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Items: 37

1.

A peptide derived from melanotransferrin delivers a protein-based interleukin 1 receptor antagonist across the BBB and ameliorates neuropathic pain in a preclinical model.

Thom G, Tian MM, Hatcher JP, Rodrigo N, Burrell M, Gurrell I, Vitalis TZ, Abraham T, Jefferies WA, Webster CI, Gabathuler R.

J Cereb Blood Flow Metab. 2018 May 30:271678X18772998. doi: 10.1177/0271678X18772998. [Epub ahead of print]

PMID:
29845881
2.

Anti-cancer Antibody Trastuzumab-Melanotransferrin Conjugate (BT2111) for the Treatment of Metastatic HER2+ Breast Cancer Tumors in the Brain: an In-Vivo Study.

Nounou MI, Adkins CE, Rubinchik E, Terrell-Hall TB, Afroz M, Vitalis T, Gabathuler R, Tian MM, Lockman PR.

Pharm Res. 2016 Dec;33(12):2930-2942. Epub 2016 Aug 15.

3.

[New protein vectors for physiological transfer of therapeutic agents to the central nervous system].

Gabathuler R.

Biol Aujourdhui. 2012;206(3):191-203. doi: 10.1051/jbio/2012018. Epub 2012 Nov 22. Review. French.

PMID:
23171842
4.
5.

Transport characteristics of a novel peptide platform for CNS therapeutics.

Bertrand Y, Currie JC, Demeule M, Régina A, Ché C, Abulrob A, Fatehi D, Sartelet H, Gabathuler R, Castaigne JP, Stanimirovic D, Béliveau R.

J Cell Mol Med. 2010 Dec;14(12):2827-39. doi: 10.1111/j.1582-4934.2009.00930.x.

6.

Approaches to transport therapeutic drugs across the blood-brain barrier to treat brain diseases.

Gabathuler R.

Neurobiol Dis. 2010 Jan;37(1):48-57. doi: 10.1016/j.nbd.2009.07.028. Epub 2009 Aug 5. Review.

PMID:
19664710
7.

Blood-brain barrier transport of drugs for the treatment of brain diseases.

Gabathuler R.

CNS Neurol Disord Drug Targets. 2009 Jun;8(3):195-204. Review.

PMID:
19601817
8.

A unique carrier for delivery of therapeutic compounds beyond the blood-brain barrier.

Karkan D, Pfeifer C, Vitalis TZ, Arthur G, Ujiie M, Chen Q, Tsai S, Koliatis G, Gabathuler R, Jefferies WA.

PLoS One. 2008 Jun 25;3(6):e2469. doi: 10.1371/journal.pone.0002469. Erratum in: PLoS ONE. 2008;3(7). doi: 10.1371/annotation/40c256ca-5d98-4ca9-a388-c9dac8f20924. PLoS ONE. 2008;3(7). doi: 10.1371/annotation/a08f47c0-6236-4116-821f-fa68c6b9a182. PLoS ONE. 2008;3(7). doi: 10.1371/annotation/8183042c-af40-4227-8a00-8f362de22220.

9.

Antitumour activity of ANG1005, a conjugate between paclitaxel and the new brain delivery vector Angiopep-2.

Régina A, Demeule M, Ché C, Lavallée I, Poirier J, Gabathuler R, Béliveau R, Castaigne JP.

Br J Pharmacol. 2008 Sep;155(2):185-97. doi: 10.1038/bjp.2008.260. Epub 2008 Jun 23.

10.

Involvement of the low-density lipoprotein receptor-related protein in the transcytosis of the brain delivery vector angiopep-2.

Demeule M, Currie JC, Bertrand Y, Ché C, Nguyen T, Régina A, Gabathuler R, Castaigne JP, Béliveau R.

J Neurochem. 2008 Aug;106(4):1534-44. doi: 10.1111/j.1471-4159.2008.05492.x. Epub 2008 May 19.

11.

Identification and design of peptides as a new drug delivery system for the brain.

Demeule M, Régina A, Ché C, Poirier J, Nguyen T, Gabathuler R, Castaigne JP, Béliveau R.

J Pharmacol Exp Ther. 2008 Mar;324(3):1064-72. Epub 2007 Dec 21.

12.

Identification of a novel route of iron transcytosis across the mammalian blood-brain barrier.

Moroo I, Ujiie M, Walker BL, Tiong JW, Vitalis TZ, Karkan D, Gabathuler R, Moise AR, Jefferies WA.

Microcirculation. 2003 Dec;10(6):457-62.

PMID:
14745458
13.

The adenovirus E3-6.7K protein adopts diverse membrane topologies following posttranslational translocation.

Moise AR, Grant JR, Lippé R, Gabathuler R, Jefferies WA.

J Virol. 2004 Jan;78(1):454-63.

14.

Expression of melanotransferrin isoforms in human serum: relevance to Alzheimer's disease.

