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Items: 1 to 50 of 113

1.

Aldose reductase modulates acute activation of mesenchymal markers via the β-catenin pathway during cardiac ischemia-reperfusion.

Thiagarajan D, O' Shea K, Sreejit G, Ananthakrishnan R, Quadri N, Li Q, Schmidt AM, Gabbay K, Ramasamy R.

PLoS One. 2017 Nov 30;12(11):e0188981. doi: 10.1371/journal.pone.0188981. eCollection 2017.

2.

Insulin sensitivity is a Rubik's Cube.

Gabbay KH.

Am J Clin Nutr. 2016 Jun;103(6):1381-2. doi: 10.3945/ajcn.116.136127. Epub 2016 May 18. No abstract available.

PMID:
27194307
3.

Aldose reductase modulates cardiac glycogen synthase kinase-3β phosphorylation during ischemia-reperfusion.

Abdillahi M, Ananthakrishnan R, Vedantham S, Shang L, Zhu Z, Rosario R, Zirpoli H, Bohren KM, Gabbay KH, Ramasamy R.

Am J Physiol Heart Circ Physiol. 2012 Aug 1;303(3):H297-308. doi: 10.1152/ajpheart.00999.2011. Epub 2012 Jun 1.

4.

Ascorbate synthesis pathway: dual role of ascorbate in bone homeostasis.

Gabbay KH, Bohren KM, Morello R, Bertin T, Liu J, Vogel P.

J Biol Chem. 2010 Jun 18;285(25):19510-20. doi: 10.1074/jbc.M110.110247. Epub 2010 Apr 21.

5.

Affinity chromatography of native SUMO proteins using His-tagged recombinant UBC9 bound to Co2+-charged talon resin.

Bohren KM, Gabbay KH, Owerbach D.

Protein Expr Purif. 2007 Aug;54(2):289-94. Epub 2007 Mar 27.

PMID:
17459725
6.

A proline-90 residue unique to SUMO-4 prevents maturation and sumoylation.

Owerbach D, McKay EM, Yeh ET, Gabbay KH, Bohren KM.

Biochem Biophys Res Commun. 2005 Nov 18;337(2):517-20. Epub 2005 Sep 22.

PMID:
16198310
7.

The structure of Apo R268A human aldose reductase: hinges and latches that control the kinetic mechanism.

Bohren KM, Brownlee JM, Milne AC, Gabbay KH, Harrison DH.

Biochim Biophys Acta. 2005 May 15;1748(2):201-12.

PMID:
15769597
8.
9.

Association of a CAG/CAA repeat sequence in the TBP gene with type I diabetes.

Owerbach D, Piña L, Gabbay KH.

Biochem Biophys Res Commun. 2004 Oct 22;323(3):865-9.

PMID:
15381080
10.
11.
12.

Human aldehyde reductase promoter allows simultaneous expression of two genes in opposite directions.

Barski OA, Siller-Lopez F, Bohren KM, Gabbay KH, Aguilar-Cordova E.

Biotechniques. 2004 Mar;36(3):382-4, 386, 388. No abstract available.

13.

Regulation of aldehyde reductase expression by STAF and CHOP.

Barski OA, Papusha VZ, Kunkel GR, Gabbay KH.

Genomics. 2004 Jan;83(1):119-29.

PMID:
14667815
14.

Cyclosporine A inhibits the adaptive responses to hypertonicity: a potential mechanism of nephrotoxicity.

Sheikh-Hamad D, Nadkarni V, Choi YJ, Truong LD, Wideman C, Hodjati R, Gabbay KH.

J Am Soc Nephrol. 2001 Dec;12(12):2732-41.

15.

Characterization of the human aldehyde reductase gene and promoter.

Barski OA, Gabbay KH, Bohren KM.

Genomics. 1999 Sep 1;60(2):188-98.

PMID:
10486210
16.
17.

Factors affecting counteraction by methylamines of urea effects on aldose reductase.

Burg MB, Peters EM, Bohren KM, Gabbay KH.

Proc Natl Acad Sci U S A. 1999 May 25;96(11):6517-22.

18.

The alrestatin double-decker: binding of two inhibitor molecules to human aldose reductase reveals a new specificity determinant.

Harrison DH, Bohren KM, Petsko GA, Ringe D, Gabbay KH.

Biochemistry. 1997 Dec 23;36(51):16134-40.

PMID:
9405046
19.

Linkage analyses in type I diabetes mellitus using CASPAR, a software and statistical program for conditional analysis of polygenic diseases.

Buhler J, Owerbach D, Schäffer AA, Kimmel M, Gabbay KH.

Hum Hered. 1997 Jul-Aug;47(4):211-22.

PMID:
9239508
20.

Identification and characterization of multiple osmotic response sequences in the human aldose reductase gene.

Ko BC, Ruepp B, Bohren KM, Gabbay KH, Chung SS.

J Biol Chem. 1997 Jun 27;272(26):16431-7.

21.

Analysis of candidate genes for susceptibility to type I diabetes: a case-control and family-association study of genes on chromosome 2q31-35.

Owerbach D, Naya FJ, Tsai MJ, Allander SV, Powell DR, Gabbay KH.

Diabetes. 1997 Jun;46(6):1069-74.

PMID:
9166681
22.

Characterization of an element resembling an androgen response element (ARE) in the human aldose reductase promoter.

