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Items: 1 to 50 of 87

1.

Single-cell Proteomic Profiling Identifies Combined AXL and JAK1 Inhibition as a Novel Therapeutic Strategy for Lung Cancer.

Taverna JA, Hung CN, DeArmond DT, Chen M, Lin CL, Osmulski PA, Gaczynska ME, Wang CM, Lucio ND, Chou CW, Chen CL, Nazarullah A, Lampkin SR, Qiu L, Bearss DJ, Warner S, Whatcott CJ, Mouritsen L, Wade M, Weitman S, Mesa RA, Kirma NB, Chao WT, Huang TH.

Cancer Res. 2020 Jan 28. pii: canres.3183.2019. doi: 10.1158/0008-5472.CAN-19-3183. [Epub ahead of print]

PMID:
31992541
2.

Inhibitory Interplay of SULT2B1b Sulfotransferase with AKR1C3 Aldo-keto Reductase in Prostate Cancer.

Park S, Song CS, Lin CL, Jiang S, Osmulski PA, Wang CM, Marck BT, Matsumoto AM, Morrissey C, Gaczynska ME, Chen Y, Mostaghel EA, Chatterjee B.

Endocrinology. 2020 Jan 2. pii: bqz042. doi: 10.1210/endocr/bqz042. [Epub ahead of print]

PMID:
31894239
3.

Pipecolic esters as minimized templates for proteasome inhibition.

Giletto MB, Osmulski PA, Jones CL, Gaczynska ME, Tepe JJ.

Org Biomol Chem. 2019 Mar 6;17(10):2734-2746. doi: 10.1039/c9ob00122k.

PMID:
30778435
4.

Proline- and Arginine-Rich Peptides as Flexible Allosteric Modulators of Human Proteasome Activity.

Giżyńska M, Witkowska J, Karpowicz P, Rostankowski R, Chocron ES, Pickering AM, Osmulski P, Gaczynska M, Jankowska E.

J Med Chem. 2019 Jan 10;62(1):359-370. doi: 10.1021/acs.jmedchem.8b01025. Epub 2018 Dec 3.

5.

Adipokines Deregulate Cellular Communication via Epigenetic Repression of Gap Junction Loci in Obese Endometrial Cancer.

Polusani SR, Huang YW, Huang G, Chen CW, Wang CM, Lin LL, Osmulski P, Lucio ND, Liu L, Hsu YT, Zhou Y, Lin CL, Aguilera-Barrantes I, Valente PT, Kost ER, Chen CL, Shim EY, Lee SE, Ruan J, Gaczynska ME, Yan P, Goodfellow PJ, Mutch DG, Jin VX, Nicholson BJ, Huang TH, Kirma NB.

Cancer Res. 2019 Jan 1;79(1):196-208. doi: 10.1158/0008-5472.CAN-18-1615. Epub 2018 Nov 2.

6.

Small Molecule Modulation of Proteasome Assembly.

Njomen E, Osmulski PA, Jones CL, Gaczynska M, Tepe JJ.

Biochemistry. 2018 Jul 17;57(28):4214-4224. doi: 10.1021/acs.biochem.8b00579. Epub 2018 Jun 27.

7.

Targeting Protein-Protein Interactions in the Ubiquitin-Proteasome Pathway.

Gaczynska M, Osmulski PA.

Adv Protein Chem Struct Biol. 2018;110:123-165. doi: 10.1016/bs.apcsb.2017.09.001. Epub 2017 Oct 18. Review.

PMID:
29412995
8.

Sustained NFκB inhibition improves insulin sensitivity but is detrimental to muscle health.

Zhang N, Valentine JM, Zhou Y, Li ME, Zhang Y, Bhattacharya A, Walsh ME, Fischer KE, Austad SN, Osmulski P, Gaczynska M, Shoelson SE, Van Remmen H, Chen HI, Chen Y, Liang H, Musi N.

Aging Cell. 2017 Aug;16(4):847-858. doi: 10.1111/acel.12613. Epub 2017 May 29.

9.

Cholesterol Regulates Monocyte Rolling through CD44 Distribution.

