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Items: 1 to 50 of 1296

1.

Existence of FGFR1-5-HT1AR heteroreceptor complexes in hippocampal astrocytes. Putative link to 5-HT and FGF2 modulation of hippocampal gamma oscillations.

Narváez M, Andrade-Talavera Y, Valladolid-Acebes I, Fredriksson M, Siegele P, Hernandez-Sosa A, Fisahn A, Fuxe K, Borroto-Escuela DO.

Neuropharmacology. 2020 Mar 27:108070. doi: 10.1016/j.neuropharm.2020.108070. [Epub ahead of print] Review.

PMID:
32229140
2.

Acute cocaine treatment enhances the antagonistic allosteric adenosine A2A-dopamine D2 receptor-receptor interactions in rat dorsal striatum without increasing significantly extracellular dopamine levels.

Romero-Fernandez W, Zhou Z, Beggiato S, Wydra K, Filip M, Tanganelli S, Borroto-Escuela DO, Ferraro L, Fuxe K.

Pharmacol Rep. 2020 Apr;72(2):332-339. doi: 10.1007/s43440-020-00069-3. Epub 2020 Mar 2.

PMID:
32124388
3.

A2AR Transmembrane 2 Peptide Administration Disrupts the A2AR-A2AR Homoreceptor but Not the A2AR-D2R Heteroreceptor Complex: Lack of Actions on Rodent Cocaine Self-Administration.

Borroto-Escuela DO, Wydra K, Romero-Fernandez W, Zhou Z, Frankowska M, Filip M, Fuxe K.

Int J Mol Sci. 2019 Dec 3;20(23). pii: E6100. doi: 10.3390/ijms20236100.

4.

OSU-6162, a Sigma1R Ligand in Low Doses, Can Further Increase the Effects of Cocaine Self-Administration on Accumbal D2R Heteroreceptor Complexes.

Borroto-Escuela DO, Romero-Fernandez W, Wydra K, Zhou Z, Suder A, Filip M, Fuxe K.

Neurotox Res. 2020 Feb;37(2):433-444. doi: 10.1007/s12640-019-00134-7. Epub 2019 Nov 28.

5.

Differential allosteric modulation within dopamine D2R - neurotensin NTS1R and D2R - serotonin 5-HT2AR receptor complexes gives bias to intracellular calcium signalling.

Plach M, Schäfer T, Borroto-Escuela DO, Weikert D, Gmeiner P, Fuxe K, Friedland K.

Sci Rep. 2019 Nov 8;9(1):16312. doi: 10.1038/s41598-019-52540-8.

6.

Desipramine restores the alterations in circadian entrainment induced by prenatal exposure to glucocorticoids.

Spulber S, Conti M, Elberling F, Raciti M, Borroto-Escuela DO, Fuxe K, Ceccatelli S.

Transl Psychiatry. 2019 Oct 17;9(1):263. doi: 10.1038/s41398-019-0594-3.

7.
8.

Can Allosteric Receptor-Protein Interactions in Receptor Complexes Be a Molecular Mechanism Involved in Cancer Immune Therapy?

Borroto-Escuela DO, Fuxe K.

Front Endocrinol (Lausanne). 2019 Aug 20;10:574. doi: 10.3389/fendo.2019.00574. eCollection 2019.

9.

Increased Ethanol Consumption and Locomotion Develop upon Ethanol Deprivation in Rats Overexpressing the Adenosine (A)2A Receptor.

Zaniewska M, Gawliński D, Wyczesana M, Nowak E, Kula K, Maciów-Głąb M, Jastrzębska J, Sadakierska-Chudy A, Bader M, Fuxe K.

Neuroscience. 2019 Oct 15;418:133-148. doi: 10.1016/j.neuroscience.2019.08.030. Epub 2019 Aug 23.

PMID:
31449988
10.

Potentiation of cannabinoid signaling in microglia by adenosine A2A receptor antagonists.

Franco R, Reyes-Resina I, Aguinaga D, Lillo A, Jiménez J, Raïch I, Borroto-Escuela DO, Ferreiro-Vera C, Canela EI, Sánchez de Medina V, Del Ser-Badia A, Fuxe K, Saura CA, Navarro G.

Glia. 2019 Dec;67(12):2410-2423. doi: 10.1002/glia.23694. Epub 2019 Aug 19.

PMID:
31429130
11.

Heterodimerization of Mu Opioid Receptor Protomer with Dopamine D2 Receptor Modulates Agonist-Induced Internalization of Mu Opioid Receptor.

Vasudevan L, Borroto-Escuela DO, Huysentruyt J, Fuxe K, Saini DK, Stove C.

