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Recognition protein C1q of innate immunity agglutinates nanodiamonds without activating complement.

Belime A, Thielens NM, Gravel E, Frachet P, Ancelet S, Tacnet P, Caneiro C, Chuprin J, Gaboriaud C, Schoehn G, Doris E, Ling WL.

Nanomedicine. 2018 Oct 24. pii: S1549-9634(18)30528-8. doi: 10.1016/j.nano.2018.09.009. [Epub ahead of print]


C1q and Mannose-Binding Lectin Interact with CR1 in the Same Region on CCP24-25 Modules.

Jacquet M, Cioci G, Fouet G, Bally I, Thielens NM, Gaboriaud C, Rossi V.

Front Immunol. 2018 Mar 7;9:453. doi: 10.3389/fimmu.2018.00453. eCollection 2018.


Structure of the C1 complex of complement.

Arlaud GJ, Gaboriaud C, Ling WL, Thielens NM.

Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):E5766-E5767. doi: 10.1073/pnas.1703977114. Epub 2017 Jul 12. No abstract available.


C1q: A fresh look upon an old molecule.

Thielens NM, Tedesco F, Bohlson SS, Gaboriaud C, Tenner AJ.

Mol Immunol. 2017 Sep;89:73-83. doi: 10.1016/j.molimm.2017.05.025. Epub 2017 Jun 7. Review.


Human Immune Protein C1q Selectively Disaggregates Carbon Nanotubes.

Saint-Cricq M, Carrete J, Gaboriaud C, Gravel E, Doris E, Thielens N, Mingo N, Ling WL.

Nano Lett. 2017 Jun 14;17(6):3409-3415. doi: 10.1021/acs.nanolett.7b00189. Epub 2017 May 30.


Deciphering Key Residues Involved in the Virulence-promoting Interactions between Streptococcus pneumoniae and Human Plasminogen.

Moreau C, Terrasse R, Thielens NM, Vernet T, Gaboriaud C, Di Guilmi AM.

J Biol Chem. 2017 Feb 10;292(6):2217-2225. doi: 10.1074/jbc.M116.764209. Epub 2016 Dec 23.


Structures of parasite calreticulins provide insights into their flexibility and dual carbohydrate/peptide-binding properties.

Moreau C, Cioci G, Iannello M, Laffly E, Chouquet A, Ferreira A, Thielens NM, Gaboriaud C.

IUCrJ. 2016 Sep 14;3(Pt 6):408-419. eCollection 2016 Nov 1.


Editorial: State-of-the-Art Research on C1q and the Classical Complement Pathway.

Kishore U, Thielens NM, Gaboriaud C.

Front Immunol. 2016 Oct 4;7:398. eCollection 2016. No abstract available.


Periodontal Ehlers-Danlos Syndrome Is Caused by Mutations in C1R and C1S, which Encode Subcomponents C1r and C1s of Complement.

Kapferer-Seebacher I, Pepin M, Werner R, Aitman TJ, Nordgren A, Stoiber H, Thielens N, Gaboriaud C, Amberger A, Schossig A, Gruber R, Giunta C, Bamshad M, Björck E, Chen C, Chitayat D, Dorschner M, Schmitt-Egenolf M, Hale CJ, Hanna D, Hennies HC, Heiss-Kisielewsky I, Lindstrand A, Lundberg P, Mitchell AL, Nickerson DA, Reinstein E, Rohrbach M, Romani N, Schmuth M, Silver R, Taylan F, Vandersteen A, Vandrovcova J, Weerakkody R, Yang M, Pope FM; Molecular Basis of Periodontal EDS Consortium, Byers PH, Zschocke J.

Am J Hum Genet. 2016 Nov 3;99(5):1005-1014. doi: 10.1016/j.ajhg.2016.08.019. Epub 2016 Oct 13.


Structural and Functional Characterization of a Single-Chain Form of the Recognition Domain of Complement Protein C1q.

Moreau C, Bally I, Chouquet A, Bottazzi B, Ghebrehiwet B, Gaboriaud C, Thielens N.

Front Immunol. 2016 Mar 2;7:79. doi: 10.3389/fimmu.2016.00079. eCollection 2016.


Next-generation monitoring of aquatic biodiversity using environmental DNA metabarcoding.

