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Items: 36

1.

Targeting the NRG1/HER3 pathway in tumor cells and cancer-associated fibroblasts with an anti-neuregulin 1 antibody inhibits tumor growth in pre-clinical models of pancreatic cancer.

Ogier C, Colombo PE, Bousquet C, Canterel-Thouennon L, Sicard P, Garambois V, Thomas G, Gaborit N, Jarlier M, Pirot N, Pugnière M, Vie N, Gongora C, Martineau P, Robert B, Pèlegrin A, Chardès T, Larbouret C.

Cancer Lett. 2018 Sep 28;432:227-236. doi: 10.1016/j.canlet.2018.06.023. Epub 2018 Jun 20.

PMID:
29935372
2.

Mental stress test: a rapid, simple, and efficient test to unmask long QT syndrome.

Etienne P, Huchet F, Gaborit N, Barc J, Thollet A, Kyndt F, Guyomarch B, Le Marec H, Charpentier F, Schott JJ, Redon R, Probst V, Gourraud JB.

Europace. 2018 Apr 20. doi: 10.1093/europace/euy078. [Epub ahead of print]

PMID:
29688407
3.

An oligoclonal antibody durably overcomes resistance of lung cancer to third-generation EGFR inhibitors.

Mancini M, Gal H, Gaborit N, Mazzeo L, Romaniello D, Salame TM, Lindzen M, Mahlknecht G, Enuka Y, Burton DG, Roth L, Noronha A, Marrocco I, Adreka D, Altstadter RE, Bousquet E, Downward J, Maraver A, Krizhanovsky V, Yarden Y.

EMBO Mol Med. 2018 Feb;10(2):294-308. doi: 10.15252/emmm.201708076.

4.

CRISPR-assisted receptor deletion reveals distinct roles for ERBB2 and ERBB3 in skin keratinocytes.

Dahlhoff M, Gaborit N, Bultmann S, Leonhardt H, Yarden Y, Schneider MR.

FEBS J. 2017 Oct;284(19):3339-3349. doi: 10.1111/febs.14196. Epub 2017 Sep 14.

PMID:
28805349
5.

The β4 subunit of the voltage-gated calcium channel (Cacnb4) regulates the rate of cell proliferation in Chinese Hamster Ovary cells.

Rima M, Daghsni M, De Waard S, Gaborit N, Fajloun Z, Ronjat M, Mori Y, Brusés JL, De Waard M.

Int J Biochem Cell Biol. 2017 Aug;89:57-70. doi: 10.1016/j.biocel.2017.05.032. Epub 2017 Jun 3.

PMID:
28587927
6.

HIV-Tat induces a decrease in IKr and IKsvia reduction in phosphatidylinositol-(4,5)-bisphosphate availability.

Es-Salah-Lamoureux Z, Jouni M, Malak OA, Belbachir N, Al Sayed ZR, Gandon-Renard M, Lamirault G, Gauthier C, Baró I, Charpentier F, Zibara K, Lemarchand P, Beaumelle B, Gaborit N, Loussouarn G.

J Mol Cell Cardiol. 2016 Oct;99:1-13. doi: 10.1016/j.yjmcc.2016.08.022. Epub 2016 Aug 31.

7.

Loss of Iroquois homeobox transcription factors 3 and 5 in osteoblasts disrupts cranial mineralization.

Cain CJ, Gaborit N, Lwin W, Barruet E, Ho S, Bonnard C, Hamamy H, Shboul M, Reversade B, Kayserili H, Bruneau BG, Hsiao EC.

Bone Rep. 2016 Apr 13;5:86-95. doi: 10.1016/j.bonr.2016.02.005. eCollection 2016 Dec.

8.

Emerging anti-cancer antibodies and combination therapies targeting HER3/ERBB3.

Gaborit N, Lindzen M, Yarden Y.

Hum Vaccin Immunother. 2016 Mar 3;12(3):576-92. doi: 10.1080/21645515.2015.1102809. Epub 2015 Nov 3. Review.

