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Chk1-mediated Cdc25A degradation as a critical mechanism for normal cell-cycle progression.

Goto H, Natsume T, Kanemaki MT, Kaito A, Wang S, Gabazza EC, Inagaki M, Mizoguchi A.

J Cell Sci. 2019 Jan 11. pii: jcs.223123. doi: 10.1242/jcs.223123. [Epub ahead of print]


Canagliflozin improves obesity and insulin resistance in a diabetic patient with Cushings disease undergoing postoperative steroid therapy: A case report.

Nishihama K, Furuta N, Maki K, Okano Y, Hashimoto R, Hotta Y, Uemura M, Yasuma T, Suzuki T, D'Alessandro-Gabazza CN, Yano Y, Gabazza EC.

Biomed Rep. 2018 Dec;9(6):497-502. doi: 10.3892/br.2018.1153. Epub 2018 Oct 1.


Role of Matrix Metalloproteinase-2 in Eosinophil-Mediated Airway Remodeling.

Kuwabara Y, Kobayashi T, D'Alessandro-Gabazza CN, Toda M, Yasuma T, Nishihama K, Takeshita A, Fujimoto H, Nagao M, Fujisawa T, Gabazza EC.

Front Immunol. 2018 Sep 20;9:2163. doi: 10.3389/fimmu.2018.02163. eCollection 2018.


Renal Injury during Long-Term Crizotinib Therapy.

Yasuma T, Kobayashi T, D'Alessandro-Gabazza CN, Fujimoto H, Ito K, Nishii Y, Nishihama K, Baffour Tonto P, Takeshita A, Toda M, Gabazza EC, Taguchi O, Yonemura S, Hataji O.

Int J Mol Sci. 2018 Sep 25;19(10). pii: E2902. doi: 10.3390/ijms19102902.


Identification of Halophilic Microbes in Lung Fibrotic Tissue by Oligotyping.

D'Alessandro-Gabazza CN, Méndez-García C, Hataji O, Westergaard S, Watanabe F, Yasuma T, Toda M, Fujimoto H, Nishihama K, Fujiwara K, Taguchi O, Kobayashi T, Mackie RI, Cann I, Gabazza EC.

Front Microbiol. 2018 Aug 30;9:1892. doi: 10.3389/fmicb.2018.01892. eCollection 2018.


Comparable immunoreactivity rates of PD-L1 in archival and recent specimens from non-small cell lung cancer.

Nakamura Y, Kobayashi T, Nishii Y, Suzuki Y, Saiki H, Ito K, Watanabe F, Nishihama K, Yasuma T, D'Alessandro-Gabazza CN, Katsuta K, Fujimoto H, Gabazza EC, Taguchi O, Hataji O.

Thorac Cancer. 2018 Nov;9(11):1476-1482. doi: 10.1111/1759-7714.12861. Epub 2018 Sep 12.


Risks of Treating Idiopathic Pulmonary Fibrosis with a TAM Receptor Kinase Inhibitor.

D'Alessandro-Gabazza CN, Kobayashi T, Gabazza EC.

Am J Respir Crit Care Med. 2018 Oct 1;198(7):970-971. doi: 10.1164/rccm.201805-0871LE. No abstract available.


Protein S Exacerbates Chronic Liver Injury and Fibrosis.

Totoki T, D' Alessandro-Gabazza CN, Toda M, Tonto PB, Takeshita A, Yasuma T, Nishihama K, Iwasa M, Horiki N, Takei Y, Gabazza EC.

Am J Pathol. 2018 May;188(5):1195-1203. doi: 10.1016/j.ajpath.2018.01.007. Epub 2018 Feb 16.


Mice overexpressing latent matrix metalloproteinase-2 develop lung emphysema after short-term exposure to cigarette smoke extract.