Valentini A, Taberlet P, Miaud C, Civade R, Herder J, Thomsen PF, Bellemain E, Besnard A, Coissac E, Boyer F, Gaboriaud C, Jean P, Poulet N, Roset N, Copp GH, Geniez P, Pont D, Argillier C, Baudoin JM, Peroux T, Crivelli AJ, Olivier A, Acqueberge M, Le Brun M, Møller PR, Willerslev E, Dejean T.

Mol Ecol. 2016 Feb;25(4):929-42. doi: 10.1111/mec.13428. Epub 2016 Jan 18.


Human ficolin-2 recognition versatility extended: an update on the binding of ficolin-2 to sulfated/phosphated carbohydrates.

Laffly E, Lacroix M, Martin L, Vassal-Stermann E, Thielens NM, Gaboriaud C.

FEBS Lett. 2014 Dec 20;588(24):4694-700. doi: 10.1016/j.febslet.2014.10.042. Epub 2014 Nov 11.


Deciphering the fine details of c1 assembly and activation mechanisms: "mission impossible"?

Gaboriaud C, Ling WL, Thielens NM, Bally I, Rossi V.

Front Immunol. 2014 Nov 6;5:565. doi: 10.3389/fimmu.2014.00565. eCollection 2014. Review.


Human L-ficolin recognizes phosphocholine moieties of pneumococcal teichoic acid.

Vassal-Stermann E, Lacroix M, Gout E, Laffly E, Pedersen CM, Martin L, Amoroso A, Schmidt RR, Zähringer U, Gaboriaud C, Di Guilmi AM, Thielens NM.

J Immunol. 2014 Dec 1;193(11):5699-708. doi: 10.4049/jimmunol.1400127. Epub 2014 Oct 24.


Trypanosoma cruzi calreticulin inhibits the complement lectin pathway activation by direct interaction with L-Ficolin.

Sosoniuk E, Vallejos G, Kenawy H, Gaboriaud C, Thielens N, Fujita T, Schwaeble W, Ferreira A, Valck C.

Mol Immunol. 2014 Jul;60(1):80-5. doi: 10.1016/j.molimm.2014.03.014. Epub 2014 Apr 24.


Long-distance dispersal maximizes evolutionary potential during rapid geographic range expansion.

Berthouly-Salazar C, Hui C, Blackburn TM, Gaboriaud C, van Rensburg BJ, van Vuuren BJ, Le Roux JJ.

Mol Ecol. 2013 Dec;22(23):5793-804. doi: 10.1111/mec.12538. Epub 2013 Nov 6.


The serine protease domain of MASP-3: enzymatic properties and crystal structure in complex with ecotin.

Gaboriaud C, Gupta RK, Martin L, Lacroix M, Serre L, Teillet F, Arlaud GJ, Rossi V, Thielens NM.

PLoS One. 2013 Jul 4;8(7):e67962. doi: 10.1371/journal.pone.0067962. Print 2013.


Deciphering complement receptor type 1 interactions with recognition proteins of the lectin complement pathway.

Jacquet M, Lacroix M, Ancelet S, Gout E, Gaboriaud C, Thielens NM, Rossi V.

J Immunol. 2013 Apr 1;190(7):3721-31. doi: 10.4049/jimmunol.1202451. Epub 2013 Mar 4.


Structure and properties of the Ca(2+)-binding CUB domain, a widespread ligand-recognition unit involved in major biological functions.

Gaboriaud C, Gregory-Pauron L, Teillet F, Thielens NM, Bally I, Arlaud GJ.

Biochem J. 2011 Oct 15;439(2):185-93. doi: 10.1042/BJ20111027. Review.


X-ray structure of the human calreticulin globular domain reveals a peptide-binding area and suggests a multi-molecular mechanism.

Chouquet A, Païdassi H, Ling WL, Frachet P, Houen G, Arlaud GJ, Gaboriaud C.

PLoS One. 2011 Mar 15;6(3):e17886. doi: 10.1371/journal.pone.0017886.


Investigations on the C1q-calreticulin-phosphatidylserine interactions yield new insights into apoptotic cell recognition.

Païdassi H, Tacnet-Delorme P, Verneret M, Gaboriaud C, Houen G, Duus K, Ling WL, Arlaud GJ, Frachet P.

