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Functional properties of human platelets derived in vitro from CD34+ cells.

Do Sacramento V, Mallo L, Freund M, Eckly A, Hechler B, Mangin P, Lanza F, Gachet C, Strassel C.

Sci Rep. 2020 Jan 22;10(1):914. doi: 10.1038/s41598-020-57754-9.


Use of electron microscopy to study megakaryocytes.

Scandola C, Erhardt M, Rinckel JY, Proamer F, Gachet C, Eckly A.

Platelets. 2020 Jan 5:1-10. doi: 10.1080/09537104.2019.1708885. [Epub ahead of print]


Does a Useful Test Exist to Properly Evaluate the Pathogenicity of Donor-Specific Antibodies? Lessons from a Comprehensive Analysis in a Well-Studied Single-Center Kidney Transplant Cohort.

Gautier Vargas G, Olagne J, Parissiadis A, Joly M, Cognard N, Perrin P, Froelich N, Guntz P, Gachet C, Moulin B, Caillard S.

Transplantation. 2019 Dec 27. doi: 10.1097/TP.0000000000003080. [Epub ahead of print]


Shear rate gradients promote a bi-phasic thrombus formation on weak adhesive proteins, such as fibrinogen in a VWF-dependent manner.

Receveur N, Nechipurenko D, Knapp Y, Yakusheva A, Maurer E, Denis CV, Lanza F, Panteleev M, Gachet C, Mangin PH.

Haematologica. 2019 Nov 14. pii: haematol.2019.235754. doi: 10.3324/haematol.2019.235754. [Epub ahead of print]


Severe bleeding and absent ADP-induced platelet aggregation associated with inherited combined CalDAG-GEFI and P2Y12 deficiencies.

Lunghi B, Lecchi A, Santacroce R, Scavone M, Paniccia R, Artoni A, Gachet C, Castaman G, Margaglione M, Bernardi F, Cattaneo M.

Haematologica. 2019 Oct 24. pii: haematol.2019.232850. doi: 10.3324/haematol.2019.232850. [Epub ahead of print]


Platelet preparation for function testing in the laboratory and clinic: Historical and practical aspects.

Hechler B, Dupuis A, Mangin PH, Gachet C.

Res Pract Thromb Haemost. 2019 Jul 16;3(4):615-625. doi: 10.1002/rth2.12240. eCollection 2019 Oct.


Combined deficiency of RAB32 and RAB38 in the mouse mimics Hermansky-Pudlak syndrome and critically impairs thrombosis.

Aguilar A, Weber J, Boscher J, Freund M, Ziessel C, Eckly A, Magnenat S, Bourdon C, Hechler B, Mangin PH, Gachet C, Lanza F, Léon C.

Blood Adv. 2019 Aug 13;3(15):2368-2380. doi: 10.1182/bloodadvances.2019031286.


Cell surface expression of HLA I molecules as a marker of young platelets.

Angénieux C, Dupuis A, Gachet C, de la Salle H, Maître B.

J Thromb Haemost. 2019 Sep;17(9):1511-1521. doi: 10.1111/jth.14537. Epub 2019 Jun 27.


The ATP-gated P2X1 ion channel contributes to the severity of antibody-mediated Transfusion-Related Acute Lung Injury in mice.

El Mdawar MB, Maître B, Magnenat S, Gachet C, Hechler B, de la Salle H.

Sci Rep. 2019 Mar 26;9(1):5159. doi: 10.1038/s41598-019-41742-9.


Hypersensitivity transfusion reactions to platelet concentrate: a retrospective analysis of the French hemovigilance network.

Mertes PM, Tacquard C, Andreu G, Kientz D, Gross S, Malard L, Drouet C, Carlier M, Gachet C, Sandid I, Boudjedir K.

Transfusion. 2019 Mar 25. doi: 10.1111/trf.15275. [Epub ahead of print]


An essential role for α4A-tubulin in platelet biogenesis.