Onishi M, Kobayashi T, D'Alessandro-Gabazza CN, Fujimoto H, Chelakkot-Govindalayathil AL, Takahashi Y, Yasuma T, Nishihama K, Toda M, Takei Y, Taguchi O, Gabazza EC.

Biochem Biophys Res Commun. 2018 Feb 26;497(1):332-338. doi: 10.1016/j.bbrc.2018.02.081. Epub 2018 Feb 8.


Efficacy of osimertinib in a patient with non-small cell lung cancer harboring epithelial growth factor receptor exon 19 deletion/T790M mutation, with poor performance status.

Nishii Y, Hataji O, Ito K, Watanabe F, Kobayashi T, D'Alessandro-Gabazza C, Toda M, Taguchi O, Yamamoto N, Gabazza EC.

Mol Clin Oncol. 2018 Feb;8(2):246-249. doi: 10.3892/mco.2017.1522. Epub 2017 Nov 29.


Anti-apoptotic activity of human matrix metalloproteinase-2 attenuates diabetes mellitus.

Nishihama K, Yasuma T, Yano Y, D' Alessandro-Gabazza CN, Toda M, Hinneh JA, Baffour Tonto P, Takeshita A, Totoki T, Mifuji-Moroka R, Kobayashi T, Iwasa M, Takei Y, Morser J, Cann I, Gabazza EC.

Metabolism. 2018 May;82:88-99. doi: 10.1016/j.metabol.2018.01.016. Epub 2018 Jan 31.


A Retrospective Comparison of the Clinical Efficacy of Gefitinib, Erlotinib, and Afatinib in Japanese Patients With Non-Small Cell Lung Cancer.

Fujiwara A, Yoshida M, Fujimoto H, Nakahara H, Ito K, Nishihama K, Yasuma T, Hataji O, Taguchi O, D'Alessandro-Gabazza CN, Gabazza EC, Kobayashi T.

Oncol Res. 2018 Aug 23;26(7):1031-1036. doi: 10.3727/096504018X15151523767752. Epub 2018 Jan 10.


The Medicinal Mushroom, Grifola gargal, Ameliorates Allergic Bronchial Asthma.

Harada E, D'Alessandro-Gabazza CN, Toda M, Morizono T, Totoki T, Yasuma T, Nishihama K, Kobayashi T, Sumiya T, Kawagishi H, Gabazza EC.

J Med Food. 2018 Feb;21(2):136-145. doi: 10.1089/jmf.2017.4016. Epub 2017 Dec 20.


Recent studies move closer to answering questions about sequential therapy for anaplastic lymphoma kinase-rearranged non-small cell lung cancer.

Kobayashi T, Fujimoto H, D'Alessandro-Gabazza C, Gabazza EC, Hataji O.

J Thorac Dis. 2017 Sep;9(9):2847-2851. doi: 10.21037/jtd.2017.08.114. No abstract available.


Smart watch-based coaching with tiotropium and olodaterol ameliorates physical activity in patients with chronic obstructive pulmonary disease.

Hataji O, Nishii Y, Ito K, Sakaguchi T, Saiki H, Suzuki Y, D'Alessandro-Gabazza C, Fujimoto H, Kobayashi T, Gabazza EC, Taguchi O.

Exp Ther Med. 2017 Nov;14(5):4061-4064. doi: 10.3892/etm.2017.5088. Epub 2017 Sep 1.


Low dose of alcohol attenuates pro-atherosclerotic activity of thrombin.

Toda M, Totoki T, Nakamura C, Yasuma T, D' Alessandro-Gabazza CN, Mifuji-Moroka R, Nishihama K, Iwasa M, Horiki N, Gabazza EC, Takei Y.

Atherosclerosis. 2017 Oct;265:215-224. doi: 10.1016/j.atherosclerosis.2017.09.005. Epub 2017 Sep 5.


Comparison of Glucose Area Under the Curve Measured Using Minimally Invasive Interstitial Fluid Extraction Technology with Continuous Glucose Monitoring System in Diabetic Patients.

