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Items: 28

1.

gPKPDSim: a SimBiology®-based GUI application for PKPD modeling in drug development.

Hosseini I, Gajjala A, Bumbaca Yadav D, Sukumaran S, Ramanujan S, Paxson R, Gadkar K.

J Pharmacokinet Pharmacodyn. 2018 Apr;45(2):259-275. doi: 10.1007/s10928-017-9562-9. Epub 2018 Jan 4.

2.

Erratum: Clinical responses to ERK inhibition in BRAFV600E-mutant colorectal cancer predicted using a computational model.

Kirouac DC, Schaefer G, Chan J, Merchant M, Orr C, Huang SA, Moffat J, Liu L, Gadkar K, Ramanujan S.

NPJ Syst Biol Appl. 2017 Sep 4;3:25. doi: 10.1038/s41540-017-0026-z. eCollection 2017.

3.

Widespread brain distribution and activity following i.c.v. infusion of anti-β-secretase (BACE1) in nonhuman primates.

Yadav DB, Maloney JA, Wildsmith KR, Fuji RN, Meilandt WJ, Solanoy H, Lu Y, Peng K, Wilson B, Chan P, Gadkar K, Kosky A, Goo M, Daugherty A, Couch JA, Keene T, Hayes K, Nikolas LJ, Lane D, Switzer R, Adams E, Watts RJ, Scearce-Levie K, Prabhu S, Shafer L, Thakker DR, Hildebrand K, Atwal JK.

Br J Pharmacol. 2017 Nov;174(22):4173-4185. doi: 10.1111/bph.14021. Epub 2017 Oct 6.

PMID:
28859225
4.

Clinical responses to ERK inhibition in BRAFV600E-mutant colorectal cancer predicted using a computational model.

Kirouac DC, Schaefer G, Chan J, Merchant M, Orr C, Huang SA, Moffat J, Liu L, Gadkar K, Ramanujan S.

NPJ Syst Biol Appl. 2017 Jun 2;3:14. doi: 10.1038/s41540-017-0016-1. eCollection 2017. Erratum in: NPJ Syst Biol Appl. 2017 Sep 4;3:25.

5.

Ocular Pharmacokinetics of Therapeutic Antibodies Given by Intravitreal Injection: Estimation of Retinal Permeabilities Using a 3-Compartment Semi-Mechanistic Model.

Hutton-Smith LA, Gaffney EA, Byrne HM, Maini PK, Gadkar K, Mazer NA.

Mol Pharm. 2017 Aug 7;14(8):2690-2696. doi: 10.1021/acs.molpharmaceut.7b00164. Epub 2017 Jul 3.

PMID:
28631484
6.

Methodologies for Quantitative Systems Pharmacology (QSP) Models: Design and Estimation.

Ribba B, Grimm HP, Agoram B, Davies MR, Gadkar K, Niederer S, van Riel N, Timmis J, van der Graaf PH.

CPT Pharmacometrics Syst Pharmacol. 2017 Aug;6(8):496-498. doi: 10.1002/psp4.12206. Epub 2017 Jul 11.

7.

Quantitative systems pharmacology: a promising approach for translational pharmacology.

Gadkar K, Kirouac D, Parrott N, Ramanujan S.

Drug Discov Today Technol. 2016 Sep - Dec;21-22:57-65. doi: 10.1016/j.ddtec.2016.11.001. Epub 2016 Nov 24. Review.

PMID:
27978989
8.

Development and Translational Application of an Integrated, Mechanistic Model of Antibody-Drug Conjugate Pharmacokinetics.

Sukumaran S, Zhang C, Leipold DD, Saad OM, Xu K, Gadkar K, Samineni D, Wang B, Milojic-Blair M, Carrasco-Triguero M, Rubinfeld B, Fielder P, Lin K, Ramanujan S.

AAPS J. 2017 Jan;19(1):130-140. doi: 10.1208/s12248-016-9993-z. Epub 2016 Sep 27.