J Mol Biol. 2011 Apr 29;408(2):277-90. doi: 10.1016/j.jmb.2011.02.029. Epub 2011 Feb 23.


The human c1q globular domain: structure and recognition of non-immune self ligands.

Gaboriaud C, Frachet P, Thielens NM, Arlaud GJ.

Front Immunol. 2012 Jan 6;2:92. doi: 10.3389/fimmu.2011.00092. eCollection 2011.


Structural and functional characterization of the recombinant human mitochondrial trifunctional protein.

Fould B, Garlatti V, Neumann E, Fenel D, Gaboriaud C, Arlaud GJ.

Biochemistry. 2010 Oct 5;49(39):8608-17. doi: 10.1021/bi100742w. Epub 2010 Sep 8.


Mapping surface accessibility of the C1r/C1s tetramer by chemical modification and mass spectrometry provides new insights into assembly of the human C1 complex.

Brier S, Pflieger D, Le Mignon M, Bally I, Gaboriaud C, Arlaud GJ, Daniel R.

J Biol Chem. 2010 Oct 15;285(42):32251-63. doi: 10.1074/jbc.M110.149112. Epub 2010 Jun 30.


Cutting edge: C1q binds deoxyribose and heparan sulfate through neighboring sites of its recognition domain.

Garlatti V, Chouquet A, Lunardi T, Vivès R, Païdassi H, Lortat-Jacob H, Thielens NM, Arlaud GJ, Gaboriaud C.

J Immunol. 2010 Jul 15;185(2):808-12. doi: 10.4049/jimmunol.1000184. Epub 2010 Jun 14.


Structural insights into the recognition properties of human ficolins.

Garlatti V, Martin L, Lacroix M, Gout E, Arlaud GJ, Thielens NM, Gaboriaud C.

J Innate Immun. 2010;2(1):17-23. doi: 10.1159/000233475. Epub 2009 Aug 6. Review.


Carbohydrate recognition properties of human ficolins: glycan array screening reveals the sialic acid binding specificity of M-ficolin.

Gout E, Garlatti V, Smith DF, Lacroix M, Dumestre-Pérard C, Lunardi T, Martin L, Cesbron JY, Arlaud GJ, Gaboriaud C, Thielens NM.

J Biol Chem. 2010 Feb 26;285(9):6612-22. doi: 10.1074/jbc.M109.065854. Epub 2009 Dec 23.


Identification of the C1q-binding Sites of Human C1r and C1s: a refined three-dimensional model of the C1 complex of complement.

Bally I, Rossi V, Lunardi T, Thielens NM, Gaboriaud C, Arlaud GJ.

J Biol Chem. 2009 Jul 17;284(29):19340-8. doi: 10.1074/jbc.M109.004473. Epub 2009 May 27.


Crystal structure of the CUB1-EGF-CUB2 domain of human MASP-1/3 and identification of its interaction sites with mannan-binding lectin and ficolins.

Teillet F, Gaboriaud C, Lacroix M, Martin L, Arlaud GJ, Thielens NM.

J Biol Chem. 2008 Sep 12;283(37):25715-24. doi: 10.1074/jbc.M803551200. Epub 2008 Jul 2.


C1q binds phosphatidylserine and likely acts as a multiligand-bridging molecule in apoptotic cell recognition.

Païdassi H, Tacnet-Delorme P, Garlatti V, Darnault C, Ghebrehiwet B, Gaboriaud C, Arlaud GJ, Frachet P.

J Immunol. 2008 Feb 15;180(4):2329-38.


Structural basis for innate immune sensing by M-ficolin and its control by a pH-dependent conformational switch.

Garlatti V, Martin L, Gout E, Reiser JB, Fujita T, Arlaud GJ, Thielens NM, Gaboriaud C.

J Biol Chem. 2007 Dec 7;282(49):35814-20. Epub 2007 Sep 26.


Deciphering complement mechanisms: the contributions of structural biology.

Arlaud GJ, Barlow PN, Gaboriaud C, Gros P, Narayana SV.

Mol Immunol. 2007 Sep;44(16):3809-22. Review.


Assembly of C1 and the MBL- and ficolin-MASP complexes: structural insights.

Gaboriaud C, Teillet F, Gregory LA, Thielens NM, Arlaud GJ.

Immunobiology. 2007;212(4-5):279-88. Epub 2006 Dec 20. Review.