9.

Toward Personalized Medicine: Using Cardiomyocytes Differentiated From Urine-Derived Pluripotent Stem Cells to Recapitulate Electrophysiological Characteristics of Type 2 Long QT Syndrome.

Jouni M, Si-Tayeb K, Es-Salah-Lamoureux Z, Latypova X, Champon B, Caillaud A, Rungoat A, Charpentier F, Loussouarn G, Baró I, Zibara K, Lemarchand P, Gaborit N.

J Am Heart Assoc. 2015 Sep 1;4(9):e002159. doi: 10.1161/JAHA.115.002159.

10.

ErbB3-ErbB2 Complexes as a Therapeutic Target in a Subset of Wild-type BRAF/NRAS Cutaneous Melanomas.

Capparelli C, Rosenbaum S, Berman-Booty LD, Salhi A, Gaborit N, Zhan T, Chervoneva I, Roszik J, Woodman SE, Davies MA, Setiady YY, Osman I, Yarden Y, Aplin AE.

Cancer Res. 2015 Sep 1;75(17):3554-67. doi: 10.1158/0008-5472.CAN-14-2959. Epub 2015 Jul 23.

11.

[The HER3/ERBB3 receptor: the dark side of the ERBB planet].

Larbouret C, Gaborit N, Poul MA, Pèlegrin A, Chardès T.

Med Sci (Paris). 2015 May;31(5):465-8. doi: 10.1051/medsci/20153105002. Epub 2015 Jun 9. French. No abstract available.

12.

Combining three antibodies nullifies feedback-mediated resistance to erlotinib in lung cancer.

Mancini M, Gaborit N, Lindzen M, Salame TM, Dall'Ora M, Sevilla-Sharon M, Abdul-Hai A, Downward J, Yarden Y.

Sci Signal. 2015 Jun 2;8(379):ra53. doi: 10.1126/scisignal.aaa0725.

PMID:
26038598
13.

Examination of HER3 targeting in cancer using monoclonal antibodies.

Gaborit N, Abdul-Hai A, Mancini M, Lindzen M, Lavi S, Leitner O, Mounier L, Chentouf M, Dunoyer S, Ghosh M, Larbouret C, Chardès T, Bazin H, Pèlegrin A, Sela M, Yarden Y.

Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):839-44. doi: 10.1073/pnas.1423645112. Epub 2015 Jan 6.

14.

HER3 as biomarker and therapeutic target in pancreatic cancer: new insights in pertuzumab therapy in preclinical models.

Thomas G, Chardès T, Gaborit N, Mollevi C, Leconet W, Robert B, Radosevic-Robin N, Penault-Llorca F, Gongora C, Colombo PE, Lazrek Y, Bras-Goncalves R, Savina A, Azria D, Bazin H, Pèlegrin A, Larbouret C.

Oncotarget. 2014 Aug 30;5(16):7138-48.

15.

Regional ion channel gene expression heterogeneity and ventricular fibrillation dynamics in human hearts.

Sivagangabalan G, Nazzari H, Bignolais O, Maguy A, Naud P, Farid T, Massé S, Gaborit N, Varro A, Nair K, Backx P, Vigmond E, Nattel S, Demolombe S, Nanthakumar K.

PLoS One. 2014 Jan 10;9(1):e82179. doi: 10.1371/journal.pone.0082179. eCollection 2014.

16.

Anti-HER3 domain 1 and 3 antibodies reduce tumor growth by hindering HER2/HER3 dimerization and AKT-induced MDM2, XIAP, and FoxO1 phosphorylation.

Lazrek Y, Dubreuil O, Garambois V, Gaborit N, Larbouret C, Le Clorennec C, Thomas G, Leconet W, Jarlier M, Pugnière M, Vié N, Robert B, Monnet C, Bouayadi K, Kharrat H, Mondon P, Pèlegrin A, Chardès T.

Neoplasia. 2013 Mar;15(3):335-47.

17.

