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Structural analyses of NudT16-ADP-ribose complexes direct rational design of mutants with improved processing of poly(ADP-ribosyl)ated proteins.

Thirawatananond P, McPherson RL, Malhi J, Nathan S, Lambrecht MJ, Brichacek M, Hergenrother PJ, Leung AKL, Gabelli SB.

Sci Rep. 2019 Apr 11;9(1):5940. doi: 10.1038/s41598-019-39491-w.


Ca2+-dependent regulation of sodium channels NaV1.4 and NaV1.5 is controlled by the post-IQ motif.

Yoder JB, Ben-Johny M, Farinelli F, Srinivasan L, Shoemaker SR, Tomaselli GF, Gabelli SB, Amzel LM.

Nat Commun. 2019 Apr 3;10(1):1514. doi: 10.1038/s41467-019-09570-7.


Structural Determinants of Isoform Selectivity in PI3K Inhibitors.

Miller MS, Thompson PE, Gabelli SB.

Biomolecules. 2019 Feb 26;9(3). pii: E82. doi: 10.3390/biom9030082. Review.


Getting the Most Out of Your Crystals: Data Collection at the New High-Flux, Microfocus MX Beamlines at NSLS-II.

Miller MS, Maheshwari S, Shi W, Gao Y, Chu N, Soares AS, Cole PA, Amzel LM, Fuchs MR, Jakoncic J, Gabelli SB.

Molecules. 2019 Jan 30;24(3). pii: E496. doi: 10.3390/molecules24030496.


Diacylglycerol kinases: Relationship to other lipid kinases.

Ma Q, Gabelli SB, Raben DM.

Adv Biol Regul. 2019 Jan;71:104-110. doi: 10.1016/j.jbior.2018.09.014. Epub 2018 Sep 28. Review.


Effects of copper occupancy on the conformational landscape of peptidylglycine α-hydroxylating monooxygenase.

Maheshwari S, Shimokawa C, Rudzka K, Kline CD, Eipper BA, Mains RE, Gabelli SB, Blackburn N, Amzel LM.

Commun Biol. 2018 Jun 25;1:74. doi: 10.1038/s42003-018-0082-y. eCollection 2018.


Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis.

Chu N, Salguero AL, Liu AZ, Chen Z, Dempsey DR, Ficarro SB, Alexander WM, Marto JA, Li Y, Amzel LM, Gabelli SB, Cole PA.

Cell. 2018 Aug 9;174(4):897-907.e14. doi: 10.1016/j.cell.2018.07.003. Epub 2018 Aug 2.


Bilobal architecture is a requirement for calmodulin signaling to CaV1.3 channels.

Banerjee R, Yoder JB, Yue DT, Amzel LM, Tomaselli GF, Gabelli SB, Ben-Johny M.

Proc Natl Acad Sci U S A. 2018 Mar 27;115(13):E3026-E3035. doi: 10.1073/pnas.1716381115. Epub 2018 Mar 12.


Nudt19 is a renal CoA diphosphohydrolase with biochemical and regulatory properties that are distinct from the hepatic Nudt7 isoform.

Shumar SA, Kerr EW, Geldenhuys WJ, Montgomery GE, Fagone P, Thirawatananond P, Saavedra H, Gabelli SB, Leonardi R.

J Biol Chem. 2018 Mar 16;293(11):4134-4148. doi: 10.1074/jbc.RA117.001358. Epub 2018 Jan 29.


Intracellular production of hydrogels and synthetic RNA granules by multivalent molecular interactions.

Nakamura H, Lee AA, Afshar AS, Watanabe S, Rho E, Razavi S, Suarez A, Lin YC, Tanigawa M, Huang B, DeRose R, Bobb D, Hong W, Gabelli SB, Goutsias J, Inoue T.

Nat Mater. 2018 Jan;17(1):79-89. doi: 10.1038/nmat5006. Epub 2017 Nov 6.


Corrigendum to "Rapid PD-L1 detection in tumors with PET using a highly specific peptide" [Biochemical and Biophysical Research Communications 483/1 (2017) 258-263].

Chatterjee S, Lesniak WG, Miller MS, Lisok A, Sikorska E, Wharram B, Kumar D, Gabrielson M, Pomper MG, Gabelli SB, Nimmagadda S.

Biochem Biophys Res Commun. 2017 Sep 30;491(4):1125. doi: 10.1016/j.bbrc.2017.08.001. Epub 2017 Aug 8. No abstract available.


Kinetic and structural analyses reveal residues in phosphoinositide 3-kinase α that are critical for catalysis and substrate recognition.

