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Fermentable carbohydrate stimulates FFAR2-dependent colonic PYY cell expansion to increase satiety.

Brooks L, Viardot A, Tsakmaki A, Stolarczyk E, Howard JK, Cani PD, Everard A, Sleeth ML, Psichas A, Anastasovskaj J, Bell JD, Bell-Anderson K, Mackay CR, Ghatei MA, Bloom SR, Frost G, Bewick GA.

Mol Metab. 2016 Nov 4;6(1):48-60. doi: 10.1016/j.molmet.2016.10.011. eCollection 2017 Jan.


Mycoprotein reduces energy intake and postprandial insulin release without altering glucagon-like peptide-1 and peptide tyrosine-tyrosine concentrations in healthy overweight and obese adults: a randomised-controlled trial.

Bottin JH, Swann JR, Cropp E, Chambers ES, Ford HE, Ghatei MA, Frost GS.

Br J Nutr. 2016 Jul;116(2):360-74. doi: 10.1017/S0007114516001872. Epub 2016 May 20.


Kisspeptin Expression in the Human Infundibular Nucleus in Relation to Sex, Gender Identity, and Sexual Orientation.

Taziaux M, Staphorsius AS, Ghatei MA, Bloom SR, Swaab DF, Bakker J.

J Clin Endocrinol Metab. 2016 Jun;101(6):2380-9. doi: 10.1210/jc.2015-4175. Epub 2016 Apr 5.


Direct comparison of the effects of intravenous kisspeptin-10, kisspeptin-54 and GnRH on gonadotrophin secretion in healthy men.

Jayasena CN, Abbara A, Narayanaswamy S, Comninos AN, Ratnasabapathy R, Bassett P, Mogford JT, Malik Z, Calley J, Ghatei MA, Bloom SR, Dhillo WS.

Hum Reprod. 2015 Aug;30(8):1934-41. doi: 10.1093/humrep/dev143. Epub 2015 Jun 18.


Kisspeptin signaling in the amygdala modulates reproductive hormone secretion.

Comninos AN, Anastasovska J, Sahuri-Arisoylu M, Li X, Li S, Hu M, Jayasena CN, Ghatei MA, Bloom SR, Matthews PM, O'Byrne KT, Bell JD, Dhillo WS.

Brain Struct Funct. 2016 May;221(4):2035-47. doi: 10.1007/s00429-015-1024-9. Epub 2015 Mar 11.


Neurokinin B administration induces hot flushes in women.

Jayasena CN, Comninos AN, Stefanopoulou E, Buckley A, Narayanaswamy S, Izzi-Engbeaya C, Abbara A, Ratnasabapathy R, Mogford J, Ng N, Sarang Z, Ghatei MA, Bloom SR, Hunter MS, Dhillo WS.

Sci Rep. 2015 Feb 16;5:8466. doi: 10.1038/srep08466.


Comparison of the utility of Cocaine- and Amphetamine-Regulated Transcript (CART), chromogranin A, and chromogranin B in neuroendocrine tumor diagnosis and assessment of disease progression.

Ramachandran R, Bech P, Murphy KG, Caplin ME, Patel M, Vohra S, Khan MS, Dhillo WS, Sharma R, Palazzo FF, Win Z, Tan T, Khoo B, Meeran K, Frilling A, Ghatei MA, Bloom SR, Martin NM.

J Clin Endocrinol Metab. 2015 Apr;100(4):1520-8. doi: 10.1210/jc.2014-3640. Epub 2015 Feb 9.


Circulating pancreatic polypeptide concentrations predict visceral and liver fat content.

Sam AH, Sleeth ML, Thomas EL, Ismail NA, Mat Daud N, Chambers E, Shojaee-Moradie F, Umpleby M, Goldstone AP, Le Roux CW, Bech P, Busbridge M, Laurie R, Cuthbertson DJ, Buckley A, Ghatei MA, Bloom SR, Frost GS, Bell JD, Murphy KG.

J Clin Endocrinol Metab. 2015 Mar;100(3):1048-52. doi: 10.1210/jc.2014-3450. Epub 2014 Dec 9.


Hypophysiotropic gonadotropin-releasing hormone projections are exposed to dense plexuses of kisspeptin, neurokinin B and substance p immunoreactive fibers in the human: a study on tissues from postmenopausal women.

Borsay BÁ, Skrapits K, Herczeg L, Ciofi P, Bloom SR, Ghatei MA, Dhillo WS, Liposits Z, Hrabovszky E.

