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Items: 30

1.

Protein kinase C (PKC) participates in acetaminophen hepatotoxicity through c-jun-N-terminal kinase (JNK)-dependent and -independent signaling pathways.

Saberi B, Ybanez MD, Johnson HS, Gaarde WA, Han D, Kaplowitz N.

Hepatology. 2014 Apr;59(4):1543-1554. doi: 10.1002/hep.26625. Epub 2014 Mar 3.

2.

Hepatic vascular endothelial growth factor regulates recruitment of rat liver sinusoidal endothelial cell progenitor cells.

Wang L, Wang X, Wang L, Chiu JD, van de Ven G, Gaarde WA, Deleve LD.

Gastroenterology. 2012 Dec;143(6):1555-1563.e2. doi: 10.1053/j.gastro.2012.08.008. Epub 2012 Aug 15.

3.

Unique O-methoxyethyl ribose-DNA chimeric oligonucleotide induces an atypical melanoma differentiation-associated gene 5-dependent induction of type I interferon response.

Burel SA, Machemer T, Ragone FL, Kato H, Cauntay P, Greenlee S, Salim A, Gaarde WA, Hung G, Peralta R, Freier SM, Henry SP.

J Pharmacol Exp Ther. 2012 Jul;342(1):150-62. doi: 10.1124/jpet.112.193789. Epub 2012 Apr 13.

PMID:
22505629
4.

Role of differentiation of liver sinusoidal endothelial cells in progression and regression of hepatic fibrosis in rats.

Xie G, Wang X, Wang L, Wang L, Atkinson RD, Kanel GC, Gaarde WA, Deleve LD.

Gastroenterology. 2012 Apr;142(4):918-927.e6. doi: 10.1053/j.gastro.2011.12.017. Epub 2011 Dec 16.

5.

Silencing glycogen synthase kinase-3beta inhibits acetaminophen hepatotoxicity and attenuates JNK activation and loss of glutamate cysteine ligase and myeloid cell leukemia sequence 1.

Shinohara M, Ybanez MD, Win S, Than TA, Jain S, Gaarde WA, Han D, Kaplowitz N.

J Biol Chem. 2010 Mar 12;285(11):8244-55. doi: 10.1074/jbc.M109.054999. Epub 2010 Jan 8.

6.

Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance.

Singh R, Wang Y, Xiang Y, Tanaka KE, Gaarde WA, Czaja MJ.

Hepatology. 2009 Jan;49(1):87-96. doi: 10.1002/hep.22578.

7.

Regulation of H(2)O(2)-induced necrosis by PKC and AMP-activated kinase signaling in primary cultured hepatocytes.

Saberi B, Shinohara M, Ybanez MD, Hanawa N, Gaarde WA, Kaplowitz N, Han D.

Am J Physiol Cell Physiol. 2008 Jul;295(1):C50-63. doi: 10.1152/ajpcell.90654.2007. Epub 2008 May 7.

8.

Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury.

Hanawa N, Shinohara M, Saberi B, Gaarde WA, Han D, Kaplowitz N.

J Biol Chem. 2008 May 16;283(20):13565-77. doi: 10.1074/jbc.M708916200. Epub 2008 Mar 12.

9.

Anti-inflammatory activity of inhaled IL-4 receptor-alpha antisense oligonucleotide in mice.

Karras JG, Crosby JR, Guha M, Tung D, Miller DA, Gaarde WA, Geary RS, Monia BP, Gregory SA.

Am J Respir Cell Mol Biol. 2007 Mar;36(3):276-85. Epub 2006 Sep 21.

PMID:
16990616
10.

c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity.

Gunawan BK, Liu ZX, Han D, Hanawa N, Gaarde WA, Kaplowitz N.

Gastroenterology. 2006 Jul;131(1):165-78.

PMID:
16831600
11.

Ezrin/radixin/moesin proteins are phosphorylated by TNF-alpha and modulate permeability increases in human pulmonary microvascular endothelial cells.

Koss M, Pfeiffer GR 2nd, Wang Y, Thomas ST, Yerukhimovich M, Gaarde WA, Doerschuk CM, Wang Q.

J Immunol. 2006 Jan 15;176(2):1218-27.

12.

MKK3 and -6-dependent activation of p38alpha MAP kinase is required for cytoskeletal changes in pulmonary microvascular endothelial cells induced by ICAM-1 ligation.

Wang Q, Yerukhimovich M, Gaarde WA, Popoff IJ, Doerschuk CM.

Am J Physiol Lung Cell Mol Physiol. 2005 Feb;288(2):L359-69. Epub 2004 Oct 29.

13.

Reduction in glucagon receptor expression by an antisense oligonucleotide ameliorates diabetic syndrome in db/db mice.

