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T cell cytolytic capacity is independent of initial stimulation strength.

Richard AC, Lun ATL, Lau WWY, Göttgens B, Marioni JC, Griffiths GM.

Nat Immunol. 2018 Jul 16. doi: 10.1038/s41590-018-0160-9. [Epub ahead of print]


Impact of performance in a mandatory postgraduate surgical examination on selection into specialty training.

Scrimgeour DSG, Cleland J, Lee AJ, Griffiths G, McKinley AJ, Marx C, Brennan PA.

BJS Open. 2017 Aug 29;1(3):67-74. doi: 10.1002/bjs5.7. eCollection 2017 Jun.


Land Cover and Climate Change May Limit Invasiveness of Rhododendron ponticum in Wales.

Manzoor SA, Griffiths G, Iizuka K, Lukac M.

Front Plant Sci. 2018 May 18;9:664. doi: 10.3389/fpls.2018.00664. eCollection 2018.


Murine alveolar epithelial cells and their lentivirus-mediated immortalisation.

Sapich S, Hittinger M, Hendrix-Jastrzebski R, Repnik U, Griffiths G, May T, Wirth D, Bals R, Schneider-Daum N, Lehr CM.

Altern Lab Anim. 2018 May;46(2):73-89.


Species distribution model transferability and model grain size - finer may not always be better.

Manzoor SA, Griffiths G, Lukac M.

Sci Rep. 2018 May 8;8(1):7168. doi: 10.1038/s41598-018-25437-1.


MENOS4 trial: a multicentre randomised controlled trial (RCT) of a breast care nurse delivered cognitive behavioural therapy (CBT) intervention to reduce the impact of hot flushes in women with breast cancer: Study Protocol.

Fenlon D, Nuttall J, May C, Raftery J, Fields J, Kirkpatrick E, Abab J, Ellis M, Rose T, Khambhaita P, Galanopoulou A, Maishman T, Haviland J, Griffiths G, Turner L, Hunter M.

BMC Womens Health. 2018 May 8;18(1):63. doi: 10.1186/s12905-018-0550-z.


CONFIRM: a double-blind, placebo-controlled phase III clinical trial investigating the effect of nivolumab in patients with relapsed mesothelioma: study protocol for a randomised controlled trial.

Fennell DA, Kirkpatrick E, Cozens K, Nye M, Lester J, Hanna G, Steele N, Szlosarek P, Danson S, Lord J, Ottensmeier C, Barnes D, Hill S, Kalevras M, Maishman T, Griffiths G.

Trials. 2018 Apr 18;19(1):233. doi: 10.1186/s13063-018-2602-y.


An early history of T cell-mediated cytotoxicity.

Golstein P, Griffiths GM.

Nat Rev Immunol. 2018 Apr 16. doi: 10.1038/s41577-018-0009-3. [Epub ahead of print] Review.


Fas Ligand localizes to intraluminal vesicles within NK cell cytolytic granules and is enriched at the immune synapse.

Lee J, Dieckmann NMG, Edgar JR, Griffiths GM, Siegel RM.

Immun Inflamm Dis. 2018 Jun;6(2):312-321. doi: 10.1002/iid3.219. Epub 2018 Apr 11.


SPIRE - combining SGI-110 with cisplatin and gemcitabine chemotherapy for solid malignancies including bladder cancer: study protocol for a phase Ib/randomised IIa open label clinical trial.

Crabb S, Danson SJ, Catto JWF, McDowell C, Lowder JN, Caddy J, Dunkley D, Rajaram J, Ellis D, Hill S, Hathorn D, Whitehead A, Kalevras M, Huddart R, Griffiths G.

Trials. 2018 Apr 3;19(1):216. doi: 10.1186/s13063-018-2586-7.


Development and Application of High-Content Biological Screening for Modulators of NET Production.

Chicca IJ, Milward MR, Chapple ILC, Griffiths G, Benson R, Dietrich T, Cooper PR.

