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Items: 1 to 50 of 51

1.

Zika Virus NS3 Mimics a Cellular 14-3-3-Binding Motif to Antagonize RIG-I- and MDA5-Mediated Innate Immunity.

Riedl W, Acharya D, Lee JH, Liu G, Serman T, Chiang C, Chan YK, Diamond MS, Gack MU.

Cell Host Microbe. 2019 Oct 9;26(4):493-503.e6. doi: 10.1016/j.chom.2019.09.012.

PMID:
31600501
2.

Disassembly of the TRIM23-TBK1 Complex by the Us11 Protein of Herpes Simplex Virus 1 Impairs Autophagy.

Liu X, Matrenec R, Gack MU, He B.

J Virol. 2019 Aug 13;93(17). pii: e00497-19. doi: 10.1128/JVI.00497-19. Print 2019 Sep 1.

PMID:
31189704
3.

Endogenous Nucleic Acid Recognition by RIG-I-Like Receptors and cGAS.

Lee JH, Chiang C, Gack MU.

J Interferon Cytokine Res. 2019 Aug;39(8):450-458. doi: 10.1089/jir.2019.0015. Epub 2019 May 7.

PMID:
31066607
4.

FBXO38 Drives PD-1 to Destruction.

Serman TM, Gack MU.

Trends Immunol. 2019 Feb;40(2):81-83. doi: 10.1016/j.it.2018.12.005. Epub 2019 Jan 1.

PMID:
30609969
5.

Centrosomal protein TRIM43 restricts herpesvirus infection by regulating nuclear lamina integrity.

Full F, van Gent M, Sparrer KMJ, Chiang C, Zurenski MA, Scherer M, Brockmeyer NH, Heinzerling L, Stürzl M, Korn K, Stamminger T, Ensser A, Gack MU.

Nat Microbiol. 2019 Jan;4(1):164-176. doi: 10.1038/s41564-018-0285-5. Epub 2018 Nov 12.

6.

Dusting for flu's fingerprints.

Riedl W, Gack MU.

Nat Microbiol. 2018 Nov;3(11):1196-1197. doi: 10.1038/s41564-018-0270-z. No abstract available.

PMID:
30356151
7.

TRIM25 Binds RNA to Modulate Cellular Anti-viral Defense.

Sanchez JG, Sparrer KMJ, Chiang C, Reis RA, Chiang JJ, Zurenski MA, Wan Y, Gack MU, Pornillos O.

J Mol Biol. 2018 Dec 7;430(24):5280-5293. doi: 10.1016/j.jmb.2018.10.003. Epub 2018 Oct 17.

PMID:
30342007
8.

Viral Anti-CRISPR Tactics: No Success without Sacrifice.

van Gent M, Gack MU.

Immunity. 2018 Sep 18;49(3):391-393. doi: 10.1016/j.immuni.2018.08.023.

9.

TRIM Proteins and Their Roles in Antiviral Host Defenses.

van Gent M, Sparrer KMJ, Gack MU.

Annu Rev Virol. 2018 Sep 29;5(1):385-405. doi: 10.1146/annurev-virology-092917-043323. Epub 2018 Jun 27. Review.

10.

TRIM proteins: New players in virus-induced autophagy.

Sparrer KMJ, Gack MU.

PLoS Pathog. 2018 Feb 1;14(2):e1006787. doi: 10.1371/journal.ppat.1006787. eCollection 2018 Feb. No abstract available.

11.

The Human Papillomavirus E6 Oncoprotein Targets USP15 and TRIM25 To Suppress RIG-I-Mediated Innate Immune Signaling.

Chiang C, Pauli EK, Biryukov J, Feister KF, Meng M, White EA, Münger K, Howley PM, Meyers C, Gack MU.

J Virol. 2018 Feb 26;92(6). pii: e01737-17. doi: 10.1128/JVI.01737-17. Print 2018 Mar 15.

12.

Identification of a second binding site on the TRIM25 B30.2 domain.

