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NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress.

Höglinger D, Burgoyne T, Sanchez-Heras E, Hartwig P, Colaco A, Newton J, Futter CE, Spiegel S, Platt FM, Eden ER.

Nat Commun. 2019 Sep 19;10(1):4276. doi: 10.1038/s41467-019-12152-2.


Remodeling of the Basal Labyrinth of Retinal Pigment Epithelial Cells With Osmotic Challenge, Age, and Disease.

Hayes MJ, Burgoyne T, Wavre-Shapton ST, Tolmachova T, Seabra MC, Futter CE.

Invest Ophthalmol Vis Sci. 2019 Jun 3;60(7):2515-2524. doi: 10.1167/iovs.19-26784.


Frequency and clinical spectrum of in-flight medical incidents during domestic and international flights.

Epstein CR, Forbes JM, Futter CL, Hosegood IM, Brown RG, Van Zundert AA.

Anaesth Intensive Care. 2019 Jan;47(1):16-22. doi: 10.1177/0310057X18811748. Epub 2019 Feb 13.


Phagosomal and mitochondrial alterations in RPE may contribute to KCNJ13 retinopathy.

Toms M, Burgoyne T, Tracey-White D, Richardson R, Dubis AM, Webster AR, Futter C, Moosajee M.

Sci Rep. 2019 Mar 7;9(1):3793. doi: 10.1038/s41598-019-40507-8.


Selective Ablation of Megalin in the Retinal Pigment Epithelium Results in Megaophthalmos, Macromelanosome Formation and Severe Retina Degeneration.

Storm T, Burgoyne T, Dunaief JL, Christensen EI, Futter C, Nielsen R.

Invest Ophthalmol Vis Sci. 2019 Jan 2;60(1):322-330. doi: 10.1167/iovs.18-25667.


Roles for ER:endosome membrane contact sites in ligand-stimulated intraluminal vesicle formation.

Wong LH, Eden ER, Futter CE.

Biochem Soc Trans. 2018 Oct 19;46(5):1055-1062. doi: 10.1042/BST20170432. Epub 2018 Sep 20. Review.


ALIX Regulates Tumor-Mediated Immunosuppression by Controlling EGFR Activity and PD-L1 Presentation.

Monypenny J, Milewicz H, Flores-Borja F, Weitsman G, Cheung A, Chowdhury R, Burgoyne T, Arulappu A, Lawler K, Barber PR, Vicencio JM, Keppler M, Wulaningsih W, Davidson SM, Fraternali F, Woodman N, Turmaine M, Gillett C, Franz D, Quezada SA, Futter CE, Von Kriegsheim A, Kolch W, Vojnovic B, Carlton JG, Ng T.

Cell Rep. 2018 Jul 17;24(3):630-641. doi: 10.1016/j.celrep.2018.06.066.


Correlative light and immuno-electron microscopy of retinal tissue cryostat sections.

Burgoyne T, Lane A, Laughlin WE, Cheetham ME, Futter CE.

PLoS One. 2018 Jan 9;13(1):e0191048. doi: 10.1371/journal.pone.0191048. eCollection 2018.


HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model.

Melo E, Oertle P, Trepp C, Meistermann H, Burgoyne T, Sborgi L, Cabrera AC, Chen CY, Hoflack JC, Kam-Thong T, Schmucki R, Badi L, Flint N, Ghiani ZE, Delobel F, Stucki C, Gromo G, Einhaus A, Hornsperger B, Golling S, Siebourg-Polster J, Gerber F, Bohrmann B, Futter C, Dunkley T, Hiller S, Schilling O, Enzmann V, Fauser S, Plodinec M, Iacone R.

EBioMedicine. 2018 Jan;27:258-274. doi: 10.1016/j.ebiom.2017.12.011. Epub 2017 Dec 13.


Membrane dynamics and organelle biogenesis-lipid pipelines and vesicular carriers.