Strassel C, Magiera MM, Dupuis A, Batzenschlager M, Hovasse A, Pleines I, Guéguen P, Eckly A, Moog S, Mallo L, Kimmerlin Q, Chappaz S, Strub JM, Kathiresan N, de la Salle H, Van Dorsselaer A, Ferec C, Py JY, Gachet C, Schaeffer-Reiss C, Kile BT, Janke C, Lanza F.

Life Sci Alliance. 2019 Feb 13;2(1). pii: e201900309. doi: 10.26508/lsa.201900309. Print 2019 Feb.


Clot Contraction Drives the Translocation of Procoagulant Platelets to Thrombus Surface.

Nechipurenko DY, Receveur N, Yakimenko AO, Shepelyuk TO, Yakusheva AA, Kerimov RR, Obydennyy SI, Eckly A, Léon C, Gachet C, Grishchuk EL, Ataullakhanov FI, Mangin PH, Panteleev MA.

Arterioscler Thromb Vasc Biol. 2019 Jan;39(1):37-47. doi: 10.1161/ATVBAHA.118.311390.


The PI 3-kinase PI3KC2α regulates mouse platelet membrane structure and function independently of membrane lipid composition.

Selvadurai MV, Brazilek RJ, Moon MJ, Rinckel JY, Eckly A, Gachet C, Meikle PJ, Nandurkar HH, Nesbitt WS, Hamilton JR.

FEBS Lett. 2019 Jan;593(1):88-96. doi: 10.1002/1873-3468.13295. Epub 2018 Nov 24.


Microtubule plus-end tracking Adenopolyposis Coli negatively regulates proplatelet formation.

Strassel C, Moog S, Mallo L, Eckly A, Freund M, Gachet C, Lanza F.

Sci Rep. 2018 Oct 25;8(1):15808. doi: 10.1038/s41598-018-34118-y.


Neuroprotective effects of microglial P2Y1 receptors against ischemic neuronal injury.

Fukumoto Y, Tanaka KF, Parajuli B, Shibata K, Yoshioka H, Kanemaru K, Gachet C, Ikenaka K, Koizumi S, Kinouchi H.

J Cereb Blood Flow Metab. 2019 Nov;39(11):2144-2156. doi: 10.1177/0271678X18805317. Epub 2018 Oct 18.


Laboratory monitoring of P2Y12 inhibitors: communication from the SSC of the ISTH.

Frelinger AL 3rd, Gachet C, Mumford AD, Noris P, Mezzano D, Harrison P, Gresele P; Subcommittee on Platelet Physiology.

J Thromb Haemost. 2018 Nov;16(11):2341-2346. doi: 10.1111/jth.14282. Epub 2018 Oct 3. No abstract available.


On the Way to in vitro Platelet Production.

Strassel C, Gachet C, Lanza F.

Front Med (Lausanne). 2018 Aug 28;5:239. doi: 10.3389/fmed.2018.00239. eCollection 2018. Review.


High-Resolution 3D Imaging of Megakaryocytes Using Focused Ion Beam-Scanning Electron Microscopy.

Eckly A, Rinckel JY, Proamer F, Gachet C.

Methods Mol Biol. 2018;1812:217-231. doi: 10.1007/978-1-4939-8585-2_13.


Three-Dimensional Culture in a Methylcellulose-Based Hydrogel to Study the Impact of Stiffness on Megakaryocyte Differentiation.

Aguilar A, Boscher J, Pertuy F, Gachet C, Léon C.

Methods Mol Biol. 2018;1812:139-153. doi: 10.1007/978-1-4939-8585-2_9.


On the way to in vitro platelet production.

Strassel C, Gachet C, Lanza F.

Transfus Clin Biol. 2018 Sep;25(3):220-227. doi: 10.1016/j.tracli.2018.07.005. Epub 2018 Aug 25. Review.


In vitro quality of amotosalen-UVA pathogen-inactivated mini-pool plasma prepared from whole blood stored overnight.

