 2015 Oct 16.

14.

Factors Regulating Stem Cell Biology in Development and Disease.

Liebau S, Gadue P, Nalapareddy K, von Figura G, Kleger A.

Stem Cells Int. 2016;2016:7170642. doi: 10.1155/2016/7170642. Epub 2015 Dec 20. No abstract available.

15.

Understanding platelet generation from megakaryocytes: implications for in vitro-derived platelets.

Sim X, Poncz M, Gadue P, French DL.

Blood. 2016 Mar 10;127(10):1227-33. doi: 10.1182/blood-2015-08-607929. Epub 2016 Jan 19. Review.

16.

OCT4 Coordinates with WNT Signaling to Pre-pattern Chromatin at the SOX17 Locus during Human ES Cell Differentiation into Definitive Endoderm.

Ying L, Mills JA, French DL, Gadue P.

Stem Cell Reports. 2015 Oct 13;5(4):490-8. doi: 10.1016/j.stemcr.2015.08.014. Epub 2015 Sep 24.

17.

Correction: AAV-Mediated Gene Therapy for Choroideremia: Preclinical Studies in Personalized Models.

Vasireddy V, Mills JA, Gaddameedi R, Basner-Tschakarjan E, Kohnke M, Black AD, Alexandrov K, Zhou S, Maguire AM, Chung DC, Mac H, Sullivan L, Gadue P, Bennicelli JL, French DL, Bennett J.

PLoS One. 2015 Jun 19;10(6):e0129982. doi: 10.1371/journal.pone.0129982. eCollection 2015. No abstract available.

18.

Inducible Gata1 suppression expands megakaryocyte-erythroid progenitors from embryonic stem cells.

Noh JY, Gandre-Babbe S, Wang Y, Hayes V, Yao Y, Gadue P, Sullivan SK, Chou ST, Machlus KR, Italiano JE Jr, Kyba M, Finkelstein D, Ulirsch JC, Sankaran VG, French DL, Poncz M, Weiss MJ.

J Clin Invest. 2015 Jun;125(6):2369-74. doi: 10.1172/JCI77670. Epub 2015 May 11.

19.

Human definitive haemogenic endothelium and arterial vascular endothelium represent distinct lineages.

Ditadi A, Sturgeon CM, Tober J, Awong G, Kennedy M, Yzaguirre AD, Azzola L, Ng ES, Stanley EG, French DL, Cheng X, Gadue P, Speck NA, Elefanty AG, Keller G.

Nat Cell Biol. 2015 May;17(5):580-91. doi: 10.1038/ncb3161. Epub 2015 Apr 27.

20.

Comparative analysis of human ex vivo-generated platelets vs megakaryocyte-generated platelets in mice: a cautionary tale.

Wang Y, Hayes V, Jarocha D, Sim X, Harper DC, Fuentes R, Sullivan SK, Gadue P, Chou ST, Torok-Storb BJ, Marks MS, French DL, Poncz M.

Blood. 2015 Jun 4;125(23):3627-36. doi: 10.1182/blood-2014-08-593053. Epub 2015 Apr 7.

21.

Emergence of a stage-dependent human liver disease signature with directed differentiation of alpha-1 antitrypsin-deficient iPS cells.

Wilson AA, Ying L, Liesa M, Segeritz CP, Mills JA, Shen SS, Jean J, Lonza GC, Liberti DC, Lang AH, Nazaire J, Gower AC, Müeller FJ, Mehta P, Ordóñez A, Lomas DA, Vallier L, Murphy GJ, Mostoslavsky G, Spira A, Shirihai OS, Ramirez MI, Gadue P, Kotton DN.

Stem Cell Reports. 2015 May 12;4(5):873-85. doi: 10.1016/j.stemcr.2015.02.021. Epub 2015 Apr 2.

22.

A Doxycycline-Inducible System for Genetic Correction of iPSC Disease Models.

Sim X, Cardenas-Diaz FL, French DL, Gadue P.

Methods Mol Biol. 2016;1353:13-23. doi: 10.1007/7651_2014_179.

23.

Pluripotent stem cells reveal erythroid-specific activities of the GATA1 N-terminus.

Byrska-Bishop M, VanDorn D, Campbell AE, Betensky M, Arca PR, Yao Y, Gadue P, Costa FF, Nemiroff RL, Blobel GA, French DL, Hardison RC, Weiss MJ, Chou ST.

J Clin Invest. 2015 Mar 2;125(3):993-1005. doi: 10.1172/JCI75714. Epub 2015 Jan 26.

24.

Dynamics of genomic H3K27me3 domains and role of EZH2 during pancreatic endocrine specification.

Xu CR, Li LC, Donahue G, Ying L, Zhang YW, Gadue P, Zaret KS.

EMBO J. 2014 Oct 1;33(19):2157-70. doi: 10.15252/embj.201488671. Epub 2014 Aug 8.

25.

Hematopoietic differentiation of pluripotent stem cells in culture.

Mills JA, Paluru P, Weiss MJ, Gadue P, French DL.