Biomolecules. 2019 Aug 14;9(8). pii: E368. doi: 10.3390/biom9080368.

12.

Conventional and Novel Pharmacological Approaches to Treat Dopamine-Related Disorders: Focus on Parkinson's Disease and Schizophrenia.

Perez de la Mora M, Hernandez-Mondragon C, Crespo-Ramirez M, Rejon-Orantes J, Borroto-Escuela DO, Fuxe K.

Neuroscience. 2019 Jul 23. pii: S0306-4522(19)30510-X. doi: 10.1016/j.neuroscience.2019.07.026. [Epub ahead of print] Review.

PMID:
31349007
13.

On the G Protein-Coupled Receptor Neuromodulation of the Claustrum.

Borroto-Escuela DO, Fuxe K.

Neurochem Res. 2020 Jan;45(1):5-15. doi: 10.1007/s11064-019-02822-4. Epub 2019 Jun 6.

14.

Galanin (1-15)-fluoxetine interaction in the novel object recognition test. Involvement of 5-HT1A receptors in the prefrontal cortex of the rats.

Flores-Burgess A, Millón C, Gago B, García-Durán L, Cantero-García N, Coveñas R, Narváez JA, Fuxe K, Santín L, Díaz-Cabiale Z.

Neuropharmacology. 2019 Sep 1;155:104-112. doi: 10.1016/j.neuropharm.2019.05.023. Epub 2019 May 22.

PMID:
31128121
15.

Role of the galanin N-terminal fragment (1-15) in anhedonia: Involvement of the dopaminergic mesolimbic system.

Millón C, Flores-Burgess A, Gago B, Alén F, Orio L, García-Durán L, Narváez JA, Fuxe K, Santín L, Díaz-Cabiale Z.

J Psychopharmacol. 2019 Jun;33(6):737-747. doi: 10.1177/0269881119844188. Epub 2019 May 13.

PMID:
31081442
16.

Understanding receptor heteromerization and its allosteric integration of signals.

Fuxe K, Borroto-Escuela DO.

Neuropharmacology. 2019 Jul 1;152:1-3. doi: 10.1016/j.neuropharm.2019.05.001. Epub 2019 May 2. No abstract available.

PMID:
31054939
17.

Attenuation of Oxytocin and Serotonin 2A Receptor Signaling through Novel Heteroreceptor Formation.

Chruścicka B, Wallace Fitzsimons SE, Borroto-Escuela DO, Druelle C, Stamou P, Nally K, Dinan TG, Cryan JF, Fuxe K, Schellekens H.

ACS Chem Neurosci. 2019 Jul 17;10(7):3225-3240. doi: 10.1021/acschemneuro.8b00665. Epub 2019 May 8.

PMID:
31038917
18.

Acute Cocaine Enhances Dopamine D2R Recognition and Signaling and Counteracts D2R Internalization in Sigma1R-D2R Heteroreceptor Complexes.

Borroto-Escuela DO, Narváez M, Romero-Fernández W, Pinton L, Wydra K, Filip M, Beggiato S, Tanganelli S, Ferraro L, Fuxe K.

Mol Neurobiol. 2019 Oct;56(10):7045-7055. doi: 10.1007/s12035-019-1580-8. Epub 2019 Apr 10.

19.

On Nobel Laureate Arvid Carlsson.

Fuxe K.

J Neural Transm (Vienna). 2019 Apr;126(4):357. doi: 10.1007/s00702-019-01994-1. No abstract available.

PMID:
30888512
20.

Adenosine heteroreceptor complexes in the basal ganglia are implicated in Parkinson's disease and its treatment.

Borroto-Escuela DO, Fuxe K.

J Neural Transm (Vienna). 2019 Apr;126(4):455-471. doi: 10.1007/s00702-019-01969-2. Epub 2019 Jan 14.

21.

Effects of intra-accumbal or intra-prefrontal cortex microinjections of adenosine 2A receptor ligands on responses to cocaine reward and seeking in rats.

Wydra K, Suder A, Frankowska M, Borroto Escuela DO, Fuxe K, Filip M.

Psychopharmacology (Berl). 2018 Dec;235(12):3509-3523. doi: 10.1007/s00213-018-5072-8. Epub 2018 Nov 13.

22.

A2AR-D2R Heteroreceptor Complexes in Cocaine Reward and Addiction.

Borroto-Escuela DO, Wydra K, Filip M, Fuxe K.

Trends Pharmacol Sci. 2018 Dec;39(12):1008-1020. doi: 10.1016/j.tips.2018.10.007. Epub 2018 Oct 29. Review.

