Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 42

1.

Heliotropiumides A and B, new phenolamides with N-carbamoyl putrescine moiety from Heliotropium foertherianum collected in Hawaii and their biological activities.

Cai YS, Sarotti AM, Gündisch D, Kondratyuk TP, Pezzuto JM, Turkson J, Cao S.

Bioorg Med Chem Lett. 2017 Oct 15;27(20):4630-4634. doi: 10.1016/j.bmcl.2017.09.021. Epub 2017 Sep 9.

PMID:
28927792
2.

Privileged Scaffolds in Natural Products and Drug Discovery.

Sun D, Gündisch D.

Curr Top Med Chem. 2016;16(11):1199. No abstract available.

PMID:
26456462
3.

Bispidine as a Privileged Scaffold.

Tomassoli I, Gündisch D.

Curr Top Med Chem. 2016;16(11):1314-42. Review.

PMID:
26369817
4.

Carbazole Scaffold in Medicinal Chemistry and Natural Products: A Review from 2010-2015.

Tsutsumi LS, Gündisch D, Sun D.

Curr Top Med Chem. 2016;16(11):1290-313. Review.

PMID:
26369811
5.

The twin drug approach for novel nicotinic acetylcholine receptor ligands.

Tomassoli I, Gündisch D.

Bioorg Med Chem. 2015 Aug 1;23(15):4375-89. doi: 10.1016/j.bmc.2015.06.034. Epub 2015 Jun 20.

6.

Semisynthetic analogues of toxiferine I and their pharmacological properties at α7 nAChRs, muscle-type nAChRs, and the allosteric binding site of muscarinic M2 receptors.

Zlotos DP, Tränkle C, Holzgrabe U, Gündisch D, Jensen AA.

J Nat Prod. 2014 Sep 26;77(9):2006-13. doi: 10.1021/np500259j. Epub 2014 Sep 5.

7.

The 3,7-diazabicyclo[3.3.1]nonane scaffold for subtype selective nicotinic acetylcholine receptor (nAChR) ligands. Part 1: the influence of different hydrogen bond acceptor systems on alkyl and (hetero)aryl substituents.

Eibl C, Tomassoli I, Munoz L, Stokes C, Papke RL, Gündisch D.

Bioorg Med Chem. 2013 Dec 1;21(23):7283-308. doi: 10.1016/j.bmc.2013.09.059. Epub 2013 Oct 5.

8.

The 3,7-diazabicyclo[3.3.1]nonane scaffold for subtype selective nicotinic acetylcholine receptor ligands. Part 2: carboxamide derivatives with different spacer motifs.

Eibl C, Munoz L, Tomassoli I, Stokes C, Papke RL, Gündisch D.

Bioorg Med Chem. 2013 Dec 1;21(23):7309-29. doi: 10.1016/j.bmc.2013.09.060. Epub 2013 Oct 5.

9.

Synthesis and evaluation of N(1)-alkylindole-3-ylalkylammonium compounds as nicotinic acetylcholine receptor ligands.

Pérez EG, Cassels BK, Eibl C, Gündisch D.

Bioorg Med Chem. 2012 Jun 15;20(12):3719-27. doi: 10.1016/j.bmc.2012.04.050. Epub 2012 May 2.

PMID:
22609074
10.

Feasibility of [18F]-2-Fluoro-A85380-PET imaging of human vascular nicotinic acetylcholine receptors in vivo.

Bucerius J, Manka C, Schmaljohann J, Mani V, Gündisch D, Rudd JH, Bippus R, Mottaghy FM, Wüllner U, Fayad ZA, Biersack HJ.

JACC Cardiovasc Imaging. 2012 May;5(5):528-36. doi: 10.1016/j.jcmg.2011.11.024.

11.

Nicotinic acetylcholine receptor ligands, a patent review (2006-2011).

Gündisch D, Eibl C.

Expert Opin Ther Pat. 2011 Dec;21(12):1867-96. doi: 10.1517/13543776.2011.637919. Review.

12.

A hydrazide linker strategy for heterobivalent compounds as ortho- and allosteric ligands of acetylcholine-binding proteins.

Elsinghorst PW, Härtig W, Gündisch D, Mohr K, Tränkle C, Gütschow M.

Curr Top Med Chem. 2011 Nov;11(22):2731-48. Review.

PMID:
22039876
13.

Nicotine decreases food intake through activation of POMC neurons.

Mineur YS, Abizaid A, Rao Y, Salas R, DiLeone RJ, Gündisch D, Diano S, De Biasi M, Horvath TL, Gao XB, Picciotto MR.

Science. 2011 Jun 10;332(6035):1330-2. doi: 10.1126/science.1201889.

14.

