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Items: 14


Transgenic and Genome Editing Approaches for Modifying Plant Oils.

Wayne LL, Gachotte DJ, Walsh TA.

Methods Mol Biol. 2019;1864:367-394. doi: 10.1007/978-1-4939-8778-8_23. Review.


Canola engineered with a microalgal polyketide synthase-like system produces oil enriched in docosahexaenoic acid.

Walsh TA, Bevan SA, Gachotte DJ, Larsen CM, Moskal WA, Merlo PA, Sidorenko LV, Hampton RE, Stoltz V, Pareddy D, Anthony GI, Bhaskar PB, Marri PR, Clark LM, Chen W, Adu-Peasah PS, Wensing ST, Zirkle R, Metz JG.

Nat Biotechnol. 2016 Aug;34(8):881-7. doi: 10.1038/nbt.3585. Epub 2016 Jul 11.


Preliminary safety assessment of a membrane-bound delta 9 desaturase candidate protein for transgenic oilseed crops.

Madduri KM, Schafer BW, Hasler JM, Lin G, Foster ML, Embrey SK, Sastry-Dent L, Song P, Larrinua IM, Gachotte DJ, Herman RA.

Food Chem Toxicol. 2012 Oct;50(10):3776-84. doi: 10.1016/j.fct.2012.07.013. Epub 2012 Jul 17.


Transcriptional activation of Brassica napus β-ketoacyl-ACP synthase II with an engineered zinc finger protein transcription factor.

Gupta M, DeKelver RC, Palta A, Clifford C, Gopalan S, Miller JC, Novak S, Desloover D, Gachotte D, Connell J, Flook J, Patterson T, Robbins K, Rebar EJ, Gregory PD, Urnov FD, Petolino JF.

Plant Biotechnol J. 2012 Sep;10(7):783-91. doi: 10.1111/j.1467-7652.2012.00695.x. Epub 2012 Apr 23.


The protein kinase SnRK2.6 mediates the regulation of sucrose metabolism and plant growth in Arabidopsis.

Zheng Z, Xu X, Crosley RA, Greenwalt SA, Sun Y, Blakeslee B, Wang L, Ni W, Sopko MS, Yao C, Yau K, Burton S, Zhuang M, McCaskill DG, Gachotte D, Thompson M, Greene TW.

Plant Physiol. 2010 May;153(1):99-113. doi: 10.1104/pp.109.150789. Epub 2010 Mar 3.


A novel gene conserved from yeast to humans is involved in sterol biosynthesis.

Gachotte D, Eckstein J, Barbuch R, Hughes T, Roberts C, Bard M.

J Lipid Res. 2001 Jan;42(1):150-4.


Functional discovery via a compendium of expression profiles.

Hughes TR, Marton MJ, Jones AR, Roberts CJ, Stoughton R, Armour CD, Bennett HA, Coffey E, Dai H, He YD, Kidd MJ, King AM, Meyer MR, Slade D, Lum PY, Stepaniants SB, Shoemaker DD, Gachotte D, Chakraburtty K, Simon J, Bard M, Friend SH.

Cell. 2000 Jul 7;102(1):109-26.


Characterization of the Saccharomyces cerevisiae ERG27 gene encoding the 3-keto reductase involved in C-4 sterol demethylation.

Gachotte D, Sen SE, Eckstein J, Barbuch R, Krieger M, Ray BD, Bard M.

Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12655-60.


Delta7-sterol-C5-desaturase: molecular characterization and functional expression of wild-type and mutant alleles.

Husselstein T, Schaller H, Gachotte D, Benveniste P.

Plant Mol Biol. 1999 Mar;39(5):891-906.


Characterization of the Saccharomyces cerevisiae ERG26 gene encoding the C-3 sterol dehydrogenase (C-4 decarboxylase) involved in sterol biosynthesis.

Gachotte D, Barbuch R, Gaylor J, Nickel E, Bard M.

Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13794-9. Erratum in: Proc Natl Acad Sci U S A 1999 Feb 16;96(4):1810.


A yeast sterol auxotroph (erg25) is rescued by addition of azole antifungals and reduced levels of heme.

Gachotte D, Pierson CA, Lees ND, Barbuch R, Koegel C, Bard M.

Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11173-8.


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