PMID:
30384981
23.

Mapping the Interface of a GPCR Dimer: A Structural Model of the A2A Adenosine and D2 Dopamine Receptor Heteromer.

Borroto-Escuela DO, Rodriguez D, Romero-Fernandez W, Kapla J, Jaiteh M, Ranganathan A, Lazarova T, Fuxe K, Carlsson J.

Front Pharmacol. 2018 Aug 30;9:829. doi: 10.3389/fphar.2018.00829. eCollection 2018.

24.

Glutamate heteroreceptor complexes in the brain.

Borroto-Escuela DO, Tarakanov AO, Brito I, Fuxe K.

Pharmacol Rep. 2018 Sep;70(5):936-950. doi: 10.1016/j.pharep.2018.04.002. Epub 2018 Apr 11. Review.

PMID:
32002960
25.

Brain of the tree pangolin (Manis tricuspis). III. The unusual locus coeruleus complex.

Imam A, Bhagwandin A, Ajao MS, Ihunwo AO, Fuxe K, Manger PR.

J Comp Neurol. 2018 Nov 1;526(16):2570-2684. doi: 10.1002/cne.24519. Epub 2018 Oct 16.

PMID:
30125941
26.

Glutamate heteroreceptor complexes in the brain.

Borroto-Escuela DO, Tarakanov AO, Brito I, Fuxe K.

Pharmacol Rep. 2018 Oct;70(5):936-950. doi: 10.1016/j.pharep.2018.04.002. Epub 2018 Apr 11. Review.

PMID:
30103174
27.

Brain Dopamine Transmission in Health and Parkinson's Disease: Modulation of Synaptic Transmission and Plasticity Through Volume Transmission and Dopamine Heteroreceptors.

Borroto-Escuela DO, Perez De La Mora M, Manger P, Narváez M, Beggiato S, Crespo-Ramírez M, Navarro G, Wydra K, Díaz-Cabiale Z, Rivera A, Ferraro L, Tanganelli S, Filip M, Franco R, Fuxe K.

Front Synaptic Neurosci. 2018 Jul 10;10:20. doi: 10.3389/fnsyn.2018.00020. eCollection 2018. Review.

28.

Dopamine D2 Receptor Supersensitivity as a Spectrum of Neurotoxicity and Status in Psychiatric Disorders.

Kostrzewa RM, Wydra K, Filip M, Crawford CA, McDougall SA, Brown RW, Borroto-Escuela DO, Fuxe K, Gainetdinov RR.

J Pharmacol Exp Ther. 2018 Sep;366(3):519-526. doi: 10.1124/jpet.118.247981. Epub 2018 Jun 19. Review.

29.

Receptor⁻Receptor Interactions in Multiple 5-HT1A Heteroreceptor Complexes in Raphe-Hippocampal 5-HT Transmission and Their Relevance for Depression and Its Treatment.

Borroto-Escuela DO, Narváez M, Ambrogini P, Ferraro L, Brito I, Romero-Fernandez W, Andrade-Talavera Y, Flores-Burgess A, Millon C, Gago B, Narvaez JA, Odagaki Y, Palkovits M, Diaz-Cabiale Z, Fuxe K.

Molecules. 2018 Jun 3;23(6). pii: E1341. doi: 10.3390/molecules23061341. Review.

30.

Neuronal adenosine A2A receptor overexpression is neuroprotective towards 3-nitropropionic acid-induced striatal toxicity: a rat model of Huntington's disease.

Domenici MR, Chiodi V, Averna M, Armida M, Pèzzola A, Pepponi R, Ferrante A, Bader M, Fuxe K, Popoli P.

Purinergic Signal. 2018 Sep;14(3):235-243. doi: 10.1007/s11302-018-9609-4. Epub 2018 May 16.

31.

A Novel Integrative Mechanism in Anxiolytic Behavior Induced by Galanin 2/Neuropeptide Y Y1 Receptor Interactions on Medial Paracapsular Intercalated Amygdala in Rats.

Narváez M, Borroto-Escuela DO, Santín L, Millón C, Gago B, Flores-Burgess A, Barbancho MA, Pérez de la Mora M, Narváez J, Díaz-Cabiale Z, Fuxe K.

Front Cell Neurosci. 2018 May 1;12:119. doi: 10.3389/fncel.2018.00119. eCollection 2018.

32.

Transcriptomic integration of D4R and MOR signaling in the rat caudate putamen.

Valderrama-Carvajal A, Irizar H, Gago B, Jiménez-Urbieta H, Fuxe K, Rodríguez-Oroz MC, Otaegui D, Rivera A.