Methods Mol Biol. 2014;1185:181-94. doi: 10.1007/978-1-4939-1133-2_12.

PMID:
25062629
26.

Utilization of the AAVS1 safe harbor locus for hematopoietic specific transgene expression and gene knockdown in human ES cells.

Tiyaboonchai A, Mac H, Shamsedeen R, Mills JA, Kishore S, French DL, Gadue P.

Stem Cell Res. 2014 May;12(3):630-7. doi: 10.1016/j.scr.2014.02.004. Epub 2014 Feb 21.

27.

MicroRNA screen of human embryonic stem cell differentiation reveals miR-105 as an enhancer of megakaryopoiesis from adult CD34+ cells.

Kamat V, Paluru P, Myint M, French DL, Gadue P, Diamond SL.

Stem Cells. 2014 May;32(5):1337-46. doi: 10.1002/stem.1640.

28.

The negative impact of Wnt signaling on megakaryocyte and primitive erythroid progenitors derived from human embryonic stem cells.

Paluru P, Hudock KM, Cheng X, Mills JA, Ying L, Galvão AM, Lu L, Tiyaboonchai A, Sim X, Sullivan SK, French DL, Gadue P.

Stem Cell Res. 2014 Mar;12(2):441-51. doi: 10.1016/j.scr.2013.12.003. Epub 2013 Dec 16.

29.

High-level transgene expression in induced pluripotent stem cell-derived megakaryocytes: correction of Glanzmann thrombasthenia.

Sullivan SK, Mills JA, Koukouritaki SB, Vo KK, Lyde RB, Paluru P, Zhao G, Zhai L, Sullivan LM, Wang Y, Kishore S, Gharaibeh EZ, Lambert MP, Wilcox DA, French DL, Poncz M, Gadue P.

Blood. 2014 Jan 30;123(5):753-7. doi: 10.1182/blood-2013-10-530725. Epub 2013 Dec 13.

30.

Clonal genetic and hematopoietic heterogeneity among human-induced pluripotent stem cell lines.

Mills JA, Wang K, Paluru P, Ying L, Lu L, Galvão AM, Xu D, Yao Y, Sullivan SK, Sullivan LM, Mac H, Omari A, Jean JC, Shen S, Gower A, Spira A, Mostoslavsky G, Kotton DN, French DL, Weiss MJ, Gadue P.

Blood. 2013 Sep 19;122(12):2047-51. doi: 10.1182/blood-2013-02-484444. Epub 2013 Aug 12.

31.

iPSC Reprogramming from Human Peripheral Blood Using Sendai Virus Mediated Gene Transfer.

Yang W, Mills JA, Sullivan S, Liu Y, French DL, Gadue P.

StemBook [Internet]. Cambridge (MA): Harvard Stem Cell Institute; 2008-.
2012 Jun 10.

32.

Ribosomal and hematopoietic defects in induced pluripotent stem cells derived from Diamond Blackfan anemia patients.

Garçon L, Ge J, Manjunath SH, Mills JA, Apicella M, Parikh S, Sullivan LM, Podsakoff GM, Gadue P, French DL, Mason PJ, Bessler M, Weiss MJ.

Blood. 2013 Aug 8;122(6):912-21. doi: 10.1182/blood-2013-01-478321. Epub 2013 Jun 6.

33.

The aryl hydrocarbon receptor directs hematopoietic progenitor cell expansion and differentiation.

Smith BW, Rozelle SS, Leung A, Ubellacker J, Parks A, Nah SK, French D, Gadue P, Monti S, Chui DH, Steinberg MH, Frelinger AL, Michelson AD, Theberge R, McComb ME, Costello CE, Kotton DN, Mostoslavsky G, Sherr DH, Murphy GJ.

Blood. 2013 Jul 18;122(3):376-85. doi: 10.1182/blood-2012-11-466722. Epub 2013 May 30.

34.

AAV-mediated gene therapy for choroideremia: preclinical studies in personalized models.

Vasireddy V, Mills JA, Gaddameedi R, Basner-Tschakarjan E, Kohnke M, Black AD, Alexandrov K, Zhou S, Maguire AM, Chung DC, Mac H, Sullivan L, Gadue P, Bennicelli JL, French DL, Bennett J.

PLoS One. 2013 May 7;8(5):e61396. doi: 10.1371/journal.pone.0061396. Print 2013. Erratum in: PLoS One. 2015;10(6):e0129982.

35.

Monolayer endoderm differentiation from human ESCs.

Cheng X, Ying L, Lu L, Galvão AM, Mills JA, Lin HC, Kotton DN, Shen SS, Nostro MC, Choi JK, Weiss MJ, French DL, Gadue P.

StemBook [Internet]. Cambridge (MA): Harvard Stem Cell Institute; 2008-.
2012 Jun 10.

36.

Generation of human induced pluripotent stem cells from peripheral blood using the STEMCCA lentiviral vector.

Gianotti-Sommer A, Rozelle SS, Sullivan S, Mills JA, Park SM, Smith BW, Iyer AM, French DL, Kotton DN, Gadue P, Murphy GJ, Mostoslavsky G.