Ruepp BU, Bohren KM, Gabbay KH.

Adv Exp Med Biol. 1997;414:515-9. No abstract available.

PMID:
9059657
23.

Characterization of a novel murine aldo-keto reductase.

Bohren KM, Barski OA, Gabbay KH.

Adv Exp Med Biol. 1997;414:455-64. No abstract available.

PMID:
9059651
24.

Aldehyde reductase. Catalytic mechanism and substrate recognition.

Barski OA, Gabbay KH, Bohren KM.

Adv Exp Med Biol. 1997;414:443-51. No abstract available.

PMID:
9059649
25.

The C-terminal loop of aldehyde reductase determines the substrate and inhibitor specificity.

Barski OA, Gabbay KH, Bohren KM.

Biochemistry. 1996 Nov 12;35(45):14276-80.

PMID:
8916913
26.

Characterization of the osmotic response element of the human aldose reductase gene promoter.

Ruepp B, Bohren KM, Gabbay KH.

Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8624-9.

27.

The search for IDDM susceptibility genes: the next generation.

Owerbach D, Gabbay KH.

Diabetes. 1996 May;45(5):544-51. Review.

PMID:
8621001
28.

Human aldose reductase: pK of tyrosine 48 reveals the preferred ionization state for catalysis and inhibition.

Grimshaw CE, Bohren KM, Lai CJ, Gabbay KH.

Biochemistry. 1995 Nov 7;34(44):14374-84.

PMID:
7578041
29.

Human aldose reductase: subtle effects revealed by rapid kinetic studies of the C298A mutant enzyme.

Grimshaw CE, Bohren KM, Lai CJ, Gabbay KH.

Biochemistry. 1995 Nov 7;34(44):14366-73.

PMID:
7578040
30.
31.

Mechanism of human aldehyde reductase: characterization of the active site pocket.

Barski OA, Gabbay KH, Grimshaw CE, Bohren KM.

Biochemistry. 1995 Sep 5;34(35):11264-75.

PMID:
7669785
32.
33.

Expression, crystallization and preliminary crystallographic analysis of human carbonyl reductase.

Bohren KM, Wermuth B, Harrison D, Ringe D, Petsko GA, Gabbay KH.

J Mol Biol. 1994 Dec 16;244(5):659-64.

PMID:
7990149
34.

Mechanism of aldose reductase inhibition: binding of NADP+/NADPH and alrestatin-like inhibitors.

Ehrig T, Bohren KM, Prendergast FG, Gabbay KH.

Biochemistry. 1994 Jun 14;33(23):7157-65.

PMID:
8003482
35.

Retinal circulatory abnormalities in type 1 diabetes.

Feke GT, Buzney SM, Ogasawara H, Fujio N, Goger DG, Spack NP, Gabbay KH.

Invest Ophthalmol Vis Sci. 1994 Jun;35(7):2968-75.

PMID:
8206714
36.
38.

An anion binding site in human aldose reductase: mechanistic implications for the binding of citrate, cacodylate, and glucose 6-phosphate.

Harrison DH, Bohren KM, Ringe D, Petsko GA, Gabbay KH.

Biochemistry. 1994 Mar 1;33(8):2011-20.

PMID:
8117658
39.
40.

Characterization of the human aldose reductase gene promoter.

Wang K, Bohren KM, Gabbay KH.

J Biol Chem. 1993 Jul 25;268(21):16052-8.

41.

Cys298 is responsible for reversible thiol-induced variation in aldose reductase activity.

Bohren KM, Gabbay KH.

Adv Exp Med Biol. 1993;328:267-77. No abstract available.

PMID:
8493903
42.

Catalytic effectiveness of human aldose reductase. Critical role of C-terminal domain.

Bohren KM, Grimshaw CE, Gabbay KH.

J Biol Chem. 1992 Oct 15;267(29):20965-70.

43.
44.

Expression of human aldose and aldehyde reductases. Site-directed mutagenesis of a critical lysine 262.

Bohren KM, Page JL, Shankar R, Henry SP, Gabbay KH.

J Biol Chem. 1991 Dec 15;266(35):24031-7.

45.

Effect of puberty on insulinlike growth factor I and HbA1 in type I diabetes.

Rogers DG, Sherman LD, Gabbay KH.

Diabetes Care. 1991 Nov;14(11):1031-5.

PMID:
1797483
46.

Multigenic basis for type I diabetes. Association of HRAS1 polymorphism with HLA-DR3, DQw2/DR4, DQw8.

Owerbach D, Gunn S, Gabbay KH.

Diabetes. 1990 Dec;39(12):1504-9.

PMID:
1978827
48.

Primary association of HLA-DQw8 with type I diabetes in DR4 patients.

Owerbach D, Gunn S, Gabbay KH.

Diabetes. 1989 Jul;38(7):942-5.

PMID:
2786821
49.

The aldo-keto reductase superfamily. cDNAs and deduced amino acid sequences of human aldehyde and aldose reductases.

Bohren KM, Bullock B, Wermuth B, Gabbay KH.

J Biol Chem. 1989 Jun 5;264(16):9547-51.

50.

Human carbonyl reductase. Nucleotide sequence analysis of a cDNA and amino acid sequence of the encoded protein.

Wermuth B, Bohren KM, Heinemann G, von Wartburg JP, Gabbay KH.

J Biol Chem. 1988 Nov 5;263(31):16185-8.

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