Neuroendocrinology. 2014;100(2-3):141-52. doi: 10.1159/000368362. Epub 2014 Sep 19.


L-cysteine suppresses ghrelin and reduces appetite in rodents and humans.

McGavigan AK, O'Hara HC, Amin A, Kinsey-Jones J, Spreckley E, Alamshah A, Agahi A, Banks K, France R, Hyberg G, Wong C, Bewick GA, Gardiner JV, Lehmann A, Martin NM, Ghatei MA, Bloom SR, Murphy KG.

Int J Obes (Lond). 2015 Mar;39(3):447-55. doi: 10.1038/ijo.2014.172. Epub 2014 Sep 15.


The identification of elevated urinary kisspeptin-immunoreactivity during pregnancy.

Jayasena CN, Comninos AN, Narayanaswamy S, Abbara A, Nijher GM, Cheema M, Malik Z, Ghatei MA, Bloom SR, Dhillo WS.

Ann Clin Biochem. 2015 May;52(Pt 3):395-8. doi: 10.1177/0004563214551612. Epub 2014 Aug 28.


Combination of peptide YY3-36 with GLP-1(7-36) amide causes an increase in first-phase insulin secretion after IV glucose.

Tan TM, Salem V, Troke RC, Alsafi A, Field BC, De Silva A, Misra S, Baynes KC, Donaldson M, Minnion J, Ghatei MA, Godsland IF, Bloom SR.

J Clin Endocrinol Metab. 2014 Nov;99(11):E2317-24. doi: 10.1210/jc.2014-2143. Epub 2014 Aug 21.


Reduced levels of plasma kisspeptin during the antenatal booking visit are associated with increased risk of miscarriage.

Jayasena CN, Abbara A, Izzi-Engbeaya C, Comninos AN, Harvey RA, Gonzalez Maffe J, Sarang Z, Ganiyu-Dada Z, Padilha AI, Dhanjal M, Williamson C, Regan L, Ghatei MA, Bloom SR, Dhillo WS.

J Clin Endocrinol Metab. 2014 Dec;99(12):E2652-60. doi: 10.1210/jc.2014-1953.


The short chain fatty acid propionate stimulates GLP-1 and PYY secretion via free fatty acid receptor 2 in rodents.

Psichas A, Sleeth ML, Murphy KG, Brooks L, Bewick GA, Hanyaloglu AC, Ghatei MA, Bloom SR, Frost G.

Int J Obes (Lond). 2015 Mar;39(3):424-9. doi: 10.1038/ijo.2014.153. Epub 2014 Aug 11.


Colocalization of cocaine- and amphetamine-regulated transcript with kisspeptin and neurokinin B in the human infundibular region.

Skrapits K, Borsay BÁ, Herczeg L, Ciofi P, Bloom SR, Ghatei MA, Dhillo WS, Liposits Z, Hrabovszky E.

PLoS One. 2014 Aug 1;9(8):e103977. doi: 10.1371/journal.pone.0103977. eCollection 2014.


Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization.

Jayasena CN, Abbara A, Comninos AN, Nijher GM, Christopoulos G, Narayanaswamy S, Izzi-Engbeaya C, Sridharan M, Mason AJ, Warwick J, Ashby D, Ghatei MA, Bloom SR, Carby A, Trew GH, Dhillo WS.

J Clin Invest. 2014 Aug;124(8):3667-77. doi: 10.1172/JCI75730. Epub 2014 Jul 18.


Coinfusion of low-dose GLP-1 and glucagon in man results in a reduction in food intake.

Cegla J, Troke RC, Jones B, Tharakan G, Kenkre J, McCullough KA, Lim CT, Parvizi N, Hussein M, Chambers ES, Minnion J, Cuenco J, Ghatei MA, Meeran K, Tan TM, Bloom SR.

Diabetes. 2014 Nov;63(11):3711-20. doi: 10.2337/db14-0242. Epub 2014 Jun 17.


Acute and chronic effects of kisspeptin-54 administration on GH, prolactin and TSH secretion in healthy women.

Jayasena CN, Comninos AN, Narayanaswamy S, Bhalla S, Abbara A, Ganiyu-Dada Z, Busbridge M, Ghatei MA, Bloom SR, Dhillo WS.

Clin Endocrinol (Oxf). 2014 Dec;81(6):891-8. doi: 10.1111/cen.12512. Epub 2014 Jun 25.


Ghrelin mimics fasting to enhance human hedonic, orbitofrontal cortex, and hippocampal responses to food.