Cytisine-based nicotinic partial agonists as novel antidepressant compounds.

Mineur YS, Eibl C, Young G, Kochevar C, Papke RL, Gündisch D, Picciotto MR.

J Pharmacol Exp Ther. 2009 Apr;329(1):377-86. doi: 10.1124/jpet.108.149609. Epub 2009 Jan 22.

15.

Smoking upregulates alpha4beta2* nicotinic acetylcholine receptors in the human brain.

Wüllner U, Gündisch D, Herzog H, Minnerop M, Joe A, Warnecke M, Jessen F, Schütz C, Reinhardt M, Eschner W, Klockgether T, Schmaljohann J.

Neurosci Lett. 2008 Jan 3;430(1):34-7. Epub 2007 Oct 22.

PMID:
17997038
16.

Synthetic approaches and bio-distribution studies of [11C]methyl-phenidate.

Patt M, Solbach C, Wüllner U, Blocher A, Stahlschmidt A, Gündisch D, Kovar KA, Machulla HJ.

J Pharm Pharm Sci. 2007;10(2):312s-320s.

17.

In vitro evaluation of nicotinic acetylcholine receptors with 2-[18F]F-A85380 in Parkinson's disease.

Schmaljohann J, Gündisch D, Minnerop M, Bucerius J, Joe A, Reinhardt M, Guhlke S, Biersack HJ, Wüllner U.

Nucl Med Biol. 2006 Apr;33(3):305-9. Epub 2006 Mar 9.

PMID:
16631078
18.

Feasibility of 2-deoxy-2-[18F]fluoro-D-glucose- A85380-PET for imaging of human cardiac nicotinic acetylcholine receptors in vivo.

Bucerius J, Joe AY, Schmaljohann J, Gündisch D, Minnerop M, Biersack HJ, Wüllner U, Reinhardt MJ.

Clin Res Cardiol. 2006 Feb;95(2):105-9. Epub 2006 Jan 19. Erratum in: Clin Res Cardiol. 2006 Jun;95(6):354.

PMID:
16598519
19.

6H,13H-Pyrazino[1,2-a;4,5-a']diindole analogs: probing the pharmacophore for allosteric ligands of muscarinic M2 receptors.

Zlotos DP, Tränkle C, Abdelrahman A, Gündisch D, Radacki K, Braunschweig H, Mohr K.

Bioorg Med Chem Lett. 2006 Mar 15;16(6):1481-5. Epub 2006 Jan 4.

PMID:
16387499
20.

[Nuclides and tracers--mechanisms and application. Radiodiagnosis for peripheral organ diseases].

Gündisch D.

Pharm Unserer Zeit. 2005;34(6):484-9. Review. German. No abstract available.

PMID:
16320636
21.

A simple and fast method for the preparation of n.c.a. 2-[18F]F-A85380 for human use.

Schmaljohann J, Gündisch D, Minnerop M, Joe A, Bucerius J, Dittmar C, Jessen F, Guhlke S, Wüllner U.

Appl Radiat Isot. 2005 Oct;63(4):433-5.

PMID:
16024252
22.
23.

Halogenated and isosteric cytisine derivatives with increased affinity and functional activity at nicotinic acetylcholine receptors.

Fitch RW, Kaneko Y, Klaperski P, Daly JW, Seitz G, Gündisch D.

Bioorg Med Chem Lett. 2005 Feb 15;15(4):1221-4.

PMID:
15686946
24.

In vitro characterization of 6-[18F]fluoro-A-85380, a high-affinity ligand for alpha4beta2* nicotinic acetylcholine receptors.

Gündisch D, Koren AO, Horti AG, Pavlova OA, Kimes AS, Mukhin AG, London ED.

Synapse. 2005 Feb;55(2):89-97.

PMID:
15529332
25.

Bisquaternary caracurine V and iso-caracurine V salts as ligands for the muscle type of nicotinic acetylcholine receptors: SAR and QSAR studies.

Zlotos DP, Gündisch D, Ferraro S, Tilotta MC, Stiefl N, Baumann K.

Bioorg Med Chem. 2004 Dec 1;12(23):6277-85.

PMID:
15519170
26.

Prenylated indole alkaloids from Flustra foliacea with subtype specific binding on NAChRs.

Peters L, Wright AD, Kehraus S, Gündisch D, Tilotta MC, König GM.

Planta Med. 2004 Oct;70(10):883-6.

PMID:
15490312
27.

Imaging of central nAChReceptors with 2-[18F]F-A85380: optimized synthesis and in vitro evaluation in Alzheimer's disease.

Schmaljohann J, Minnerop M, Karwath P, Gündisch D, Falkai P, Guhlke S, Wüllner U.