Sci Rep. 2018 May 9;8(1):7337. doi: 10.1038/s41598-018-25604-4.

33.

Adenosine A2A receptor ligand recognition and signaling is blocked by A2B receptors.

Hinz S, Navarro G, Borroto-Escuela D, Seibt BF, Ammon YC, de Filippo E, Danish A, Lacher SK, Červinková B, Rafehi M, Fuxe K, Schiedel AC, Franco R, Müller CE.

Oncotarget. 2018 Feb 6;9(17):13593-13611. doi: 10.18632/oncotarget.24423. eCollection 2018 Mar 2.

34.

Understanding the Role of Adenosine A2AR Heteroreceptor Complexes in Neurodegeneration and Neuroinflammation.

Borroto-Escuela DO, Hinz S, Navarro G, Franco R, Müller CE, Fuxe K.

Front Neurosci. 2018 Feb 6;12:43. doi: 10.3389/fnins.2018.00043. eCollection 2018.

35.

Disruption of A2AR-D2R Heteroreceptor Complexes After A2AR Transmembrane 5 Peptide Administration Enhances Cocaine Self-Administration in Rats.

Borroto-Escuela DO, Wydra K, Li X, Rodriguez D, Carlsson J, Jastrzębska J, Filip M, Fuxe K.

Mol Neurobiol. 2018 Aug;55(8):7038-7048. doi: 10.1007/s12035-018-0887-1. Epub 2018 Jan 30.

36.

Differential activation of arginine-vasopressin receptor subtypes in the amygdaloid modulation of anxiety in the rat by arginine-vasopressin.

Hernández-Pérez OR, Crespo-Ramírez M, Cuza-Ferrer Y, Anias-Calderón J, Zhang L, Roldan-Roldan G, Aguilar-Roblero R, Borroto-Escuela DO, Fuxe K, Perez de la Mora M.

Psychopharmacology (Berl). 2018 Apr;235(4):1015-1027. doi: 10.1007/s00213-017-4817-0. Epub 2018 Jan 7.

PMID:
29306965
37.

Central administration of galanin N-terminal fragment 1-15 decreases the voluntary alcohol intake in rats.

Millón C, Flores-Burgess A, Castilla-Ortega E, Gago B, García-Fernandez M, Serrano A, Rodriguez de Fonseca F, Narváez JA, Fuxe K, Santín L, Díaz-Cabiale Z.

Addict Biol. 2019 Jan;24(1):76-87. doi: 10.1111/adb.12582. Epub 2017 Dec 6.

PMID:
29210146
38.

Effects of Long-Term Alcohol Drinking on the Dopamine D2 Receptor: Gene Expression and Heteroreceptor Complexes in the Striatum in Rats.

Feltmann K, Borroto-Escuela DO, Rüegg J, Pinton L, de Oliveira Sergio T, Narváez M, Jimenez-Beristain A, Ekström TJ, Fuxe K, Steensland P.

Alcohol Clin Exp Res. 2018 Feb;42(2):338-351. doi: 10.1111/acer.13568. Epub 2018 Jan 24.

39.

Disturbances in the FGFR1-5-HT1A Heteroreceptor Complexes in the Raphe-Hippocampal 5-HT System Develop in a Genetic Rat Model of Depression.

Borroto-Escuela DO, DuPont CM, Li X, Savelli D, Lattanzi D, Srivastava I, Narváez M, Di Palma M, Barbieri E, Andrade-Talavera Y, Cuppini R, Odagaki Y, Palkovits M, Ambrogini P, Lindskog M, Fuxe K.

Front Cell Neurosci. 2017 Oct 10;11:309. doi: 10.3389/fncel.2017.00309. eCollection 2017.

40.

Cocaine modulates allosteric D21 receptor-receptor interactions on dopamine and glutamate nerve terminals from rat striatum.

Beggiato S, Borelli AC, Borroto-Escuela D, Corbucci I, Tomasini MC, Marti M, Antonelli T, Tanganelli S, Fuxe K, Ferraro L.

Cell Signal. 2017 Dec;40:116-124. doi: 10.1016/j.cellsig.2017.09.007. Epub 2017 Sep 18.

PMID:
28923416
41.

Existence of Brain 5-HT1A-5-HT2A Isoreceptor Complexes with Antagonistic Allosteric Receptor-Receptor Interactions Regulating 5-HT1A Receptor Recognition.

Borroto-Escuela DO, Li X, Tarakanov AO, Savelli D, Narváez M, Shumilov K, Andrade-Talavera Y, Jimenez-Beristain A, Pomierny B, Díaz-Cabiale Z, Cuppini R, Ambrogini P, Lindskog M, Fuxe K.