PMID:
27679517
9.

Prospective Design of Anti-Transferrin Receptor Bispecific Antibodies for Optimal Delivery into the Human Brain.

Kanodia JS, Gadkar K, Bumbaca D, Zhang Y, Tong RK, Luk W, Hoyte K, Lu Y, Wildsmith KR, Couch JA, Watts RJ, Dennis MS, Ernst JA, Scearce-Levie K, Atwal JK, Ramanujan S, Joseph S.

CPT Pharmacometrics Syst Pharmacol. 2016 May;5(5):283-91. doi: 10.1002/psp4.12081. Epub 2016 May 17.

10.

A Six-Stage Workflow for Robust Application of Systems Pharmacology.

Gadkar K, Kirouac DC, Mager DE, van der Graaf PH, Ramanujan S.

CPT Pharmacometrics Syst Pharmacol. 2016 May;5(5):235-49. doi: 10.1002/psp4.12071. Epub 2016 Apr 16.

11.

Mathematical PKPD and safety model of bispecific TfR/BACE1 antibodies for the optimization of antibody uptake in brain.

Gadkar K, Yadav DB, Zuchero JY, Couch JA, Kanodia J, Kenrick MK, Atwal JK, Dennis MS, Prabhu S, Watts RJ, Joseph SB, Ramanujan S.

Eur J Pharm Biopharm. 2016 Apr;101:53-61. doi: 10.1016/j.ejpb.2016.01.009. Epub 2016 Jan 25.

PMID:
26820920
12.

Evaluation of HDL-modulating interventions for cardiovascular risk reduction using a systems pharmacology approach.

Gadkar K, Lu J, Sahasranaman S, Davis J, Mazer NA, Ramanujan S.

J Lipid Res. 2016 Jan;57(1):46-55. doi: 10.1194/jlr.M057943. Epub 2015 Nov 1.

13.

Design and Pharmacokinetic Characterization of Novel Antibody Formats for Ocular Therapeutics.

Gadkar K, Pastuskovas CV, Le Couter JE, Elliott JM, Zhang J, Lee CV, Sanowar S, Fuh G, Kim HS, Lombana TN, Spiess C, Nakamura M, Hass P, Shatz W, Meng YG, Scheer JM.

Invest Ophthalmol Vis Sci. 2015 Aug;56(9):5390-400. doi: 10.1167/iovs.15-17108.

PMID:
26275136
14.

Mechanism-Based Pharmacokinetic/Pharmacodynamic Model for THIOMAB™ Drug Conjugates.

Sukumaran S, Gadkar K, Zhang C, Bhakta S, Liu L, Xu K, Raab H, Yu SF, Mai E, Fourie-O'Donohue A, Kozak KR, Ramanujan S, Junutula JR, Lin K.

Pharm Res. 2015 Jun;32(6):1884-93. doi: 10.1007/s11095-014-1582-1. Epub 2014 Dec 2.

PMID:
25446772
15.

A Mechanistic Systems Pharmacology Model for Prediction of LDL Cholesterol Lowering by PCSK9 Antagonism in Human Dyslipidemic Populations.

Gadkar K, Budha N, Baruch A, Davis JD, Fielder P, Ramanujan S.

CPT Pharmacometrics Syst Pharmacol. 2014 Nov 26;3:e149. doi: 10.1038/psp.2014.47.

16.

Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates.

Yu YJ, Atwal JK, Zhang Y, Tong RK, Wildsmith KR, Tan C, Bien-Ly N, Hersom M, Maloney JA, Meilandt WJ, Bumbaca D, Gadkar K, Hoyte K, Luk W, Lu Y, Ernst JA, Scearce-Levie K, Couch JA, Dennis MS, Watts RJ.

Sci Transl Med. 2014 Nov 5;6(261):261ra154. doi: 10.1126/scitranslmed.3009835.

17.

A Mechanistic Systems Pharmacology Model for Prediction of LDL Cholesterol Lowering by PCSK9 Antagonism in Human Dyslipidemic Populations.

