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Items: 1 to 50 of 407

1.

A multistage murine breast cancer model reveals long-lived premalignant clones refractory to parity-induced protection.

Li S, Gestl SA, Gunther EJ.

Cancer Prev Res (Phila). 2019 Nov 7. pii: canprevres.0322.2019. doi: 10.1158/1940-6207.CAPR-19-0322. [Epub ahead of print]

PMID:
31699706
2.

Anti-PrPC antibody rescues cognition and synapses in transgenic alzheimer mice.

Cox TO, Gunther EC, Brody AH, Chiasseu MT, Stoner A, Smith LM, Haas LT, Hammersley J, Rees G, Dosanjh B, Groves M, Gardener M, Dobson C, Vaughan T, Chessell I, Billinton A, Strittmatter SM.

Ann Clin Transl Neurol. 2019 Feb 27;6(3):554-574. doi: 10.1002/acn3.730. eCollection 2019 Mar.

3.

Effect of oral supplementation of probiotic strains of Lactobacillus rhamnosus and Enterococcus faecium on the composition of the faecal microbiota of foals.

Urubschurov V, Stroebel C, Günther E, Romanowski K, Büsing K, Zeyner A.

J Anim Physiol Anim Nutr (Berl). 2019 May;103(3):915-924. doi: 10.1111/jpn.13079. Epub 2019 Mar 10.

PMID:
30854744
4.

qPSMA: Semiautomatic Software for Whole-Body Tumor Burden Assessment in Prostate Cancer Using 68Ga-PSMA11 PET/CT.

Gafita A, Bieth M, Krönke M, Tetteh G, Navarro F, Wang H, Günther E, Menze B, Weber WA, Eiber M.

J Nucl Med. 2019 Sep;60(9):1277-1283. doi: 10.2967/jnumed.118.224055. Epub 2019 Mar 8.

PMID:
30850484
5.

Rescue of Transgenic Alzheimer's Pathophysiology by Polymeric Cellular Prion Protein Antagonists.

Gunther EC, Smith LM, Kostylev MA, Cox TO, Kaufman AC, Lee S, Folta-Stogniew E, Maynard GD, Um JW, Stagi M, Heiss JK, Stoner A, Noble GP, Takahashi H, Haas LT, Schneekloth JS, Merkel J, Teran C, Naderi ZK, Supattapone S, Strittmatter SM.

Cell Rep. 2019 Jan 29;26(5):1368. doi: 10.1016/j.celrep.2019.01.064. No abstract available.

6.

Evolution of Relapse-Proficient Subclones Constrained by Collateral Sensitivity to Oncogene Overdose in Wnt-Driven Mammary Cancer.

Keller RR, Gunther EJ.

Cell Rep. 2019 Jan 22;26(4):893-905.e4. doi: 10.1016/j.celrep.2018.12.096.

7.

Rescue of Transgenic Alzheimer's Pathophysiology by Polymeric Cellular Prion Protein Antagonists.

Gunther EC, Smith LM, Kostylev MA, Cox TO, Kaufman AC, Lee S, Folta-Stogniew E, Maynard GD, Um JW, Stagi M, Heiss JK, Stoner A, Noble GP, Takahashi H, Haas LT, Schneekloth JS, Merkel J, Teran C, Naderi ZK, Supattapone S, Strittmatter SM.

Cell Rep. 2019 Jan 2;26(1):145-158.e8. doi: 10.1016/j.celrep.2018.12.021. Erratum in: Cell Rep. 2019 Jan 29;26(5):1368.

8.

Liquid and Hydrogel Phases of PrPC Linked to Conformation Shifts and Triggered by Alzheimer's Amyloid-β Oligomers.

Kostylev MA, Tuttle MD, Lee S, Klein LE, Takahashi H, Cox TO, Gunther EC, Zilm KW, Strittmatter SM.

Mol Cell. 2018 Nov 1;72(3):426-443.e12. doi: 10.1016/j.molcel.2018.10.009. Epub 2018 Oct 25.

9.

Effects of oral supplementation of probiotic strains of Lactobacillus rhamnosus and Enterococcus faecium on diarrhoea events of foals in their first weeks of life.

Ströbel C, Günther E, Romanowski K, Büsing K, Urubschurov V, Zeyner A.