D'Cruz AA, Kershaw NJ, Hayman TJ, Linossi EM, Chiang JJ, Wang MK, Dagley LF, Kolesnik TB, Zhang JG, Masters SL, Griffin MDW, Gack MU, Murphy JM, Nicola NA, Babon JJ, Nicholson SE.

Biochem J. 2018 Jan 23;475(2):429-440. doi: 10.1042/BCJ20170427.

13.

Viral unmasking of cellular 5S rRNA pseudogene transcripts induces RIG-I-mediated immunity.

Chiang JJ, Sparrer KMJ, van Gent M, Lässig C, Huang T, Osterrieder N, Hopfner KP, Gack MU.

Nat Immunol. 2018 Jan;19(1):53-62. doi: 10.1038/s41590-017-0005-y. Epub 2017 Nov 27.

14.

Proteasome-independent polyubiquitin linkage regulates synapse scaffolding, efficacy, and plasticity.

Ma Q, Ruan H, Peng L, Zhang M, Gack MU, Yao WD.

Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):E8760-E8769. doi: 10.1073/pnas.1620153114. Epub 2017 Sep 25.

15.

TRIM23 mediates virus-induced autophagy via activation of TBK1.

Sparrer KMJ, Gableske S, Zurenski MA, Parker ZM, Full F, Baumgart GJ, Kato J, Pacheco-Rodriguez G, Liang C, Pornillos O, Moss J, Vaughan M, Gack MU.

Nat Microbiol. 2017 Nov;2(11):1543-1557. doi: 10.1038/s41564-017-0017-2. Epub 2017 Sep 4.

16.

What viruses can teach us about the human immune system.

Gack MU.

PLoS Pathog. 2017 Jul 13;13(7):e1006364. doi: 10.1371/journal.ppat.1006364. eCollection 2017 Jul. Review. No abstract available.

17.

Viral pathogenesis: Dengue virus takes on cGAS.

van Gent M, Gack MU.

Nat Microbiol. 2017 Mar 27;2:17050. doi: 10.1038/nmicrobiol.2017.50. No abstract available.

PMID:
28346454
18.

Post-translational Control of Intracellular Pathogen Sensing Pathways.

Chiang C, Gack MU.

Trends Immunol. 2017 Jan;38(1):39-52. doi: 10.1016/j.it.2016.10.008. Epub 2016 Nov 15. Review.

19.

Innate immune escape by Dengue and West Nile viruses.

Gack MU, Diamond MS.

Curr Opin Virol. 2016 Oct;20:119-128. doi: 10.1016/j.coviro.2016.09.013. Epub 2016 Oct 25. Review.

20.

Mechanism of TRIM25 Catalytic Activation in the Antiviral RIG-I Pathway.

Sanchez JG, Chiang JJ, Sparrer KMJ, Alam SL, Chi M, Roganowicz MD, Sankaran B, Gack MU, Pornillos O.

Cell Rep. 2016 Aug 2;16(5):1315-1325. doi: 10.1016/j.celrep.2016.06.070. Epub 2016 Jul 14.

21.

Viral evasion of intracellular DNA and RNA sensing.

Chan YK, Gack MU.

Nat Rev Microbiol. 2016 Jun;14(6):360-73. doi: 10.1038/nrmicro.2016.45. Epub 2016 May 13. Review.

22.

A phosphomimetic-based mechanism of dengue virus to antagonize innate immunity.

Chan YK, Gack MU.

Nat Immunol. 2016 May;17(5):523-30. doi: 10.1038/ni.3393. Epub 2016 Mar 21.

23.

Reading the fine print: sequence-specific activation of cGAS.

Chiang JJ, Gack MU.

Nat Immunol. 2015 Oct;16(10):1009-10. doi: 10.1038/ni.3274. No abstract available.

PMID:
26382862
24.

Delicate coordination of TRIM21's dual activity in virus neutralization and signaling.

Full F, Gack MU.

Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):9797-8. doi: 10.1073/pnas.1512642112. Epub 2015 Aug 3. No abstract available.

25.

Intracellular detection of viral nucleic acids.

Sparrer KM, Gack MU.

