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Items: 1 to 50 of 55

1.

An RNA polymerase II-associated TFIIF-like complex is indispensable for SL RNA gene transcription in Trypanosoma brucei.

Srivastava A, Badjatia N, Lee JH, Hao B, Günzl A.

Nucleic Acids Res. 2018 Feb 28;46(4):1695-1709. doi: 10.1093/nar/gkx1198.

2.

Metacyclic VSG expression site promoters are recognized by the same general transcription factor that is required for RNA polymerase I transcription of bloodstream expression sites.

Kolev NG, Günzl A, Tschudi C.

Mol Biochem Parasitol. 2017 Sep;216:52-55. doi: 10.1016/j.molbiopara.2017.07.002. Epub 2017 Jul 14.

3.

Correction for Kirkham et al., "Dynein Light Chain LC8 Is Required for RNA Polymerase I-Mediated Transcription in Trypanosoma brucei, Facilitating Assembly and Promoter Binding of Class I Transcription Factor A".

Kirkham JK, Park SH, Nguyen TN, Lee JH, Günzl A.

Mol Cell Biol. 2017 May 31;37(12). pii: e00166-17. doi: 10.1128/MCB.00166-17. Print 2017 Jun 15. No abstract available.

4.

Cyclin-Dependent Kinase CRK9, Required for Spliced Leader trans Splicing of Pre-mRNA in Trypanosomes, Functions in a Complex with a New L-Type Cyclin and a Kinetoplastid-Specific Protein.

Badjatia N, Park SH, Ambrósio DL, Kirkham JK, Günzl A.

PLoS Pathog. 2016 Mar 8;12(3):e1005498. doi: 10.1371/journal.ppat.1005498. eCollection 2016 Mar.

5.

Dynein Light Chain LC8 Is Required for RNA Polymerase I-Mediated Transcription in Trypanosoma brucei, Facilitating Assembly and Promoter Binding of Class I Transcription Factor A.

Kirkham JK, Park SH, Nguyen TN, Lee JH, Günzl A.

Mol Cell Biol. 2015 Oct 12;36(1):95-107. doi: 10.1128/MCB.00705-15. Print 2016 Jan 1. Erratum in: Mol Cell Biol. 2017 May 31;37(12 ):.

6.

The spliceosomal PRP19 complex of trypanosomes.

Ambrósio DL, Badjatia N, Günzl A.

Mol Microbiol. 2015 Mar;95(5):885-901. doi: 10.1111/mmi.12910. Epub 2015 Jan 30.

7.

Mono-allelic VSG expression by RNA polymerase I in Trypanosoma brucei: expression site control from both ends?

Günzl A, Kirkham JK, Nguyen TN, Badjatia N, Park SH.

Gene. 2015 Feb 1;556(1):68-73. doi: 10.1016/j.gene.2014.09.047. Epub 2014 Sep 26. Review.

8.

Phosphorylation of the TATA-binding protein activates the spliced leader silencing pathway in Trypanosoma brucei.

Hope R, Ben-Mayor E, Friedman N, Voloshin K, Biswas D, Matas D, Drori Y, Günzl A, Michaeli S.

Sci Signal. 2014 Sep 2;7(341):ra85. doi: 10.1126/scisignal.2005234.

PMID:
25185157
9.

A new strategy of RNA interference that targets heterologous sequences reveals CITFA1 as an essential component of class I transcription factor A in Trypanosoma brucei.

Park SH, Nguyen BN, Kirkham JK, Nguyen TN, Günzl A.

Eukaryot Cell. 2014 Jun;13(6):785-95. doi: 10.1128/EC.00014-14. Epub 2014 Apr 11.

10.

Promoter occupancy of the basal class I transcription factor A differs strongly between active and silent VSG expression sites in Trypanosoma brucei.

Nguyen TN, Müller LS, Park SH, Siegel TN, Günzl A.

Nucleic Acids Res. 2014 Mar;42(5):3164-76. doi: 10.1093/nar/gkt1301. Epub 2013 Dec 17.

11.

Trypanosoma brucei harbours a divergent XPB helicase paralogue that is specialized in nucleotide excision repair and conserved among kinetoplastid organisms.

Badjatia N, Nguyen TN, Lee JH, Günzl A.

Mol Microbiol. 2013 Dec;90(6):1293-308. doi: 10.1111/mmi.12435. Epub 2013 Nov 8.

12.

Trypanosome cdc2-related kinase 9 controls spliced leader RNA cap4 methylation and phosphorylation of RNA polymerase II subunit RPB1.

Badjatia N, Ambrósio DL, Lee JH, Günzl A.

Mol Cell Biol. 2013 May;33(10):1965-75. doi: 10.1128/MCB.00156-13. Epub 2013 Mar 11.

13.

MCM-BP is required for repression of life-cycle specific genes transcribed by RNA polymerase I in the mammalian infectious form of Trypanosoma brucei.

Kim HS, Park SH, Günzl A, Cross GA.