Saha AK, Osmulski P, Dallo SF, Gaczynska M, Huang TH, Ramasubramanian AK.

Biophys J. 2017 Apr 11;112(7):1481-1488. doi: 10.1016/j.bpj.2017.02.021.

10.

EGFR-Dependent Regulated Intramembrane Proteolysis of EpCAM-Response.

Hsu YT, Osmulski P, Wang Y, Huang YW, Liu L, Ruan J, Jin VX, Kirma NB, Gaczynska ME, Huang TH.

Cancer Res. 2017 Apr 1;77(7):1777. doi: 10.1158/0008-5472.CAN-16-3440. Epub 2017 Mar 22. No abstract available.

11.

Cellular cholesterol regulates monocyte deformation.

Saha AK, Dallo SF, Detmar AL, Osmulski P, Gaczynska M, Huang TH, Ramasubramanian AK.

J Biomech. 2017 Feb 8;52:83-88. doi: 10.1016/j.jbiomech.2016.12.033. Epub 2016 Dec 30.

12.

EpCAM-Regulated Transcription Exerts Influences on Nanomechanical Properties of Endometrial Cancer Cells That Promote Epithelial-to-Mesenchymal Transition.

Hsu YT, Osmulski P, Wang Y, Huang YW, Liu L, Ruan J, Jin VX, Kirma NB, Gaczynska ME, Huang TH.

Cancer Res. 2016 Nov 1;76(21):6171-6182. Epub 2016 Aug 28. Erratum in: Cancer Res. 2017 Apr 1;77(7):1778.

13.

TGF-β signal rewiring sustains epithelial-mesenchymal transition of circulating tumor cells in prostate cancer xenograft hosts.

Huang G, Osmulski PA, Bouamar H, Mahalingam D, Lin CL, Liss MA, Kumar AP, Chen CL, Thompson IM, Sun LZ, Gaczynska ME, Huang TH.

Oncotarget. 2016 Nov 22;7(47):77124-77137. doi: 10.18632/oncotarget.12808.

14.

AFM Imaging Reveals Topographic Diversity of Wild Type and Z Variant Polymers of Human α1-Proteinase Inhibitor.

Gaczynska M, Karpowicz P, Stuart CE, Norton MG, Teckman JH, Marszal E, Osmulski PA.

PLoS One. 2016 Mar 23;11(3):e0151902. doi: 10.1371/journal.pone.0151902. eCollection 2016.

15.

Interplay between Structure and Charge as a Key to Allosteric Modulation of Human 20S Proteasome by the Basic Fragment of HIV-1 Tat Protein.

Karpowicz P, Osmulski PA, Witkowska J, Sikorska E, Giżyńska M, Belczyk-Ciesielska A, Gaczynska ME, Jankowska E.

PLoS One. 2015 Nov 17;10(11):e0143038. doi: 10.1371/journal.pone.0143038. eCollection 2015.

16.

Targeting Protein-Protein Interactions in the Proteasome Super-Assemblies.

Gaczynska M, Osmulski PA.

Curr Top Med Chem. 2015;15(20):2056-67. Review.

PMID:
25986687
17.

Nanomechanical biomarkers of single circulating tumor cells for detection of castration resistant prostate cancer.

Osmulski P, Mahalingam D, Gaczynska ME, Liu J, Huang S, Horning AM, Wang CM, Thompson IM, Huang TH, Chen CL.

Prostate. 2014 Sep;74(13):1297-307. doi: 10.1002/pros.22846. Epub 2014 Jul 25.

18.

A cytosolic protein factor from the naked mole-rat activates proteasomes of other species and protects these from inhibition.

Rodriguez KA, Osmulski PA, Pierce A, Weintraub ST, Gaczynska M, Buffenstein R.

Biochim Biophys Acta. 2014 Nov;1842(11):2060-72. doi: 10.1016/j.bbadis.2014.07.005. Epub 2014 Jul 10.

19.

Dissecting a role of a charge and conformation of Tat2 peptide in allosteric regulation of 20S proteasome.

Witkowska J, Karpowicz P, Gaczynska M, Osmulski PA, Jankowska E.

