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Items: 1 to 50 of 77

1.

Novel protein therapeutic joint retention strategy based on collagen-binding Avimers.

Hulme JT, D'Souza WN, McBride HJ, Yoon BP, Willee AM, Duguay A, Thomas M, Fan B, Dayao MR, Rottman JB, Merriam K, Xie J, Smith R, Alba BM, Case RB, Dang K, Montalvan A, Grinberg N, Sun H, Black RA, Gabel CA, Sims JE, Moore K, Bakker A, Li P.

J Orthop Res. 2018 Apr;36(4):1238-1247. doi: 10.1002/jor.23756. Epub 2017 Nov 22.

2.

Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36α, IL-36β, and IL-36γ) or antagonist (IL-36Ra) activity.

Towne JE, Renshaw BR, Douangpanya J, Lipsky BP, Shen M, Gabel CA, Sims JE.

J Biol Chem. 2011 Dec 9;286(49):42594-602. doi: 10.1074/jbc.M111.267922. Epub 2011 Sep 29.

3.

Discovery, synthesis and SAR of azinyl- and azolylbenzamides antagonists of the P2X₇ receptor.

Subramanyam C, Duplantier AJ, Dombroski MA, Chang SP, Gabel CA, Whitney-Pickett C, Perregaux DG, Labasi JM, Yoon K, Shepard RM, Fisher M.

Bioorg Med Chem Lett. 2011 Sep 15;21(18):5475-9. doi: 10.1016/j.bmcl.2011.06.117. Epub 2011 Jul 2.

PMID:
21782426
4.

Optimization of the physicochemical and pharmacokinetic attributes in a 6-azauracil series of P2X7 receptor antagonists leading to the discovery of the clinical candidate CE-224,535.

Duplantier AJ, Dombroski MA, Subramanyam C, Beaulieu AM, Chang SP, Gabel CA, Jordan C, Kalgutkar AS, Kraus KG, Labasi JM, Mussari C, Perregaux DG, Shepard R, Taylor TJ, Trevena KA, Whitney-Pickett C, Yoon K.

Bioorg Med Chem Lett. 2011 Jun 15;21(12):3708-11. doi: 10.1016/j.bmcl.2011.04.077. Epub 2011 Apr 24.

PMID:
21565499
5.

Externalization of the leaderless cytokine IL-1F6 occurs in response to lipopolysaccharide/ATP activation of transduced bone marrow macrophages.

Martin U, Scholler J, Gurgel J, Renshaw B, Sims JE, Gabel CA.

J Immunol. 2009 Sep 15;183(6):4021-30. doi: 10.4049/jimmunol.0803301. Epub 2009 Aug 28.

6.

P2 purinergic receptor modulation of cytokine production.

Gabel CA.

Purinergic Signal. 2007 Mar;3(1-2):27-38. doi: 10.1007/s11302-006-9034-y. Epub 2007 Jan 3.

7.

Periodate oxidized ATP (oATP) reduces hyperalgesia in mice: involvement of P2X7 receptors and implications for therapy.

Fulgenzi A, Ticozzi P, Gabel CA, Dell'Antonio G, Quattrini A, Franzone JS, Ferrero ME.

Int J Immunopathol Pharmacol. 2008 Jan-Mar;21(1):61-71.

PMID:
18336732
8.

Structure-activity relationships of triazolopyridine oxazole p38 inhibitors: identification of candidates for clinical development.

McClure KF, Letavic MA, Kalgutkar AS, Gabel CA, Audoly L, Barberia JT, Braganza JF, Carter D, Carty TJ, Cortina SR, Dombroski MA, Donahue KM, Elliott NC, Gibbons CP, Jordan CK, Kuperman AV, Labasi JM, Laliberte RE, McCoy JM, Naiman BM, Nelson KL, Nguyen HT, Peese KM, Sweeney FJ, Taylor TJ, Trebino CE, Abramov YA, Laird ER, Volberg WA, Zhou J, Bach J, Lombardo F.

Bioorg Med Chem Lett. 2006 Aug 15;16(16):4339-44. Epub 2006 Jun 12.

PMID:
16759861
9.

Theoretical and experimental design of atypical kinase inhibitors: application to p38 MAP kinase.

McClure KF, Abramov YA, Laird ER, Barberia JT, Cai W, Carty TJ, Cortina SR, Danley DE, Dipesa AJ, Donahue KM, Dombroski MA, Elliott NC, Gabel CA, Han S, Hynes TR, Lemotte PK, Mansour MN, Marr ES, Letavic MA, Pandit J, Ripin DB, Sweeney FJ, Tan D, Tao Y.

J Med Chem. 2005 Sep 8;48(18):5728-37.

