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Items: 1 to 50 of 100

1.

Chemically reactive intermediates and pulmonary xenobiotic toxicity.

Gram TE.

Pharmacol Rev. 1997 Dec;49(4):297-341. Review.

PMID:
9443161
2.

Metabolic activation and toxicity of some chemical agents to lung tissue and cells.

Gram TE.

Biochem Pharmacol. 1995 Jun 16;49(12):1721-7. No abstract available.

PMID:
7598733
3.

Pulmonary toxicity of 4-ipomeanol.

Gram TE.

Pharmacol Ther. 1989;43(2):291-7. Review. No abstract available.

PMID:
2675137
4.

A possible role for membrane lipid peroxidation in anthracycline nephrotoxicity.

Mimnaugh EG, Trush MA, Gram TE.

Biochem Pharmacol. 1986 Dec 1;35(23):4327-35.

PMID:
3024646
5.
7.

Tissue distribution and covalent binding of [14C]1,1-dichloroethylene in mice: in vivo and in vitro studies.

Okine LK, Gram TE.

Adv Exp Med Biol. 1986;197:903-10. No abstract available.

PMID:
3766300
8.

The metabolism of xenobiotics by certain extrahepatic organs and its relation to toxicity.

Gram TE, Okine LK, Gram RA.

Annu Rev Pharmacol Toxicol. 1986;26:259-91. Review. No abstract available.

PMID:
3521457
9.
10.

The utility of changes in cardiac weight as an index of drug-induced cardiotoxicity.

Lowe MC, Gram TE, Guarino AM.

J Environ Pathol Toxicol Oncol. 1985 Sep-Oct;6(1):57-68.

PMID:
4067835
11.

Enhancement of reactive oxygen-dependent mitochondrial membrane lipid peroxidation by the anticancer drug adriamycin.

Mimnaugh EG, Trush MA, Bhatnagar M, Gram TE.

Biochem Pharmacol. 1985 Mar 15;34(6):847-56.

PMID:
3977958
12.

Selective damage to nonciliated bronchiolar epithelial cells in relation to impairment of pulmonary monooxygenase activities by 1,1-dichloroethylene in mice.

Krijgsheld KR, Lowe MC, Mimnaugh EG, Trush MA, Ginsburg E, Gram TE.

Toxicol Appl Pharmacol. 1984 Jun 30;74(2):201-13.

PMID:
6740671
13.
14.

Interaction of the oncolytic drug, 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea with the mixed-function oxidase system in rats.

Tong S, Hirokata Y, Litterst CL, Gram TE.

Chem Biol Interact. 1984 Apr;49(1-2):105-19.

PMID:
6722931
15.

A comparison of the pulmonary toxicity and chemotherapeutic activity of bleomycin-BAPP to bleomycin and pepleomycin.

Ginsburg E, Gram TE, Trush MA.

Cancer Chemother Pharmacol. 1984;12(2):111-5.

PMID:
6199131
17.

Enhancement of rat heart microsomal lipid peroxidation following doxorubicin treatment in vivo.

Mimnaugh EG, Trush MA, Gram TE.

Cancer Treat Rep. 1983 Jul-Aug;67(7-8):731-3.

PMID:
6871890
18.

Bleomycin-metal interaction: ferrous iron-initiated chemiluminescence.

Trush MA, Mimnaugh EG, Siddik ZH, Gram TE.

Biochem Biophys Res Commun. 1983 Apr 29;112(2):378-83.

PMID:
6189484
19.

Lung-selective impairment of cytochrome P-450-dependent monooxygenases and cellular injury by 1,1-dichloroethylene in mice.

Krijgsheld KR, Lowe MC, Mimnaugh EG, Trush MA, Ginsburg E, Gram TE.

Biochem Biophys Res Commun. 1983 Jan 27;110(2):675-81.

PMID:
6838545
20.

Bronchiolar epithelial damage and impairment of pulmonary microsomal monooxygenase activity in mice by naphthalene.

Tong SS, Lowe MC, Trush MA, Mimnaugh EG, Ginsburg E, Hirokata Y, Gram TE.

Exp Mol Pathol. 1982 Dec;37(3):358-69. No abstract available.

PMID:
7151981
21.

Activation of pharmacologic agents to radical intermediates. Implications for the role of free radicals in drug action and toxicity.

Trush MA, Mimnaugh EG, Gram TE.

Biochem Pharmacol. 1982 Nov 1;31(21):3335-46. Review. No abstract available.

PMID:
6756414
22.
23.
24.
25.
26.

Sex differences in the uptake and retention of imipramine and desmethylimipramine in the rat lung.

Ginsburg E, Hirokata Y, Gram TE.

Life Sci. 1982 Mar 1;30(9):757-60.

PMID:
7070230
27.

Sex-dependent differences in the effects of portacaval anastomosis on hepatic monooxygenases in rats.

Hirokata Y, Tong S, Siddik ZH, Trush MA, Mimnaugh EG, Gram TE.

Biochem Pharmacol. 1982 Feb 15;31(4):499-502.

PMID:
6802138
28.

The effects of adriamycin in vitro and in vivo on hepatic microsomal drug-metabolizing enzymes: role of microsomal lipid peroxidation.

Mimnaugh EG, Trush MA, Ginsburg E, Hirokata Y, Gram TE.

Toxicol Appl Pharmacol. 1981 Dec;61(3):313-25. No abstract available.

PMID:
6277041
29.

Stimulation by adriamycin of rat heart and liver microsomal NADPH-dependent lipid peroxidation.