Front Immunol. 2018 Mar 5;9:337. doi: 10.3389/fimmu.2018.00337. eCollection 2018.


High content screening of patient-derived cell lines highlights the potential of non-standard chemotherapeutic agents for the treatment of glioblastoma.

Yu KK, Taylor JT, Pathmanaban ON, Youshani AS, Beyit D, Dutko-Gwozdz J, Benson R, Griffiths G, Peers I, Cueppens P, Telfer BA, Williams KJ, McBain C, Kamaly-Asl ID, Bigger BW.

PLoS One. 2018 Mar 2;13(3):e0193694. doi: 10.1371/journal.pone.0193694. eCollection 2018.


Cancer cachexia: rationale for the MENAC (Multimodal-Exercise, Nutrition and Anti-inflammatory medication for Cachexia) trial.

Solheim TS, Laird BJA, Balstad TR, Bye A, Stene G, Baracos V, Strasser F, Griffiths G, Maddocks M, Fallon M, Kaasa S, Fearon K.

BMJ Support Palliat Care. 2018 Feb 9. pii: bmjspcare-2017-001440. doi: 10.1136/bmjspcare-2017-001440. [Epub ahead of print] Review.


Phthiocerol dimycocerosates promote access to the cytosol and intracellular burden of Mycobacterium tuberculosis in lymphatic endothelial cells.

Lerner TR, Queval CJ, Fearns A, Repnik U, Griffiths G, Gutierrez MG.

BMC Biol. 2018 Jan 4;16(1):1. doi: 10.1186/s12915-017-0471-6.


Excision of nonmelanoma skin cancer overlying arteriovenous fistulae.

O'Brennan EA, Severn A, Griffiths G, Affleck A.

Clin Exp Dermatol. 2018 Jun;43(4):471-472. doi: 10.1111/ced.13339. Epub 2017 Dec 20. No abstract available.


Effect of ornithine decarboxylase and norspermidine in modulating cell division in the green alga Chlamydomonas reinhardtii.

Tassoni A, Awad N, Griffiths G.

Plant Physiol Biochem. 2018 Feb;123:125-131. doi: 10.1016/j.plaphy.2017.12.014. Epub 2017 Dec 7.


Association between miR-31-3p expression and cetuximab efficacy in patients with KRAS wild-type metastatic colorectal cancer: a post-hoc analysis of the New EPOC trial.

Pugh S, Thiébaut R, Bridgewater J, Grisoni ML, Moutasim K, Rousseau F, Thomas GJ, Griffiths G, Liebaert F, Primrose J, Laurent-Puig P.

Oncotarget. 2017 Sep 27;8(55):93856-93866. doi: 10.18632/oncotarget.21291. eCollection 2017 Nov 7.


Co-culture of human alveolar epithelial (hAELVi) and macrophage (THP-1) cell lines.

Kletting S, Barthold S, Repnik U, Griffiths G, Loretz B, Schneider-Daum N, de Souza Carvalho-Wodarz C, Lehr CM.

ALTEX. 2018;35(2):211-222. doi: 10.14573/altex.1607191. Epub 2017 Nov 23.


Production, Characterisation and Testing of an Ovine Antitoxin against Ricin; Efficacy, Potency and Mechanisms of Action.

Whitfield SJC, Griffiths GD, Jenner DC, Gwyther RJ, Stahl FM, Cork LJ, Holley JL, Green AC, Clark GC.

Toxins (Basel). 2017 Oct 18;9(10). pii: E329. doi: 10.3390/toxins9100329.


Targeting neutrophils for host-directed therapy to treat tuberculosis.

Dallenga T, Linnemann L, Paudyal B, Repnik U, Griffiths G, Schaible UE.

Int J Med Microbiol. 2017 Oct 7. pii: S1438-4221(17)30329-6. doi: 10.1016/j.ijmm.2017.10.001. [Epub ahead of print] Review.