Liang Y, Osborne MC, Monia BP, Bhanot S, Gaarde WA, Reed C, She P, Jetton TL, Demarest KT.

Diabetes. 2004 Feb;53(2):410-7.

14.

Inhibition of cell proliferation and cell cycle progression by specific inhibition of basal JNK activity: evidence that mitotic Bcl-2 phosphorylation is JNK-independent.

Du L, Lyle CS, Obey TB, Gaarde WA, Muir JA, Bennett BL, Chambers TC.

J Biol Chem. 2004 Mar 19;279(12):11957-66. Epub 2004 Jan 2.

15.

Activation of SRC tyrosine kinases in response to ICAM-1 ligation in pulmonary microvascular endothelial cells.

Wang Q, Pfeiffer GR 2nd, Gaarde WA.

J Biol Chem. 2003 Nov 28;278(48):47731-43. Epub 2003 Sep 22.

16.

Shear-induced cyclooxygenase-2 via a JNK2/c-Jun-dependent pathway regulates prostaglandin receptor expression in chondrocytic cells.

Abulencia JP, Gaspard R, Healy ZR, Gaarde WA, Quackenbush J, Konstantopoulos K.

J Biol Chem. 2003 Aug 1;278(31):28388-94. Epub 2003 May 12.

17.

Targets of c-Jun NH(2)-terminal kinase 2-mediated tumor growth regulation revealed by serial analysis of gene expression.

Potapova O, Anisimov SV, Gorospe M, Dougherty RH, Gaarde WA, Boheler KR, Holbrook NJ.

Cancer Res. 2002 Jun 1;62(11):3257-63.

18.

Specific inhibition of PTEN expression reverses hyperglycemia in diabetic mice.

Butler M, McKay RA, Popoff IJ, Gaarde WA, Witchell D, Murray SF, Dean NM, Bhanot S, Monia BP.

Diabetes. 2002 Apr;51(4):1028-34.

19.
20.

Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase.

Bulavin DV, Higashimoto Y, Popoff IJ, Gaarde WA, Basrur V, Potapova O, Appella E, Fornace AJ Jr.

Nature. 2001 May 3;411(6833):102-7.

PMID:
11333986
21.

Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress.

Buschmann T, Potapova O, Bar-Shira A, Ivanov VN, Fuchs SY, Henderson S, Fried VA, Minamoto T, Alarcon-Vargas D, Pincus MR, Gaarde WA, Holbrook NJ, Shiloh Y, Ronai Z.

Mol Cell Biol. 2001 Apr;21(8):2743-54.

22.

Vinblastine-induced phosphorylation of Bcl-2 and Bcl-XL is mediated by JNK and occurs in parallel with inactivation of the Raf-1/MEK/ERK cascade.

Fan M, Goodwin M, Vu T, Brantley-Finley C, Gaarde WA, Chambers TC.

J Biol Chem. 2000 Sep 29;275(39):29980-5.

23.

c-Jun N-terminal kinase is essential for growth of human T98G glioblastoma cells.

Potapova O, Gorospe M, Bost F, Dean NM, Gaarde WA, Mercola D, Holbrook NJ.

J Biol Chem. 2000 Aug 11;275(32):24767-75.

24.

Elucidating cell signaling mechanisms using antisense technology.

Koller E, Gaarde WA, Monia BP.

Trends Pharmacol Sci. 2000 Apr;21(4):142-8. Review.

PMID:
10740290
25.

Inhibition of c-Jun N-terminal kinase 2 expression suppresses growth and induces apoptosis of human tumor cells in a p53-dependent manner.

Potapova O, Gorospe M, Dougherty RH, Dean NM, Gaarde WA, Holbrook NJ.

Mol Cell Biol. 2000 Mar;20(5):1713-22.

26.
27.

SP100030 is a novel T-cell-specific transcription factor inhibitor that possesses immunosuppressive activity in vivo.

Goldman ME, Ransone LJ, Anderson DW, Gaarde WA, Suto MJ, Sullivan RW, Shorthouse R, Morikawa M, Morris RE.

Transplant Proc. 1996 Dec;28(6):3106-9. No abstract available.

PMID:
8962204
28.

Role of transforming growth factor beta and decorin in controlling fibrosis.

Harper JR, Spiro RC, Gaarde WA, Tamura RN, Pierschbacher MD, Noble NA, Stecker KK, Border WA.

Methods Enzymol. 1994;245:241-54. No abstract available.

PMID:
7760736
29.
30.

Parameters altering the success of the one-anastomosis rat heart-lung transplant.

Scott MH, D'Silva M, Gaarde WA, Leisten JC, Sadoff JA, Axtelle TS, Hahn GS, Plummer JM, Chang ES, Lee S.

Microsurgery. 1987;8(4):225-9.

PMID:
3123870

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