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Items: 10


Does the Lipid Bilayer Orchestrate Access and Binding of Ligands to Transmembrane Orthosteric/Allosteric Sites of G Protein-Coupled Receptors?

Szlenk CT, Gc JB, Natesan S.

Mol Pharmacol. 2019 Nov;96(5):527-541. doi: 10.1124/mol.118.115113. Epub 2019 Apr 8.


Integrin activation by the lipid molecule 25-hydroxycholesterol induces a proinflammatory response.

Pokharel SM, Shil NK, Gc JB, Colburn ZT, Tsai SY, Segovia JA, Chang TH, Bandyopadhyay S, Natesan S, Jones JCR, Bose S.

Nat Commun. 2019 Apr 1;10(1):1482. doi: 10.1038/s41467-019-09453-x.


A cationic, C-terminal patch and structural rearrangements in Ebola virus matrix VP40 protein control its interactions with phosphatidylserine.

Del Vecchio K, Frick CT, Gc JB, Oda SI, Gerstman BS, Saphire EO, Chapagain PP, Stahelin RV.

J Biol Chem. 2018 Mar 2;293(9):3335-3349. doi: 10.1074/jbc.M117.816280. Epub 2018 Jan 18.


Graphene-VP40 interactions and potential disruption of the Ebola virus matrix filaments.

Gc JB, Pokhrel R, Bhattarai N, Johnson KA, Gerstman BS, Stahelin RV, Chapagain PP.

Biochem Biophys Res Commun. 2017 Nov 4;493(1):176-181. doi: 10.1016/j.bbrc.2017.09.052. Epub 2017 Sep 13.


Membrane association and localization dynamics of the Ebola virus matrix protein VP40.

Gc JB, Gerstman BS, Chapagain PP.

Biochim Biophys Acta Biomembr. 2017 Oct;1859(10):2012-2020. doi: 10.1016/j.bbamem.2017.07.007. Epub 2017 Jul 13.


Plasma membrane association facilitates conformational changes in the Marburg virus protein VP40 dimer.

Bhattarai N, Gc JB, Gerstman BS, Stahelin RV, Chapagain PP.

RSC Adv. 2017 Apr 26;7(37):22741-22748. doi: 10.1039/c7ra02940c.


The Ebola virus protein VP40 hexamer enhances the clustering of PI(4,5)P2 lipids in the plasma membrane.

Gc JB, Gerstman BS, Stahelin RV, Chapagain PP.

Phys Chem Chem Phys. 2016 Oct 19;18(41):28409-28417.


Interdomain salt-bridges in the Ebola virus protein VP40 and their role in domain association and plasma membrane localization.

Gc JB, Johnson KA, Husby ML, Frick CT, Gerstman BS, Stahelin RV, Chapagain PP.

Protein Sci. 2016 Sep;25(9):1648-58. doi: 10.1002/pro.2969. Epub 2016 Jul 4.


The Role of the Interdomain Interactions on RfaH Dynamics and Conformational Transformation.

GC JB, Gerstman BS, Chapagain PP.

J Phys Chem B. 2015 Oct 8;119(40):12750-9. doi: 10.1021/acs.jpcb.5b05681. Epub 2015 Sep 28.


Molecular dynamics investigations of the α-helix to β-barrel conformational transformation in the RfaH transcription factor.

Gc JB, Bhandari YR, Gerstman BS, Chapagain PP.

J Phys Chem B. 2014 May 15;118(19):5101-8. doi: 10.1021/jp502193v. Epub 2014 May 6.


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