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Items: 1 to 50 of 86

1.

STRUCTURE, GATING, AND REGULATION OF THE CFTR ANION CHANNEL.

Csanády L, Vergani P, Gadsby DC.

Physiol Rev. 2019 Jan 1;99(1):707-738. doi: 10.1152/physrev.00007.2018. Review.

PMID:
30516439
2.

Hypothermia-induced dystonia and abnormal cerebellar activity in a mouse model with a single disease-mutation in the sodium-potassium pump.

Isaksen TJ, Kros L, Vedovato N, Holm TH, Vitenzon A, Gadsby DC, Khodakhah K, Lykke-Hartmann K.

PLoS Genet. 2017 May 4;13(5):e1006763. doi: 10.1371/journal.pgen.1006763. eCollection 2017 May.

3.

Molecular Structure of the Human CFTR Ion Channel.

Liu F, Zhang Z, Csanády L, Gadsby DC, Chen J.

Cell. 2017 Mar 23;169(1):85-95.e8. doi: 10.1016/j.cell.2017.02.024.

4.

Cysteine accessibility probes timing and extent of NBD separation along the dimer interface in gating CFTR channels.

Chaves LA, Gadsby DC.

J Gen Physiol. 2015 Apr;145(4):261-83. doi: 10.1085/jgp.201411347.

5.

Route, mechanism, and implications of proton import during Na+/K+ exchange by native Na+/K+-ATPase pumps.

Vedovato N, Gadsby DC.

J Gen Physiol. 2014 Apr;143(4):449-64. doi: 10.1085/jgp.201311148.

6.

The dynamic relationships between the three events that release individual Na⁺ ions from the Na⁺/K⁺-ATPase.

Gadsby DC, Bezanilla F, Rakowski RF, De Weer P, Holmgren M.

Nat Commun. 2012 Feb 14;3:669. doi: 10.1038/ncomms1673.

7.

Energy landscape of the reactions governing the Na+ deeply occluded state of the Na+/K+-ATPase in the giant axon of the Humboldt squid.

Castillo JP, De Giorgis D, Basilio D, Gadsby DC, Rosenthal JJ, Latorre R, Holmgren M, Bezanilla F.

Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20556-61. doi: 10.1073/pnas.1116439108. Epub 2011 Dec 5.

8.

Electrophysiological, biochemical, and bioinformatic methods for studying CFTR channel gating and its regulation.

Csanády L, Vergani P, Gulyás-Kovács A, Gadsby DC.

Methods Mol Biol. 2011;741:443-69. doi: 10.1007/978-1-61779-117-8_28.

PMID:
21594801
9.

The two C-terminal tyrosines stabilize occluded Na/K pump conformations containing Na or K ions.

Vedovato N, Gadsby DC.

J Gen Physiol. 2010 Jul;136(1):63-82. doi: 10.1085/jgp.201010407. Epub 2010 Jun 14.

10.

Strict coupling between CFTR's catalytic cycle and gating of its Cl- ion pore revealed by distributions of open channel burst durations.

Csanády L, Vergani P, Gadsby DC.

Proc Natl Acad Sci U S A. 2010 Jan 19;107(3):1241-6. doi: 10.1073/pnas.0911061107. Epub 2009 Dec 4.

11.

Visualizing the mapped ion pathway through the Na,K-ATPase pump.

Takeuchi A, Reyes N, Artigas P, Gadsby DC.

Channels (Austin). 2009 Nov;3(6):383-6. Epub 2009 Nov 10. Review.

12.

Ion channels versus ion pumps: the principal difference, in principle.

Gadsby DC.

Nat Rev Mol Cell Biol. 2009 May;10(5):344-52. doi: 10.1038/nrm2668. Epub 2009 Apr 2. Review.

13.

Review. Peering into an ATPase ion pump with single-channel recordings.

Gadsby DC, Takeuchi A, Artigas P, Reyes N.

Philos Trans R Soc Lond B Biol Sci. 2009 Jan 27;364(1514):229-38. doi: 10.1098/rstb.2008.0243. Review.

14.