Gadkar K, Budha N, Baruch A, Davis JD, Fielder P, Ramanujan S.

CPT Pharmacometrics Syst Pharmacol. 2014 Nov;3(11):1-9. doi: 10.1038/psp.2014.47.

18.

Addressing safety liabilities of TfR bispecific antibodies that cross the blood-brain barrier.

Couch JA, Yu YJ, Zhang Y, Tarrant JM, Fuji RN, Meilandt WJ, Solanoy H, Tong RK, Hoyte K, Luk W, Lu Y, Gadkar K, Prabhu S, Ordonia BA, Nguyen Q, Lin Y, Lin Z, Balazs M, Scearce-Levie K, Ernst JA, Dennis MS, Watts RJ.

Sci Transl Med. 2013 May 1;5(183):183ra57, 1-12. doi: 10.1126/scitranslmed.3005338.

19.

The Type 1 Diabetes PhysioLab Platform: a validated physiologically based mathematical model of pathogenesis in the non-obese diabetic mouse.

Shoda L, Kreuwel H, Gadkar K, Zheng Y, Whiting C, Atkinson M, Bluestone J, Mathis D, Young D, Ramanujan S.

Clin Exp Immunol. 2010 Aug;161(2):250-67. doi: 10.1111/j.1365-2249.2010.04166.x. Epub 2010 May 18.

20.

Towards optimal virtual patients: an online adaptive control approach.

Ghosh S, Young DL, Gadkar KG, Wennerberg L, Basu K.

Conf Proc IEEE Eng Med Biol Soc. 2007;2007:3292-5.

PMID:
18002699
21.

Dosing and timing effects of anti-CD40L therapy: predictions from a mathematical model of type 1 diabetes.

Gadkar KG, Shoda LK, Kreuwel HT, Ramanujan S, Zheng Y, Whiting CC, Young DL.

Ann N Y Acad Sci. 2007 Apr;1103:63-8. Epub 2007 Mar 21.

PMID:
17376835
22.

The virtual NOD mouse: applying predictive biosimulation to research in type 1 diabetes.

Zheng Y, Kreuwel HT, Young DL, Shoda LK, Ramanujan S, Gadkar KG, Atkinson MA, Whiting CC.

Ann N Y Acad Sci. 2007 Apr;1103:45-62. Epub 2007 Mar 21.

PMID:
17376834
23.

Mechanisms mediating anti-CD3 antibody efficacy: insights from a mathematical model of type 1 diabetes.

Young DL, Ramanujan S, Kreuwel HT, Whiting CC, Gadkar KG, Shoda LK.

Ann N Y Acad Sci. 2006 Oct;1079:369-73.

PMID:
17130581
24.

Model identification of signal transduction networks from data using a state regulator problem.

Gadkar KG, Varner J, Doyle FJ 3rd.

Syst Biol (Stevenage). 2005 Mar;2(1):17-30.

PMID:
17091579
25.

Iterative approach to model identification of biological networks.

Gadkar KG, Gunawan R, Doyle FJ 3rd.

BMC Bioinformatics. 2005 Jun 20;6:155.

26.

Estimating optimal profiles of genetic alterations using constraint-based models.

Gadkar KG, Doyle Iii FJ, Edwards JS, Mahadevan R.

Biotechnol Bioeng. 2005 Jan 20;89(2):243-51.

PMID:
15593263
27.

A benchmark for methods in reverse engineering and model discrimination: problem formulation and solutions.

Kremling A, Fischer S, Gadkar K, Doyle FJ, Sauter T, Bullinger E, Allgöwer F, Gilles ED.

Genome Res. 2004 Sep;14(9):1773-85.

28.

Cybernetic model predictive control of a continuous bioreactor with cell recycle.

Gadkar KG, Doyle FJ 3rd, Crowley TJ, Varner JD.

Biotechnol Prog. 2003 Sep-Oct;19(5):1487-97.

PMID:
14524710

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