ACS Omega. 2017 Aug 31;2(8):4779-4789. doi: 10.1021/acsomega.7b00629. Epub 2017 Aug 22.

42.

Receptor-heteromer mediated regulation of endocannabinoid signaling in activated microglia. Role of CB1 and CB2 receptors and relevance for Alzheimer's disease and levodopa-induced dyskinesia.

Navarro G, Borroto-Escuela D, Angelats E, Etayo Í, Reyes-Resina I, Pulido-Salgado M, Rodríguez-Pérez AI, Canela EI, Saura J, Lanciego JL, Labandeira-García JL, Saura CA, Fuxe K, Franco R.

Brain Behav Immun. 2018 Jan;67:139-151. doi: 10.1016/j.bbi.2017.08.015. Epub 2017 Aug 24.

PMID:
28843453
43.

Cocaine self-administration specifically increases A2AR-D2R and D2R-sigma1R heteroreceptor complexes in the rat nucleus accumbens shell. Relevance for cocaine use disorder.

Borroto-Escuela DO, Narváez M, Wydra K, Pintsuk J, Pinton L, Jimenez-Beristain A, Di Palma M, Jastrzębska J, Filip M, Fuxe K.

Pharmacol Biochem Behav. 2017 Apr;155:24-31. doi: 10.1016/j.pbb.2017.03.003. Epub 2017 Mar 12.

PMID:
28300546
44.

Galanin (1-15) enhancement of the behavioral effects of Fluoxetine in the forced swimming test gives a new therapeutic strategy against depression.

Flores-Burgess A, Millón C, Gago B, Narváez M, Borroto-Escuela DO, Mengod G, Narváez JA, Fuxe K, Santín L, Díaz-Cabiale Z.

Neuropharmacology. 2017 May 15;118:233-241. doi: 10.1016/j.neuropharm.2017.03.010. Epub 2017 Mar 11.

PMID:
28288814
45.

Understanding the Role of GPCR Heteroreceptor Complexes in Modulating the Brain Networks in Health and Disease.

Borroto-Escuela DO, Carlsson J, Ambrogini P, Narváez M, Wydra K, Tarakanov AO, Li X, Millón C, Ferraro L, Cuppini R, Tanganelli S, Liu F, Filip M, Diaz-Cabiale Z, Fuxe K.

Front Cell Neurosci. 2017 Feb 21;11:37. doi: 10.3389/fncel.2017.00037. eCollection 2017. Review.

46.

IL1R2, CCR2, and CXCR4 May Form Heteroreceptor Complexes with NMDAR and D2R: Relevance for Schizophrenia.

Borroto-Escuela DO, Tarakanov AO, Bechter K, Fuxe K.

Front Psychiatry. 2017 Feb 15;8:24. doi: 10.3389/fpsyt.2017.00024. eCollection 2017.

47.

Is There Volume Transmission Along Extracellular Fluid Pathways Corresponding to the Acupuncture Meridians?

Zhang W, Wang Z, Jia S, Tian Y, Wang G, Li H, Fuxe K.

J Acupunct Meridian Stud. 2017 Jan;10(1):5-19. doi: 10.1016/j.jams.2016.12.004. Epub 2016 Dec 18.

48.

The neuropeptides Galanin and Galanin(1-15) in depression-like behaviours.

Millón C, Flores-Burgess A, Narváez M, Borroto-Escuela DO, Gago B, Santín L, Castilla-Ortega E, Narváez JÁ, Fuxe K, Díaz-Cabiale Z.

Neuropeptides. 2017 Aug;64:39-45. doi: 10.1016/j.npep.2017.01.004. Epub 2017 Jan 31. Review.

PMID:
28196617
49.

Alterations in ventral and dorsal striatal allosteric A2AR-D2R receptor-receptor interactions after amphetamine challenge: Relevance for schizophrenia.

Pintsuk J, Borroto-Escuela DO, Lai TK, Liu F, Fuxe K.

Life Sci. 2016 Oct 29. pii: S0024-3205(16)30629-4. doi: 10.1016/j.lfs.2016.10.027. [Epub ahead of print]

PMID:
27984074
50.

Hypothalamic Vasopressinergic Projections Innervate Central Amygdala GABAergic Neurons: Implications for Anxiety and Stress Coping.

Hernández VS, Hernández OR, Perez de la Mora M, Gómora MJ, Fuxe K, Eiden LE, Zhang L.

Front Neural Circuits. 2016 Nov 18;10:92. eCollection 2016.

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