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Items: 37


Efficacy and safety of the first-in-class imidazoline-2 receptor ligand CR4056 in pain from knee osteoarthritis and disease phenotypes: a randomized, double-blind, placebo-controlled phase 2 trial.

Rovati LC, Brambilla N, Blicharski T, Connell J, Vitalini C, Bonazzi A, Giacovelli G, Girolami F, D'Amato M.

Osteoarthritis Cartilage. 2019 Sep 14. pii: S1063-4584(19)31208-7. doi: 10.1016/j.joca.2019.09.002. [Epub ahead of print]


A nutraceutical combination reduces left ventricular mass in subjects with metabolic syndrome e and left ventricular hypertrophy: A multicenter, randomized, double-blind, placebo-controlled trial.

Mercurio V, Pucci G, Bosso G, Fazio V, Battista F, Iannuzzi A, Brambilla N, Vitalini C, D'Amato M, Giacovelli G, Vaudo G, Schillaci G, Galletti F, Bonaduce D.

Clin Nutr. 2019 Jul 19. pii: S0261-5614(19)30283-3. doi: 10.1016/j.clnu.2019.06.026. [Epub ahead of print]


Efficacy of a nutraceutical combination on lipid metabolism in patients with metabolic syndrome: a multicenter, double blind, randomized, placebo controlled trial.

Galletti F, Fazio V, Gentile M, Schillaci G, Pucci G, Battista F, Mercurio V, Bosso G, Bonaduce D, Brambilla N, Vitalini C, D'Amato M, Giacovelli G.

Lipids Health Dis. 2019 Mar 18;18(1):66. doi: 10.1186/s12944-019-1002-y.


Association of Pharmacological Treatments With Long-term Pain Control in Patients With Knee Osteoarthritis: A Systematic Review and Meta-analysis.

Gregori D, Giacovelli G, Minto C, Barbetta B, Gualtieri F, Azzolina D, Vaghi P, Rovati LC.

JAMA. 2018 Dec 25;320(24):2564-2579. doi: 10.1001/jama.2018.19319.


The role of diet and exercise and of glucosamine sulfate in the prevention of knee osteoarthritis: Further results from the PRevention of knee Osteoarthritis in Overweight Females (PROOF) study.

Runhaar J, Deroisy R, van Middelkoop M, Barretta F, Barbetta B, Oei EH, Vroegindeweij D, Giacovelli G, Bruyère O, Rovati LC, Reginster JY, Bierma-Zeinstra SM.

Semin Arthritis Rheum. 2016 Feb;45(4 Suppl):S42-8. doi: 10.1016/j.semarthrit.2015.11.001. Epub 2015 Nov 19.


Effects of glucosamine sulfate on the use of rescue non-steroidal anti-inflammatory drugs in knee osteoarthritis: Results from the Pharmaco-Epidemiology of GonArthroSis (PEGASus) study.

Rovati LC, Girolami F, D'Amato M, Giacovelli G.

Semin Arthritis Rheum. 2016 Feb;45(4 Suppl):S34-41. doi: 10.1016/j.semarthrit.2015.10.009. Epub 2015 Oct 29.


Evaluation of Levothyroxine Bioavailability after Oral Administration of a Fixed Combination of Soy Isoflavones in Post-menopausal Female Volunteers.

Persiani S, Sala F, Manzotti C, Colovic M, Zangarini M, Donazzolo Y, Barbetta B, Vitalini C, Giacovelli G, Benvenuti C, Rovati LC.

Drug Res (Stuttg). 2016 Mar;66(3):136-40. doi: 10.1055/s-0035-1555784. Epub 2015 Jun 30.


Efficacy of Andolast in Mild to Moderate Asthma: A Randomized, Controlled, Double-Blind Multicenter Study (The Andast Trial).

Malerba M, D Amato M, Radaeli A, Giacovelli G, Rovati L, Arshad SH, Holgate ST.

Curr Pharm Des. 2015;21(26):3835-43.


Antiviral activity and safety profile of silibinin in HCV patients with advanced fibrosis after liver transplantation: a randomized clinical trial.

Rendina M, D'Amato M, Castellaneta A, Castellaneta NM, Brambilla N, Giacovelli G, Rovati L, Rizzi SF, Zappimbulso M, Bringiotti RS, Di Leo A.

Transpl Int. 2014 Jul;27(7):696-704. doi: 10.1111/tri.12324. Epub 2014 May 10.


Republished: Value of biomarkers in osteoarthritis: current status and perspectives.