PLoS One. 2013;8(2):e57001. doi: 10.1371/journal.pone.0057001. Epub 2013 Feb 25.

14.

Characterization of a novel class I transcription factor A (CITFA) subunit that is indispensable for transcription by the multifunctional RNA polymerase I of Trypanosoma brucei.

Nguyen TN, Nguyen BN, Lee JH, Panigrahi AK, Günzl A.

Eukaryot Cell. 2012 Dec;11(12):1573-81. doi: 10.1128/EC.00250-12. Epub 2012 Oct 26.

15.

Development of an efficient in vitro transcription system for bloodstream form Trypanosoma brucei reveals life cycle-independent functionality of class I transcription factor A.

Park SH, Nguyen TN, Günzl A.

Mol Biochem Parasitol. 2012 Jan;181(1):29-36. doi: 10.1016/j.molbiopara.2011.09.009. Epub 2011 Sep 29.

16.

Response to "Role of RPB7 in RNA pol I transcription in Trypanosoma brucei".

Günzl A, Park SH, Nguyen TN, Kirkham JK, Lee JH.

Mol Biochem Parasitol. 2011 Nov;180(1):45-6. doi: 10.1016/j.molbiopara.2011.07.006. Epub 2011 Jul 23. No abstract available.

PMID:
21816182
17.

Transcription by the multifunctional RNA polymerase I in Trypanosoma brucei functions independently of RPB7.

Park SH, Nguyen TN, Kirkham JK, Lee JH, Günzl A.

Mol Biochem Parasitol. 2011 Nov;180(1):35-42. doi: 10.1016/j.molbiopara.2011.06.008. Epub 2011 Jul 23.

18.

A TFIIH-associated mediator head is a basal factor of small nuclear spliced leader RNA gene transcription in early-diverged trypanosomes.

Lee JH, Cai G, Panigrahi AK, Dunham-Ems S, Nguyen TN, Radolf JD, Asturias FJ, Günzl A.

Mol Cell Biol. 2010 Dec;30(23):5502-13. doi: 10.1128/MCB.00966-10. Epub 2010 Sep 27.

19.

The pre-mRNA splicing machinery of trypanosomes: complex or simplified?

Günzl A.

Eukaryot Cell. 2010 Aug;9(8):1159-70. doi: 10.1128/EC.00113-10. Epub 2010 Jun 25. Review.

20.

SMN-assisted assembly of snRNP-specific Sm cores in trypanosomes.

Palfi Z, Jaé N, Preusser C, Kaminska KH, Bujnicki JM, Lee JH, Günzl A, Kambach C, Urlaub H, Bindereif A.

Genes Dev. 2009 Jul 15;23(14):1650-64. doi: 10.1101/gad.526109.

21.

Spliceosomal proteomics in Trypanosoma brucei reveal new RNA splicing factors.

Luz Ambrósio D, Lee JH, Panigrahi AK, Nguyen TN, Cicarelli RM, Günzl A.

Eukaryot Cell. 2009 Jul;8(7):990-1000. doi: 10.1128/EC.00075-09. Epub 2009 May 8.

22.

Transcriptionally active TFIIH of the early-diverged eukaryote Trypanosoma brucei harbors two novel core subunits but not a cyclin-activating kinase complex.

Lee JH, Jung HS, Günzl A.

Nucleic Acids Res. 2009 Jun;37(11):3811-20. doi: 10.1093/nar/gkp236. Epub 2009 Apr 22.

23.

Tandem affinity purification of proteins.

Günzl A, Schimanski B.

Curr Protoc Protein Sci. 2009 Feb;Chapter 19:Unit 19.19. doi: 10.1002/0471140864.ps1919s55.

PMID:
19235137
24.

Identification of a novel chromosomal passenger complex and its unique localization during cytokinesis in Trypanosoma brucei.

Li Z, Lee JH, Chu F, Burlingame AL, Günzl A, Wang CC.

PLoS One. 2008 Jun 11;3(6):e2354. doi: 10.1371/journal.pone.0002354.

25.

Multifunctional class I transcription in Trypanosoma brucei depends on a novel protein complex.

Brandenburg J, Schimanski B, Nogoceke E, Nguyen TN, Padovan JC, Chait BT, Cross GA, Günzl A.

EMBO J. 2007 Nov 28;26(23):4856-66. Epub 2007 Nov 1.

26.

Antimalarial activity of the anticancer and proteasome inhibitor bortezomib and its analog ZL3B.

Reynolds JM, El Bissati K, Brandenburg J, Günzl A, Mamoun CB.

BMC Clin Pharmacol. 2007 Oct 23;7:13.

27.

Active RNA polymerase I of Trypanosoma brucei harbors a novel subunit essential for transcription.

Nguyen TN, Schimanski B, Günzl A.

Mol Cell Biol. 2007 Sep;27(17):6254-63. Epub 2007 Jul 2.

28.

Purification of components of the translation elongation factor complex of Plasmodium falciparum by tandem affinity purification.