Structural insights into the innate immune recognition specificities of L- and H-ficolins.

Garlatti V, Belloy N, Martin L, Lacroix M, Matsushita M, Endo Y, Fujita T, Fontecilla-Camps JC, Arlaud GJ, Thielens NM, Gaboriaud C.

EMBO J. 2007 Jan 24;26(2):623-33. Epub 2007 Jan 11.


Functional role of the linker between the complement control protein modules of complement protease C1s.

Bally I, Rossi V, Thielens NM, Gaboriaud C, Arlaud GJ.

J Immunol. 2005 Oct 1;175(7):4536-42.


C1q and tumor necrosis factor superfamily: modularity and versatility.

Kishore U, Gaboriaud C, Waters P, Shrive AK, Greenhough TJ, Reid KB, Sim RB, Arlaud GJ.

Trends Immunol. 2004 Oct;25(10):551-61. Review.


Structure and activation of the C1 complex of complement: unraveling the puzzle.

Gaboriaud C, Thielens NM, Gregory LA, Rossi V, Fontecilla-Camps JC, Arlaud GJ.

Trends Immunol. 2004 Jul;25(7):368-73. Review. No abstract available.


The X-ray structure of human mannan-binding lectin-associated protein 19 (MAp19) and its interaction site with mannan-binding lectin and L-ficolin.

Gregory LA, Thielens NM, Matsushita M, Sorensen R, Arlaud GJ, Fontecilla-Camps JC, Gaboriaud C.

J Biol Chem. 2004 Jul 9;279(28):29391-7. Epub 2004 Apr 26.


The crystal structure of the globular head of complement protein C1q provides a basis for its versatile recognition properties.

Gaboriaud C, Juanhuix J, Gruez A, Lacroix M, Darnault C, Pignol D, Verger D, Fontecilla-Camps JC, Arlaud GJ.

J Biol Chem. 2003 Nov 21;278(47):46974-82. Epub 2003 Sep 5.


X-ray structure of the Ca2+-binding interaction domain of C1s. Insights into the assembly of the C1 complex of complement.

Gregory LA, Thielens NM, Arlaud GJ, Fontecilla-Camps JC, Gaboriaud C.

J Biol Chem. 2003 Aug 22;278(34):32157-64. Epub 2003 Jun 4.


Structural biology of C1.

Arlaud GJ, Gaboriaud C, Thielens NM, Rossi V.

Biochem Soc Trans. 2002 Nov;30(Pt 6):1001-6. Review.


Monomeric structures of the zymogen and active catalytic domain of complement protease c1r: further insights into the c1 activation mechanism.

Budayova-Spano M, Grabarse W, Thielens NM, Hillen H, Lacroix M, Schmidt M, Fontecilla-Camps JC, Arlaud GJ, Gaboriaud C.

Structure. 2002 Nov;10(11):1509-19.


Structural biology of the C1 complex of complement unveils the mechanisms of its activation and proteolytic activity.

Arlaud GJ, Gaboriaud C, Thielens NM, Budayova-Spano M, Rossi V, Fontecilla-Camps JC.

Mol Immunol. 2002 Nov;39(7-8):383-94. Review.


Structure, function and molecular genetics of human and murine C1r.

Arlaud GJ, Gaboriaud C, Garnier G, Circolo A, Thielens NM, Budayova-Spano M, Fontecilla-Camps JC, Volanakis JE.

Immunobiology. 2002 Sep;205(4-5):365-82. Review.


Structural biology of C1: dissection of a complex molecular machinery.

Arlaud GJ, Gaboriaud C, Thielens NM, Rossi V, Bersch B, Hernandez JF, Fontecilla-Camps JC.

Immunol Rev. 2001 Apr;180:136-45. Review.


Crystal structure of the catalytic domain of human complement c1s: a serine protease with a handle.

Gaboriaud C, Rossi V, Bally I, Arlaud GJ, Fontecilla-Camps JC.

EMBO J. 2000 Apr 17;19(8):1755-65.


Structural and functional studies on C1r and C1s: new insights into the mechanisms involved in C1 activity and assembly.

Arlaud GJ, Rossi V, Thielens NM, Gaboriaud C, Bersch B, Hernandez JF.

Immunobiology. 1998 Aug;199(2):303-16. Review.


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