Stefan CJ, Trimble WS, Grinstein S, Drin G, Reinisch K, De Camilli P, Cohen S, Valm AM, Lippincott-Schwartz J, Levine TP, Iaea DB, Maxfield FR, Futter CE, Eden ER, Judith D, van Vliet AR, Agostinis P, Tooze SA, Sugiura A, McBride HM.

BMC Biol. 2017 Oct 31;15(1):102. doi: 10.1186/s12915-017-0432-0.


Aβ accumulation causes MVB enlargement and is modelled by dominant negative VPS4A.

Willén K, Edgar JR, Hasegawa T, Tanaka N, Futter CE, Gouras GK.

Mol Neurodegener. 2017 Aug 23;12(1):61. doi: 10.1186/s13024-017-0203-y.


Stress-specific p38 MAPK activation is sufficient to drive EGFR endocytosis but not its nuclear translocation.

Tomas A, Jones S, Vaughan SO, Hochhauser D, Futter CE.

J Cell Sci. 2017 Aug 1;130(15):2481-2490. doi: 10.1242/jcs.202358. Epub 2017 Jun 23.


REEP6 deficiency leads to retinal degeneration through disruption of ER homeostasis and protein trafficking.

Agrawal SA, Burgoyne T, Eblimit A, Bellingham J, Parfitt DA, Lane A, Nichols R, Asomugha C, Hayes MJ, Munro PM, Xu M, Wang K, Futter CE, Li Y, Chen R, Cheetham ME.

Hum Mol Genet. 2017 Jul 15;26(14):2667-2677. doi: 10.1093/hmg/ddx149.


Endothelial MAPKs Direct ICAM-1 Signaling to Divergent Inflammatory Functions.

Dragoni S, Hudson N, Kenny BA, Burgoyne T, McKenzie JA, Gill Y, Blaber R, Futter CE, Adamson P, Greenwood J, Turowski P.

J Immunol. 2017 May 15;198(10):4074-4085. doi: 10.4049/jimmunol.1600823. Epub 2017 Apr 3.


An Endosomal NAADP-Sensitive Two-Pore Ca2+ Channel Regulates ER-Endosome Membrane Contact Sites to Control Growth Factor Signaling.

Kilpatrick BS, Eden ER, Hockey LN, Yates E, Futter CE, Patel S.

Cell Rep. 2017 Feb 14;18(7):1636-1645. doi: 10.1016/j.celrep.2017.01.052.


Probing the Heterogeneity of Protein Kinase Activation in Cells by Super-resolution Microscopy.

Zhang R, Fruhwirth GO, Coban O, Barrett JE, Burgoyne T, Lee SH, Simonson PD, Baday M, Kholodenko BN, Futter CE, Ng T, Selvin PR.

ACS Nano. 2017 Jan 24;11(1):249-257. doi: 10.1021/acsnano.6b05356. Epub 2016 Nov 3.


Coming or going? Un-BLOC-ing delivery and recycling pathways during melanosome maturation.

Futter CE, Cutler DF.

J Cell Biol. 2016 Aug 1;214(3):245-7. doi: 10.1083/jcb.201607023.


Annexin A1 Tethers Membrane Contact Sites that Mediate ER to Endosome Cholesterol Transport.

Eden ER, Sanchez-Heras E, Tsapara A, Sobota A, Levine TP, Futter CE.

Dev Cell. 2016 Jun 6;37(5):473-83. doi: 10.1016/j.devcel.2016.05.005.


New light on photoreceptor renewal.

Burgoyne T, Meschede IP, Futter CE.

Cell Cycle. 2016 Jun 2;15(11):1389-90. doi: 10.1080/15384101.2016.1164579. Epub 2016 May 6. No abstract available.


Rod disc renewal occurs by evagination of the ciliary plasma membrane that makes cadherin-based contacts with the inner segment.

Burgoyne T, Meschede IP, Burden JJ, Bailly M, Seabra MC, Futter CE.

Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):15922-7. doi: 10.1073/pnas.1509285113. Epub 2015 Dec 14.