Ravanat C, Dupuis A, Marpaux N, Naegelen C, Mourey G, Isola H, Laforêt M, Morel P, Gachet C.

Vox Sang. 2018 Oct;113(7):622-631. doi: 10.1111/vox.12697. Epub 2018 Aug 6.


Inherited platelet disorders : Management of the bleeding risk.

Dupuis A, Gachet C.

Transfus Clin Biol. 2018 Sep;25(3):228-235. doi: 10.1016/j.tracli.2018.07.003. Epub 2018 Aug 1. Review.


[Comparative study on platelet transfusion in Lorraine-Champagne and Alsace in 2015].

Humbrecht C, Somme S, Renaudier P, Gross S, Gachet C, Schlanger S.

Transfus Clin Biol. 2018 Sep;25(3):179-186. doi: 10.1016/j.tracli.2018.06.001. Epub 2018 Jul 31. French.


Platelets: A more than a centenary old Odyssey and more to come.

Garraud O, Gachet C.

Transfus Clin Biol. 2018 Sep;25(3):149-150. doi: 10.1016/j.tracli.2018.06.007. Epub 2018 Jul 23. No abstract available.


Platelet transfusion: Current challenges.

Humbrecht C, Kientz D, Gachet C.

Transfus Clin Biol. 2018 Sep;25(3):151-164. doi: 10.1016/j.tracli.2018.06.004. Epub 2018 Jul 20. Review.


[Adaptation of platelet concentrates delivery to HAS/ANSM requirements evolution in EFS Grand-Est].

Kientz D, Humbrecht C, Isola H, Gachet C.

Transfus Clin Biol. 2018 Sep;25(3):187-191. doi: 10.1016/j.tracli.2018.06.006. Epub 2018 Jul 17. Review. French.


Platelets expressing IgG receptor FcγRIIA/CD32A determine the severity of experimental anaphylaxis.

Beutier H, Hechler B, Godon O, Wang Y, Gillis CM, de Chaisemartin L, Gouel-Chéron A, Magnenat S, Macdonald LE, Murphy AJ; NASA study group, Chollet-Martin S, Longrois D, Gachet C, Bruhns P, Jönsson F.

Sci Immunol. 2018 Apr 13;3(22). pii: eaan5997. doi: 10.1126/sciimmunol.aan5997.


Imaging thrombosis with 99mTc-labeled RAM.1-antibody in vivo.

Ouadi A, Bekaert V, Receveur N, Thomas L, Lanza F, Marchand P, Gachet C, Mangin PH, Brasse D, Laquerriere P.

Nucl Med Biol. 2018 Jun;61:21-27. doi: 10.1016/j.nucmedbio.2018.03.003. Epub 2018 Mar 17.


Retinoic acid receptor-α regulates synthetic events in human platelets: comment.

de la Salle H, Angénieux C, Lanza F, Gachet C.

J Thromb Haemost. 2018 May;16(5):1013-1014. doi: 10.1111/jth.13992. Epub 2018 Apr 1. No abstract available.


Immobilized fibrinogen activates human platelets through glycoprotein VI.

Mangin PH, Onselaer MB, Receveur N, Le Lay N, Hardy AT, Wilson C, Sanchez X, Loyau S, Dupuis A, Babar AK, Miller JL, Philippou H, Hughes CE, Herr AB, Ariëns RA, Mezzano D, Jandrot-Perrus M, Gachet C, Watson SP.

Haematologica. 2018 May;103(5):898-907. doi: 10.3324/haematol.2017.182972. Epub 2018 Feb 22.


A unique microenvironment in the developing liver supports the expansion of megakaryocyte progenitors.

Brouard N, Jost C, Matthias N, Albrecht C, Egard S, Gandhi P, Strassel C, Inoue T, Sugiyama D, Simmons PJ, Gachet C, Lanza F.

Blood Adv. 2017 Sep 26;1(21):1854-1866. doi: 10.1182/bloodadvances.2016003541. eCollection 2017 Sep 26.