Curr Opin Microbiol. 2015 Aug;26:1-9. doi: 10.1016/j.mib.2015.03.001. Epub 2015 Mar 18. Review.

26.

RIG-I works double duty.

Chan YK, Gack MU.

Cell Host Microbe. 2015 Mar 11;17(3):285-287. doi: 10.1016/j.chom.2015.02.014.

27.

Ubiquitination in the antiviral immune response.

Davis ME, Gack MU.

Virology. 2015 May;479-480:52-65. doi: 10.1016/j.virol.2015.02.033. Epub 2015 Mar 7. Review.

28.

RIG-I-like receptor regulation in virus infection and immunity.

Chan YK, Gack MU.

Curr Opin Virol. 2015 Jun;12:7-14. doi: 10.1016/j.coviro.2015.01.004. Epub 2015 Jan 30. Review.

29.

The bioactive lipid 4-hydroxyphenyl retinamide inhibits flavivirus replication.

Carocci M, Hinshaw SM, Rodgers MA, Villareal VA, Burri DJ, Pilankatta R, Maharaj NP, Gack MU, Stavale EJ, Warfield KL, Yang PL.

Antimicrob Agents Chemother. 2015 Jan;59(1):85-95. doi: 10.1128/AAC.04177-14. Epub 2014 Oct 13.

30.

Regulation of RIG-I-like receptor signaling by host and viral proteins.

Chiang JJ, Davis ME, Gack MU.

Cytokine Growth Factor Rev. 2014 Oct;25(5):491-505. doi: 10.1016/j.cytogfr.2014.06.005. Epub 2014 Jun 21. Review.

PMID:
25023063
31.

Measles virus suppresses RIG-I-like receptor activation in dendritic cells via DC-SIGN-mediated inhibition of PP1 phosphatases.

Mesman AW, Zijlstra-Willems EM, Kaptein TM, de Swart RL, Davis ME, Ludlow M, Duprex WP, Gack MU, Gringhuis SI, Geijtenbeek TB.

Cell Host Microbe. 2014 Jul 9;16(1):31-42. doi: 10.1016/j.chom.2014.06.008.

32.

Antagonism of the phosphatase PP1 by the measles virus V protein is required for innate immune escape of MDA5.

Davis ME, Wang MK, Rennick LJ, Full F, Gableske S, Mesman AW, Gringhuis SI, Geijtenbeek TB, Duprex WP, Gack MU.

Cell Host Microbe. 2014 Jul 9;16(1):19-30. doi: 10.1016/j.chom.2014.06.007.

33.

Cyclic guanosine monophosphate/adenosine monophosphate synthase (cGAS), innate immune responses, and viral hepatitis.

Verrier ER, Gack MU, Baumert TF.

Hepatology. 2014 Sep;60(3):1098-100. doi: 10.1002/hep.27187. Epub 2014 Jun 20. No abstract available.

PMID:
24753097
34.

Prostaglandin E2: the villain in the host response to influenza virus.

Full F, Gack MU.

Immunity. 2014 Apr 17;40(4):453-4. doi: 10.1016/j.immuni.2014.03.008.

35.

Mechanisms of RIG-I-like receptor activation and manipulation by viral pathogens.

Gack MU.

J Virol. 2014 May;88(10):5213-6. doi: 10.1128/JVI.03370-13. Epub 2014 Mar 12. Review.

36.

The ubiquitin-specific protease USP15 promotes RIG-I-mediated antiviral signaling by deubiquitylating TRIM25.

Pauli EK, Chan YK, Davis ME, Gableske S, Wang MK, Feister KF, Gack MU.

Sci Signal. 2014 Jan 7;7(307):ra3. doi: 10.1126/scisignal.2004577.

37.

Crystal structure of the TRIM25 B30.2 (PRYSPRY) domain: a key component of antiviral signalling.

D'Cruz AA, Kershaw NJ, Chiang JJ, Wang MK, Nicola NA, Babon JJ, Gack MU, Nicholson SE.

Biochem J. 2013 Dec 1;456(2):231-40. doi: 10.1042/BJ20121425.

38.