Inhibition of triple-negative breast cancer models by combinations of antibodies to EGFR.

Ferraro DA, Gaborit N, Maron R, Cohen-Dvashi H, Porat Z, Pareja F, Lavi S, Lindzen M, Ben-Chetrit N, Sela M, Yarden Y.

Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1815-20. doi: 10.1073/pnas.1220763110. Epub 2013 Jan 14.

18.

Cooperative and antagonistic roles for Irx3 and Irx5 in cardiac morphogenesis and postnatal physiology.

Gaborit N, Sakuma R, Wylie JN, Kim KH, Zhang SS, Hui CC, Bruneau BG.

Development. 2012 Nov;139(21):4007-19. doi: 10.1242/dev.081703. Epub 2012 Sep 19.

19.

Quantification of HER expression and dimerization in patients' tumor samples using time-resolved Förster resonance energy transfer.

Ho-Pun-Cheung A, Bazin H, Gaborit N, Larbouret C, Garnero P, Assenat E, Castan F, Bascoul-Mollevi C, Ramos J, Ychou M, Pèlegrin A, Mathis G, Lopez-Crapez E.

PLoS One. 2012;7(7):e37065. doi: 10.1371/journal.pone.0037065. Epub 2012 Jul 19.

20.
21.

Iroquois homeobox gene 3 establishes fast conduction in the cardiac His-Purkinje network.

Zhang SS, Kim KH, Rosen A, Smyth JW, Sakuma R, Delgado-Olguín P, Davis M, Chi NC, Puviindran V, Gaborit N, Sukonnik T, Wylie JN, Brand-Arzamendi K, Farman GP, Kim J, Rose RA, Marsden PA, Zhu Y, Zhou YQ, Miquerol L, Henkelman RM, Stainier DY, Shaw RM, Hui CC, Bruneau BG, Backx PH.

Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13576-81. doi: 10.1073/pnas.1106911108. Epub 2011 Aug 8.

22.

Time-resolved fluorescence resonance energy transfer (TR-FRET) to analyze the disruption of EGFR/HER2 dimers: a new method to evaluate the efficiency of targeted therapy using monoclonal antibodies.

Gaborit N, Larbouret C, Vallaghe J, Peyrusson F, Bascoul-Mollevi C, Crapez E, Azria D, Chardès T, Poul MA, Mathis G, Bazin H, Pèlegrin A.

J Biol Chem. 2011 Apr 1;286(13):11337-45. doi: 10.1074/jbc.M111.223503. Epub 2011 Jan 31.

23.

Gender-related differences in ion-channel and transporter subunit expression in non-diseased human hearts.

Gaborit N, Varro A, Le Bouter S, Szuts V, Escande D, Nattel S, Demolombe S.

J Mol Cell Cardiol. 2010 Oct;49(4):639-46. doi: 10.1016/j.yjmcc.2010.06.005. Epub 2010 Jun 21.

PMID:
20600101
24.

Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated alpha-synuclein gene mutations precede central nervous system changes.

Kuo YM, Li Z, Jiao Y, Gaborit N, Pani AK, Orrison BM, Bruneau BG, Giasson BI, Smeyne RJ, Gershon MD, Nussbaum RL.

Hum Mol Genet. 2010 May 1;19(9):1633-50. doi: 10.1093/hmg/ddq038. Epub 2010 Jan 27.

25.

Ion-channel mRNA-expression profiling: Insights into cardiac remodeling and arrhythmic substrates.

Nattel S, Frelin Y, Gaborit N, Louault C, Demolombe S.

J Mol Cell Cardiol. 2010 Jan;48(1):96-105. doi: 10.1016/j.yjmcc.2009.07.016. Epub 2009 Jul 23. Review. Erratum in: J Mol Cell Cardiol. 2010 Jun;48(6):1335-9.

PMID:
19631654
26.

Local induction of heat shock protein 70 (Hsp70) by proteasome inhibition confers chondroprotection during surgically induced osteoarthritis in the rat knee.