M. tuberculosis-Induced Necrosis of Infected Neutrophils Promotes Bacterial Growth Following Phagocytosis by Macrophages.

Dallenga T, Repnik U, Corleis B, Eich J, Reimer R, Griffiths GW, Schaible UE.

Cell Host Microbe. 2017 Oct 11;22(4):519-530.e3. doi: 10.1016/j.chom.2017.09.003.


Poly(I:C)-Encapsulating Nanoparticles Enhance Innate Immune Responses to the Tuberculosis Vaccine Bacille Calmette-Guérin (BCG) via Synergistic Activation of Innate Immune Receptors.

Speth MT, Repnik U, Müller E, Spanier J, Kalinke U, Corthay A, Griffiths G.

Mol Pharm. 2017 Nov 6;14(11):4098-4112. doi: 10.1021/acs.molpharmaceut.7b00795. Epub 2017 Oct 19.


Seeing is understanding: Salmonella's way to penetrate the intestinal epithelium.

Zhang K, Griffiths G, Repnik U, Hornef M.

Int J Med Microbiol. 2017 Sep 14. pii: S1438-4221(17)30370-3. doi: 10.1016/j.ijmm.2017.09.011. [Epub ahead of print] Review.


Uva-ursi extract and ibuprofen as alternative treatments of adult female urinary tract infection (ATAFUTI): study protocol for a randomised controlled trial.

Trill J, Simpson C, Webley F, Radford M, Stanton L, Maishman T, Galanopoulou A, Flower A, Eyles C, Willcox M, Hay A, Griffiths G, Little P, Lewith G, Moore M.

Trials. 2017 Sep 8;18(1):421. doi: 10.1186/s13063-017-2145-7.


L-leucyl-L-leucine methyl ester does not release cysteine cathepsins to the cytosol but inactivates them in transiently permeabilized lysosomes.

Repnik U, Borg Distefano M, Speth MT, Ng MYW, Progida C, Hoflack B, Gruenberg J, Griffiths G.

J Cell Sci. 2017 Sep 15;130(18):3124-3140. doi: 10.1242/jcs.204529. Epub 2017 Jul 28.


Sensitive Detection of MMP9 Enzymatic Activities in Single Cell-Encapsulated Microdroplets as an Assay of Cancer Cell Invasiveness.

Yu Z, Zhou L, Zhang T, Shen R, Li C, Fang X, Griffiths G, Liu J.

ACS Sens. 2017 May 26;2(5):626-634. doi: 10.1021/acssensors.6b00731. Epub 2017 Mar 24.


Cortical actin recovery at the immunological synapse leads to termination of lytic granule secretion in cytotoxic T lymphocytes.

Ritter AT, Kapnick SM, Murugesan S, Schwartzberg PL, Griffiths GM, Lippincott-Schwartz J.

Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):E6585-E6594. doi: 10.1073/pnas.1710751114. Epub 2017 Jul 17.


Investigation of a Novel Predictive Biomarker Profile for the Outcome of Periodontal Treatment.

Gul SS, Griffiths GS, Stafford GP, Al-Zubidi MI, Rawlinson A, Douglas CWI.

J Periodontol. 2017 Nov;88(11):1135-1144. doi: 10.1902/jop.2017.170187. Epub 2017 Jul 3.


Treatment of Francisella infections via PLGA- and lipid-based nanoparticle delivery of antibiotics in a zebrafish model.

Ulanova LS, Pinheiro M, Vibe C, Nunes C, Misaghian D, Wilson S, Zhu K, Fenaroli F, Winther-Larsen HC, Reis S, Griffiths G.

Dis Aquat Organ. 2017 Jun 19;125(1):19-29. doi: 10.3354/dao03129.


Long-term results and recurrence patterns from SCALOP: a phase II randomised trial of gemcitabine- or capecitabine-based chemoradiation for locally advanced pancreatic cancer.

Hurt CN, Falk S, Crosby T, McDonald A, Ray R, Joseph G, Staffurth J, Abrams RA, Griffiths G, Maughan T, Mukherjee S.