Uemura M, Yano Y, Suzuki T, Yasuma T, Sato T, Morimoto A, Hosoya S, Suminaka C, Nakajima H, Gabazza EC, Takei Y.

Diabetes Metab J. 2017 Aug;41(4):265-274. doi: 10.4093/dmj.2017.41.4.265.


Oligonucleotide-targeting periostin ameliorates pulmonary fibrosis.

Tomaru A, Kobayashi T, Hinneh JA, Baffour Tonto P, D'Alessandro-Gabazza CN, Fujimoto H, Fujiwara K, Takahashi Y, Ohnishi M, Yasuma T, Nishihama K, Yoshino M, Takao K, Toda M, Totoki T, Takei Y, Yoshikawa K, Taguchi O, Gabazza EC.

Gene Ther. 2017 Nov;24(11):706-716. doi: 10.1038/gt.2017.80. Epub 2017 Aug 18.


Inhibition of Cell Apoptosis and Amelioration of Pulmonary Fibrosis by Thrombomodulin.

Fujiwara K, Kobayashi T, Fujimoto H, Nakahara H, D'Alessandro-Gabazza CN, Hinneh JA, Takahashi Y, Yasuma T, Nishihama K, Toda M, Kajiki M, Takei Y, Taguchi O, Gabazza EC.

Am J Pathol. 2017 Oct;187(10):2312-2322. doi: 10.1016/j.ajpath.2017.06.013. Epub 2017 Jul 21.


β2 adrenergic agonist suppresses eosinophil-induced epithelial-to-mesenchymal transition of bronchial epithelial cells.

Kainuma K, Kobayashi T, D'Alessandro-Gabazza CN, Toda M, Yasuma T, Nishihama K, Fujimoto H, Kuwabara Y, Hosoki K, Nagao M, Fujisawa T, Gabazza EC.

Respir Res. 2017 May 2;18(1):79. doi: 10.1186/s12931-017-0563-4.


Efficacy of crizotinib in ALK fusion variants.

Kobayashi T, Fujimoto H, Gabazza EC.

J Thorac Dis. 2016 Oct;8(10):E1381-E1383. No abstract available.


Sequential Use of ALK Inhibitors: An Optional Approach.

Ito K, Hataji O, Fujimoto H, Kobayashi T, D'Alessandro-Gabazza CN, Gabazza EC.

J Thorac Oncol. 2016 Dec;11(12):e153-e154. doi: 10.1016/j.jtho.2016.10.005. No abstract available.


Erratum. Amelioration of Diabetes by Protein S. Diabetes 2016;65:1940-1951.

Yasuma T, Yano Y, D'Alessandro-Gabazza CN, Toda M, Gil-Bernabe P, Kobayashi T, Nishihama K, Hinneh JA, Mifuji-Moroka R, Roeen Z, Morser J, Cann I, Motoh I, Takei Y, Gabazza EC.

Diabetes. 2016 Dec;65(12):3812. Epub 2016 Nov 1. No abstract available.


Interleukin-33 induces mucin gene expression and goblet cell hyperplasia in human nasal epithelial cells.

Ishinaga H, Kitano M, Toda M, D'Alessandro-Gabazza CN, Gabazza EC, Shah SA, Takeuchi K.

Cytokine. 2017 Feb;90:60-65. doi: 10.1016/j.cyto.2016.10.010. Epub 2016 Oct 21.


Enhanced wound healing by topical application of ointment containing a low concentration of povidone-iodine.

Mitani O, Nishikawa A, Kurokawa I, Gabazza EC, Ikeda M, Mizutani H.

J Wound Care. 2016 Sep;25(9):521-9. doi: 10.12968/jowc.2016.25.9.521.


Restrictive IL-10 induction by an innocuous parainfluenza virus vector ameliorates nasal allergy.