Lotz M, Martel-Pelletier J, Christiansen C, Brandi ML, Bruyère O, Chapurlat R, Collette J, Cooper C, Giacovelli G, Kanis JA, Karsdal MA, Kraus V, Lems WF, Meulenbelt I, Pelletier JP, Raynauld JP, Reiter-Niesert S, Rizzoli R, Sandell LJ, Van Spil WE, Reginster JY.

Postgrad Med J. 2014 Mar;90(1061):171-8. doi: 10.1136/postgradmedj-2013-203726rep.


Value of biomarkers in osteoarthritis: current status and perspectives.

Lotz M, Martel-Pelletier J, Christiansen C, Brandi ML, Bruyère O, Chapurlat R, Collette J, Cooper C, Giacovelli G, Kanis JA, Karsdal MA, Kraus V, Lems WF, Meulenbelt I, Pelletier JP, Raynauld JP, Reiter-Niesert S, Rizzoli R, Sandell LJ, Van Spil WE, Reginster JY.

Ann Rheum Dis. 2013 Nov;72(11):1756-63. doi: 10.1136/annrheumdis-2013-203726. Epub 2013 Jul 29. Review. Erratum in: Ann Rheum Dis. 2017 May 25;:.


What is the predictive value of MRI for the occurrence of knee replacement surgery in knee osteoarthritis?

Pelletier JP, Cooper C, Peterfy C, Reginster JY, Brandi ML, Bruyère O, Chapurlat R, Cicuttini F, Conaghan PG, Doherty M, Genant H, Giacovelli G, Hochberg MC, Hunter DJ, Kanis JA, Kloppenburg M, Laredo JD, McAlindon T, Nevitt M, Raynauld JP, Rizzoli R, Zilkens C, Roemer FW, Martel-Pelletier J, Guermazi A.

Ann Rheum Dis. 2013 Oct;72(10):1594-604. doi: 10.1136/annrheumdis-2013-203631. Epub 2013 Jul 25. Review. Erratum in: Ann Rheum Dis. 2017 May 25;:.


Intravenous silibinin monotherapy shows significant antiviral activity in HCV-infected patients in the peri-transplantation period.

Mariño Z, Crespo G, D'Amato M, Brambilla N, Giacovelli G, Rovati L, Costa J, Navasa M, Forns X.

J Hepatol. 2013 Mar;58(3):415-20. doi: 10.1016/j.jhep.2012.09.034. Epub 2012 Oct 11.


A randomised, double-blind, controlled trial comparing two intra-articular hyaluronic acid preparations differing by their molecular weight in symptomatic knee osteoarthritis.

Berenbaum F, Grifka J, Cazzaniga S, D'Amato M, Giacovelli G, Chevalier X, Rannou F, Rovati LC, Maheu E.

Ann Rheum Dis. 2012 Sep;71(9):1454-60. doi: 10.1136/annrheumdis-2011-200972. Epub 2012 Jan 31.


Crystalline glucosamine sulfate in the treatment of osteoarthritis: evidence of long-term cardiovascular safety from clinical trials.

Palma Dos Reis R, Giacovelli G, Girolami F, André R, Bonazzi A, Rovati LC.

Open Rheumatol J. 2011;5:69-77. doi: 10.2174/1874312901105010069. Epub 2011 Nov 29.


OARSI-OMERACT initiative: defining thresholds for symptomatic severity and structural changes in disease modifying osteoarthritis drug (DMOAD) clinical trials.

Manno RL, Bingham CO 3rd, Paternotte S, Gossec L, Halhol H, Giacovelli G, Rovati L, Mazzuca SA, Clegg DO, Shi H, Tajana Messi E, Lanzarotti A, Dougados M.

Osteoarthritis Cartilage. 2012 Feb;20(2):93-101. doi: 10.1016/j.joca.2011.11.013. Epub 2011 Nov 28.


OARSI/OMERACT initiative to define states of severity and indication for joint replacement in hip and knee osteoarthritis. An OMERACT 10 Special Interest Group.

Gossec L, Paternotte S, Bingham CO 3rd, Clegg DO, Coste P, Conaghan PG, Davis AM, Giacovelli G, Gunther KP, Hawker G, Hochberg MC, Jordan JM, Katz JN, Kloppenburg M, Lanzarotti A, Lim K, Lohmander LS, Mahomed NN, Maillefert JF, Manno RL, March LM, Mazzuca SA, Pavelka K, Punzi L, Roos EM, Rovati LC, Shi H, Singh JA, Suarez-Almazor ME, Tajana-Messi E, Dougados M; OARSI-OMERACT Task Force Total Articular Replacement as Outcome Measure in OA.

J Rheumatol. 2011 Aug;38(8):1765-9. doi: 10.3899/jrheum.110403.


Glucosamine and osteoarthritis. Conclusions not supported by methods and results.

Giacovelli G, Rovati LC.