J Pept Sci. 2014 Aug;20(8):649-56. doi: 10.1002/psc.2642. Epub 2014 May 13.

PMID:
24819612
20.

Harnessing proteasome dynamics and allostery in drug design.

Gaczynska M, Osmulski PA.

Antioxid Redox Signal. 2014 Dec 10;21(17):2286-301. doi: 10.1089/ars.2013.5816. Epub 2014 Feb 21. Review.

21.

Rapamycin allosterically inhibits the proteasome.

Osmulski PA, Gaczynska M.

Mol Pharmacol. 2013 Jul;84(1):104-13. doi: 10.1124/mol.112.083873. Epub 2013 Apr 25.

PMID:
23619386
22.

Amyloid beta and the longest-lived rodent: the naked mole-rat as a model for natural protection from Alzheimer's disease.

Edrey YH, Medina DX, Gaczynska M, Osmulski PA, Oddo S, Caccamo A, Buffenstein R.

Neurobiol Aging. 2013 Oct;34(10):2352-60. doi: 10.1016/j.neurobiolaging.2013.03.032. Epub 2013 Apr 22.

23.

Single-cell analysis of circulating tumor cells identifies cumulative expression patterns of EMT-related genes in metastatic prostate cancer.

Chen CL, Mahalingam D, Osmulski P, Jadhav RR, Wang CM, Leach RJ, Chang TC, Weitman SD, Kumar AP, Sun L, Gaczynska ME, Thompson IM, Huang TH.

Prostate. 2013 Jun;73(8):813-26. doi: 10.1002/pros.22625. Epub 2012 Dec 31.

24.

The proteasome in health and disease.

Jankowska E, Stoj J, Karpowicz P, Osmulski PA, Gaczynska M.

Curr Pharm Des. 2013;19(6):1010-28. Review.

PMID:
23016682
25.

Altered composition of liver proteasome assemblies contributes to enhanced proteasome activity in the exceptionally long-lived naked mole-rat.

Rodriguez KA, Edrey YH, Osmulski P, Gaczynska M, Buffenstein R.

PLoS One. 2012;7(5):e35890. doi: 10.1371/journal.pone.0035890. Epub 2012 May 2.

26.

The growth-suppressive function of the polycomb group protein polyhomeotic is mediated by polymerization of its sterile alpha motif (SAM) domain.

Robinson AK, Leal BZ, Chadwell LV, Wang R, Ilangovan U, Kaur Y, Junco SE, Schirf V, Osmulski PA, Gaczynska M, Hinck AP, Demeler B, McEwen DG, Kim CA.

J Biol Chem. 2012 Mar 16;287(12):8702-13. doi: 10.1074/jbc.M111.336115. Epub 2012 Jan 24.

27.

Atomic force microscopy of proteasome assemblies.

Gaczynska M, Osmulski PA.

Methods Mol Biol. 2011;736:117-32. doi: 10.1007/978-1-61779-105-5_9.

PMID:
21660725
28.

Phosphorylation by Nek1 regulates opening and closing of voltage dependent anion channel 1.

Chen Y, Gaczynska M, Osmulski P, Polci R, Riley DJ.

Biochem Biophys Res Commun. 2010 Apr 9;394(3):798-803. doi: 10.1016/j.bbrc.2010.03.077. Epub 2010 Mar 15.

29.

Potential allosteric modulators of the proteasome activity.

Jankowska E, Gaczynska M, Osmulski P, Sikorska E, Rostankowski R, Madabhushi S, Tokmina-Lukaszewska M, Kasprzykowski F.

Biopolymers. 2010 May;93(5):481-95. doi: 10.1002/bip.21381.

30.

Molecular mechanisms of proteasome plasticity in aging.

Rodriguez KA, Gaczynska M, Osmulski PA.

Mech Ageing Dev. 2010 Feb;131(2):144-55. doi: 10.1016/j.mad.2010.01.002. Epub 2010 Jan 18.

31.

AFM of biological complexes: what can we learn?

Gaczynska M, Osmulski PA.

Curr Opin Colloid Interface Sci. 2008 Oct;13(5):351-367.

32.

A tetrahedral transition state at the active sites of the 20S proteasome is coupled to opening of the alpha-ring channel.