Goldstone AP, Prechtl CG, Scholtz S, Miras AD, Chhina N, Durighel G, Deliran SS, Beckmann C, Ghatei MA, Ashby DR, Waldman AD, Gaylinn BD, Thorner MO, Frost GS, Bloom SR, Bell JD.

Am J Clin Nutr. 2014 Jun;99(6):1319-30. doi: 10.3945/ajcn.113.075291. Epub 2014 Apr 23.


Relaxin-3 stimulates the neuro-endocrine stress axis via corticotrophin-releasing hormone.

McGowan BM, Minnion JS, Murphy KG, Roy D, Stanley SA, Dhillo WS, Gardiner JV, Ghatei MA, Bloom SR.

J Endocrinol. 2014 May 12;221(2):337-46. doi: 10.1530/JOE-13-0603. Print 2014 May.


Increasing LH pulsatility in women with hypothalamic amenorrhoea using intravenous infusion of Kisspeptin-54.

Jayasena CN, Abbara A, Veldhuis JD, Comninos AN, Ratnasabapathy R, De Silva A, Nijher GM, Ganiyu-Dada Z, Mehta A, Todd C, Ghatei MA, Bloom SR, Dhillo WS.

J Clin Endocrinol Metab. 2014 Jun;99(6):E953-61. doi: 10.1210/jc.2013-1569. Epub 2014 Feb 11.


Effects of neurokinin B administration on reproductive hormone secretion in healthy men and women.

Jayasena CN, Comninos AN, De Silva A, Abbara A, Veldhuis JD, Nijher GM, Ganiyu-Dada Z, Vaal M, Stamp G, Ghatei MA, Bloom SR, Dhillo WS.

J Clin Endocrinol Metab. 2014 Jan;99(1):E19-27. doi: 10.1210/jc.2012-2880. Epub 2013 Dec 20.


Pituitary protein 7B2 plasma levels in patients with liver disease: Comparisons with other hormones and neuropeptides.

Venetikou MS, Meleagros L, Ghatei MA, Bloom SR.

Oncol Lett. 2013 Aug;6(2):499-506. Epub 2013 Jun 7.


Neuromedin B stimulates the hypothalamic-pituitary-gonadal axis in male rats.

Boughton CK, Patel SA, Thompson EL, Patterson M, Curtis AE, Amin A, Chen K, Ghatei MA, Bloom SR, Murphy KG.

Regul Pept. 2013 Nov 10;187:6-11. doi: 10.1016/j.regpep.2013.10.002. Epub 2013 Oct 10.


Twice-daily subcutaneous injection of kisspeptin-54 does not abolish menstrual cyclicity in healthy female volunteers.

Jayasena CN, Comninos AN, Nijher GM, Abbara A, De Silva A, Veldhuis JD, Ratnasabapathy R, Izzi-Engbeaya C, Lim A, Patel DA, Ghatei MA, Bloom SR, Dhillo WS.

J Clin Endocrinol Metab. 2013 Nov;98(11):4464-74. doi: 10.1210/jc.2013-1069. Epub 2013 Sep 12.


Substance P immunoreactivity exhibits frequent colocalization with kisspeptin and neurokinin B in the human infundibular region.

Hrabovszky E, Borsay BÁ, Rácz K, Herczeg L, Ciofi P, Bloom SR, Ghatei MA, Dhillo WS, Liposits Z.

PLoS One. 2013 Aug 19;8(8):e72369. doi: 10.1371/journal.pone.0072369. eCollection 2013.


Obese patients after gastric bypass surgery have lower brain-hedonic responses to food than after gastric banding.

Scholtz S, Miras AD, Chhina N, Prechtl CG, Sleeth ML, Daud NM, Ismail NA, Durighel G, Ahmed AR, Olbers T, Vincent RP, Alaghband-Zadeh J, Ghatei MA, Waldman AD, Frost GS, Bell JD, le Roux CW, Goldstone AP.

Gut. 2014 Jun;63(6):891-902. doi: 10.1136/gutjnl-2013-305008. Epub 2013 Aug 20.


Age-dependent elevations in plasma kisspeptin are observed in boys and girls when compared with adults.

Jayasena CN, Nijher GM, Narayanaswamy S, De Silva A, Abbara A, Ghatei MA, Bloom SR, Bridges N, Dhillo WS.

Ann Clin Biochem. 2014 Jan;51(Pt 1):89-96. doi: 10.1177/0004563213485230. Epub 2013 Jul 18.


Changes in levels of peripheral hormones controlling appetite are inconsistent with hyperphagia in leptin-deficient subjects.