Takebe S, Witola WH, Schimanski B, Günzl A, Ben Mamoun C.

Eukaryot Cell. 2007 Apr;6(4):584-91. Epub 2007 Feb 16.

29.

Spliced leader RNA gene transcription in Trypanosoma brucei requires transcription factor TFIIH.

Lee JH, Nguyen TN, Schimanski B, Günzl A.

Eukaryot Cell. 2007 Apr;6(4):641-9. Epub 2007 Jan 26.

30.

alpha-tubulin minichromosome promoters in the stichotrichous ciliate Stylonychia lemnae.

Skovorodkin I, Pimenov A, Raykhel I, Schimanski B, Ammermann D, Günzl A.

Eukaryot Cell. 2007 Jan;6(1):28-36. Epub 2006 Nov 3.

31.

Purification of an eight subunit RNA polymerase I complex in Trypanosoma brucei.

Nguyen TN, Schimanski B, Zahn A, Klumpp B, Günzl A.

Mol Biochem Parasitol. 2006 Sep;149(1):27-37. Epub 2006 May 11.

PMID:
16730080
32.

A TFIIB-like protein is indispensable for spliced leader RNA gene transcription in Trypanosoma brucei.

Schimanski B, Brandenburg J, Nguyen TN, Caimano MJ, Günzl A.

Nucleic Acids Res. 2006 Mar 22;34(6):1676-84. Print 2006. Erratum in: Nucleic Acids Res. 2006;34(7):2151.

33.
35.

U1 small nuclear RNP from Trypanosoma brucei: a minimal U1 snRNA with unusual protein components.

Palfi Z, Schimanski B, Günzl A, Lücke S, Bindereif A.

Nucleic Acids Res. 2005 Apr 29;33(8):2493-503. Print 2005.

36.
37.

The Trypanosoma brucei spliced leader RNA and rRNA gene promoters have interchangeable TbSNAP50-binding elements.

Schimanski B, Laufer G, Gontcharova L, Günzl A.

Nucleic Acids Res. 2004 Feb 2;32(2):700-9. Print 2004.

38.

RNA polymerase I transcribes procyclin genes and variant surface glycoprotein gene expression sites in Trypanosoma brucei.

Günzl A, Bruderer T, Laufer G, Schimanski B, Tu LC, Chung HM, Lee PT, Lee MG.

Eukaryot Cell. 2003 Jun;2(3):542-51.

39.

The second largest subunit of Trypanosoma brucei's multifunctional RNA polymerase I has a unique N-terminal extension domain.

Schimanski B, Klumpp B, Laufer G, Marhöfer RJ, Selzer PM, Günzl A.

Mol Biochem Parasitol. 2003 Feb;126(2):193-200.

PMID:
12615318
40.

Ex vivo and in vitro identification of a consensus promoter for VSG genes expressed by metacyclic-stage trypanosomes in the tsetse fly.

Ginger ML, Blundell PA, Lewis AM, Browitt A, Günzl A, Barry JD.

Eukaryot Cell. 2002 Dec;1(6):1000-9.

41.

Analysis of RNA-protein complexes by oligonucleotide-targeted RNase H digestion.

Günzl A, Palfi Z, Bindereif A.

Methods. 2002 Feb;26(2):162-9.

PMID:
12054893
42.

Minichromosomal DNA replication in the macronucleus of the hypotrichous ciliate Stylonychia lemnae is independent of chromosome-internal sequences.

Skovorodkin IN, Zassoukhina IB, Hojak S, Ammermann D, Günzl A.

Chromosoma. 2001 Sep;110(5):352-9.

PMID:
11685535
43.
44.
45.

Oligonucleotide-targeted RNase H protection analysis of RNA-protein complexes.

Günzl A, Bindereif A.

Methods Mol Biol. 1999;118:93-103. No abstract available.

PMID:
10549517
47.

Structure of the Trypanosoma brucei U6 snRNA gene promoter.

Nakaar V, Günzl A, Ullu E, Tschudi C.

Mol Biochem Parasitol. 1997 Sep;88(1-2):13-23.

PMID:
9274863
48.

Transcription of the Trypanosoma brucei spliced leader RNA gene is dependent only on the presence of upstream regulatory elements.

Günzl A, Ullu E, Dörner M, Fragoso SP, Hoffmann KF, Milner JD, Morita Y, Nguu EK, Vanacova S, Wünsch S, Dare AO, Kwon H, Tschudi C.

Mol Biochem Parasitol. 1997 Mar;85(1):67-76.

PMID:
9108549
49.

Accurate transcription of the Trypanosoma brucei U2 small nuclear RNA gene in a homologous extract.

Günzl A, Tschudi C, Nakaar V, Ullu E.

J Biol Chem. 1995 Jul 21;270(29):17287-91.

50.

Assembly of the U2 small nuclear ribonucleoprotein from Trypanosoma brucei. A mutational analysis.

Günzl A, Cross M, Palfi Z, Bindereif A.

J Biol Chem. 1993 Jun 25;268(18):13336-43.

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