The role of extracellular matrix stiffness in megakaryocyte and platelet development and function.

Leiva O, Leon C, Kah Ng S, Mangin P, Gachet C, Ravid K.

Am J Hematol. 2018 Mar;93(3):430-441. doi: 10.1002/ajh.25008. Epub 2018 Jan 12. Review.


Migrating Platelets Are Mechano-scavengers that Collect and Bundle Bacteria.

Gaertner F, Ahmad Z, Rosenberger G, Fan S, Nicolai L, Busch B, Yavuz G, Luckner M, Ishikawa-Ankerhold H, Hennel R, Benechet A, Lorenz M, Chandraratne S, Schubert I, Helmer S, Striednig B, Stark K, Janko M, Böttcher RT, Verschoor A, Leon C, Gachet C, Gudermann T, Mederos Y Schnitzler M, Pincus Z, Iannacone M, Haas R, Wanner G, Lauber K, Sixt M, Massberg S.

Cell. 2017 Nov 30;171(6):1368-1382.e23. doi: 10.1016/j.cell.2017.11.001.


Amotosalen/UVA pathogen inactivation technology reduces platelet activability, induces apoptosis and accelerates clearance.

Hechler B, Ravanat C, Gachet C.

Haematologica. 2017 Dec;102(12):e502-e503. doi: 10.3324/haematol.2017.180539. No abstract available.


Platelet Integrins in Tumor Metastasis: Do They Represent a Therapeutic Target?

Lavergne M, Janus-Bell E, Schaff M, Gachet C, Mangin PH.

Cancers (Basel). 2017 Sep 28;9(10). pii: E133. doi: 10.3390/cancers9100133. Review.


The role of 5-HT2B receptors in mitral valvulopathy: bone marrow mobilization of endothelial progenitors.

Ayme-Dietrich E, Lawson R, Côté F, de Tapia C, Da Silva S, Ebel C, Hechler B, Gachet C, Guyonnet J, Rouillard H, Stoltz J, Quentin E, Banas S, Daubeuf F, Frossard N, Gasser B, Mazzucotelli JP, Hermine O, Maroteaux L, Monassier L.

Br J Pharmacol. 2017 Nov;174(22):4123-4139. doi: 10.1111/bph.13981. Epub 2017 Oct 15.


Transformation of Astrocytes to a Neuroprotective Phenotype by Microglia via P2Y1 Receptor Downregulation.

Shinozaki Y, Shibata K, Yoshida K, Shigetomi E, Gachet C, Ikenaka K, Tanaka KF, Koizumi S.

Cell Rep. 2017 May 9;19(6):1151-1164. doi: 10.1016/j.celrep.2017.04.047.


Delayed-onset of procoagulant signalling revealed by kinetic analysis of COAT platelet formation.

Alberio L, Ravanat C, Hechler B, Mangin PH, Lanza F, Gachet C.

Thromb Haemost. 2017 Jun 2;117(6):1101-1114. doi: 10.1160/TH16-09-0711. Epub 2017 Apr 6.


Macrothrombocytopenia and dense granule deficiency associated with FLI1 variants: ultrastructural and pathogenic features.

Saultier P, Vidal L, Canault M, Bernot D, Falaise C, Pouymayou C, Bordet JC, Saut N, Rostan A, Baccini V, Peiretti F, Favier M, Lucca P, Deleuze JF, Olaso R, Boland A, Morange PE, Gachet C, Malergue F, Fauré S, Eckly A, Trégouët DA, Poggi M, Alessi MC.

Haematologica. 2017 Jun;102(6):1006-1016. doi: 10.3324/haematol.2016.153577. Epub 2017 Mar 2.


Dual role of IL-21 in megakaryopoiesis and platelet homeostasis.

Benbarche S, Strassel C, Angénieux C, Mallo L, Freund M, Gachet C, Lanza F, de la Salle H.

Haematologica. 2017 Apr;102(4):637-646. doi: 10.3324/haematol.2016.143958. Epub 2017 Jan 5.