Saeed S, Bech PR, Hafeez T, Alam R, Falchi M, Ghatei MA, Bloom SR, Arslan M, Froguel P.

Endocrine. 2014 Apr;45(3):401-8. doi: 10.1007/s12020-013-0009-9. Epub 2013 Jul 4.


High protein intake stimulates postprandial GLP1 and PYY release.

van der Klaauw AA, Keogh JM, Henning E, Trowse VM, Dhillo WS, Ghatei MA, Farooqi IS.

Obesity (Silver Spring). 2013 Aug;21(8):1602-7. doi: 10.1002/oby.20154. Epub 2013 May 13.


Gut hormone release and appetite regulation in healthy non-obese participants following oligofructose intake. A dose-escalation study.

Pedersen C, Lefevre S, Peters V, Patterson M, Ghatei MA, Morgan LM, Frost GS.

Appetite. 2013 Jul;66:44-53. doi: 10.1016/j.appet.2013.02.017. Epub 2013 Mar 5.


A single injection of kisspeptin-54 temporarily increases luteinizing hormone pulsatility in healthy women.

Jayasena CN, Comninos AN, Veldhuis JD, Misra S, Abbara A, Izzi-Engbeaya C, Donaldson M, Ghatei MA, Bloom SR, Dhillo WS.

Clin Endocrinol (Oxf). 2013 Oct;79(4):558-63. doi: 10.1111/cen.12179. Epub 2013 May 20.


Glucagon and GLP-1 inhibit food intake and increase c-fos expression in similar appetite regulating centres in the brainstem and amygdala.

Parker JA, McCullough KA, Field BC, Minnion JS, Martin NM, Ghatei MA, Bloom SR.

Int J Obes (Lond). 2013 Oct;37(10):1391-8. doi: 10.1038/ijo.2012.227. Epub 2013 Jan 22.


Coadministration of glucagon-like peptide-1 during glucagon infusion in humans results in increased energy expenditure and amelioration of hyperglycemia.

Tan TM, Field BC, McCullough KA, Troke RC, Chambers ES, Salem V, Gonzalez Maffe J, Baynes KC, De Silva A, Viardot A, Alsafi A, Frost GS, Ghatei MA, Bloom SR.

Diabetes. 2013 Apr;62(4):1131-8. doi: 10.2337/db12-0797. Epub 2012 Dec 17.


Morphological evidence for enhanced kisspeptin and neurokinin B signaling in the infundibular nucleus of the aging man.

Molnár CS, Vida B, Sipos MT, Ciofi P, Borsay BÁ, Rácz K, Herczeg L, Bloom SR, Ghatei MA, Dhillo WS, Liposits Z, Hrabovszky E.

Endocrinology. 2012 Nov;153(11):5428-39. doi: 10.1210/en.2012-1739. Epub 2012 Sep 25.


Peripheral administration of prokineticin 2 potently reduces food intake and body weight in mice via the brainstem.

Beale K, Gardiner JV, Bewick GA, Hostomska K, Patel NA, Hussain SS, Jayasena CN, Ebling FJ, Jethwa PH, Prosser HM, Lattanzi R, Negri L, Ghatei MA, Bloom SR, Dhillo WS.

Br J Pharmacol. 2013 Jan;168(2):403-10. doi: 10.1111/j.1476-5381.2012.02191.x.


Low degree of overlap between kisspeptin, neurokinin B, and dynorphin immunoreactivities in the infundibular nucleus of young male human subjects challenges the KNDy neuron concept.

Hrabovszky E, Sipos MT, Molnár CS, Ciofi P, Borsay BÁ, Gergely P, Herczeg L, Bloom SR, Ghatei MA, Dhillo WS, Liposits Z.

Endocrinology. 2012 Oct;153(10):4978-89. Epub 2012 Aug 17.


The role of bile after Roux-en-Y gastric bypass in promoting weight loss and improving glycaemic control.

Pournaras DJ, Glicksman C, Vincent RP, Kuganolipava S, Alaghband-Zadeh J, Mahon D, Bekker JH, Ghatei MA, Bloom SR, Walters JR, Welbourn R, le Roux CW.

Endocrinology. 2012 Aug;153(8):3613-9. doi: 10.1210/en.2011-2145. Epub 2012 Jun 6.


Selective ablation of peptide YY cells in adult mice reveals their role in beta cell survival.

Sam AH, Gunner DJ, King A, Persaud SJ, Brooks L, Hostomska K, Ford HE, Liu B, Ghatei MA, Bloom SR, Bewick GA.