Appl Radiat Isot. 2004 Dec;61(6):1235-40.

PMID:
15388115
28.

Synthesis and evaluation of phenylcarbamate derivatives as ligands for nicotinic acetylcholine receptors.

Gündisch D, Andrä M, Munoz L, Cristina Tilotta M.

Bioorg Med Chem. 2004 Sep 15;12(18):4953-62.

PMID:
15336274
29.

Novel enantiopure ferrugininoids active as nicotinic agents: synthesis and radioligand binding studies.

Seifert S, Stehl A, Tilotta MC, Gündisch D, Seitz G.

Pharmazie. 2004 Jun;59(6):427-34.

PMID:
15248455
30.

Improved synthesis and in vitro evaluation of quinuclidin-2-ene based ligands for the nicotinic acetylcholine receptor.

Seifert S, Gündisch D, Tilotta MC, Seitz G.

Pharmazie. 2003 May;58(5):353-4. No abstract available.

PMID:
12779056
31.

Synthesis and nicotinic binding studies on enantiopure pinnamine variants with an 8-azabicyclo[3.2.1]octane moiety.

Schwarz S, Kämpchen T, Tilotta MC, Gündisch D, Seitz G.

Pharmazie. 2003 May;58(5):295-9.

PMID:
12779043
32.

3D QSAR analyses-guided rational design of novel ligands for the (alpha4)2(beta2)3 nicotinic acetylcholine receptor.

Gohlke H, Schwarz S, Gündisch D, Tilotta MC, Weber A, Wegge T, Seitz G.

J Med Chem. 2003 May 22;46(11):2031-48.

PMID:
12747776
33.

Synthesis and nicotinic binding studies on enantiopure diazine analogues of the novel (2-chloro-5-pyridyl)-9-azabicyclo[4.2.1]non-2-ene UB-165.

Gohlke H, Gündisch D, Schwarz S, Seitz G, Tilotta MC, Wegge T.

J Med Chem. 2002 Feb 28;45(5):1064-72.

PMID:
11855986
34.
35.

Synthesis and evaluation of diazine containing bioisosteres of (-)-ferruginine as ligands for nicotinic acetylcholine receptors.

Gündisch D, Harms K, Schwarz S, Seitz G, Stubbs MT, Wegge T.

Bioorg Med Chem. 2001 Oct;9(10):2683-91.

PMID:
11557356
36.

Syntheses and evaluation of halogenated cytisine derivatives and of bioisosteric thiocytisine as potent and selective nAChR ligands.

Imming P, Klaperski P, Stubbs MT, Seitz G, Gündisch D.

Eur J Med Chem. 2001 Apr;36(4):375-88.

PMID:
11461763
37.

6-[18F]fluoro-A-85380, a novel radioligand for in vivo imaging of central nicotinic acetylcholine receptors.

Horti AG, Chefer SI, Mukhin AG, Koren AO, Gündisch D, Links JM, Kurian V, Dannals RF, London ED.

Life Sci. 2000 Jun 16;67(4):463-9.

PMID:
11003056
38.

Development of a 5-hydroxytryptamine(2A) receptor binding assay for high throughput screening using 96-well microfilter plates.

Harms A, Gündisch D, Müller CE, Kovar KA.

J Biomol Screen. 2000 Aug;5(4):269-78.

PMID:
10992048
39.

Nicotinic acetylcholine receptors and imaging.

Gündisch D.

Curr Pharm Des. 2000 Jul;6(11):1143-57. Review.

PMID:
10903387
40.

5-Iodo-A-85380, an alpha4beta2 subtype-selective ligand for nicotinic acetylcholine receptors.

Mukhin AG, Gündisch D, Horti AG, Koren AO, Tamagnan G, Kimes AS, Chambers J, Vaupel DB, King SL, Picciotto MR, Innis RB, London ED.

Mol Pharmacol. 2000 Mar;57(3):642-9.

41.

2-[18F]F-A-85380: a PET radioligand for alpha4beta2 nicotinic acetylcholine receptors.

Chefer SI, Horti AG, Koren AO, Gündisch D, Links JM, Kurian V, Dannals RF, Mukhin AG, London ED.

Neuroreport. 1999 Sep 9;10(13):2715-21.

PMID:
10511429
42.

2-, 5-, and 6-Halo-3-(2(S)-azetidinylmethoxy)pyridines: synthesis, affinity for nicotinic acetylcholine receptors, and molecular modeling.

Koren AO, Horti AG, Mukhin AG, Gündisch D, Kimes AS, Dannals RF, London ED.

J Med Chem. 1998 Sep 10;41(19):3690-8.

PMID:
9733494

Supplemental Content

Loading ...
Support Center