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Items: 7

1.

Direct Substitution of Arylalkynyl Carbinols Provides Access to Diverse Terminal Acetylene Building Blocks.

G-Dayanandan N, Scocchera EW, Keshipeddy S, Jones HF, Anderson AC, Wright DL.

Org Lett. 2017 Jan 6;19(1):142-145. doi: 10.1021/acs.orglett.6b03438. Epub 2016 Dec 13.

2.

Crystal Structures of Trimethoprim-Resistant DfrA1 Rationalize Potent Inhibition by Propargyl-Linked Antifolates.

Lombardo MN, G-Dayanandan N, Wright DL, Anderson AC.

ACS Infect Dis. 2016 Feb 12;2(2):149-56. doi: 10.1021/acsinfecdis.5b00129. Epub 2016 Jan 4.

3.

Propargyl-Linked Antifolates Are Potent Inhibitors of Drug-Sensitive and Drug-Resistant Mycobacterium tuberculosis.

Hajian B, Scocchera E, Keshipeddy S, G-Dayanandan N, Shoen C, Krucinska J, Reeve S, Cynamon M, Anderson AC, Wright DL.

PLoS One. 2016 Aug 31;11(8):e0161740. doi: 10.1371/journal.pone.0161740. eCollection 2016.

4.

Charged Propargyl-Linked Antifolates Reveal Mechanisms of Antifolate Resistance and Inhibit Trimethoprim-Resistant MRSA Strains Possessing Clinically Relevant Mutations.

Reeve SM, Scocchera E, Ferreira JJ, G-Dayanandan N, Keshipeddy S, Wright DL, Anderson AC.

J Med Chem. 2016 Jul 14;59(13):6493-500. doi: 10.1021/acs.jmedchem.6b00688. Epub 2016 Jun 28.

5.

Propargyl-linked antifolates are dual inhibitors of Candida albicans and Candida glabrata.

G-Dayanandan N, Paulsen JL, Viswanathan K, Keshipeddy S, Lombardo MN, Zhou W, Lamb KM, Sochia AE, Alverson JB, Priestley ND, Wright DL, Anderson AC.

J Med Chem. 2014 Mar 27;57(6):2643-56. doi: 10.1021/jm401916j. Epub 2014 Mar 6.

6.

Elucidating features that drive the design of selective antifolates using crystal structures of human dihydrofolate reductase.

Lamb KM, G-Dayanandan N, Wright DL, Anderson AC.

Biochemistry. 2013 Oct 15;52(41):7318-26. doi: 10.1021/bi400852h. Epub 2013 Oct 3.

7.

Tandem metathesis reactions of oxabicyclo[2.2.1]heptenes: studies on the spirocyclic core of cyclopamine.

Oblak EZ, G-Dayanandan N, Wright DL.

Org Lett. 2011 May 6;13(9):2433-5. doi: 10.1021/ol200706f. Epub 2011 Apr 1.

PMID:
21456515

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