Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 12

1.

Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4'-fluoro and 4'-chloro analogues of amodiaquine. Identification of a suitable "back-up" compound for N-tert-butyl isoquine.

O'Neill PM, Shone AE, Stanford D, Nixon G, Asadollahy E, Park BK, Maggs JL, Roberts P, Stocks PA, Biagini G, Bray PG, Davies J, Berry N, Hall C, Rimmer K, Winstanley PA, Hindley S, Bambal RB, Davis CB, Bates M, Gresham SL, Brigandi RA, Gomez-de-Las-Heras FM, Gargallo DV, Parapini S, Vivas L, Lander H, Taramelli D, Ward SA.

J Med Chem. 2009 Apr 9;52(7):1828-44. doi: 10.1021/jm8012757.

2.

A murine model of falciparum-malaria by in vivo selection of competent strains in non-myelodepleted mice engrafted with human erythrocytes.

Angulo-Barturen I, Jiménez-Díaz MB, Mulet T, Rullas J, Herreros E, Ferrer S, Jiménez E, Mendoza A, Regadera J, Rosenthal PJ, Bathurst I, Pompliano DL, Gómez de las Heras F, Gargallo-Viola D.

PLoS One. 2008 May 21;3(5):e2252. doi: 10.1371/journal.pone.0002252.

3.

Synthesis and structure-activity relationships of 4-pyridones as potential antimalarials.

Yeates CL, Batchelor JF, Capon EC, Cheesman NJ, Fry M, Hudson AT, Pudney M, Trimming H, Woolven J, Bueno JM, Chicharro J, Fernández E, Fiandor JM, Gargallo-Viola D, Gómez de las Heras F, Herreros E, León ML.

J Med Chem. 2008 May 8;51(9):2845-52. doi: 10.1021/jm0705760. Epub 2008 Apr 9.

PMID:
18396855
4.

Identification and activity of a series of azole-based compounds with lactate dehydrogenase-directed anti-malarial activity.

Cameron A, Read J, Tranter R, Winter VJ, Sessions RB, Brady RL, Vivas L, Easton A, Kendrick H, Croft SL, Barros D, Lavandera JL, Martin JJ, Risco F, García-Ochoa S, Gamo FJ, Sanz L, Leon L, Ruiz JR, Gabarró R, Mallo A, Gómez de las Heras F.

J Biol Chem. 2004 Jul 23;279(30):31429-39. Epub 2004 Apr 26.

5.

Antifungal Sordarins. Part 4: synthesis and structure--activity relationships of 3',4'-fused alkyl-tetrahydrofuran derivatives.

Bueno JM, Chicharro J, Fiandor JM, Gómez de las Heras F, Huss S.

Bioorg Med Chem Lett. 2002 Jul 8;12(13):1697-700.

PMID:
12067540
6.

Antifungal sordarins. Synthesis and structure-activity relationships of 3',4'-fused dioxolane and dioxane derivatives.

Bueno JM, Cuevas JC, Fiandor JM, García-Ochoa S, Gómez de las Heras F.

Bioorg Med Chem Lett. 2002 Jan 21;12(2):121-4.

PMID:
11755335
7.

Antifungal sordarins. Synthesis and structure-activity relationships of 3'-O-substituted derivatives.

Arribas EM, Castro J, Clemens IR, Cuevas JC, Chicharro J, Fraile MT, García-Ochoa S, Gómez de las Heras F, Ruiz JR.

Bioorg Med Chem Lett. 2002 Jan 21;12(2):117-20.

PMID:
11755334
8.

Antifungal activities and cytotoxicity studies of six new azasordarins.

Herreros E, Almela MJ, Lozano S, Gomez de las Heras F, Gargallo-Viola D.

Antimicrob Agents Chemother. 2001 Nov;45(11):3132-9.

9.

Animal pharmacokinetics and interspecies scaling of sordarin derivatives following intravenous administration.

Aviles P, Pateman A, San Roman R, Guillén MJ, Gómez De Las Heras F, Gargallo-Viola D.

Antimicrob Agents Chemother. 2001 Oct;45(10):2787-92.

10.
11.

Translation elongation factor 2 is part of the target for a new family of antifungals.

Capa L, Mendoza A, Lavandera JL, Gómez de las Heras F, García-Bustos JF.

Antimicrob Agents Chemother. 1998 Oct;42(10):2694-9.

12.

Sordarins: A new class of antifungals with selective inhibition of the protein synthesis elongation cycle in yeasts.

Domínguez JM, Kelly VA, Kinsman OS, Marriott MS, Gómez de las Heras F, Martín JJ.

Antimicrob Agents Chemother. 1998 Sep;42(9):2274-8.

Supplemental Content

Loading ...
Support Center