J Anim Physiol Anim Nutr (Berl). 2018 Oct;102(5):1357-1365. doi: 10.1111/jpn.12923. Epub 2018 May 23.

PMID:
29790614
10.

["Rosario escapes": Child and adolescent mental health and rights].

Gunther EG.

Vertex. 2017 Jul;28(134):299-301. Spanish.

PMID:
29522596
11.

Prostate cancer infiltrating the bladder sphincter successfully treated with Electrochemotherapy: a case report.

Klein N, Gunther E, Zapf S, El-Idrissi R, Atta J, Stehling M.

Clin Case Rep. 2017 Nov 13;5(12):2127-2132. doi: 10.1002/ccr3.1270. eCollection 2017 Dec.

12.

Cryoelectrolysis; an acute case study in the pig liver.

Lugnani F, Gunther E, Torrecillas P, Galacho C, Garrido AJ, Mikus P, Klein N, Stehling MK, Macchioro M, Rubinsky L, Raju N, Rubinsky B.

Cryobiology. 2017 Oct;78:110-114. doi: 10.1016/j.cryobiol.2017.08.001. Epub 2017 Aug 3.

PMID:
28782504
13.

Treatment of lymph node metastases from gastric cancer with a combination of Irreversible Electroporation and Electrochemotherapy: a case report.

Klein N, Zapf S, Gunther E, Stehling M.

Clin Case Rep. 2017 Jul 14;5(8):1389-1394. doi: 10.1002/ccr3.1079. eCollection 2017 Aug.

14.

A UHF RFID positioning system for use in warehouse navigation by employees with cognitive disability.

Gunther EJM, Sliker LJ, Bodine C.

Disabil Rehabil Assist Technol. 2017 Nov;12(8):832-842. doi: 10.1080/17483107.2016.1274342. Epub 2017 Jan 18.

PMID:
28100087
15.

Carcinogen-specific mutations in preferred Ras-Raf pathway oncogenes directed by strand bias.

Keller RR, Gestl SA, Lu AQ, Hoke A, Feith DJ, Gunther EJ.

Carcinogenesis. 2016 Aug;37(8):810-816. doi: 10.1093/carcin/bgw061. Epub 2016 May 17.

16.

New ligands of the ghrelin receptor based on the 1,2,4-triazole scaffold by introduction of a second chiral center.

Maingot M, Blayo AL, Denoyelle S, M'Kadmi C, Damian M, Mary S, Gagne D, Sanchez P, Aicher B, Schmidt P, Müller G, Teifel M, Günther E, Marie J, Banères JL, Martinez J, Fehrentz JA.

Bioorg Med Chem Lett. 2016 May 15;26(10):2408-2412. doi: 10.1016/j.bmcl.2016.04.003. Epub 2016 Apr 4.

PMID:
27072910
17.

Adding Value to Fruit Processing Waste: Innovative Ways to Incorporate Fibers from Berry Pomace in Baked and Extruded Cereal-based Foods-A SUSFOOD Project.

Rohm H, Brennan C, Turner C, Günther E, Campbell G, Hernando I, Struck S, Kontogiorgos V.

Foods. 2015 Nov 24;4(4):690-697. doi: 10.3390/foods4040690.

18.

Prion-Protein-interacting Amyloid-β Oligomers of High Molecular Weight Are Tightly Correlated with Memory Impairment in Multiple Alzheimer Mouse Models.

Kostylev MA, Kaufman AC, Nygaard HB, Patel P, Haas LT, Gunther EC, Vortmeyer A, Strittmatter SM.

J Biol Chem. 2015 Jul 10;290(28):17415-38. doi: 10.1074/jbc.M115.643577. Epub 2015 May 27.

19.

Fyn inhibition rescues established memory and synapse loss in Alzheimer mice.

Kaufman AC, Salazar SV, Haas LT, Yang J, Kostylev MA, Jeng AT, Robinson SA, Gunther EC, van Dyck CH, Nygaard HB, Strittmatter SM.

Ann Neurol. 2015 Jun;77(6):953-71. doi: 10.1002/ana.24394. Epub 2015 Mar 21.

20.

New trisubstituted 1,2,4-triazoles as ghrelin receptor antagonists.

Blayo AL, Maingot M, Aicher B, M'Kadmi C, Schmidt P, Müller G, Teifel M, Günther E, Gagne D, Denoyelle S, Martinez J, Fehrentz JA.

