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Items: 33

1.

A genetics-led approach defines the drug target landscape of 30 immune-related traits.

Fang H; ULTRA-DD Consortium, De Wolf H, Knezevic B, Burnham KL, Osgood J, Sanniti A, Lledó Lara A, Kasela S, De Cesco S, Wegner JK, Handunnetthi L, McCann FE, Chen L, Sekine T, Brennan PE, Marsden BD, Damerell D, O'Callaghan CA, Bountra C, Bowness P, Sundström Y, Milani L, Berg L, Göhlmann HW, Peeters PJ, Fairfax BP, Sundström M, Knight JC.

Nat Genet. 2019 Jul;51(7):1082-1091. doi: 10.1038/s41588-019-0456-1. Epub 2019 Jun 28.

PMID:
31253980
2.

A random effects model for the identification of differential splicing (REIDS) using exon and HTA arrays.

Van Moerbeke M, Kasim A, Talloen W, Reumers J, Göhlmann HWH, Shkedy Z.

BMC Bioinformatics. 2017 May 25;18(1):273. doi: 10.1186/s12859-017-1687-8.

3.

Progressive leukoencephalopathy impairs neurobehavioral development in sialin-deficient mice.

Stroobants S, Van Acker NG, Verheijen FW, Goris I, Daneels GF, Schot R, Verbeek E, Knaapen MW, De Bondt A, Göhlmann HW, Crauwels ML, Mancini GM, Andries LJ, Moechars DW, D'Hooge R.

Exp Neurol. 2017 May;291:106-119. doi: 10.1016/j.expneurol.2017.02.009. Epub 2017 Feb 9.

4.

Weighted similarity-based clustering of chemical structures and bioactivity data in early drug discovery.

Perualila-Tan NJ, Shkedy Z, Talloen W, Göhlmann HW; Quantitative Structure Transcription Assay Relationships (QSTAR) Consortium, Moerbeke MV, Kasim A.

J Bioinform Comput Biol. 2016 Aug;14(4):1650018. doi: 10.1142/S0219720016500189. Epub 2016 Apr 26.

PMID:
27312313
5.

A joint modeling approach for uncovering associations between gene expression, bioactivity and chemical structure in early drug discovery to guide lead selection and genomic biomarker development.

Perualila-Tan N, Kasim A, Talloen W, Verbist B, Göhlmann HW; QSTAR Consortium, Shkedy Z.

Stat Appl Genet Mol Biol. 2016 Aug 1;15(4):291-304. doi: 10.1515/sagmb-2014-0086.

PMID:
27269248
6.

Transcriptional Characterization of Compounds: Lessons Learned from the Public LINCS Data.

De Wolf H, De Bondt A, Turner H, Göhlmann HW.

Assay Drug Dev Technol. 2016 May;14(4):252-60. doi: 10.1089/adt.2016.715.

7.

Understanding drugs in breast cancer through drug sensitivity screening.

Uhr K, Prager-van der Smissen WJ, Heine AA, Ozturk B, Smid M, Göhlmann HW, Jager A, Foekens JA, Martens JW.

Springerplus. 2015 Oct 15;4:611. doi: 10.1186/s40064-015-1406-8. eCollection 2015.

8.

Translation of disease associated gene signatures across tissues.

Kasim A, Shkedy Z, Lin D, Van Sanden S, Abrahantes JC, Göhlmann HW, Bijnens L, Yekutieli D, Camilleri M, Aerssens J, Talloen W.

Int J Data Min Bioinform. 2015;11(3):301-13.

PMID:
26333264
9.

Integrating High-Dimensional Transcriptomics and Image Analysis Tools into Early Safety Screening: Proof of Concept for a New Early Drug Development Strategy.

Verbist BM, Verheyen GR, Vervoort L, Crabbe M, Beerens D, Bosmans C, Jaensch S, Osselaer S, Talloen W, Van den Wyngaert I, Van Hecke G, Wuyts D; QSTAR Consortium, Van Goethem F, Göhlmann HW.

Chem Res Toxicol. 2015 Oct 19;28(10):1914-25. doi: 10.1021/acs.chemrestox.5b00103. Epub 2015 Sep 15.

10.

Using transcriptomics to guide lead optimization in drug discovery projects: Lessons learned from the QSTAR project.