The ion pathway through the opened Na(+),K(+)-ATPase pump.

Takeuchi A, Reyes N, Artigas P, Gadsby DC.

Nature. 2008 Nov 20;456(7220):413-6. doi: 10.1038/nature07350. Epub 2008 Oct 8.

15.

Structural biology: ion pumps made crystal clear.

Gadsby DC.

Nature. 2007 Dec 13;450(7172):957-9. No abstract available.

PMID:
18075569
16.

Sodium flux ratio in Na/K pump-channels opened by palytoxin.

Rakowski RF, Artigas P, Palma F, Holmgren M, De Weer P, Gadsby DC.

J Gen Physiol. 2007 Jul;130(1):41-54. Epub 2007 Jun 11.

17.

Thermodynamics of CFTR channel gating: a spreading conformational change initiates an irreversible gating cycle.

Csanády L, Nairn AC, Gadsby DC.

J Gen Physiol. 2006 Nov;128(5):523-33. Epub 2006 Oct 16.

18.

In vivo phosphorylation of CFTR promotes formation of a nucleotide-binding domain heterodimer.

Mense M, Vergani P, White DM, Altberg G, Nairn AC, Gadsby DC.

EMBO J. 2006 Oct 18;25(20):4728-39. Epub 2006 Oct 12.

19.

Ion permeation through the Na+,K+-ATPase.

Reyes N, Gadsby DC.

Nature. 2006 Sep 28;443(7110):470-4.

PMID:
17006516
20.

Ouabain affinity determining residues lie close to the Na/K pump ion pathway.

Artigas P, Gadsby DC.

Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12613-8. Epub 2006 Aug 7.

21.

The ABC protein turned chloride channel whose failure causes cystic fibrosis.

Gadsby DC, Vergani P, Csanády L.

Nature. 2006 Mar 23;440(7083):477-83. Review.

22.

Control of the CFTR channel's gates.

Vergani P, Basso C, Mense M, Nairn AC, Gadsby DC.

Biochem Soc Trans. 2005 Nov;33(Pt 5):1003-7.

23.

CFTR channel opening by ATP-driven tight dimerization of its nucleotide-binding domains.

Vergani P, Lockless SW, Nairn AC, Gadsby DC.

Nature. 2005 Feb 24;433(7028):876-80.

24.

Preferential phosphorylation of R-domain Serine 768 dampens activation of CFTR channels by PKA.

Csanády L, Seto-Young D, Chan KW, Cenciarelli C, Angel BB, Qin J, McLachlin DT, Krutchinsky AN, Chait BT, Nairn AC, Gadsby DC.

J Gen Physiol. 2005 Feb;125(2):171-86. Epub 2005 Jan 18.

25.

Functional roles of nonconserved structural segments in CFTR's NH2-terminal nucleotide binding domain.

Csanády L, Chan KW, Nairn AC, Gadsby DC.

J Gen Physiol. 2005 Jan;125(1):43-55. Epub 2004 Dec 13.

26.
27.

Ion transport: spot the difference.

Gadsby DC.

Nature. 2004 Feb 26;427(6977):795-7. No abstract available.

PMID:
14985745
28.
29.

Ion occlusion/deocclusion partial reactions in individual palytoxin-modified Na/K pumps.

Artigas P, Gadsby DC.

Ann N Y Acad Sci. 2003 Apr;986:116-26.

PMID:
12763784
30.

Na+/K+-pump ligands modulate gating of palytoxin-induced ion channels.

Artigas P, Gadsby DC.

Proc Natl Acad Sci U S A. 2003 Jan 21;100(2):501-5. Epub 2002 Dec 23.

31.

On the mechanism of MgATP-dependent gating of CFTR Cl- channels.

Vergani P, Nairn AC, Gadsby DC.

J Gen Physiol. 2003 Jan;121(1):17-36.

32.

Ion channel-like properties of the Na+/K+ Pump.

Artigas P, Gadsby DC.

Ann N Y Acad Sci. 2002 Nov;976:31-40.

PMID:
12502531
33.