Osmulski PA, Hochstrasser M, Gaczynska M.

Structure. 2009 Aug 12;17(8):1137-47. doi: 10.1016/j.str.2009.06.011.

33.

Atomic force microscopy as a tool to study the proteasome assemblies.

Gaczynska M, Osmulski PA.

Methods Cell Biol. 2008;90:39-60. doi: 10.1016/S0091-679X(08)00803-0.

PMID:
19195545
34.

The central unit within the 19S regulatory particle of the proteasome.

Rosenzweig R, Osmulski PA, Gaczynska M, Glickman MH.

Nat Struct Mol Biol. 2008 Jun;15(6):573-80. doi: 10.1038/nsmb.1427. Epub 2008 May 30.

35.

Allosteric regulators of the proteasome: potential drugs and a novel approach for drug design.

Tan X, Osmulski PA, Gaczynska M.

Curr Med Chem. 2006;13(2):155-65. Review.

PMID:
16472211
36.

Highbrow proteasome in high-throughput technology.

Gaczynska M, Rodriguez K, Madabhushi S, Osmulski PA.

Expert Rev Proteomics. 2006 Feb;3(1):115-27. Review.

PMID:
16445356
37.

Characterization of noncompetitive regulators of proteasome activity.

Gaczynska M, Osmulski PA.

Methods Enzymol. 2005;398:425-38. Review.

PMID:
16275348
38.

Atomic force microscopy of the proteasome.

Osmulski PA, Gaczynska M.

Methods Enzymol. 2005;398:414-25. Review.

PMID:
16275347
39.

Small-molecule inhibitors of proteasome activity.

Gaczynska M, Osmulski PA.

Methods Mol Biol. 2005;301:3-22. Review.

PMID:
15917622
40.

Atomic force microscopic analysis of the binding of the Schizosaccharomyces pombe origin recognition complex and the spOrc4 protein with origin DNA.

Gaczynska M, Osmulski PA, Jiang Y, Lee JK, Bermudez V, Hurwitz J.

Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):17952-7. Epub 2004 Dec 14.

41.

DNA-looping by RXR tetramers permits transcriptional regulation "at a distance".

Yasmin R, Yeung KT, Chung RH, Gaczynska ME, Osmulski PA, Noy N.

J Mol Biol. 2004 Oct 15;343(2):327-38.

PMID:
15451664
42.

Proline- and arginine-rich peptides constitute a novel class of allosteric inhibitors of proteasome activity.

Gaczynska M, Osmulski PA, Gao Y, Post MJ, Simons M.

Biochemistry. 2003 Jul 29;42(29):8663-70.

PMID:
12873125
43.

Nanoenzymology of the 20S proteasome: proteasomal actions are controlled by the allosteric transition.

Osmulski PA, Gaczynska M.

Biochemistry. 2002 Jun 4;41(22):7047-53.

PMID:
12033938
44.

Caretaker or undertaker? The role of the proteasome in aging.

Gaczynska M, Osmulski PA, Ward WF.

Mech Ageing Dev. 2001 Mar;122(3):235-54. Review.

PMID:
11311314
45.

Atomic force microscopy reveals two conformations of the 20 S proteasome from fission yeast.

Osmulski PA, Gaczynska M.

J Biol Chem. 2000 May 5;275(18):13171-4.

46.
47.

A proteolytic system that compensates for loss of proteasome function.

Glas R, Bogyo M, McMaster JS, Gaczynska M, Ploegh HL.

Nature. 1998 Apr 9;392(6676):618-22.

PMID:
9560160
48.

Covalent modification of the active site threonine of proteasomal beta subunits and the Escherichia coli homolog HslV by a new class of inhibitors.

Bogyo M, McMaster JS, Gaczynska M, Tortorella D, Goldberg AL, Ploegh H.

Proc Natl Acad Sci U S A. 1997 Jun 24;94(13):6629-34.

49.
50.

Proteasome inhibitors and antigen presentation.

Bogyo M, Gaczynska M, Ploegh HL.

Biopolymers. 1997;43(4):269-80. Review.

PMID:
9316392

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