Bioorg Med Chem Lett. 2015 Jan 1;25(1):20-4. doi: 10.1016/j.bmcl.2014.11.031. Epub 2014 Nov 15.

PMID:
25435152
21.

Organocatalytic stereoselective iodoamination of alkenes.

Mizar P, Burrelli A, Günther E, Söftje M, Farooq U, Wirth T.

Chemistry. 2014 Oct 6;20(41):13113-6. doi: 10.1002/chem.201404762. Epub 2014 Aug 22.

PMID:
25156303
22.

Discovery of (7-aryl-1,5-naphthyridin-2-yl)ureas as dual inhibitors of ERK2 and Aurora B kinases with antiproliferative activity against cancer cells.

Defaux J, Antoine M, Logé C, Le Borgne M, Schuster T, Seipelt I, Aicher B, Teifel M, Günther E, Gerlach M, Marchand P.

Bioorg Med Chem Lett. 2014 Aug 15;24(16):3748-52. doi: 10.1016/j.bmcl.2014.06.078. Epub 2014 Jul 3.

PMID:
25022204
23.

Tumour cell heterogeneity maintained by cooperating subclones in Wnt-driven mammary cancers.

Cleary AS, Leonard TL, Gestl SA, Gunther EJ.

Nature. 2014 Apr 3;508(7494):113-7. doi: 10.1038/nature13187.

24.

Discovery of 7-aryl-substituted (1,5-naphthyridin-4-yl)ureas as aurora kinase inhibitors.

Defaux J, Antoine M, Le Borgne M, Schuster T, Seipelt I, Aicher B, Teifel M, Günther E, Gerlach M, Marchand P.

ChemMedChem. 2014 Jan;9(1):217-32. doi: 10.1002/cmdc.201300384. Epub 2013 Nov 24.

PMID:
24273104
25.

Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein.

Um JW, Kaufman AC, Kostylev M, Heiss JK, Stagi M, Takahashi H, Kerrisk ME, Vortmeyer A, Wisniewski T, Koleske AJ, Gunther EC, Nygaard HB, Strittmatter SM.

Neuron. 2013 Sep 4;79(5):887-902. doi: 10.1016/j.neuron.2013.06.036. Erratum in: Neuron. 2013 Oct 16;80(2):531.

26.

Synthesis and antiproliferative activity of new cytotoxic tri- and tetraazabenzo[3,2-a]fluorene-5,6-dione derivatives.

Leepasert T, Shahabi M, Shanab K, Schirmer E, Holzer W, Spreitzer H, Aicher B, Müller G, Günther E.

Bioorg Med Chem Lett. 2013 Oct 1;23(19):5264-6. doi: 10.1016/j.bmcl.2013.08.021. Epub 2013 Aug 13.

PMID:
23988351
27.

Synthesis and biological evaluation of new cytotoxic indazolo[4,3-gh]isoquinolinone derivatives.

Shahabi M, Schirmer E, Shanab K, Leepasert T, Ruzicka J, Holzer W, Spreitzer H, Aicher B, Schmidt P, Blumenstein L, Müller G, Günther E.

Bioorg Med Chem Lett. 2013 Mar 15;23(6):1846-52. doi: 10.1016/j.bmcl.2013.01.022. Epub 2013 Jan 23.

PMID:
23395656
28.

Basal but not luminal mammary epithelial cells require PI3K/mTOR signaling for Ras-driven overgrowth.

Plichta KA, Mathers JL, Gestl SA, Glick AB, Gunther EJ.

Cancer Res. 2012 Nov 15;72(22):5856-66. doi: 10.1158/0008-5472.CAN-12-1635. Epub 2012 Sep 24.

29.

Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons.

Um JW, Nygaard HB, Heiss JK, Kostylev MA, Stagi M, Vortmeyer A, Wisniewski T, Gunther EC, Strittmatter SM.

Nat Neurosci. 2012 Sep;15(9):1227-35. doi: 10.1038/nn.3178. Epub 2012 Jul 22.

30.

Rapid functional evaluation of beta-cells by extracellular recording of membrane potential oscillations with microelectrode arrays.

Pfeiffer T, Kraushaar U, Düfer M, Schönecker S, Haspel D, Günther E, Drews G, Krippeit-Drews P.