StemBook [Internet]. Cambridge (MA): Harvard Stem Cell Institute; 2008-.
2013 Apr 29.

37.

Endodermal stem cell populations derived from pluripotent stem cells.

Cheng X, Tiyaboonchai A, Gadue P.

Curr Opin Cell Biol. 2013 Apr;25(2):265-71. doi: 10.1016/j.ceb.2013.01.006. Epub 2013 Feb 26. Review.

38.

Foxa2 and H2A.Z mediate nucleosome depletion during embryonic stem cell differentiation.

Li Z, Gadue P, Chen K, Jiao Y, Tuteja G, Schug J, Li W, Kaestner KH.

Cell. 2012 Dec 21;151(7):1608-16. doi: 10.1016/j.cell.2012.11.018.

39.

Generation of human induced pluripotent stem cells from peripheral blood using the STEMCCA lentiviral vector.

Sommer AG, Rozelle SS, Sullivan S, Mills JA, Park SM, Smith BW, Iyer AM, French DL, Kotton DN, Gadue P, Murphy GJ, Mostoslavsky G.

J Vis Exp. 2012 Oct 31;(68). pii: 4327. doi: 10.3791/4327.

40.

Trisomy 21-associated defects in human primitive hematopoiesis revealed through induced pluripotent stem cells.

Chou ST, Byrska-Bishop M, Tober JM, Yao Y, Vandorn D, Opalinska JB, Mills JA, Choi JK, Speck NA, Gadue P, Hardison RC, Nemiroff RL, French DL, Weiss MJ.

Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17573-8. doi: 10.1073/pnas.1211175109. Epub 2012 Oct 8.

41.

Self-renewing endodermal progenitor lines generated from human pluripotent stem cells.

Cheng X, Ying L, Lu L, Galvão AM, Mills JA, Lin HC, Kotton DN, Shen SS, Nostro MC, Choi JK, Weiss MJ, French DL, Gadue P.

Cell Stem Cell. 2012 Apr 6;10(4):371-84. doi: 10.1016/j.stem.2012.02.024.

42.

High-throughput screening assay for embryoid body differentiation of human embryonic stem cells.

Outten JT, Gadue P, French DL, Diamond SL.

Curr Protoc Stem Cell Biol. 2012 Mar;Chapter 1:Unit 1D.6. doi: 10.1002/9780470151808.sc01d06s20.

43.

An endothelial cell niche induces hepatic specification through dual repression of Wnt and Notch signaling.

Han S, Dziedzic N, Gadue P, Keller GM, Gouon-Evans V.

Stem Cells. 2011 Feb;29(2):217-28. doi: 10.1002/stem.576.

44.

Mouse ES and iPS cells can form similar definitive endoderm despite differences in imprinted genes.

Christodoulou C, Longmire TA, Shen SS, Bourdon A, Sommer CA, Gadue P, Spira A, Gouon-Evans V, Murphy GJ, Mostoslavsky G, Kotton DN.

J Clin Invest. 2011 Jun;121(6):2313-25. doi: 10.1172/JCI43853. Epub 2011 May 2.

45.

A high-throughput multiplexed screening assay for optimizing serum-free differentiation protocols of human embryonic stem cells.

Outten JT, Cheng X, Gadue P, French DL, Diamond SL.

Stem Cell Res. 2011 Mar;6(2):129-42. doi: 10.1016/j.scr.2010.11.001. Epub 2010 Nov 16.

46.

Liver regeneration from induced pluripotent stem cells.

Cheng X, Gadue P.

Mol Ther. 2010 Dec;18(12):2044-5. doi: 10.1038/mt.2010.237. No abstract available.

47.

Generation of transgene-free lung disease-specific human induced pluripotent stem cells using a single excisable lentiviral stem cell cassette.

Somers A, Jean JC, Sommer CA, Omari A, Ford CC, Mills JA, Ying L, Sommer AG, Jean JM, Smith BW, Lafyatis R, Demierre MF, Weiss DJ, French DL, Gadue P, Murphy GJ, Mostoslavsky G, Kotton DN.

Stem Cells. 2010 Oct;28(10):1728-40. doi: 10.1002/stem.495.

48.

Transcriptional competence and the active marking of tissue-specific enhancers by defined transcription factors in embryonic and induced pluripotent stem cells.

Xu J, Watts JA, Pope SD, Gadue P, Kamps M, Plath K, Zaret KS, Smale ST.

Genes Dev. 2009 Dec 15;23(24):2824-38. doi: 10.1101/gad.1861209.

49.

Stem cells unscramble yolk sac hematopoiesis.

Gadue P, Weiss MJ.

Blood. 2009 Aug 20;114(8):1455-6. doi: 10.1182/blood-2009-06-226209.

50.

Generation of monoclonal antibodies specific for cell surface molecules expressed on early mouse endoderm.

Gadue P, Gouon-Evans V, Cheng X, Wandzioch E, Zaret KS, Grompe M, Streeter PR, Keller GM.

Stem Cells. 2009 Sep;27(9):2103-13. doi: 10.1002/stem.147.

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