Dephosphorylation of the RNA sensors RIG-I and MDA5 by the phosphatase PP1 is essential for innate immune signaling.

Wies E, Wang MK, Maharaj NP, Chen K, Zhou S, Finberg RW, Gack MU.

Immunity. 2013 Mar 21;38(3):437-49. doi: 10.1016/j.immuni.2012.11.018. Epub 2013 Mar 14.

39.

Species-specific inhibition of RIG-I ubiquitination and IFN induction by the influenza A virus NS1 protein.

Rajsbaum R, Albrecht RA, Wang MK, Maharaj NP, Versteeg GA, Nistal-Villán E, García-Sastre A, Gack MU.

PLoS Pathog. 2012;8(11):e1003059. doi: 10.1371/journal.ppat.1003059. Epub 2012 Nov 29.

40.

Conventional protein kinase C-α (PKC-α) and PKC-β negatively regulate RIG-I antiviral signal transduction.

Maharaj NP, Wies E, Stoll A, Gack MU.

J Virol. 2012 Feb;86(3):1358-71. doi: 10.1128/JVI.06543-11. Epub 2011 Nov 23.

41.

TRIMming Flavivirus infection.

Gack MU.

Cell Host Microbe. 2011 Sep 15;10(3):175-7. doi: 10.1016/j.chom.2011.08.012.

42.

Linear ubiquitin assembly complex negatively regulates RIG-I- and TRIM25-mediated type I interferon induction.

Inn KS, Gack MU, Tokunaga F, Shi M, Wong LY, Iwai K, Jung JU.

Mol Cell. 2011 Feb 4;41(3):354-65. doi: 10.1016/j.molcel.2010.12.029.

43.

Negative role of RIG-I serine 8 phosphorylation in the regulation of interferon-beta production.

Nistal-Villán E, Gack MU, Martínez-Delgado G, Maharaj NP, Inn KS, Yang H, Wang R, Aggarwal AK, Jung JU, García-Sastre A.

J Biol Chem. 2010 Jun 25;285(26):20252-61. doi: 10.1074/jbc.M109.089912. Epub 2010 Apr 20.

44.

Phosphorylation-mediated negative regulation of RIG-I antiviral activity.

Gack MU, Nistal-Villán E, Inn KS, García-Sastre A, Jung JU.

J Virol. 2010 Apr;84(7):3220-9. doi: 10.1128/JVI.02241-09. Epub 2010 Jan 13.

45.

Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I.

Gack MU, Albrecht RA, Urano T, Inn KS, Huang IC, Carnero E, Farzan M, Inoue S, Jung JU, García-Sastre A.

Cell Host Microbe. 2009 May 8;5(5):439-49. doi: 10.1016/j.chom.2009.04.006.

46.

Cytosolic viral sensor RIG-I is a 5'-triphosphate-dependent translocase on double-stranded RNA.

Myong S, Cui S, Cornish PV, Kirchhofer A, Gack MU, Jung JU, Hopfner KP, Ha T.

Science. 2009 Feb 20;323(5917):1070-4. doi: 10.1126/science.1168352. Epub 2009 Jan 1.

47.

Roles of RIG-I N-terminal tandem CARD and splice variant in TRIM25-mediated antiviral signal transduction.

Gack MU, Kirchhofer A, Shin YC, Inn KS, Liang C, Cui S, Myong S, Ha T, Hopfner KP, Jung JU.

Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16743-8. doi: 10.1073/pnas.0804947105. Epub 2008 Oct 23.

48.

Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking.

Liang C, Lee JS, Inn KS, Gack MU, Li Q, Roberts EA, Vergne I, Deretic V, Feng P, Akazawa C, Jung JU.

Nat Cell Biol. 2008 Jul;10(7):776-87. doi: 10.1038/ncb1740. Epub 2008 Jun 15.

49.
50.

TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity.

Gack MU, Shin YC, Joo CH, Urano T, Liang C, Sun L, Takeuchi O, Akira S, Chen Z, Inoue S, Jung JU.

Nature. 2007 Apr 19;446(7138):916-920.

PMID:
17392790

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