Photoreceptor phagosome processing defects and disturbed autophagy in retinal pigment epithelium of Cln3Δex1-6 mice modelling juvenile neuronal ceroid lipofuscinosis (Batten disease).

Wavre-Shapton ST, Calvi AA, Turmaine M, Seabra MC, Cutler DF, Futter CE, Mitchison HM.

Hum Mol Genet. 2015 Dec 15;24(24):7060-74. doi: 10.1093/hmg/ddv406. Epub 2015 Oct 8.


Stress reveals new destination for EGF receptor.

Tomas A, Futter CE.

Cell Cycle. 2015;14(21):3343-4. doi: 10.1080/15384101.2015.1093432. No abstract available.


Host cell autophagy contributes to Plasmodium liver development.

Thieleke-Matos C, Lopes da Silva M, Cabrita-Santos L, Portal MD, Rodrigues IP, Zuzarte-Luis V, Ramalho JS, Futter CE, Mota MM, Barral DC, Seabra MC.

Cell Microbiol. 2016 Mar;18(3):437-50. doi: 10.1111/cmi.12524. Epub 2015 Nov 4.


Retinal Pigment Epithelial Cells Mitigate the Effects of Complement Attack by Endocytosis of C5b-9.

Georgiannakis A, Burgoyne T, Lueck K, Futter C, Greenwood J, Moss SE.

J Immunol. 2015 Oct 1;195(7):3382-9. doi: 10.4049/jimmunol.1500937. Epub 2015 Aug 31.


WASH and Tsg101/ALIX-dependent diversion of stress-internalized EGFR from the canonical endocytic pathway.

Tomas A, Vaughan SO, Burgoyne T, Sorkin A, Hartley JA, Hochhauser D, Futter CE.

Nat Commun. 2015 Jun 12;6:7324. doi: 10.1038/ncomms8324.


ESCRTs regulate amyloid precursor protein sorting in multivesicular bodies and intracellular amyloid-β accumulation.

Edgar JR, Willén K, Gouras GK, Futter CE.

J Cell Sci. 2015 Jul 15;128(14):2520-8. doi: 10.1242/jcs.170233. Epub 2015 May 22.


The Leber congenital amaurosis protein AIPL1 and EB proteins co-localize at the photoreceptor cilium.

Hidalgo-de-Quintana J, Schwarz N, Meschede IP, Stern-Schneider G, Powner MB, Morrison EE, Futter CE, Wolfrum U, Cheetham ME, van der Spuy J.

PLoS One. 2015 Mar 23;10(3):e0121440. doi: 10.1371/journal.pone.0121440. eCollection 2015.


Regulation of melanosome number, shape and movement in the zebrafish retinal pigment epithelium by OA1 and PMEL.

Burgoyne T, O'Connor MN, Seabra MC, Cutler DF, Futter CE.

J Cell Sci. 2015 Apr 1;128(7):1400-7. doi: 10.1242/jcs.164400. Epub 2015 Feb 17.


Methods for monitoring lysosomal morphology.

Kilpatrick BS, Eden ER, Hockey LN, Futter CE, Patel S.

Methods Cell Biol. 2015;126:1-19. doi: 10.1016/bs.mcb.2014.10.018. Epub 2015 Jan 19.


Dysregulation of lysosomal morphology by pathogenic LRRK2 is corrected by TPC2 inhibition.

Hockey LN, Kilpatrick BS, Eden ER, Lin-Moshier Y, Brailoiu GC, Brailoiu E, Futter CE, Schapira AH, Marchant JS, Patel S.

J Cell Sci. 2015 Jan 15;128(2):232-8. doi: 10.1242/jcs.164152. Epub 2014 Nov 21.


Differential apicobasal VEGF signaling at vascular blood-neural barriers.

Hudson N, Powner MB, Sarker MH, Burgoyne T, Campbell M, Ockrim ZK, Martinelli R, Futter CE, Grant MB, Fraser PA, Shima DT, Greenwood J, Turowski P.