Br J Cancer. 2017 May 9;116(10):1264-1270. doi: 10.1038/bjc.2017.95. Epub 2017 Apr 4.


NEOSCOPE: A randomised phase II study of induction chemotherapy followed by oxaliplatin/capecitabine or carboplatin/paclitaxel based pre-operative chemoradiation for resectable oesophageal adenocarcinoma.

Mukherjee S, Hurt CN, Gwynne S, Sebag-Montefiore D, Radhakrishna G, Gollins S, Hawkins M, Grabsch HI, Jones G, Falk S, Sharma R, Bateman A, Roy R, Ray R, Canham J, Griffiths G, Maughan T, Crosby T.

Eur J Cancer. 2017 Mar;74:38-46. doi: 10.1016/j.ejca.2016.11.031. Epub 2017 Feb 8.


Interference of the T Cell and Antigen-Presenting Cell Costimulatory Pathway Using CTLA4-Ig (Abatacept) Prevents Staphylococcal Enterotoxin B Pathology.

Whitfield SJC, Taylor C, Risdall JE, Griffiths GD, Jones JTA, Williamson ED, Rijpkema S, Saraiva L, Vessillier S, Green AC, Carter AJ.

J Immunol. 2017 May 15;198(10):3989-3998. doi: 10.4049/jimmunol.1601525. Epub 2017 Mar 20.


Imaging the Effector CD8 Synapse.

Frazer GL, Asano Y, Griffiths GM.

Methods Mol Biol. 2017;1584:473-486. doi: 10.1007/978-1-4939-6881-7_29.


Mycobacterium tuberculosis replicates within necrotic human macrophages.

Lerner TR, Borel S, Greenwood DJ, Repnik U, Russell MR, Herbst S, Jones ML, Collinson LM, Griffiths G, Gutierrez MG.

J Cell Biol. 2017 Mar 6;216(3):583-594. doi: 10.1083/jcb.201603040. Epub 2017 Feb 27.


Inducible T Cell Kinase Regulates the Acquisition of Cytolytic Capacity and Degranulation in CD8+ CTLs.

Kapnick SM, Stinchcombe JC, Griffiths GM, Schwartzberg PL.

J Immunol. 2017 Apr 1;198(7):2699-2711. doi: 10.4049/jimmunol.1601202. Epub 2017 Feb 17.


Long-term results and recurrence patterns from SCOPE-1: a phase II/III randomised trial of definitive chemoradiotherapy +/- cetuximab in oesophageal cancer.

Crosby T, Hurt CN, Falk S, Gollins S, Staffurth J, Ray R, Bridgewater JA, Geh JI, Cunningham D, Blazeby J, Roy R, Maughan T, Griffiths G, Mukherjee S.

Br J Cancer. 2017 Mar 14;116(6):709-716. doi: 10.1038/bjc.2017.21. Epub 2017 Feb 14.


PTRH2 gene mutation causes progressive congenital skeletal muscle pathology.

Doe J, Kaindl AM, Jijiwa M, de la Vega M, Hu H, Griffiths GS, Fontelonga TM, Barraza P, Cruz V, Van Ry P, Ramos JW, Burkin DJ, Matter ML.

Hum Mol Genet. 2017 Apr 15;26(8):1458-1464. doi: 10.1093/hmg/ddx048.


ProCAID: a phase I clinical trial to combine the AKT inhibitor AZD5363 with docetaxel and prednisolone chemotherapy for metastatic castration resistant prostate cancer.

Crabb SJ, Birtle AJ, Martin K, Downs N, Ratcliffe I, Maishman T, Ellis M, Griffiths G, Thompson S, Ksiazek L, Khoo V, Jones RJ.

Invest New Drugs. 2017 Oct;35(5):599-607. doi: 10.1007/s10637-017-0433-4. Epub 2017 Feb 1.