Pflugers Arch. 2011 Dec;462(6):835-40. doi: 10.1007/s00424-011-1029-z. Epub 2011 Sep 24.

PMID:
21947556
31.

Molecular dissection of cis-regulatory modules at the Drosophila bithorax complex reveals critical transcription factor signature motifs.

Starr MO, Ho MC, Gunther EJ, Tu YK, Shur AS, Goetz SE, Borok MJ, Kang V, Drewell RA.

Dev Biol. 2011 Nov 15;359(2):290-302. doi: 10.1016/j.ydbio.2011.07.028. Epub 2011 Jul 28.

32.

Phenylimino-10H-anthracen-9-ones as novel antimicrotubule agents-synthesis, antiproliferative activity and inhibition of tubulin polymerization.

Prinz H, Schmidt P, Böhm KJ, Baasner S, Müller K, Gerlach M, Günther EG, Unger E.

Bioorg Med Chem. 2011 Jul 15;19(14):4183-91. doi: 10.1016/j.bmc.2011.06.010. Epub 2011 Jun 12.

PMID:
21705223
33.

N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization.

Prinz H, Chamasmani B, Vogel K, Böhm KJ, Aicher B, Gerlach M, Günther EG, Amon P, Ivanov I, Müller K.

J Med Chem. 2011 Jun 23;54(12):4247-63. doi: 10.1021/jm200436t. Epub 2011 May 26.

PMID:
21563750
34.

Synthesis and antiproliferative activity of new cytotoxic azanaphthoquinone pyrrolo-annelated derivatives: Part II.

Shanab K, Schirmer E, Wulz E, Weissenbacher B, Lassnig S, Slanz R, Fösleitner G, Holzer W, Spreitzer H, Schmidt P, Aicher B, Müller G, Günther E.

Bioorg Med Chem Lett. 2011 May 15;21(10):3117-21. doi: 10.1016/j.bmcl.2011.03.013. Epub 2011 Mar 30.

PMID:
21458262
35.

A BAC transgenic reporter recapitulates in vivo regulation of human telomerase reverse transcriptase in development and tumorigenesis.

Jia W, Wang S, Horner JW, Wang N, Wang H, Gunther EJ, DePinho RA, Zhu J.

FASEB J. 2011 Mar;25(3):979-89. doi: 10.1096/fj.10-173989. Epub 2010 Dec 6.

36.

P190B RhoGAP has pro-tumorigenic functions during MMTV-Neu mammary tumorigenesis and metastasis.

McHenry PR, Sears JC, Herrick MP, Chang P, Heckman-Stoddard BM, Rybarczyk M, Chodosh LA, Gunther EJ, Hilsenbeck SG, Rosen JM, Vargo-Gogola T.

Breast Cancer Res. 2010;12(5):R73. doi: 10.1186/bcr2643. Epub 2010 Sep 22.

37.

Synthesis and biological evaluation of new cytotoxic azanaphthoquinone pyrrolo-annelated derivatives.

Shanab K, Schirmer E, Knafl H, Wulz E, Holzer W, Spreitzer H, Schmidt P, Aicher B, Müller G, Günther E.

Bioorg Med Chem Lett. 2010 Jul 1;20(13):3950-2. doi: 10.1016/j.bmcl.2010.05.003. Epub 2010 May 7.

PMID:
20537894
38.

Synthesis, antiproliferative activity and inhibition of tubulin polymerization by 1,5- and 1,8-disubstituted 10H-anthracen-9-ones bearing a 10-benzylidene or 10-(2-oxo-2-phenylethylidene) moiety.

Nickel HC, Schmidt P, Böhm KJ, Baasner S, Müller K, Gerlach M, Unger E, Günther EG, Prinz H.

Eur J Med Chem. 2010 Aug;45(8):3420-38. doi: 10.1016/j.ejmech.2010.04.032.

PMID:
20537765
39.

Memory impairment in transgenic Alzheimer mice requires cellular prion protein.

Gimbel DA, Nygaard HB, Coffey EE, Gunther EC, Laurén J, Gimbel ZA, Strittmatter SM.

J Neurosci. 2010 May 5;30(18):6367-74. doi: 10.1523/JNEUROSCI.0395-10.2010.

40.

Identifying a resistance determinant for the antimitotic natural products disorazole C1 and A1.