Verbist B, Klambauer G, Vervoort L, Talloen W; QSTAR Consortium, Shkedy Z, Thas O, Bender A, Göhlmann HW, Hochreiter S.

Drug Discov Today. 2015 May;20(5):505-13. doi: 10.1016/j.drudis.2014.12.014. Epub 2015 Jan 10.

11.

Connecting gene expression data from connectivity map and in silico target predictions for small molecule mechanism-of-action analysis.

Ravindranath AC, Perualila-Tan N, Kasim A, Drakakis G, Liggi S, Brewerton SC, Mason D, Bodkin MJ, Evans DA, Bhagwat A, Talloen W, Göhlmann HW, Shkedy Z, Bender A; QSTAR Consortium.

Mol Biosyst. 2015 Jan;11(1):86-96. doi: 10.1039/c4mb00328d. Epub 2014 Sep 25.

PMID:
25254964
12.

Delayed bactericidal response of Mycobacterium tuberculosis to bedaquiline involves remodelling of bacterial metabolism.

Koul A, Vranckx L, Dhar N, Göhlmann HW, Özdemir E, Neefs JM, Schulz M, Lu P, Mørtz E, McKinney JD, Andries K, Bald D.

Nat Commun. 2014 Feb 26;5:3369. doi: 10.1038/ncomms4369.

13.

Comparison of methods for the selection of genomic biomarkers.

Lin D, Tilahun A, Abrahantes JC, Shkedy Z, Molenberghs G, Gohlmann HW, Talloen W, Bijnens L.

Int J Data Min Bioinform. 2013;8(1):24-41.

PMID:
23865163
14.

Gene filtering in the analysis of Illumina microarray experiments.

Forcheh AC, Verbeke G, Kasim A, Lin D, Shkedy Z, Talloen W, Göhlmann HW, Clement L.

Stat Appl Genet Mol Biol. 2012 Jan 6;11(2). pii: /j/sagmb.2012.11.issue-2/1544-6115.1710/1544-6115.1710.xml. doi: 10.2202/1544-6115.1710.

PMID:
22499694
15.

Genomic biomarkers for a binary clinical outcome in early drug development microarray experiments.

Van Sanden S, Shkedy Z, Burzykowski T, Göhlmann HW, Talloen W, Bijnens L.

J Biopharm Stat. 2012;22(1):72-92. doi: 10.1080/10543406.2010.504906.

PMID:
22204528
16.

FABIA: factor analysis for bicluster acquisition.

Hochreiter S, Bodenhofer U, Heusel M, Mayr A, Mitterecker A, Kasim A, Khamiakova T, Van Sanden S, Lin D, Talloen W, Bijnens L, Göhlmann HW, Shkedy Z, Clevert DA.

Bioinformatics. 2010 Jun 15;26(12):1520-7. doi: 10.1093/bioinformatics/btq227. Epub 2010 Apr 23.

17.

Response prediction to a multitargeted kinase inhibitor in cancer cell lines and xenograft tumors using high-content tyrosine peptide arrays with a kinetic readout.

Versele M, Talloen W, Rockx C, Geerts T, Janssen B, Lavrijssen T, King P, Göhlmann HW, Page M, Perera T.

Mol Cancer Ther. 2009 Jul;8(7):1846-55. doi: 10.1158/1535-7163.MCT-08-1029. Epub 2009 Jul 7.

18.

An investigation on performance of Significance Analysis of Microarray (SAM) for the comparisons of several treatments with one control in the presence of small-variance genes.

Lin D, Shkedy Z, Burzykowski T, Ion R, Göhlmann HW, Bondt AD, Perer T, Geerts T, Van den Wyngaert I, Bijnens L.

Biom J. 2008 Oct;50(5):801-23. doi: 10.1002/bimj.200710467.

PMID:
18932139
19.

Diarylquinolines are bactericidal for dormant mycobacteria as a result of disturbed ATP homeostasis.

Koul A, Vranckx L, Dendouga N, Balemans W, Van den Wyngaert I, Vergauwen K, Göhlmann HW, Willebrords R, Poncelet A, Guillemont J, Bald D, Andries K.

J Biol Chem. 2008 Sep 12;283(37):25273-80. doi: 10.1074/jbc.M803899200. Epub 2008 Jul 14.

20.