Bioreactivity of stent material: Activation of platelets, coagulation, leukocytes and endothelial cell dysfunction in vitro.

Ollivier V, Roques C, Receveur N, Gratz M, Feldman L, Letourneur D, Gachet C, Mangin PH, Jandrot-Perrus M.

Platelets. 2017 Sep;28(6):529-539. doi: 10.1080/09537104.2016.1252836. Epub 2016 Dec 29.


Platelet integrin α6β1 controls lung metastasis through direct binding to cancer cell-derived ADAM9.

Mammadova-Bach E, Zigrino P, Brucker C, Bourdon C, Freund M, De Arcangelis A, Abrams SI, Orend G, Gachet C, Mangin PH.

JCI Insight. 2016 Sep 8;1(14):e88245. doi: 10.1172/jci.insight.88245.


A novel platelet-type von Willebrand disease mutation (GP1BA p.Met255Ile) associated with type 2B "Malmö/New York" von Willebrand disease.

Lavenu-Bombled C, Guitton C, Dupuis A, Baas MJ, Desconclois C, Dreyfus M, Li R, Caron C, Gachet C, Fressinaud E, Lanza F.

Thromb Haemost. 2016 Nov 30;116(6):1070-1078. Epub 2016 Sep 29.


Pre-existing donor-specific antibodies are detrimental to kidney allograft only when persistent after transplantation.

Caillard S, Becmeur C, Gautier-Vargas G, Olagne J, Muller C, Cognard N, Perrin P, Braun L, Heibel F, Lefebre F, Renner V, Gachet C, Moulin B, Parissiadis A.

Transpl Int. 2017 Jan;30(1):29-40. doi: 10.1111/tri.12864. Epub 2016 Oct 17.


Respective contributions of single and compound granule fusion to secretion by activated platelets.

Eckly A, Rinckel JY, Proamer F, Ulas N, Joshi S, Whiteheart SW, Gachet C.

Blood. 2016 Nov 24;128(21):2538-2549. Epub 2016 Sep 13.


Importance of environmental stiffness for megakaryocyte differentiation and proplatelet formation.

Aguilar A, Pertuy F, Eckly A, Strassel C, Collin D, Gachet C, Lanza F, Léon C.

Blood. 2016 Oct 20;128(16):2022-2032. doi: 10.1182/blood-2016-02-699959. Epub 2016 Aug 8.


Inherited dysfunctional platelet P2Y12 receptor mutations associated with bleeding disorders.

Lecchi A, Femia EA, Paoletta S, Dupuis A, Ohlmann P, Gachet C, Jacobson KA, Machura K, Podda GM, Zieger B, Cattaneo M.

Hamostaseologie. 2016 Nov 7;36(4):279-283. Epub 2016 Aug 4. Review.


The contribution of mouse models to the understanding of constitutional thrombocytopenia.

Léon C, Dupuis A, Gachet C, Lanza F.

Haematologica. 2016 Aug;101(8):896-908. doi: 10.3324/haematol.2015.139394. Review.


Coagulation factors bound to procoagulant platelets concentrate in cap structures to promote clotting.

Podoplelova NA, Sveshnikova AN, Kotova YN, Eckly A, Receveur N, Nechipurenko DY, Obydennyi SI, Kireev II, Gachet C, Ataullakhanov FI, Mangin PH, Panteleev MA.

Blood. 2016 Sep 29;128(13):1745-55. doi: 10.1182/blood-2016-02-696898. Epub 2016 Jul 18.


Hemostatic properties and protein expression profile of therapeutic apheresis plasma treated with amotosalen and ultraviolet A for pathogen inactivation.

Ohlmann P, Hechler B, Chafey P, Ravanat C, Isola H, Wiesel ML, Cazenave JP, Gachet C.

Transfusion. 2016 Sep;56(9):2239-47. doi: 10.1111/trf.13670. Epub 2016 Jun 1.


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