Dev Cell. 2014 Sep 8;30(5):541-52. doi: 10.1016/j.devcel.2014.06.027. Epub 2014 Aug 28.


Phagosome maturation during endosome interaction revealed by partial rhodopsin processing in retinal pigment epithelium.

Wavre-Shapton ST, Meschede IP, Seabra MC, Futter CE.

J Cell Sci. 2014 Sep 1;127(Pt 17):3852-61. doi: 10.1242/jcs.154757. Epub 2014 Jul 29.


EGF receptor trafficking: consequences for signaling and cancer.

Tomas A, Futter CE, Eden ER.

Trends Cell Biol. 2014 Jan;24(1):26-34. doi: 10.1016/j.tcb.2013.11.002. Epub 2013 Nov 29. Review.


Hrs- and CD63-dependent competing mechanisms make different sized endosomal intraluminal vesicles.

Edgar JR, Eden ER, Futter CE.

Traffic. 2014 Feb;15(2):197-211. doi: 10.1111/tra.12139. Epub 2014 Jan 8.


Rab11b mediates melanin transfer between donor melanocytes and acceptor keratinocytes via coupled exo/endocytosis.

Tarafder AK, Bolasco G, Correia MS, Pereira FJC, Iannone L, Hume AN, Kirkpatrick N, Picardo M, Torrisi MR, Rodrigues IP, Ramalho JS, Futter CE, Barral DC, Seabra MC.

J Invest Dermatol. 2014 Apr;134(4):1056-1066. doi: 10.1038/jid.2013.432. Epub 2013 Oct 18.


Expression of OA1 limits the fusion of a subset of MVBs with lysosomes - a mechanism potentially involved in the initial biogenesis of melanosomes.

Burgoyne T, Jolly R, Martin-Martin B, Seabra MC, Piccirillo R, Schiaffino MV, Futter CE.

J Cell Sci. 2013 Nov 15;126(Pt 22):5143-52. doi: 10.1242/jcs.128561. Epub 2013 Sep 4. Erratum in: J Cell Sci. 2014 Feb 1;127(Pt 3):700.


The TBC/RabGAP Armus coordinates Rac1 and Rab7 functions during autophagy.

Carroll B, Mohd-Naim N, Maximiano F, Frasa MA, McCormack J, Finelli M, Thoresen SB, Perdios L, Daigaku R, Francis RE, Futter C, Dikic I, Braga VM.

Dev Cell. 2013 Apr 15;25(1):15-28. doi: 10.1016/j.devcel.2013.03.005. Epub 2013 Apr 4.


Conditional ablation of the choroideremia gene causes age-related changes in mouse retinal pigment epithelium.

Wavre-Shapton ST, Tolmachova T, Lopes da Silva M, Futter CE, Seabra MC.

PLoS One. 2013;8(2):e57769. doi: 10.1371/journal.pone.0057769. Epub 2013 Feb 27. Erratum in: PLoS One. 2013;8(5). doi:10.1371/annotation/83a88285-e6a0-41fb-ae67-4315c21e5090. da Silva, Mafalda Lopes [corrected to Lopes da Silva, Mafalda].


Distinct and opposing roles for Rab27a/Mlph/MyoVa and Rab27b/Munc13-4 in mast cell secretion.

Singh RK, Mizuno K, Wasmeier C, Wavre-Shapton ST, Recchi C, Catz SD, Futter C, Tolmachova T, Hume AN, Seabra MC.

FEBS J. 2013 Feb;280(3):892-903. doi: 10.1111/febs.12081. Epub 2013 Jan 2.


Direct mobilisation of lysosomal Ca2+ triggers complex Ca2+ signals.

Kilpatrick BS, Eden ER, Schapira AH, Futter CE, Patel S.

J Cell Sci. 2013 Jan 1;126(Pt 1):60-6. doi: 10.1242/jcs.118836. Epub 2012 Oct 29.