PMID:
16134941
10.

Role of p38 MAPK in UVB-induced inflammatory responses in the skin of SKH-1 hairless mice.

Kim AL, Labasi JM, Zhu Y, Tang X, McClure K, Gabel CA, Athar M, Bickers DR.

J Invest Dermatol. 2005 Jun;124(6):1318-25. Erratum in: J Invest Dermatol. 2005 Dec;125(6):1320.

11.

Correlation of polymorphic variation in the promoter region of the interleukin-1 beta gene with secretion of interleukin-1 beta protein.

Hall SK, Perregaux DG, Gabel CA, Woodworth T, Durham LK, Huizinga TW, Breedveld FC, Seymour AB.

Arthritis Rheum. 2004 Jun;50(6):1976-83.

12.

Benzimidazolone p38 inhibitors.

Dombroski MA, Letavic MA, McClure KF, Barberia JT, Carty TJ, Cortina SR, Csiki C, Dipesa AJ, Elliott NC, Gabel CA, Jordan CK, Labasi JM, Martin WH, Peese KM, Stock IA, Svensson L, Sweeney FJ, Yu CH.

Bioorg Med Chem Lett. 2004 Feb 23;14(4):919-23.

PMID:
15012994
13.

Deletion of the P2X7 nucleotide receptor reveals its regulatory roles in bone formation and resorption.

Ke HZ, Qi H, Weidema AF, Zhang Q, Panupinthu N, Crawford DT, Grasser WA, Paralkar VM, Li M, Audoly LP, Gabel CA, Jee WS, Dixon SJ, Sims SM, Thompson DD.

Mol Endocrinol. 2003 Jul;17(7):1356-67. Epub 2003 Apr 3.

PMID:
12677010
14.

Glutathione s-transferase omega 1-1 is a target of cytokine release inhibitory drugs and may be responsible for their effect on interleukin-1beta posttranslational processing.

Laliberte RE, Perregaux DG, Hoth LR, Rosner PJ, Jordan CK, Peese KM, Eggler JF, Dombroski MA, Geoghegan KF, Gabel CA.

J Biol Chem. 2003 May 9;278(19):16567-78. Epub 2003 Mar 6.

15.

Absence of the P2X7 receptor alters leukocyte function and attenuates an inflammatory response.

Labasi JM, Petrushova N, Donovan C, McCurdy S, Lira P, Payette MM, Brissette W, Wicks JR, Audoly L, Gabel CA.

J Immunol. 2002 Jun 15;168(12):6436-45.

16.

Antimicrobial peptides initiate IL-1 beta posttranslational processing: a novel role beyond innate immunity.

Perregaux DG, Bhavsar K, Contillo L, Shi J, Gabel CA.

J Immunol. 2002 Mar 15;168(6):3024-32.

17.

Identification and characterization of a novel class of interleukin-1 post-translational processing inhibitors.

Perregaux DG, McNiff P, Laliberte R, Hawryluk N, Peurano H, Stam E, Eggler J, Griffiths R, Dombroski MA, Gabel CA.

J Pharmacol Exp Ther. 2001 Oct;299(1):187-97.

PMID:
11561079
18.

LL-Z1271alpha: an interleukin-1beta production inhibitor.

Ichikawa K, Inagaki T, Kachi-Tonai H, Kojima Y, Nakamura T, Nishida H, Ueno Y, Binding P, Gabel CA, Lucas V, McNiff PA, Kojima N.

Biochem Biophys Res Commun. 2001 Aug 31;286(4):697-700.

PMID:
11520053
19.

ATP acts as an agonist to promote stimulus-induced secretion of IL-1 beta and IL-18 in human blood.

Perregaux DG, McNiff P, Laliberte R, Conklyn M, Gabel CA.

J Immunol. 2000 Oct 15;165(8):4615-23.

20.

Altered cytokine production in mice lacking P2X(7) receptors.

Solle M, Labasi J, Perregaux DG, Stam E, Petrushova N, Koller BH, Griffiths RJ, Gabel CA.

J Biol Chem. 2001 Jan 5;276(1):125-32.

21.

Identification, characterization, and crystal structure of the Omega class glutathione transferases.

Board PG, Coggan M, Chelvanayagam G, Easteal S, Jermiin LS, Schulte GK, Danley DE, Hoth LR, Griffor MC, Kamath AV, Rosner MH, Chrunyk BA, Perregaux DE, Gabel CA, Geoghegan KF, Pandit J.

J Biol Chem. 2000 Aug 11;275(32):24798-806.

23.

ATP treatment of human monocytes promotes caspase-1 maturation and externalization.