Yamanaka K, Nakanishi T, Isono K, Hasegawa C, Inada H, Mizutani K, Matsushima Y, Okada K, Mabuchi T, Kondo M, Yamagiwa A, Kakeda M, Habe K, Nosaka T, Gabazza EC, Yamazaki H, Mizutani H, Kawano M.

J Allergy Clin Immunol. 2017 Feb;139(2):682-686.e7. doi: 10.1016/j.jaci.2016.05.044. Epub 2016 Jul 16. No abstract available.


Sequential Therapy with Crizotinib and Alectinib in ALK-Rearranged Non-Small Cell Lung Cancer-A Multicenter Retrospective Study.

Ito K, Hataji O, Kobayashi H, Fujiwara A, Yoshida M, D'Alessandro-Gabazza CN, Itani H, Tanigawa M, Ikeda T, Fujiwara K, Fujimoto H, Kobayashi T, Gabazza EC, Taguchi O, Yamamoto N.

J Thorac Oncol. 2017 Feb;12(2):390-396. doi: 10.1016/j.jtho.2016.07.022. Epub 2016 Aug 4.


A case of type 2 diabetes mellitus with metformin-associated lactic acidosis initially presenting the appearance of a sulfonylurea-related hypoglycemic attack.

Nishihama K, Maki K, Okano Y, Hashimoto R, Hotta Y, Uemura M, Yasuma T, Suzuki T, Hayashi T, Ishikawa E, Yano Y, Gabazza EC, Ito M, Takei Y.

Acute Med Surg. 2016 Aug 3;4(1):123-126. doi: 10.1002/ams2.233. eCollection 2017 Jan.


Smart watch for monitoring physical activity in patients with chronic obstructive pulmonary disease.

Hataji O, Kobayashi T, Gabazza EC.

Respir Investig. 2016 Jul;54(4):294-5. doi: 10.1016/j.resinv.2016.01.003. Epub 2016 Mar 17. No abstract available.


Association of Waist Circumference and Body Fat Weight with Insulin Resistance in Male Subjects with Normal Body Mass Index and Normal Glucose Tolerance.

Sasaki R, Yano Y, Yasuma T, Onishi Y, Suzuki T, Maruyama-Furuta N, Gabazza EC, Sumida Y, Takei Y.

Intern Med. 2016;55(11):1425-32. doi: 10.2169/internalmedicine.55.4100. Epub 2016 Jun 1.


Amelioration of Diabetes by Protein S.

Yasuma T, Yano Y, D'Alessandro-Gabazza CN, Toda M, Gil-Bernabe P, Kobayashi T, Nishihama K, Hinneh JA, Mifuji-Moroka R, Roeen Z, Morser J, Cann I, Motoh I, Takei Y, Gabazza EC.

Diabetes. 2016 Jul;65(7):1940-51. doi: 10.2337/db15-1404. Epub 2016 May 9. Erratum in: Diabetes. 2016 Nov 1;:.


"Pseudoprogression" of Pulmonary Pleomorphic Carcinoma during Nivolumab Therapy.

Ito K, Hataji O, Katsuta K, Kobayashi T, Gabazza EC, Yatabe Y, Taguchi O, Yamamoto N.

J Thorac Oncol. 2016 Oct;11(10):e117-9. doi: 10.1016/j.jtho.2016.05.002. Epub 2016 May 14. No abstract available.


Protein S is protective in pulmonary fibrosis.

Urawa M, Kobayashi T, D'Alessandro-Gabazza CN, Fujimoto H, Toda M, Roeen Z, Hinneh JA, Yasuma T, Takei Y, Taguchi O, Gabazza EC.

J Thromb Haemost. 2016 Aug;14(8):1588-99. doi: 10.1111/jth.13362. Epub 2016 Jun 22.


Jejunoiletitis Associated with Adult-onset Familial Mediterranean Fever.