Alterations in mucosal immunity identified in the colon of patients with irritable bowel syndrome.

Aerssens J, Camilleri M, Talloen W, Thielemans L, Göhlmann HW, Van Den Wyngaert I, Thielemans T, De Hoogt R, Andrews CN, Bharucha AE, Carlson PJ, Busciglio I, Burton DD, Smyrk T, Urrutia R, Coulie B.

Clin Gastroenterol Hepatol. 2008 Feb;6(2):194-205. doi: 10.1016/j.cgh.2007.11.012.

21.

Testing for trends in dose-response microarray experiments: a comparison of several testing procedures, multiplicity and resampling-based inference.

Lin D, Shkedy Z, Yekutieli D, Burzykowski T, Göhlmann HW, De Bondt A, Perera T, Geerts T, Bijnens L.

Stat Appl Genet Mol Biol. 2007;6:Article26. Epub 2007 Oct 11.

PMID:
18052909
22.

I/NI-calls for the exclusion of non-informative genes: a highly effective filtering tool for microarray data.

Talloen W, Clevert DA, Hochreiter S, Amaratunga D, Bijnens L, Kass S, Göhlmann HW.

Bioinformatics. 2007 Nov 1;23(21):2897-902. Epub 2007 Oct 5.

PMID:
17921172
23.

The high-level similarity of some disparate gene expression measures.

Raghavan N, De Bondt AM, Talloen W, Moechars D, Göhlmann HW, Amaratunga D.

Bioinformatics. 2007 Nov 15;23(22):3032-8. Epub 2007 Sep 24.

PMID:
17893087
24.

Alterations in the brain-gut axis underlying visceral chemosensitivity in Nippostrongylus brasiliensis-infected mice.

Aerssens J, Hillsley K, Peeters PJ, de Hoogt R, Stanisz A, Lin JH, Van den Wyngaert I, Göhlmann HW, Grundy D, Stead RH, Coulie B.

Gastroenterology. 2007 Apr;132(4):1375-87. Epub 2007 Feb 7.

PMID:
17408648
25.

Analysis of Affymetrix GeneChip data using amplified RNA.

Cope L, Hartman SM, Göhlmann HW, Tiesman JP, Irizarry RA.

Biotechniques. 2006 Feb;40(2):165-6, 168, 170.

26.

Molecular profiling of murine sensory neurons in the nodose and dorsal root ganglia labeled from the peritoneal cavity.

Peeters PJ, Aerssens J, de Hoogt R, Stanisz A, Göhlmann HW, Hillsley K, Meulemans A, Grundy D, Stead RH, Coulie B.

Physiol Genomics. 2006 Feb 14;24(3):252-63. Epub 2005 Nov 22.

PMID:
16303873
27.

A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis.

Andries K, Verhasselt P, Guillemont J, Göhlmann HW, Neefs JM, Winkler H, Van Gestel J, Timmerman P, Zhu M, Lee E, Williams P, de Chaffoy D, Huitric E, Hoffner S, Cambau E, Truffot-Pernot C, Lounis N, Jarlier V.

Science. 2005 Jan 14;307(5707):223-7. Epub 2004 Dec 9.

28.

Transcriptional response to corticotropin-releasing factor in AtT-20 cells.

Peeters PJ, Göhlmann HW, Van den Wyngaert I, Swagemakers SM, Bijnens L, Kass SU, Steckler T.

Mol Pharmacol. 2004 Nov;66(5):1083-92. Epub 2004 Jul 22.

PMID:
15272051
29.

Graphical exploration of gene expression data: a comparative study of three multivariate methods.

Wouters L, Göhlmann HW, Bijnens L, Kass SU, Molenberghs G, Lewi PJ.

Biometrics. 2003 Dec;59(4):1131-9.

PMID:
14969494
30.

Transcription profiles of the bacterium Mycoplasma pneumoniae grown at different temperatures.

Weiner J 3rd, Zimmerman CU, Göhlmann HW, Herrmann R.

Nucleic Acids Res. 2003 Nov 1;31(21):6306-20.

31.

Identification of a small RNA within the pdh gene cluster of Mycoplasma pneumoniae and Mycoplasma genitalium.

Göhlmann HW, Weiner J 3rd, Schön A, Herrmann R.

J Bacteriol. 2000 Jun;182(11):3281-4.

32.
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