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DNA methylation biomarkers discovered in silico detect cancer in liquid biopsies from non-small cell lung cancer patients.

Vrba L, Oshiro MM, Kim SS, Garland LL, Placencia C, Mahadevan D, Nelson MA, Futscher BW.

Epigenetics. 2019 Nov 27:1-12. doi: 10.1080/15592294.2019.1695333. [Epub ahead of print]


Epigenetic silencing of lncRNA MORT in 16 TCGA cancer types.

Vrba L, Futscher BW.

F1000Res. 2018 Feb 21;7:211. doi: 10.12688/f1000research.13944.1. eCollection 2018.


A suite of DNA methylation markers that can detect most common human cancers.

Vrba L, Futscher BW.

Epigenetics. 2018;13(1):61-72. doi: 10.1080/15592294.2017.1412907. Epub 2018 Feb 19.


Epigenetic Silencing of MORT Is an Early Event in Cancer and Is Associated with Luminal, Receptor Positive Breast Tumor Subtypes.

Vrba L, Futscher BW.

J Breast Cancer. 2017 Jun;20(2):198-202. doi: 10.4048/jbc.2017.20.2.198. Epub 2017 Jun 26.


Semaphorin 7a exerts pleiotropic effects to promote breast tumor progression.

Black SA, Nelson AC, Gurule NJ, Futscher BW, Lyons TR.

Oncogene. 2016 Sep 29;35(39):5170-8. doi: 10.1038/onc.2016.49. Epub 2016 Apr 11.


A lincRNA connected to cell mortality and epigenetically-silenced in most common human cancers.

Vrba L, Garbe JC, Stampfer MR, Futscher BW.

Epigenetics. 2015;10(11):1074-83. doi: 10.1080/15592294.2015.1106673.


Differentially expressed microRNAs in postpartum breast cancer in Hispanic women.

Muñoz-Rodríguez JL, Vrba L, Futscher BW, Hu C, Komenaka IK, Meza-Montenegro MM, Gutierrez-Millan LE, Daneri-Navarro A, Thompson PA, Martinez ME.

PLoS One. 2015 Apr 13;10(4):e0124340. doi: 10.1371/journal.pone.0124340. eCollection 2015.


Age and the means of bypassing stasis influence the intrinsic subtype of immortalized human mammary epithelial cells.

Lee JK, Garbe JC, Vrba L, Miyano M, Futscher BW, Stampfer MR, LaBarge MA.

Front Cell Dev Biol. 2015 Mar 11;3:13. doi: 10.3389/fcell.2015.00013. eCollection 2015.


Immortalization of normal human mammary epithelial cells in two steps by direct targeting of senescence barriers does not require gross genomic alterations.

Garbe JC, Vrba L, Sputova K, Fuchs L, Novak P, Brothman AR, Jackson M, Chin K, LaBarge MA, Watts G, Futscher BW, Stampfer MR.

Cell Cycle. 2014;13(21):3423-35. doi: 10.4161/15384101.2014.954456.


Exome-wide mutation profile in benzo[a]pyrene-derived post-stasis and immortal human mammary epithelial cells.

Severson PL, Vrba L, Stampfer MR, Futscher BW.

Mutat Res Genet Toxicol Environ Mutagen. 2014 Dec;775-776:48-54. doi: 10.1016/j.mrgentox.2014.10.011. Epub 2014 Nov 4.


Hypoxia perturbs aryl hydrocarbon receptor signaling and CYP1A1 expression induced by PCB 126 in human skin and liver-derived cell lines.

Vorrink SU, Severson PL, Kulak MV, Futscher BW, Domann FE.

Toxicol Appl Pharmacol. 2014 Feb 1;274(3):408-16. doi: 10.1016/j.taap.2013.12.002. Epub 2013 Dec 16.


Characterization of hepatocellular carcinoma related genes and metabolites in human nonalcoholic fatty liver disease.

Clarke JD, Novak P, Lake AD, Shipkova P, Aranibar N, Robertson D, Severson PL, Reily MD, Futscher BW, Lehman-McKeeman LD, Cherrington NJ.

Dig Dis Sci. 2014 Feb;59(2):365-74. doi: 10.1007/s10620-013-2873-9. Epub 2013 Sep 19.


Maintenance of mitochondrial genomic integrity in the absence of manganese superoxide dismutase in mouse liver hepatocytes.

Cyr AR, Brown KE, McCormick ML, Coleman MC, Case AJ, Watts GS, Futscher BW, Spitz DR, Domann FE.

Redox Biol. 2013 Feb 5;1:172-7. doi: 10.1016/j.redox.2013.01.001. eCollection 2013.


Coordinate H3K9 and DNA methylation silencing of ZNFs in toxicant-induced malignant transformation.

Severson PL, Tokar EJ, Vrba L, Waalkes MP, Futscher BW.

Epigenetics. 2013 Oct;8(10):1080-8. doi: 10.4161/epi.25926. Epub 2013 Aug 6.


Arsenic exposure induces the Warburg effect in cultured human cells.

Zhao F, Severson P, Pacheco S, Futscher BW, Klimecki WT.

Toxicol Appl Pharmacol. 2013 Aug 15;271(1):72-7. doi: 10.1016/j.taap.2013.04.020. Epub 2013 May 4.


In Vitro Assessment of the Inflammatory Breast Cancer Cell Line SUM 149: Discovery of 2 Single Nucleotide Polymorphisms in the RNase L Gene.

Nokes BT, Cunliffe HE, Lafleur B, Mount DW, Livingston RB, Futscher BW, Lang JE.