Kitade T, Horiki N, Katsurahara M, Harada T, Tano S, Yamada R, Hamada Y, Inoue H, Gabazza EC, Hayashi H, Tanaka M, Takei Y.

Intern Med. 2016;55(9):1239. doi: 10.2169/internalmedicine.55.6365. Epub 2016 May 1. No abstract available.


Circulating fibrocytes correlate with the asthma control test score.

Kobayashi H, Naito M, Masuya M, Maruyama M, Urata K, Takahashi Y, Tomaru A, Fujiwara K, Ohnishi M, Takagi T, Kobayashi T, D'Alessandro-Gabazza C, Urawa M, Gabazza EC, Taguchi O, Takei Y.

Allergol Immunopathol (Madr). 2016 May-Jun;44(3):191-6. doi: 10.1016/j.aller.2015.09.007. Epub 2016 Jan 13.


Improvement in early diagnosis of Japanese spotted fever by using a novel Rick PCR system.

Kondo M, Akachi S, Kawano M, Yamanaka K, Yamagiwa A, Gabazza EC, Ando K, Mizutani H.

J Dermatol. 2015 Nov;42(11):1066-71. doi: 10.1111/1346-8138.13015. Epub 2015 Jul 1.


Usefulness of Small Intestinal Endoscopy in a Case of Adult-onset Familial Mediterranean Fever Associated with Jejunoileitis.

Kitade T, Horiki N, Katsurahara M, Totoki T, Harada T, Tano S, Yamada R, Hamada Y, Inoue H, Tanaka K, Gabazza EC, Hayashi H, Tanaka M, Takei Y.

Intern Med. 2015;54(11):1343-7. doi: 10.2169/internalmedicine.54.3690. Epub 2015 Jun 1.


Activated protein C modulates the proinflammatory activity of dendritic cells.

Matsumoto T, Matsushima Y, Toda M, Roeen Z, D'Alessandro-Gabazza CN, Hinneh JA, Harada E, Yasuma T, Yano Y, Urawa M, Kobayashi T, Taguchi O, Gabazza EC.

J Asthma Allergy. 2015 May 7;8:29-37. doi: 10.2147/JAA.S75261. eCollection 2015.


Effects of sugar-sweetened beverage intake on the development of type 2 diabetes mellitus in subjects with impaired glucose tolerance: the Mihama diabetes prevention study.

Teshima N, Shimo M, Miyazawa K, Konegawa S, Matsumoto A, Onishi Y, Sasaki R, Suzuki T, Yano Y, Matsumoto K, Yamada T, Gabazza EC, Takei Y, Sumida Y.

J Nutr Sci Vitaminol (Tokyo). 2015;61(1):14-9. doi: 10.3177/jnsv.61.14.


Amelioration of Atherosclerosis by the New Medicinal Mushroom Grifola gargal Singer.

Harada E, D'Alessandro-Gabazza CN, Toda M, Morizono T, Chelakkot-Govindalayathil AL, Roeen Z, Urawa M, Yasuma T, Yano Y, Sumiya T, Gabazza EC.

J Med Food. 2015 Aug;18(8):872-81. doi: 10.1089/jmf.2014.3315. Epub 2015 Mar 23.


Endoscopic findings and lesion distribution in amebic colitis.

Horiki N, Furukawa K, Kitade T, Sakuno T, Katsurahara M, Harada T, Tano S, Yamada R, Hamada Y, Inoue H, Tanaka K, Gabazza EC, Ishii N, Fukuda K, Omata F, Fujita Y, Tachibana H, Takei Y.

J Infect Chemother. 2015 Jun;21(6):444-8. doi: 10.1016/j.jiac.2015.02.004. Epub 2015 Feb 12.


Second and third-look endoscopy for the prevention of post-ESD bleeding.

Tano S, Horiki N, Omata F, Tanaka K, Hamada Y, Katsurahara M, Ninomiya K, Nishikawa K, Nojiri K, Yamada R, Inoue H, Gabazza EC, Katayama N, Takei Y.