The first catalytic synthesis of an acrylate from CO2 and an alkene-a rational approach.

Lejkowski ML, Lindner R, Kageyama T, Bódizs GÉ, Plessow PN, Müller IB, Schäfer A, Rominger F, Hofmann P, Futter C, Schunk SA, Limbach M.

Chemistry. 2012 Oct 29;18(44):14017-25. doi: 10.1002/chem.201201757. Epub 2012 Sep 20.


Methamphetamine-induced nitric oxide promotes vesicular transport in blood-brain barrier endothelial cells.

Martins T, Burgoyne T, Kenny BA, Hudson N, Futter CE, Ambrósio AF, Silva AP, Greenwood J, Turowski P.

Neuropharmacology. 2013 Feb;65:74-82. doi: 10.1016/j.neuropharm.2012.08.021. Epub 2012 Sep 1.


The host endocytic pathway is essential for Plasmodium berghei late liver stage development.

Lopes da Silva M, Thieleke-Matos C, Cabrita-Santos L, Ramalho JS, Wavre-Shapton ST, Futter CE, Barral DC, Seabra MC.

Traffic. 2012 Oct;13(10):1351-63. doi: 10.1111/j.1600-0854.2012.01398.x. Epub 2012 Aug 3.


The relationship between ER-multivesicular body membrane contacts and the ESCRT machinery.

Eden ER, Burgoyne T, Edgar JR, Sorkin A, Futter CE.

Biochem Soc Trans. 2012 Apr;40(2):464-8. doi: 10.1042/BST20110774. Review.


CHM/REP1 cDNA delivery by lentiviral vectors provides functional expression of the transgene in the retinal pigment epithelium of choroideremia mice.

Tolmachova T, Tolmachov OE, Wavre-Shapton ST, Tracey-White D, Futter CE, Seabra MC.

J Gene Med. 2012 Mar;14(3):158-68. doi: 10.1002/jgm.1652.


The role of EGF receptor ubiquitination in regulating its intracellular traffic.

Eden ER, Huang F, Sorkin A, Futter CE.

Traffic. 2012 Feb;13(2):329-37. doi: 10.1111/j.1600-0854.2011.01305.x. Epub 2011 Nov 22.


Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4.

Qureshi OS, Zheng Y, Nakamura K, Attridge K, Manzotti C, Schmidt EM, Baker J, Jeffery LE, Kaur S, Briggs Z, Hou TZ, Futter CE, Anderson G, Walker LS, Sansom DM.

Science. 2011 Apr 29;332(6029):600-3. doi: 10.1126/science.1202947. Epub 2011 Apr 7.


Retinal pigment epithelium defects accelerate photoreceptor degeneration in cell type-specific knockout mouse models of choroideremia.

Tolmachova T, Wavre-Shapton ST, Barnard AR, MacLaren RE, Futter CE, Seabra MC.

Invest Ophthalmol Vis Sci. 2010 Oct;51(10):4913-20. doi: 10.1167/iovs.09-4892. Epub 2010 May 5.


Phosphatidylinositol- and phosphatidylcholine-transfer activity of PITPbeta is essential for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum.

Carvou N, Holic R, Li M, Futter C, Skippen A, Cockcroft S.

J Cell Sci. 2010 Apr 15;123(Pt 8):1262-73. doi: 10.1242/jcs.061986. Epub 2010 Mar 23.


Disruption of endocytic trafficking in frontotemporal dementia with CHMP2B mutations.

Urwin H, Authier A, Nielsen JE, Metcalf D, Powell C, Froud K, Malcolm DS, Holm I, Johannsen P, Brown J, Fisher EM, van der Zee J, Bruyland M; FReJA Consortium, Van Broeckhoven C, Collinge J, Brandner S, Futter C, Isaacs AM.

Hum Mol Genet. 2010 Jun 1;19(11):2228-38. doi: 10.1093/hmg/ddq100. Epub 2010 Mar 10.

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