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Items: 10


Structure-Guided In Vitro to In Vivo Pharmacokinetic Optimization of Propargyl-Linked Antifolates.

Lombardo MN, G-Dayanandan N, Keshipeddy S, Zhou W, Si D, Reeve SM, Alverson J, Barney P, Walker L, Hoody J, Priestley ND, Obach RS, Wright DL.

Drug Metab Dispos. 2019 Sep;47(9):995-1003. doi: 10.1124/dmd.119.086504. Epub 2019 Jun 14.


Drugging the Folate Pathway in Mycobacterium tuberculosis: The Role of Multi-targeting Agents.

Hajian B, Scocchera E, Shoen C, Krucinska J, Viswanathan K, G-Dayanandan N, Erlandsen H, Estrada A, Mikušová K, Korduláková J, Cynamon M, Wright D.

Cell Chem Biol. 2019 Jun 20;26(6):781-791.e6. doi: 10.1016/j.chembiol.2019.02.013. Epub 2019 Mar 28.


Tropolone-induced effects on the unfolded protein response pathway and apoptosis in multiple myeloma cells are dependent on iron.

Haney SL, Varney ML, Safranek HR, Chhonker YS, G-Dayanandan N, Talmon G, Murry DJ, Wiemer AJ, Wright DL, Holstein SA.

Leuk Res. 2019 Feb;77:17-27. doi: 10.1016/j.leukres.2018.12.007. Epub 2018 Dec 21.


Direct Substitution of Arylalkynyl Carbinols Provides Access to Diverse Terminal Acetylene Building Blocks.

G-Dayanandan N, Scocchera EW, Keshipeddy S, Jones HF, Anderson AC, Wright DL.

Org Lett. 2017 Jan 6;19(1):142-145. doi: 10.1021/acs.orglett.6b03438. Epub 2016 Dec 13.


Crystal Structures of Trimethoprim-Resistant DfrA1 Rationalize Potent Inhibition by Propargyl-Linked Antifolates.

Lombardo MN, G-Dayanandan N, Wright DL, Anderson AC.

ACS Infect Dis. 2016 Feb 12;2(2):149-56. doi: 10.1021/acsinfecdis.5b00129. Epub 2016 Jan 4.


Propargyl-Linked Antifolates Are Potent Inhibitors of Drug-Sensitive and Drug-Resistant Mycobacterium tuberculosis.

Hajian B, Scocchera E, Keshipeddy S, G-Dayanandan N, Shoen C, Krucinska J, Reeve S, Cynamon M, Anderson AC, Wright DL.

PLoS One. 2016 Aug 31;11(8):e0161740. doi: 10.1371/journal.pone.0161740. eCollection 2016.


Charged Propargyl-Linked Antifolates Reveal Mechanisms of Antifolate Resistance and Inhibit Trimethoprim-Resistant MRSA Strains Possessing Clinically Relevant Mutations.

Reeve SM, Scocchera E, Ferreira JJ, G-Dayanandan N, Keshipeddy S, Wright DL, Anderson AC.

J Med Chem. 2016 Jul 14;59(13):6493-500. doi: 10.1021/acs.jmedchem.6b00688. Epub 2016 Jun 28.


Propargyl-linked antifolates are dual inhibitors of Candida albicans and Candida glabrata.

G-Dayanandan N, Paulsen JL, Viswanathan K, Keshipeddy S, Lombardo MN, Zhou W, Lamb KM, Sochia AE, Alverson JB, Priestley ND, Wright DL, Anderson AC.

J Med Chem. 2014 Mar 27;57(6):2643-56. doi: 10.1021/jm401916j. Epub 2014 Mar 6.


Elucidating features that drive the design of selective antifolates using crystal structures of human dihydrofolate reductase.

Lamb KM, G-Dayanandan N, Wright DL, Anderson AC.

Biochemistry. 2013 Oct 15;52(41):7318-26. doi: 10.1021/bi400852h. Epub 2013 Oct 3.


Tandem metathesis reactions of oxabicyclo[2.2.1]heptenes: studies on the spirocyclic core of cyclopamine.

Oblak EZ, G-Dayanandan N, Wright DL.

Org Lett. 2011 May 6;13(9):2433-5. doi: 10.1021/ol200706f. Epub 2011 Apr 1.


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