Medicine (Baltimore). 2015 Feb;94(6):e491. doi: 10.1097/MD.0000000000000491.


Olopatadine, a non-sedating H1 antihistamine, decreases the nocturnal scratching without affecting sleep quality in atopic dermatitis.

Yamanaka K, Motomura E, Noro Y, Umeda K, Morikawa T, Umeda-Togami K, Omoto Y, Isoda K, Kondo M, Tsuda K, Okuda M, Gabazza EC, Mizutani H.

Exp Dermatol. 2015 Mar;24(3):227-9. doi: 10.1111/exd.12630.


Synergistic effect of bolus exposure to zinc oxide nanoparticles on bleomycin-induced secretion of pro-fibrotic cytokines without lasting fibrotic changes in murine lungs.

Wu W, Ichihara G, Hashimoto N, Hasegawa Y, Hayashi Y, Tada-Oikawa S, Suzuki Y, Chang J, Kato M, D'Alessandro-Gabazza CN, Gabazza EC, Ichihara S.

Int J Mol Sci. 2014 Dec 30;16(1):660-76. doi: 10.3390/ijms16010660.


Thrombomodulin inhibits the activation of eosinophils and mast cells.

Roeen Z, Toda M, D'Alessandro-Gabazza CN, Onishi M, Kobayashi T, Yasuma T, Urawa M, Taguchi O, Gabazza EC.

Cell Immunol. 2015 Jan;293(1):34-40. doi: 10.1016/j.cellimm.2014.11.005. Epub 2014 Dec 5.


Is there still hope for single therapies: how do we set up experimental systems to efficiently test combination therapies?

Joos GF, Gabazza EC.

Respirology. 2015 Jan;20(1):15-23. doi: 10.1111/resp.12438. Epub 2014 Nov 19. Review.


Protein S exacerbates alcoholic hepatitis by stimulating liver natural killer T cells.

Chelakkot-Govindalayathil AL, Mifuji-Moroka R, D'Alessandro-Gabazza CN, Toda M, Matsuda Y, Gil-Bernabe P, Roeen Z, Yasuma T, Yano Y, Gabazza EC, Iwasa M, Takei Y.

J Thromb Haemost. 2015 Jan;13(1):142-54. doi: 10.1111/jth.12789. Epub 2014 Dec 11.


Persistent release of IL-1s from skin is associated with systemic cardio-vascular disease, emaciation and systemic amyloidosis: the potential of anti-IL-1 therapy for systemic inflammatory diseases.

Yamanaka K, Nakanishi T, Saito H, Maruyama J, Isoda K, Yokochi A, Imanaka-Yoshida K, Tsuda K, Kakeda M, Okamoto R, Fujita S, Iwakura Y, Suzuki N, Ito M, Maruyama K, Gabazza EC, Yoshida T, Shimaoka M, Mizutani H.

PLoS One. 2014 Aug 13;9(8):e104479. doi: 10.1371/journal.pone.0104479. eCollection 2014.


Biologic therapy improves psoriasis by decreasing the activity of monocytes and neutrophils.

Yamanaka K, Umezawa Y, Yamagiwa A, Saeki H, Kondo M, Gabazza EC, Nakagawa H, Mizutani H.

J Dermatol. 2014 Aug;41(8):679-85. doi: 10.1111/1346-8138.12560.


Montelukast suppresses epithelial to mesenchymal transition of bronchial epithelial cells induced by eosinophils.

Hosoki K, Kainuma K, Toda M, Harada E, Chelakkot-Govindalayathila AL, Roeen Z, Nagao M, D'Alessandro-Gabazza CN, Fujisawa T, Gabazza EC.

Biochem Biophys Res Commun. 2014 Jul 4;449(3):351-6. doi: 10.1016/j.bbrc.2014.05.033. Epub 2014 May 17.


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