Laliberte RE, Eggler J, Gabel CA.

J Biol Chem. 1999 Dec 24;274(52):36944-51.

24.

Human monocyte stimulus-coupled IL-1beta posttranslational processing: modulation via monovalent cations.

Perregaux DG, Gabel CA.

Am J Physiol. 1998 Dec;275(6):C1538-47. doi: 10.1152/ajpcell.1998.275.6.C1538.

PMID:
9843715
26.

Human monocyte ATP-induced IL-1 beta posttranslational processing is a dynamic process dependent on in vitro growth conditions.

Laliberte RE, Perregaux DG, McNiff P, Gabel CA.

J Leukoc Biol. 1997 Aug;62(2):227-39.

PMID:
9261337
27.

Human monocyte interleukin-1beta posttranslational processing. Evidence of a volume-regulated response.

Perregaux DG, Laliberte RE, Gabel CA.

J Biol Chem. 1996 Nov 22;271(47):29830-8.

28.
29.

Envelopment of varicella-zoster virus: targeting of viral glycoproteins to the trans-Golgi network.

Zhu Z, Gershon MD, Hao Y, Ambron RT, Gabel CA, Gershon AA.

J Virol. 1995 Dec;69(12):7951-9.

30.

Reduction of intracellular pH by tenidap. Involvement of cellular anion transporters in the pH change.

McNiff P, Robinson RP, Gabel CA.

Biochem Pharmacol. 1995 Oct 26;50(9):1421-32.

PMID:
7503793
31.

Inhibition of interleukin-1 beta production by SKF86002: evidence of two sites of in vitro activity and of a time and system dependence.

Perregaux DG, Dean D, Cronan M, Connelly P, Gabel CA.

Mol Pharmacol. 1995 Sep;48(3):433-42.

PMID:
7565623
32.

Bafilomycin A1 inhibits IL-1-stimulated proteoglycan degradation by chondrocytes without affecting stromelysin synthesis.

Yocum SA, Lopresti-Morrow LL, Gabel CA, Milici AJ, Mitchell PG.

Arch Biochem Biophys. 1995 Feb 1;316(2):827-35.

PMID:
7864640
33.
34.

Inhibition of cytokine activation processes in vitro by tenidap, a novel anti-inflammatory agent.

McNiff PA, Laliberte RE, Svensson L, Pazoles CJ, Gabel CA.

Cytokine. 1995 Feb;7(2):196-208.

PMID:
7780040
35.

Intracellular transport of newly synthesized varicella-zoster virus: final envelopment in the trans-Golgi network.

Gershon AA, Sherman DL, Zhu Z, Gabel CA, Ambron RT, Gershon MD.

J Virol. 1994 Oct;68(10):6372-90.

36.

Tenidap modulates cytoplasmic pH and inhibits anion transport in vitro. I. Mechanism and evidence of functional significance.

McNiff P, Svensson L, Pazoles CJ, Gabel CA.

J Immunol. 1994 Sep 1;153(5):2180-93.

PMID:
8051419
37.
39.
40.

An 83 kDa O-GlcNAc-glycoprotein is found in the axoplasm and nucleus of Aplysia neurons.

Elliot SP, Schmied R, Gabel CA, Ambron RT.

J Neurosci. 1993 Jun;13(6):2424-9.

41.
42.

IL-1 beta maturation: evidence that mature cytokine formation can be induced specifically by nigericin.

Perregaux D, Barberia J, Lanzetti AJ, Geoghegan KF, Carty TJ, Gabel CA.

J Immunol. 1992 Aug 15;149(4):1294-303.

PMID:
1500719
43.

A 58-kDa resident protein of the cis Golgi cisterna is not terminally glycosylated.

Hendricks LC, Gabel CA, Suh K, Farquhar MG.

J Biol Chem. 1991 Sep 15;266(26):17559-65.

45.

Mannose 6-phosphate receptors: potential mediators of germ cell-Sertoli cell interactions.

O'Brien DA, Gabel CA, Welch JE, Eddy EM.

Ann N Y Acad Sci. 1991;637:327-39. Review.

PMID:
1664679
48.

Characterization and cloning of lgp110, a lysosomal membrane glycoprotein from mouse and rat cells.

Granger BL, Green SA, Gabel CA, Howe CL, Mellman I, Helenius A.

J Biol Chem. 1990 Jul 15;265(20):12036-43.

49.
50.

Deficient glycosylation of arylsulfatase A in pseudo arylsulfatase-A deficiency.

Ameen M, Lazzarino DA, Kelly BM, Gabel CA, Chang PL.

Mol Cell Biochem. 1990 Feb 9;92(2):117-27.

PMID:
1968615

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