Mimnaugh EG, Trush MA, Gram TE.

Biochem Pharmacol. 1981 Oct;30(20):2797-804. No abstract available.

PMID:
7317075
30.

In vitro stimulation by paraquat of reactive oxygen-mediated lipid peroxidation in rat lung microsomes.

Trush MA, Mimnaugh EG, Ginsburg E, Gram TE.

Toxicol Appl Pharmacol. 1981 Sep 15;60(2):279-86. No abstract available.

PMID:
7281188
31.

Species and dose differences in the accumulation of imipramine by mammalian lungs.

Drew R, Siddik ZH, Mimnaugh EG, Gram TE.

Drug Metab Dispos. 1981 Jul-Aug;9(4):322-6.

PMID:
6114830
32.

Clara cell damage and inhibition of pulmonary mixed-function oxidase activity by naphthalene.

Tong SS, Hirokata Y, Trush MA, Mimnaugh EG, Ginsburg E, Lowe MC, Gram TE.

Biochem Biophys Res Commun. 1981 Jun 16;100(3):944-50. No abstract available.

PMID:
6791646
33.

Metabolism and biliary excretion of sulfobromophthalein in vitamin A deficiency.

Siddik ZH, Drew R, Gram TE.

Biochem Pharmacol. 1980 Oct 1;29(19):2583-8. No abstract available.

PMID:
7426064
34.
35.

Relative pulmonary toxicity and antitumor effects of two new bleomycin analogs, pepleomycin and tallysomycin A.

Sikic BI, Siddik ZH, Gram TE.

Cancer Treat Rep. 1980 Apr-May;64(4-5):659-67.

PMID:
6159079
36.

Pulmonary accumulation of drugs in vitamin A deficiency.

Siddik ZH, Trush MA, Gram TE.

Lung. 1980;157(4):209-17. No abstract available.

PMID:
7401686
37.

Hepatic cytochrome P-450-dependent metabolism and enzymatic conjugation of foreign compounds in vitamin A-deficient rats.

Siddik ZH, Drew R, Litterst CL, Mimnaugh EG, Sikic BI, Gram TE.

Pharmacology. 1980;21(6):383-90.

PMID:
7220590
38.

The distribution of 14C-imipramine in mice bearing Lewis lung carcinoma.

Drew R, Sikic BI, Mimnaugh EG, Litterst CL, Gram TE.

Life Sci. 1979 Nov 19;25(21):1813-20. No abstract available.

PMID:
529988
39.

The effect of chlorpromazine on the uptake and efflux of paraquat in rat lung slices.

Siddik ZH, Drew R, Gram TE.

Toxicol Appl Pharmacol. 1979 Sep 30;50(3):443-50. No abstract available.

PMID:
516057
40.

Uptake and efflux of 14C-paraquat by rat lung slices: the effect of imipramine and other drugs.

Drew R, Siddik ZH, Gram TE.

Toxicol Appl Pharmacol. 1979 Jul;49(3):473-8. No abstract available.

PMID:
473214
41.

The effect of unilateral pneumonectomy on in vitro drug metabolism by the contralateral lung of rabbits.

Mimnaugh EG, Siddik ZH, Trush MA, Drew R, Gram TE.

Drug Metab Dispos. 1979 Jul-Aug;7(4):208-10.

PMID:
39721
42.

The effects of alpha-tocopherol on the toxicity, disposition, and metabolism of adriamycin in mice.

Mimnaugh EG, Siddik ZH, Drew R, Sikic BI, Gram TE.

Toxicol Appl Pharmacol. 1979 Jun 15;49(1):119-26. No abstract available.

PMID:
473197
43.

Vehicle alteration of paraquat lethality in mice.

Drew R, Gram TE.

Toxicol Appl Pharmacol. 1979 May;48(3):479-87. No abstract available.

PMID:
473191
44.

Lack of correlation between cortisol-induced precocious maturation of the fetal rabbit lung and drug metabolism.

Siddik ZH, Sikic BI, Drew R, Mimnaugh EG, Litterst CL, Gram TE.

Biochem Pharmacol. 1979 Mar 1;28(5):683-5. No abstract available.

PMID:
444254
45.

Improved therapeutic index of bleomycin when administered by continuous infusion in mice.

Sikic BI, Collins JM, Mimnaugh EG, Gram TE.

Cancer Treat Rep. 1978 Dec;62(12):2011-7.

PMID:
87269
46.

Mechanism of chloramphenicol prevention of carbon tetrachloride-induced liver damage.

Castro JA, de Ferreyra EC, de Castro CR, de Fenos OM, Gram TE, Reagan RL, Guarino AM.

Exp Mol Pathol. 1978 Jun;28(3):395-405. No abstract available.

PMID:
648626
47.

In vitro drug metabolism in male and female athymic, nude mice.

Litterst CL, Sikic BI, Mimnaugh EG, Guarino AM, Gram TE.

Life Sci. 1978 May 15;22(19):1723-30. No abstract available.

PMID:
672423
48.

Effect of whole-body hyperthermia on the disposition and metabolism of adriamycin in rabbits.

Mimnaugh EG, Waring RW, Sikic BI, Magin RL, Drew R, Litterst CL, Gram TE, Guarino AM.

Cancer Res. 1978 May;38(5):1420-5. No abstract available.

49.
50.

Effect of strain differences and tumor presence on microsomal drug metabolism in the guinea pig: brief communication.

Litterst CL, Mimnaugh EG, Gram TE.

J Natl Cancer Inst. 1977 Dec;59(6):1737-9.

PMID:
200761

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