Distinct Mg(2+)-dependent steps rate limit opening and closing of a single CFTR Cl(-) channel.

Dousmanis AG, Nairn AC, Gadsby DC.

J Gen Physiol. 2002 Jun;119(6):545-59.

34.

Single ion occupancy and steady-state gating of Na channels in squid giant axon.

Rakowski RF, Gadsby DC, De Weer P.

J Gen Physiol. 2002 Mar;119(3):235-49. Erratum in: J Gen Physiol 2002 Apr;119(4):391.

35.

Voltage dependence of the apparent affinity for external Na(+) of the backward-running sodium pump.

De Weer P, Gadsby DC, Rakowski RF.

J Gen Physiol. 2001 Apr;117(4):315-28.

36.

Severed channels probe regulation of gating of cystic fibrosis transmembrane conductance regulator by its cytoplasmic domains.

Csanády L, Chan KW, Seto-Young D, Kopsco DC, Nairn AC, Gadsby DC.

J Gen Physiol. 2000 Sep;116(3):477-500.

37.
38.

Three distinct and sequential steps in the release of sodium ions by the Na+/K+-ATPase.

Holmgren M, Wagg J, Bezanilla F, Rakowski RF, De Weer P, Gadsby DC.

Nature. 2000 Feb 24;403(6772):898-901.

PMID:
10706288
39.

CFTR channel gating: incremental progress in irreversible steps.

Csanády L, Gadsby DC.

J Gen Physiol. 1999 Jul;114(1):49-53. Review. No abstract available.

40.

Regulation of CFTR Cl- ion channels by phosphorylation and dephosphorylation.

Gadsby DC, Nairn AC.

Adv Second Messenger Phosphoprotein Res. 1999;33:79-106. Review. No abstract available.

PMID:
10218115
41.

Control of CFTR channel gating by phosphorylation and nucleotide hydrolysis.

Gadsby DC, Nairn AC.

Physiol Rev. 1999 Jan;79(1 Suppl):S77-S107. Review.

42.

ATP hydrolysis cycles and the gating of CFTR Cl- channels.

Gadsby DC, Dousmanis AG, Nairn AC.

Acta Physiol Scand Suppl. 1998 Aug;643:247-56. Review.

PMID:
9789567
43.

Ordered interaction of ions with Na/K-pump may confound interpretation of unidirectional fluxes.

Wagg J, Gadsby DC.

Ann N Y Acad Sci. 1997 Nov 3;834:426-31. No abstract available.

PMID:
9405837
44.

Charge translocation by the Na/K pump.

Rakowski RF, Bezanilla F, De Weer P, Gadsby DC, Holmgren M, Wagg J.

Ann N Y Acad Sci. 1997 Nov 3;834:231-43. Review. No abstract available.

PMID:
9405811
45.

ATP hydrolysis cycles and mechanism in P-glycoprotein and CFTR.

Senior AE, Gadsby DC.

Semin Cancer Biol. 1997 Jun;8(3):143-50. Review.

PMID:
9441944
46.

Voltage dependence of the Na/K pump.

Rakowski RF, Gadsby DC, De Weer P.

J Membr Biol. 1997 Jan 15;155(2):105-12. Review. No abstract available.

PMID:
9049104
47.

Two-bit anion channel really shapes up.

Gadsby DC.

Nature. 1996 Sep 26;383(6598):295-6. No abstract available.

PMID:
8848037
48.

The CFTR chloride channel of mammalian heart.

Gadsby DC, Nagel G, Hwang TC.

Annu Rev Physiol. 1995;57:387-416. Review. No abstract available.

PMID:
7539989
49.

Regulation of CFTR channel gating.

Gadsby DC, Nairn AC.

Trends Biochem Sci. 1994 Nov;19(11):513-8.

PMID:
7531880
50.

Regulation of the gating of cystic fibrosis transmembrane conductance regulator C1 channels by phosphorylation and ATP hydrolysis.

Hwang TC, Nagel G, Nairn AC, Gadsby DC.

Proc Natl Acad Sci U S A. 1994 May 24;91(11):4698-702.

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