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Items: 6


The E3 ubiquitin ligase NEDD4 induces endocytosis and lysosomal sorting of connexin 43 to promote loss of gap junctions.

Totland MZ, Bergsland CH, Fykerud TA, Knudsen LM, Rasmussen NL, Eide PW, Yohannes Z, Sørensen V, Brech A, Lothe RA, Leithe E.

J Cell Sci. 2017 Sep 1;130(17):2867-2882. doi: 10.1242/jcs.202408. Epub 2017 Jul 21.


Mitotic cells form actin-based bridges with adjacent cells to provide intercellular communication during rounding.

Fykerud TA, Knudsen LM, Totland MZ, Sørensen V, Dahal-Koirala S, Lothe RA, Brech A, Leithe E.

Cell Cycle. 2016 Nov;15(21):2943-2957. Epub 2016 Sep 13.


Connexins in colorectal cancer pathogenesis.

Sirnes S, Lind GE, Bruun J, Fykerud TA, Mesnil M, Lothe RA, Rivedal E, Kolberg M, Leithe E.

Int J Cancer. 2015 Jul 1;137(1):1-11. doi: 10.1002/ijc.28911. Epub 2014 May 5. Review.


NEDD4 is overexpressed in colorectal cancer and promotes colonic cell growth independently of the PI3K/PTEN/AKT pathway.

Eide PW, Cekaite L, Danielsen SA, Eilertsen IA, Kjenseth A, Fykerud TA, Ågesen TH, Bruun J, Rivedal E, Lothe RA, Leithe E.

Cell Signal. 2013 Jan;25(1):12-8. doi: 10.1016/j.cellsig.2012.08.012. Epub 2012 Sep 5.


Smad ubiquitination regulatory factor-2 controls gap junction intercellular communication by modulating endocytosis and degradation of connexin43.

Fykerud TA, Kjenseth A, Schink KO, Sirnes S, Bruun J, Omori Y, Brech A, Rivedal E, Leithe E.

J Cell Sci. 2012 Sep 1;125(Pt 17):3966-76. doi: 10.1242/jcs.093500. Epub 2012 May 23.


The gap junction channel protein connexin 43 is covalently modified and regulated by SUMOylation.

Kjenseth A, Fykerud TA, Sirnes S, Bruun J, Yohannes Z, Kolberg M, Omori Y, Rivedal E, Leithe E.

J Biol Chem. 2012 May 4;287(19):15851-61. doi: 10.1074/jbc.M111.281832. Epub 2012 Mar 12.

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