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Aldose reductase modulates acute activation of mesenchymal markers via the β-catenin pathway during cardiac ischemia-reperfusion.
Thiagarajan D, O' Shea K, Sreejit G, Ananthakrishnan R, Quadri N, Li Q, Schmidt AM, Gabbay K, Ramasamy R.
PLoS One. 2017 Nov 30;12(11):e0188981. doi: 10.1371/journal.pone.0188981. eCollection 2017.
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Aldose reductase modulates cardiac glycogen synthase kinase-3β phosphorylation during ischemia-reperfusion.
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J Biol Chem. 2010 Jun 18;285(25):19510-20. doi: 10.1074/jbc.M110.110247. Epub 2010 Apr 21.
Affinity chromatography of native SUMO proteins using His-tagged recombinant UBC9 bound to Co2+-charged talon resin.
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A proline-90 residue unique to SUMO-4 prevents maturation and sumoylation.
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Association of a CAG/CAA repeat sequence in the TBP gene with type I diabetes.
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J Biol Chem. 2004 Jun 25;279(26):27233-8. Epub 2004 Apr 29.
Human aldehyde reductase promoter allows simultaneous expression of two genes in opposite directions.
Barski OA, Siller-Lopez F, Bohren KM, Gabbay KH, Aguilar-Cordova E.
Biotechniques. 2004 Mar;36(3):382-4, 386, 388. No abstract available.
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Cyclosporine A inhibits the adaptive responses to hypertonicity: a potential mechanism of nephrotoxicity.
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Genomics. 1999 Sep 1;60(2):188-98.
Osmotic response element enhancer activity. Regulation through p38 kinase and mitogen-activated extracellular signal-regulated kinase kinase.
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J Biol Chem. 1999 Jul 16;274(29):20185-90.
Factors affecting counteraction by methylamines of urea effects on aldose reductase.
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Proc Natl Acad Sci U S A. 1999 May 25;96(11):6517-22.
The alrestatin double-decker: binding of two inhibitor molecules to human aldose reductase reveals a new specificity determinant.
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Hum Hered. 1997 Jul-Aug;47(4):211-22.
Identification and characterization of multiple osmotic response sequences in the human aldose reductase gene.
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J Biol Chem. 1997 Jun 27;272(26):16431-7.
Analysis of candidate genes for susceptibility to type I diabetes: a case-control and family-association study of genes on chromosome 2q31-35.
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Diabetes. 1997 Jun;46(6):1069-74.
Characterization of an element resembling an androgen response element (ARE) in the human aldose reductase promoter.
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Adv Exp Med Biol. 1997;414:515-9. No abstract available.
Characterization of a novel murine aldo-keto reductase.
Bohren KM, Barski OA, Gabbay KH.
Adv Exp Med Biol. 1997;414:455-64. No abstract available.
Aldehyde reductase. Catalytic mechanism and substrate recognition.
Adv Exp Med Biol. 1997;414:443-51. No abstract available.
The C-terminal loop of aldehyde reductase determines the substrate and inhibitor specificity.
Biochemistry. 1996 Nov 12;35(45):14276-80.
Characterization of the osmotic response element of the human aldose reductase gene promoter.
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Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8624-9.
The search for IDDM susceptibility genes: the next generation.
Owerbach D, Gabbay KH.
Diabetes. 1996 May;45(5):544-51. Review.
Human aldose reductase: pK of tyrosine 48 reveals the preferred ionization state for catalysis and inhibition.
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Biochemistry. 1995 Nov 7;34(44):14374-84.
Human aldose reductase: subtle effects revealed by rapid kinetic studies of the C298A mutant enzyme.
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Human aldose reductase: rate constants for a mechanism including interconversion of ternary complexes by recombinant wild-type enzyme.
Biochemistry. 1995 Nov 7;34(44):14356-65.
Mechanism of human aldehyde reductase: characterization of the active site pocket.
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The HOXD8 locus (2q31) is linked to type I diabetes. Interaction with chromosome 6 and 11 disease susceptibility genes.
Diabetes. 1995 Jan;44(1):132-6.
Expression, crystallization and preliminary crystallographic analysis of human carbonyl reductase.
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J Mol Biol. 1994 Dec 16;244(5):659-64.