Gastroenterology. 2012 Aug;143(2):459-68. doi: 10.1053/j.gastro.2012.04.047. Epub 2012 May 2.


Plasma kisspeptin: a potential biomarker of tumor metastasis in patients with ovarian carcinoma.

Jayasena CN, Comninos AN, Januszewski A, Gabra H, Taylor A, Harvey RA, Ghatei MA, Bloom SR, Dhillo WS.

Clin Chem. 2012 Jun;58(6):1061-3. doi: 10.1373/clinchem.2011.177667. Epub 2012 Mar 14. No abstract available.


Improved diagnostic accuracy for neuroendocrine neoplasms using two chromogranin A assays.

Ramachandran R, Bech P, Murphy KG, Dhillo WS, Meeran KM, Chapman RS, Caplin M, Ghatei MA, Bloom SR, Martin NM.

Clin Endocrinol (Oxf). 2012 Jun;76(6):831-6. doi: 10.1111/j.1365-2265.2011.04319.x.


The gut hormones PYY 3-36 and GLP-1 7-36 amide reduce food intake and modulate brain activity in appetite centers in humans.

De Silva A, Salem V, Long CJ, Makwana A, Newbould RD, Rabiner EA, Ghatei MA, Bloom SR, Matthews PM, Beaver JD, Dhillo WS.

Cell Metab. 2011 Nov 2;14(5):700-6. doi: 10.1016/j.cmet.2011.09.010. Epub 2011 Oct 13.


The effects of kisspeptin-10 on reproductive hormone release show sexual dimorphism in humans.

Jayasena CN, Nijher GM, Comninos AN, Abbara A, Januszewki A, Vaal ML, Sriskandarajah L, Murphy KG, Farzad Z, Ghatei MA, Bloom SR, Dhillo WS.

J Clin Endocrinol Metab. 2011 Dec;96(12):E1963-72. doi: 10.1210/jc.2011-1408. Epub 2011 Oct 5.


A role for metalloendopeptidases in the breakdown of the gut hormone, PYY 3-36.

Addison ML, Minnion JS, Shillito JC, Suzuki K, Tan TM, Field BC, Germain-Zito N, Becker-Pauly C, Ghatei MA, Bloom SR, Murphy KG.

Endocrinology. 2011 Dec;152(12):4630-40. doi: 10.1210/en.2011-1195. Epub 2011 Sep 27.


Pharmacokinetics, adverse effects and tolerability of a novel analogue of human pancreatic polypeptide, PP 1420.

Tan TM, Field BC, Minnion JS, Cuenco-Shillito J, Chambers ES, Zac-Varghese S, Brindley CJ, Mt-Isa S, Fiorentino F, Ashby D, Ward I, Ghatei MA, Bloom SR.

Br J Clin Pharmacol. 2012 Feb;73(2):232-9. doi: 10.1111/j.1365-2125.2011.04082.x.


Alterations of sucrose preference after Roux-en-Y gastric bypass.

Bueter M, Miras AD, Chichger H, Fenske W, Ghatei MA, Bloom SR, Unwin RJ, Lutz TA, Spector AC, le Roux CW.

Physiol Behav. 2011 Oct 24;104(5):709-21. doi: 10.1016/j.physbeh.2011.07.025. Epub 2011 Jul 30.


Intracerebroventricular administration of vasoactive intestinal peptide inhibits food intake.

Ghourab S, Beale KE, Semjonous NM, Simpson KA, Martin NM, Ghatei MA, Bloom SR, Smith KL.

Regul Pept. 2011 Dec 10;172(1-3):8-15. doi: 10.1016/j.regpep.2011.07.006. Epub 2011 Jul 28.


Rimonabant: From RIO to Ban.

Sam AH, Salem V, Ghatei MA.

J Obes. 2011;2011:432607. doi: 10.1155/2011/432607. Epub 2011 Jul 6.


Pancreatic polypeptide meal response may predict gastric band-induced weight loss.

Dixon AF, le Roux CW, Ghatei MA, Bloom SR, McGee TL, Dixon JB.

Obes Surg. 2011 Dec;21(12):1906-13. doi: 10.1007/s11695-011-0469-z.


Exogenous peptide YY3-36 and Exendin-4 further decrease food intake, whereas octreotide increases food intake in rats after Roux-en-Y gastric bypass.

Fenske WK, Bueter M, Miras AD, Ghatei MA, Bloom SR, le Roux CW.

Int J Obes (Lond). 2012 Mar;36(3):379-84. doi: 10.1038/ijo.2011.126. Epub 2011 Jun 21.


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