Etienne S, Gaborit N, Henrionnet C, Pinzano A, Galois L, Netter P, Gillet P, Grossin L.

Biomed Mater Eng. 2008;18(4-5):253-60.

PMID:
19065031
27.

Transcriptional profiling of ion channel genes in Brugada syndrome and other right ventricular arrhythmogenic diseases.

Gaborit N, Wichter T, Varro A, Szuts V, Lamirault G, Eckardt L, Paul M, Breithardt G, Schulze-Bahr E, Escande D, Nattel S, Demolombe S.

Eur Heart J. 2009 Feb;30(4):487-96. doi: 10.1093/eurheartj/ehn520. Epub 2008 Nov 23.

PMID:
19029124
28.

Regional and tissue specific transcript signatures of ion channel genes in the non-diseased human heart.

Gaborit N, Le Bouter S, Szuts V, Varro A, Escande D, Nattel S, Demolombe S.

J Physiol. 2007 Jul 15;582(Pt 2):675-93. Epub 2007 May 3.

29.

Increased apoptosis in rat osteoarthritic cartilage corresponds to degenerative chondral lesions and concomitant expression of caspase-3.

Watrin-Pinzano A, Etienne S, Grossin L, Gaborit N, Cournil-Henrionnet C, Mainard D, Netter P, Gillet P, Galois L.

Biorheology. 2006;43(3,4):403-12. No abstract available.

PMID:
16912413
30.

Gene transfer with HSP 70 in rat chondrocytes confers cytoprotection in vitro and during experimental osteoarthritis.

Grossin L, Cournil-Henrionnet C, Pinzano A, Gaborit N, Dumas D, Etienne S, Stoltz JF, Terlain B, Netter P, Mir LM, Gillet P.

FASEB J. 2006 Jan;20(1):65-75.

PMID:
16394269
31.

Gene expression profile associated with chronic atrial fibrillation and underlying valvular heart disease in man.

Lamirault G, Gaborit N, Le Meur N, Chevalier C, Lande G, Demolombe S, Escande D, Nattel S, Léger JJ, Steenman M.

J Mol Cell Cardiol. 2006 Jan;40(1):173-84. Epub 2005 Oct 19.

PMID:
16242148
32.

Human atrial ion channel and transporter subunit gene-expression remodeling associated with valvular heart disease and atrial fibrillation.

Gaborit N, Steenman M, Lamirault G, Le Meur N, Le Bouter S, Lande G, Léger J, Charpentier F, Christ T, Dobrev D, Escande D, Nattel S, Demolombe S.

Circulation. 2005 Jul 26;112(4):471-81. Epub 2005 Jul 18.

33.

Microcomputed tomography used in the analysis of the morphology of root canals in extracted wisdom teeth.

Guillaume B, Lacoste JP, Gaborit N, Brossard G, Cruard A, Baslé MF, Chappard D.

Br J Oral Maxillofac Surg. 2006 Jun;44(3):240-4. Epub 2005 Jul 1.

PMID:
15993991
34.

Induction of heat shock protein 70 (Hsp70) by proteasome inhibitor MG 132 protects articular chondrocytes from cellular death in vitro and in vivo.

Grossin L, Etienne S, Gaborit N, Pinzano A, Cournil-Henrionnet C, Gerard C, Payan E, Netter P, Terlain B, Gillet P.

Biorheology. 2004;41(3-4):521-34.

PMID:
15299283
35.

Spectral and lifetime fluorescence imaging microscopies: new modalities of multiphoton microscopy applied to tissue or cell engineering.

Dumas D, Gaborit N, Grossin L, Riquelme B, Gigant-Huselstein C, De Isla N, Gillet P, Netter P, Stoltz JF.

Biorheology. 2004;41(3-4):459-67.

PMID:
15299277
36.

Gene therapy in cartilage using electroporation.

Grossin L, Gaborit N, Mir L, Netter P, Gillet P.

Joint Bone Spine. 2003 Dec;70(6):480-2. No abstract available.

PMID:
14667558

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