Maheshwari S, Miller MS, O'Meally R, Cole RN, Amzel LM, Gabelli SB.

J Biol Chem. 2017 Aug 18;292(33):13541-13550. doi: 10.1074/jbc.M116.772426. Epub 2017 Jul 4.


A Tunable Brake for HECT Ubiquitin Ligases.

Chen Z, Jiang H, Xu W, Li X, Dempsey DR, Zhang X, Devreotes P, Wolberger C, Amzel LM, Gabelli SB, Cole PA.

Mol Cell. 2017 May 4;66(3):345-357.e6. doi: 10.1016/j.molcel.2017.03.020.


Identification of allosteric binding sites for PI3Kα oncogenic mutant specific inhibitor design.

Miller MS, Maheshwari S, McRobb FM, Kinzler KW, Amzel LM, Vogelstein B, Gabelli SB.

Bioorg Med Chem. 2017 Feb 15;25(4):1481-1486. doi: 10.1016/j.bmc.2017.01.012. Epub 2017 Jan 16.


Rapid PD-L1 detection in tumors with PET using a highly specific peptide.

Chatterjee S, Lesniak WG, Miller MS, Lisok A, Sikorska E, Wharram B, Kumar D, Gabrielson M, Pomper MG, Gabelli SB, Nimmagadda S.

Biochem Biophys Res Commun. 2017 Jan 29;483(1):258-263. doi: 10.1016/j.bbrc.2016.12.156. Epub 2016 Dec 24. Erratum in: Biochem Biophys Res Commun. 2017 Sep 30;491(4):1125.


Kinetic and mutational studies of the adenosine diphosphate ribose hydrolase from Mycobacterium tuberculosis.

O'Handley SF, Thirawatananond P, Kang LW, Cunningham JE, Leyva JA, Amzel LM, Gabelli SB.

J Bioenerg Biomembr. 2016 Dec;48(6):557-567. Epub 2016 Sep 28.


Nudix hydrolases degrade protein-conjugated ADP-ribose.

Daniels CM, Thirawatananond P, Ong SE, Gabelli SB, Leung AK.

Sci Rep. 2015 Dec 16;5:18271. doi: 10.1038/srep18271.


Structural and Enzymatic Characterization of a Nucleoside Diphosphate Sugar Hydrolase from Bdellovibrio bacteriovorus.

de la Peña AH, Suarez A, Duong-Ly KC, Schoeffield AJ, Pizarro-Dupuy MA, Zarr M, Pineiro SA, Amzel LM, Gabelli SB.

PLoS One. 2015 Nov 2;10(11):e0141716. doi: 10.1371/journal.pone.0141716. eCollection 2015.


Calmodulin and Ca(2+) control of voltage gated Na(+) channels.

Gabelli SB, Yoder JB, Tomaselli GF, Amzel LM.

Channels (Austin). 2016;10(1):45-54. doi: 10.1080/19336950.2015.1075677. Epub 2015 Jul 28. Review.


Generation of MANAbodies specific to HLA-restricted epitopes encoded by somatically mutated genes.

Skora AD, Douglass J, Hwang MS, Tam AJ, Blosser RL, Gabelli SB, Cao J, Diaz LA Jr, Papadopoulos N, Kinzler KW, Vogelstein B, Zhou S.

Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):9967-72. doi: 10.1073/pnas.1511996112. Epub 2015 Jul 27.


Oncogenic mutations weaken the interactions that stabilize the p110α-p85α heterodimer in phosphatidylinositol 3-kinase α.

Echeverria I, Liu Y, Gabelli SB, Amzel LM.

FEBS J. 2015 Sep;282(18):3528-42. doi: 10.1111/febs.13365. Epub 2015 Jul 24.


Affinity Purification of a Recombinant Protein Expressed as a Fusion with the Maltose-Binding Protein (MBP) Tag.

Duong-Ly KC, Gabelli SB.

Methods Enzymol. 2015;559:17-26. doi: 10.1016/bs.mie.2014.11.004. Epub 2015 Apr 15.


A redox regulatory system critical for mycobacterial survival in macrophages and biofilm development.

Wolff KA, de la Peña AH, Nguyen HT, Pham TH, Amzel LM, Gabelli SB, Nguyen L.

PLoS Pathog. 2015 Apr 17;11(4):e1004839. doi: 10.1371/journal.ppat.1004839. eCollection 2015 Apr.


Regulation of the NaV1.5 cytoplasmic domain by calmodulin.