Lazo JS, Reese CE, Vogt A, Vollmer LL, Kitchens CA, Günther E, Graham TH, Hopkins CD, Wipf P.

J Pharmacol Exp Ther. 2010 Mar;332(3):906-11. doi: 10.1124/jpet.109.162842. Epub 2009 Dec 15.

41.

Beta-amyloid oligomers and cellular prion protein in Alzheimer's disease.

Gunther EC, Strittmatter SM.

J Mol Med (Berl). 2010 Apr;88(4):331-8. doi: 10.1007/s00109-009-0568-7. Epub 2009 Dec 4. Review.

42.

Synthesis and structure-activity relationships of N-aryl(indol-3-yl)glyoxamides as antitumor agents.

Marchand P, Antoine M, Le Baut G, Czech M, Baasner S, Günther E.

Bioorg Med Chem. 2009 Sep 15;17(18):6715-27. doi: 10.1016/j.bmc.2009.07.048. Epub 2009 Jul 25.

PMID:
19682911
43.

10-(2-oxo-2-phenylethylidene)-10H-anthracen-9-ones as highly active antimicrotubule agents: synthesis, antiproliferative activity, and inhibition of tubulin polymerization.

Prinz H, Schmidt P, Böhm KJ, Baasner S, Müller K, Unger E, Gerlach M, Günther EG.

J Med Chem. 2009 Mar 12;52(5):1284-94. doi: 10.1021/jm801338r.

PMID:
19220018
44.

Targeting the activator protein 1 transcription factor for the prevention of estrogen receptor-negative mammary tumors.

Shen Q, Uray IP, Li Y, Zhang Y, Hill J, Xu XC, Young MR, Gunther EJ, Hilsenbeck SG, Colburn NH, Chodosh LA, Brown PH.

Cancer Prev Res (Phila). 2008 Jun;1(1):45-55. doi: 10.1158/1940-6207.CAPR-08-0034. Epub 2008 Mar 31.

45.

Side chain modifications of (indol-3-yl)glyoxamides as antitumor agents.

Antoine M, Marchand P, Le Baut G, Czech M, Baasner S, Gunther E.

J Enzyme Inhib Med Chem. 2008 Oct;23(5):686-95. doi: 10.1080/14756360802207998 .

PMID:
18821257
46.

Tumor escape in a Wnt1-dependent mouse breast cancer model is enabled by p19Arf/p53 pathway lesions but not p16 Ink4a loss.

Debies MT, Gestl SA, Mathers JL, Mikse OR, Leonard TL, Moody SE, Chodosh LA, Cardiff RD, Gunther EJ.

J Clin Invest. 2008 Jan;118(1):51-63.

47.

Sulfonate derivatives of naphtho[2,3-b]thiophen-4(9H)-one and 9(10H)-anthracenone as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.

Zuse A, Schmidt P, Baasner S, Böhm KJ, Müller K, Gerlach M, Günther EG, Unger E, Prinz H.

J Med Chem. 2007 Nov 29;50(24):6059-66. Epub 2007 Oct 31.

PMID:
17973361
48.

Synthesis and biological evaluation of novel cytotoxic azanaphthoquinone annelated pyrrolo oximes.

Shanab K, Pongprom N, Wulz E, Holzer W, Spreitzer H, Schmidt P, Aicher B, Müller G, Günther E.

Bioorg Med Chem Lett. 2007 Nov 15;17(22):6091-5. Epub 2007 Sep 18.

PMID:
17904839
49.

9-Benzylidene-naphtho[2,3-b]thiophen-4-ones and benzylidene-9(10H)-anthracenones as novel tubulin interacting agents with high apoptosis-inducing activity.

Zuse A, Prinz H, Müller K, Schmidt P, Günther EG, Schweizer F, Prehn JH, Los M.

Eur J Pharmacol. 2007 Dec 1;575(1-3):34-45. Epub 2007 Aug 1.

PMID:
17707367
50.

9-Benzylidene-naphtho[2,3-b]thiophen-4-ones as novel antimicrotubule agents-synthesis, antiproliferative activity, and inhibition of tubulin polymerization.

Zuse A, Schmidt P, Baasner S, Böhm KJ, Müller K, Gerlach M, Günther EG, Unger E, Prinz H.

J Med Chem. 2006 Dec 28;49(26):7816-25.

PMID:
17181164

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