Mechanism of aldose reductase inhibition: binding of NADP+/NADPH and alrestatin-like inhibitors.
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Biochemistry. 1994 Jun 14;33(23):7157-65.
Retinal circulatory abnormalities in type 1 diabetes.
Feke GT, Buzney SM, Ogasawara H, Fujio N, Goger DG, Spack NP, Gabbay KH.
Invest Ophthalmol Vis Sci. 1994 Jun;35(7):2968-75.
Linkage of the VNTR/insulin-gene and type I diabetes mellitus: increased gene sharing in affected sibling pairs.
Am J Hum Genet. 1994 May;54(5):909-12.
Tyrosine-48 is the proton donor and histidine-110 directs substrate stereochemical selectivity in the reduction reaction of human aldose reductase: enzyme kinetics and crystal structure of the Y48H mutant enzyme.
Bohren KM, Grimshaw CE, Lai CJ, Harrison DH, Ringe D, Petsko GA, Gabbay KH.
Biochemistry. 1994 Mar 1;33(8):2021-32.
An anion binding site in human aldose reductase: mechanistic implications for the binding of citrate, cacodylate, and glucose 6-phosphate.
Harrison DH, Bohren KM, Ringe D, Petsko GA, Gabbay KH.
Biochemistry. 1994 Mar 1;33(8):2011-20.
Localization of a type I diabetes susceptibility locus to the variable tandem repeat region flanking the insulin gene.
Diabetes. 1993 Dec;42(12):1708-14.
Characterization of the human aldose reductase gene promoter.
Wang K, Bohren KM, Gabbay KH.
J Biol Chem. 1993 Jul 25;268(21):16052-8.
Cys298 is responsible for reversible thiol-induced variation in aldose reductase activity.
Bohren KM, Gabbay KH.
Adv Exp Med Biol. 1993;328:267-77. No abstract available.
Catalytic effectiveness of human aldose reductase. Critical role of C-terminal domain.
Bohren KM, Grimshaw CE, Gabbay KH.
J Biol Chem. 1992 Oct 15;267(29):20965-70.
An unlikely sugar substrate site in the 1.65 A structure of the human aldose reductase holoenzyme implicated in diabetic complications.
Wilson DK, Bohren KM, Gabbay KH, Quiocho FA.
Science. 1992 Jul 3;257(5066):81-4.
Expression of human aldose and aldehyde reductases. Site-directed mutagenesis of a critical lysine 262.
Bohren KM, Page JL, Shankar R, Henry SP, Gabbay KH.
J Biol Chem. 1991 Dec 15;266(35):24031-7.
Effect of puberty on insulinlike growth factor I and HbA1 in type I diabetes.
Rogers DG, Sherman LD, Gabbay KH.
Diabetes Care. 1991 Nov;14(11):1031-5.
Multigenic basis for type I diabetes. Association of HRAS1 polymorphism with HLA-DR3, DQw2/DR4, DQw8.
Owerbach D, Gunn S, Gabbay KH.
Diabetes. 1990 Dec;39(12):1504-9.
Two unrelated patients with familial hyperproinsulinemia due to a mutation substituting histidine for arginine at position 65 in the proinsulin molecule: identification of the mutation by direct sequencing of genomic deoxyribonucleic acid amplified by polymerase chain reaction.
Barbetti F, Raben N, Kadowaki T, Cama A, Accili D, Gabbay KH, Merenich JA, Taylor SI, Roth J.
J Clin Endocrinol Metab. 1990 Jul;71(1):164-9.
Primary association of HLA-DQw8 with type I diabetes in DR4 patients.
Diabetes. 1989 Jul;38(7):942-5.
The aldo-keto reductase superfamily. cDNAs and deduced amino acid sequences of human aldehyde and aldose reductases.
Bohren KM, Bullock B, Wermuth B, Gabbay KH.
J Biol Chem. 1989 Jun 5;264(16):9547-51.
Human carbonyl reductase. Nucleotide sequence analysis of a cDNA and amino acid sequence of the encoded protein.
Wermuth B, Bohren KM, Heinemann G, von Wartburg JP, Gabbay KH.
J Biol Chem. 1988 Nov 5;263(31):16185-8.
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