Gabelli SB, Boto A, Kuhns VH, Bianchet MA, Farinelli F, Aripirala S, Yoder J, Jakoncic J, Tomaselli GF, Amzel LM.

Nat Commun. 2014 Nov 5;5:5126. doi: 10.1038/ncomms6126.


Activation of PI3Kα by physiological effectors and by oncogenic mutations: structural and dynamic effects.

Gabelli SB, Echeverria I, Alexander M, Duong-Ly KC, Chaves-Moreira D, Brower ET, Vogelstein B, Amzel LM.

Biophys Rev. 2014 Mar 1;6(1):89-95.


Structural basis of nSH2 regulation and lipid binding in PI3Kα.

Miller MS, Schmidt-Kittler O, Bolduc DM, Brower ET, Chaves-Moreira D, Allaire M, Kinzler KW, Jennings IG, Thompson PE, Cole PA, Amzel LM, Vogelstein B, Gabelli SB.

Oncotarget. 2014 Jul 30;5(14):5198-208.


Explanatory chapter: troubleshooting protein expression: what to do when the protein is not soluble.

Duong-Ly KC, Gabelli SB.

Methods Enzymol. 2014;541:231-47. doi: 10.1016/B978-0-12-420119-4.00018-5.


Explanatory chapter: troubleshooting recombinant protein expression: general.

Duong-Ly KC, Gabelli SB.

Methods Enzymol. 2014;541:209-29. doi: 10.1016/B978-0-12-420119-4.00017-3.


Gel filtration chromatography (size exclusion chromatography) of proteins.

Duong-Ly KC, Gabelli SB.

Methods Enzymol. 2014;541:105-14. doi: 10.1016/B978-0-12-420119-4.00009-4.


Using ion exchange chromatography to purify a recombinantly expressed protein.

Duong-Ly KC, Gabelli SB.

Methods Enzymol. 2014;541:95-103. doi: 10.1016/B978-0-12-420119-4.00008-2.


Salting out of proteins using ammonium sulfate precipitation.

Duong-Ly KC, Gabelli SB.

Methods Enzymol. 2014;541:85-94. doi: 10.1016/B978-0-12-420119-4.00007-0.


Structural and thermodynamic basis of the inhibition of Leishmania major farnesyl diphosphate synthase by nitrogen-containing bisphosphonates.

Aripirala S, Gonzalez-Pacanowska D, Oldfield E, Kaiser M, Amzel LM, Gabelli SB.

Acta Crystallogr D Biol Crystallogr. 2014 Mar;70(Pt 3):802-10. doi: 10.1107/S1399004713033221. Epub 2014 Feb 22.


Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesis.

Bolduc D, Rahdar M, Tu-Sekine B, Sivakumaren SC, Raben D, Amzel LM, Devreotes P, Gabelli SB, Cole P.

Elife. 2013 Jul 9;2:e00691. doi: 10.7554/eLife.00691.


A UDP-X diphosphatase from Streptococcus pneumoniae hydrolyzes precursors of peptidoglycan biosynthesis.

Duong-Ly KC, Woo HN, Dunn CA, Xu W, Babič A, Bessman MJ, Amzel LM, Gabelli SB.

PLoS One. 2013 May 15;8(5):e64241. doi: 10.1371/journal.pone.0064241. Print 2013.


Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells.

Zhang F, Bhat S, Gabelli SB, Chen X, Miller MS, Nacev BA, Cheng YL, Meyers DJ, Tenney K, Shim JS, Crews P, Amzel LM, Ma D, Liu JO.

J Med Chem. 2013 May 23;56(10):3996-4016. doi: 10.1021/jm400227z. Epub 2013 May 1.


Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1.

Zhang P, Yang X, Zhang F, Gabelli SB, Wang R, Zhang Y, Bhat S, Chen X, Furlani M, Amzel LM, Liu JO, Ma D.

Bioorg Med Chem. 2013 May 1;21(9):2600-17. doi: 10.1016/j.bmc.2013.02.023. Epub 2013 Feb 21.


Design, synthesis, calorimetry, and crystallographic analysis of 2-alkylaminoethyl-1,1-bisphosphonates as inhibitors of Trypanosoma cruzi farnesyl diphosphate synthase.

Aripirala S, Szajnman SH, Jakoncic J, Rodriguez JB, Docampo R, Gabelli SB, Amzel LM.

J Med Chem. 2012 Jul 26;55(14):6445-54. doi: 10.1021/jm300425y. Epub 2012 Jul 5.


Structural studies of the Nudix GDP-mannose hydrolase from E. coli reveals a new motif for mannose recognition.