Desrosiers RR, Bertrand Y, Nguyen QT, Demeule M, Gabathuler R, Kennard ML, Gauthier S, Béliveau R.

Biochem J. 2003 Sep 1;374(Pt 2):463-71.

15.

Regulation of plasminogen activation: a role for melanotransferrin (p97) in cell migration.

Demeule M, Bertrand Y, Michaud-Levesque J, Jodoin J, Rolland Y, Gabathuler R, Béliveau R.

Blood. 2003 Sep 1;102(5):1723-31. Epub 2003 May 15.

16.

High transcytosis of melanotransferrin (P97) across the blood-brain barrier.

Demeule M, Poirier J, Jodoin J, Bertrand Y, Desrosiers RR, Dagenais C, Nguyen T, Lanthier J, Gabathuler R, Kennard M, Jefferies WA, Karkan D, Tsai S, Fenart L, Cecchelli R, Béliveau R.

J Neurochem. 2002 Nov;83(4):924-33.

17.

Serum p97 levels as an aid to identifying Alzheimer's disease.

Feldman H, Gabathuler R, Kennard M, Nurminen J, Levy D, Foti S, Foti D, Beattie BL, Jefferies WA.

J Alzheimers Dis. 2001 Oct;3(5):507-516.

PMID:
12214037
18.

TAP expression provides a general method for improving the recognition of malignant cells in vivo.

Alimonti J, Zhang QJ, Gabathuler R, Reid G, Chen SS, Jefferies WA.

Nat Biotechnol. 2000 May;18(5):515-20.

PMID:
10802618
19.

Differences in the expression and localization of human melanotransferrin in lepidopteran and dipteran insect cell lines.

Hegedus DD, Pfeifer TA, Theilmann DA, Kennard ML, Gabathuler R, Jefferies WA, Grigliatti TA.

Protein Expr Purif. 1999 Apr;15(3):296-307.

PMID:
10092489
21.

Surrogate antigen processing mediated by TAP-dependent antigenic peptide secretion.

Gabathuler R, Alimonti J, Zhang QJ, Kolaitis G, Reid G, Jefferies WA.

J Cell Biol. 1998 Jan 12;140(1):17-27.

22.

Expression of cell surface GPI-anchored human p97 in baculovirus-infected insect cells.

Kennard ML, Shimizu KY, Gabathuler R, Rothenberger S, Theilmann D, Jefferies WA.

Biotechnol Bioeng. 1997 Jul 5;55(1):41-53.

PMID:
18636443
23.

Novel peptide-binding proteins and peptide transport in normal and TAP-deficient microsomes.

Marusina K, Reid G, Gabathuler R, Jefferies W, Monaco JJ.

Biochemistry. 1997 Jan 28;36(4):856-63.

PMID:
9020784
24.

Pumping iron in the '90s.

Jefferies WA, Gabathuler R, Rothenberger S, Food M, Kennard ML.

Trends Cell Biol. 1996 Jun;6(6):223-8.

PMID:
15157460
25.

Reactive microglia specifically associated with amyloid plaques in Alzheimer's disease brain tissue express melanotransferrin.

Jefferies WA, Food MR, Gabathuler R, Rothenberger S, Yamada T, Yasuhara O, McGeer PL.

Brain Res. 1996 Mar 11;712(1):122-6.

PMID:
8705294
26.

Coincident expression and distribution of melanotransferrin and transferrin receptor in human brain capillary endothelium.

Rothenberger S, Food MR, Gabathuler R, Kennard ML, Yamada T, Yasuhara O, McGeer PL, Jefferies WA.

Brain Res. 1996 Mar 11;712(1):117-21.

PMID:
8705293
27.

A novel iron uptake mechanism mediated by GPI-anchored human p97.

Kennard ML, Richardson DR, Gabathuler R, Ponka P, Jefferies WA.

EMBO J. 1995 Sep 1;14(17):4178-86.

28.

Comparison of cell lines deficient in antigen presentation reveals a functional role for TAP-1 alone in antigen processing.

Gabathuler R, Reid G, Kolaitis G, Driscoll J, Jefferies WA.

J Exp Med. 1994 Oct 1;180(4):1415-25.

29.

Transport and expression in human melanomas of a transferrin-like glycosylphosphatidylinositol-anchored protein.

Food MR, Rothenberger S, Gabathuler R, Haidl ID, Reid G, Jefferies WA.

J Biol Chem. 1994 Jan 28;269(4):3034-40.

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35.

Abelson virus transformation of an interleukin 2-dependent antigen-specific T-cell line.

Cook WD, Fazekas de St Groth B, Miller JF, MacDonald HR, Gabathuler R.

Mol Cell Biol. 1987 Jul;7(7):2631-5.

36.

Interleukin 2 receptor traffic in a murine cytolytic T cell line.

Nabholz M, Combe MC, Corthésy P, Lowenthal J, Gabathuler R.

Eur J Immunol. 1987 Jun;17(6):783-90.

PMID:
3109923
37.

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