Changing Objective Structured Clinical Examinations Stations at Lunchtime During All Day Postgraduate Surgery Examinations Improves Examiner Morale and Stress.

Brennan PA, Scrimgeour DS, Patel S, Patel R, Griffiths G, Croke DT, Smith L, Arnett R.

J Surg Educ. 2017 Jul - Aug;74(4):736-747. doi: 10.1016/j.jsurg.2016.12.013. Epub 2017 Jan 26.


Immediate chest X-ray for patients at risk of lung cancer presenting in primary care: randomised controlled feasibility trial.

Neal RD, Barham A, Bongard E, Edwards RT, Fitzgibbon J, Griffiths G, Hamilton W, Hood K, Nelson A, Parker D, Porter C, Prout H, Roberts K, Rogers T, Thomas-Jones E, Tod A, Yeo ST, Hurt CN.

Br J Cancer. 2017 Jan;116(3):293-302. doi: 10.1038/bjc.2016.414. Epub 2017 Jan 10.


Meta-analysis of operative experiences of general surgery trainees during training.

Elsey EJ, Griffiths G, Humes DJ, West J.

Br J Surg. 2017 Jan;104(1):22-33. doi: 10.1002/bjs.10396. Review.


Savanna burning methodology for fire management and emissions reduction: a critical review of influencing factors.

Maraseni TN, Reardon-Smith K, Griffiths G, Apan A.

Carbon Balance Manag. 2016 Nov 16;11(1):25. eCollection 2016 Dec. Review.


Layer-by-layer nanocoating of live Bacille-Calmette-Guérin mycobacteria with poly(I:C) and chitosan enhances pro-inflammatory activation and bactericidal capacity in murine macrophages.

Speth MT, Repnik U, Griffiths G.

Biomaterials. 2016 Dec;111:1-12. doi: 10.1016/j.biomaterials.2016.09.027. Epub 2016 Sep 30.


Secretion from Myeloid Cells: Secretory Lysosomes.

Griffiths GM.

Microbiol Spectr. 2016 Aug;4(4). doi: 10.1128/microbiolspec.MCHD-0030-2016. Review.


Analysis of cornea curvature using radial basis functions - Part I: Methodology.

Griffiths GW, Płociniczak Ł, Schiesser WE.

Comput Biol Med. 2016 Oct 1;77:274-84. doi: 10.1016/j.compbiomed.2016.08.011. Epub 2016 Aug 15.


Analysis of cornea curvature using radial basis functions - Part II: Fitting to data-set.

Griffiths GW, Płociniczak Ł, Schiesser WE.

Comput Biol Med. 2016 Oct 1;77:285-96. doi: 10.1016/j.compbiomed.2016.06.008. Epub 2016 Jun 16.


The cytotoxic T lymphocyte immune synapse at a glance.

Dieckmann NM, Frazer GL, Asano Y, Stinchcombe JC, Griffiths GM.

J Cell Sci. 2016 Aug 1;129(15):2881-6. doi: 10.1242/jcs.186205. Review.


Development of a Decision Tree to Streamline Infrainguinal Vein Graft Surveillance.

McBride OMB, Mofidi R, Griffiths GD, Dawson AR, Chalmers RTA, Stonebridge PA.

Ann Vasc Surg. 2016 Oct;36:182-189. doi: 10.1016/j.avsg.2016.02.031. Epub 2016 Jun 25.


Translocation of nanoparticles and Mycobacterium marinum across the intestinal epithelium in zebrafish and the role of the mucosal immune system.

Løvmo SD, Speth MT, Repnik U, Koppang EO, Griffiths GW, Hildahl JP.

Dev Comp Immunol. 2017 Feb;67:508-518. doi: 10.1016/j.dci.2016.06.016. Epub 2016 Jun 22.


Origins of the cytolytic synapse.

de la Roche M, Asano Y, Griffiths GM.

Nat Rev Immunol. 2016 Jul;16(7):421-32. doi: 10.1038/nri.2016.54. Epub 2016 Jun 6. Review.


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