Boto AN, Xu W, Jakoncic J, Pannuri A, Romeo T, Bessman MJ, Gabelli SB, Amzel LM.

Proteins. 2011 Aug;79(8):2455-66. doi: 10.1002/prot.23069. Epub 2011 Jun 2.


The Nudix hydrolase CDP-chase, a CDP-choline pyrophosphatase, is an asymmetric dimer with two distinct enzymatic activities.

Duong-Ly KC, Gabelli SB, Xu W, Dunn CA, Schoeffield AJ, Bessman MJ, Amzel LM.

J Bacteriol. 2011 Jul;193(13):3175-85. doi: 10.1128/JB.00089-11. Epub 2011 Apr 29.


PI3Kα inhibitors that inhibit metastasis.

Schmidt-Kittler O, Zhu J, Yang J, Liu G, Hendricks W, Lengauer C, Gabelli SB, Kinzler KW, Vogelstein B, Huso DL, Zhou S.

Oncotarget. 2010 Sep;1(5):339-48.


Capitalizing on tumor genotyping: towards the design of mutation specific inhibitors of phosphoinsitide-3-kinase.

Gabelli SB, Duong-Ly KC, Brower ET, Amzel LM.

Adv Enzyme Regul. 2011;51(1):273-9. doi: 10.1016/j.advenzreg.2010.09.013. Epub 2010 Oct 28. Review.


Structural insights into maize viviparous14, a key enzyme in the biosynthesis of the phytohormone abscisic acid.

Messing SA, Gabelli SB, Echeverria I, Vogel JT, Guan JC, Tan BC, Klee HJ, McCarty DR, Amzel LM.

Plant Cell. 2010 Sep;22(9):2970-80. doi: 10.1105/tpc.110.074815. Epub 2010 Sep 30.


NHE3 activity is dependent on direct phosphoinositide binding at the N terminus of its intracellular cytosolic region.

Mohan S, Tse CM, Gabelli SB, Sarker R, Cha B, Fahie K, Nadella M, Zachos NC, Tu-Sekine B, Raben D, Amzel LM, Donowitz M.

J Biol Chem. 2010 Nov 5;285(45):34566-78. doi: 10.1074/jbc.M110.165712. Epub 2010 Aug 24.


Structural effects of oncogenic PI3Kα mutations.

Gabelli SB, Huang CH, Mandelker D, Schmidt-Kittler O, Vogelstein B, Amzel LM.

Curr Top Microbiol Immunol. 2010;347:43-53. doi: 10.1007/82_2010_53. Review.


Mutation of Asn28 disrupts the dimerization and enzymatic activity of SARS 3CL(pro) .

Barrila J, Gabelli SB, Bacha U, Amzel LM, Freire E.

Biochemistry. 2010 May 25;49(20):4308-17. doi: 10.1021/bi1002585.


Somatic mutations in PI3Kalpha: structural basis for enzyme activation and drug design.

Gabelli SB, Mandelker D, Schmidt-Kittler O, Vogelstein B, Amzel LM.

Biochim Biophys Acta. 2010 Mar;1804(3):533-40. doi: 10.1016/j.bbapap.2009.11.020. Epub 2009 Dec 2. Review.


Binding of nitrogen-containing bisphosphonates (N-BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimer.

Huang CH, Gabelli SB, Oldfield E, Amzel LM.

Proteins. 2010 Mar;78(4):888-99. doi: 10.1002/prot.22614.


A frequent kinase domain mutation that changes the interaction between PI3Kalpha and the membrane.

Mandelker D, Gabelli SB, Schmidt-Kittler O, Zhu J, Cheong I, Huang CH, Kinzler KW, Vogelstein B, Amzel LM.

Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):16996-7001. doi: 10.1073/pnas.0908444106. Epub 2009 Sep 23.


Structure and biological function of the RNA pyrophosphohydrolase BdRppH from Bdellovibrio bacteriovorus.

Messing SA, Gabelli SB, Liu Q, Celesnik H, Belasco JG, Piñeiro SA, Amzel LM.

Structure. 2009 Mar 11;17(3):472-81. doi: 10.1016/j.str.2008.12.022.


Identification of Bdellovibrio bacteriovorus HD100 Bd0714 as a Nudix dGTPase.

Steyert SR, Messing SA, Amzel LM, Gabelli SB, Piñeiro SA.

J Bacteriol. 2008 Dec;190(24):8215-9. doi: 10.1128/JB.01009-08. Epub 2008 Oct 17.

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