BMJ. 2010 Nov 9;341:c6338. doi: 10.1136/bmj.c6338. No abstract available.


Total joint replacement after glucosamine sulphate treatment in knee osteoarthritis: results of a mean 8-year observation of patients from two previous 3-year, randomised, placebo-controlled trials.

Bruyere O, Pavelka K, Rovati LC, Gatterová J, Giacovelli G, Olejarová M, Deroisy R, Reginster JY.

Osteoarthritis Cartilage. 2008 Feb;16(2):254-60. Epub 2007 Jul 27.


Clinical significance of the long-term symptom-modifying effects of glucosamine sulfate: comment on the article by Brandt and Mazzuca.

Bruyere O, Reginster JY, Giacovelli G, Barbetta B, Rovati LC, Pavelka K.

Arthritis Rheum. 2006 Jul;54(7):2339-41; author reply 2341-3. No abstract available.


Glucosamine oral bioavailability and plasma pharmacokinetics after increasing doses of crystalline glucosamine sulfate in man.

Persiani S, Roda E, Rovati LC, Locatelli M, Giacovelli G, Roda A.

Osteoarthritis Cartilage. 2005 Dec;13(12):1041-9. Epub 2005 Sep 13.


Glucosamine sulfate reduces osteoarthritis progression in postmenopausal women with knee osteoarthritis: evidence from two 3-year studies.

Bruyere O, Pavelka K, Rovati LC, Deroisy R, Olejarova M, Gatterova J, Giacovelli G, Reginster JY.

Menopause. 2004 Mar-Apr;11(2):138-43.


Cholecystokinin pathways modulate sensations induced by gastric distension in humans.

Lal S, McLaughlin J, Barlow J, D'Amato M, Giacovelli G, Varro A, Dockray GJ, Thompson DG.

Am J Physiol Gastrointest Liver Physiol. 2004 Jul;287(1):G72-9. Epub 2004 Feb 5.


Biochemical markers of bone and cartilage remodeling in prediction of longterm progression of knee osteoarthritis.

Bruyere O, Collette JH, Ethgen O, Rovati LC, Giacovelli G, Henrotin YE, Seidel L, Reginster JY.

J Rheumatol. 2003 May;30(5):1043-50.


Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study.

Pavelká K, Gatterová J, Olejarová M, Machacek S, Giacovelli G, Rovati LC.

Arch Intern Med. 2002 Oct 14;162(18):2113-23.


Radiologic features poorly predict clinical outcomes in knee osteoarthritis.

Bruyere O, Honore A, Rovati LC, Giacovelli G, Henrotin YE, Seidel L, Reginster JY.

Scand J Rheumatol. 2002;31(1):13-6.


Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial.

Reginster JY, Deroisy R, Rovati LC, Lee RL, Lejeune E, Bruyere O, Giacovelli G, Henrotin Y, Dacre JE, Gossett C.

Lancet. 2001 Jan 27;357(9252):251-6.


Efficacy on climacteric symptoms and safety of low dose estradiol transdermal matrix patches. A randomized, double-blind placebo-controlled study.

De Aloysio D, Rovati LC, Giacovelli G, Setnikar I, Bottiglioni F.

Arzneimittelforschung. 2000 Mar;50(3):293-300.


Glucosamine in osteoarthritis.

Rovati LC, Annefeld M, Giacovelli G, Schmid K, Setnikar I.

Lancet. 1999 Nov 6;354(9190):1640; author reply 1641-2. No abstract available.


The effect of sodium monofluorophosphate plus calcium on vertebral fracture rate in postmenopausal women with moderate osteoporosis. A randomized, controlled trial.

Reginster JY, Meurmans L, Zegels B, Rovati LC, Minne HW, Giacovelli G, Taquet AN, Setnikar I, Collette J, Gosset C.

Ann Intern Med. 1998 Jul 1;129(1):1-8.


Efficacy and safety of glucosamine sulfate versus ibuprofen in patients with knee osteoarthritis.

Qiu GX, Gao SN, Giacovelli G, Rovati L, Setnikar I.

Arzneimittelforschung. 1998 May;48(5):469-74.


Dose-response effects of oral loxiglumide on postprandial gall-bladder emptying in man.

Malesci A, De Fazio C, Festorazzi S, Bonato C, Valentini A, Tacconi M, Bekkering M, Giacovelli G, D'Amato M, Rovati LC.

Arzneimittelforschung. 1992 Nov;42(11):1359-62.


Pharmacokinetics and tolerance of repeated oral doses of loxiglumide.

Setnikar I, Chisté R, Giacovelli G, Rovati LC.

Arzneimittelforschung. 1989 Nov;39(11):1454-9.


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