J Cancer. 2013;4(2):104-16. doi: 10.7150/jca.5002. Epub 2013 Jan 10.


miRNA gene promoters are frequent targets of aberrant DNA methylation in human breast cancer.

Vrba L, Muñoz-Rodríguez JL, Stampfer MR, Futscher BW.

PLoS One. 2013;8(1):e54398. doi: 10.1371/journal.pone.0054398. Epub 2013 Jan 16.


Cell-type specific DNA methylation patterns define human breast cellular identity.

Novak P, Stampfer MR, Munoz-Rodriguez JL, Garbe JC, Ehrich M, Futscher BW, Jensen TJ.

PLoS One. 2012;7(12):e52299. doi: 10.1371/journal.pone.0052299. Epub 2012 Dec 20.


Agglomerates of aberrant DNA methylation are associated with toxicant-induced malignant transformation.

Severson PL, Tokar EJ, Vrba L, Waalkes MP, Futscher BW.

Epigenetics. 2012 Nov;7(11):1238-48. doi: 10.4161/epi.22163. Epub 2012 Sep 13.


Epigenetic changes during cell transformation.

Futscher BW.

Adv Exp Med Biol. 2013;754:179-94. doi: 10.1007/978-1-4419-9967-2_9. Review.


Genetic and epigenetic inactivation of extracellular superoxide dismutase promotes an invasive phenotype in human lung cancer by disrupting ECM homeostasis.

Teoh-Fitzgerald ML, Fitzgerald MP, Jensen TJ, Futscher BW, Domann FE.

Mol Cancer Res. 2012 Jan;10(1):40-51. doi: 10.1158/1541-7786.MCR-11-0501. Epub 2011 Nov 7.


Epigenetic regulation of normal human mammary cell type-specific miRNAs.

Vrba L, Garbe JC, Stampfer MR, Futscher BW.

Genome Res. 2011 Dec;21(12):2026-37. doi: 10.1101/gr.123935.111. Epub 2011 Aug 26.


Hypomethylation of the 14-3-3σ promoter leads to increased expression in non-small cell lung cancer.

Radhakrishnan VM, Jensen TJ, Cui H, Futscher BW, Martinez JD.

Genes Chromosomes Cancer. 2011 Oct;50(10):830-6. doi: 10.1002/gcc.20904. Epub 2011 Jul 13.


Arsenic toxicology: translating between experimental models and human pathology.

States JC, Barchowsky A, Cartwright IL, Reichard JF, Futscher BW, Lantz RC.

Environ Health Perspect. 2011 Oct;119(10):1356-63. doi: 10.1289/ehp.1103441. Epub 2011 Jun 17. Review.


Monomethylarsonous acid produces irreversible events resulting in malignant transformation of a human bladder cell line following 12 weeks of low-level exposure.

Wnek SM, Jensen TJ, Severson PL, Futscher BW, Gandolfi AJ.

Toxicol Sci. 2010 Jul;116(1):44-57. doi: 10.1093/toxsci/kfq106. Epub 2010 Apr 7.


Role for DNA methylation in the regulation of miR-200c and miR-141 expression in normal and cancer cells.

Vrba L, Jensen TJ, Garbe JC, Heimark RL, Cress AE, Dickinson S, Stampfer MR, Futscher BW.

PLoS One. 2010 Jan 13;5(1):e8697. doi: 10.1371/journal.pone.0008697.


Arsenicals produce stable progressive changes in DNA methylation patterns that are linked to malignant transformation of immortalized urothelial cells.

Jensen TJ, Novak P, Wnek SM, Gandolfi AJ, Futscher BW.

Toxicol Appl Pharmacol. 2009 Dec 1;241(2):221-9. doi: 10.1016/j.taap.2009.08.019. Epub 2009 Aug 28.


Stepwise DNA methylation changes are linked to escape from defined proliferation barriers and mammary epithelial cell immortalization.

Novak P, Jensen TJ, Garbe JC, Stampfer MR, Futscher BW.

Cancer Res. 2009 Jun 15;69(12):5251-8. doi: 10.1158/0008-5472.CAN-08-4977. Epub 2009 Jun 9.


Human Cell Surface Receptors as Molecular Imaging Candidates for Metastatic Prostate Cancer.

Sroka IC, Pond GD, Nagle RB, Porreca F, King T, Pestano G, Futscher BW, Gard JM, Riley J, Cress AE.

Open Prost Cancer J. 2009 Jan 1;2:59-66.


Epigenetic mediated transcriptional activation of WNT5A participates in arsenical-associated malignant transformation.

Jensen TJ, Wozniak RJ, Eblin KE, Wnek SM, Gandolfi AJ, Futscher BW.

Toxicol Appl Pharmacol. 2009 Feb 15;235(1):39-46. doi: 10.1016/j.taap.2008.10.013. Epub 2008 Nov 6.


Reactive oxygen species regulate properties of transformation in UROtsa cells exposed to monomethylarsonous acid by modulating MAPK signaling.

Eblin KE, Jensen TJ, Wnek SM, Buffington SE, Futscher BW, Gandolfi AJ.

Toxicology. 2009 Jan 8;255(1-2):107-14. doi: 10.1016/j.tox.2008.10.007. Epub 2008 Oct 22.


Agglomerative epigenetic aberrations are a common event in human breast cancer.

Novak P, Jensen T, Oshiro MM, Watts GS, Kim CJ, Futscher BW.

Cancer Res. 2008 Oct 15;68(20):8616-25. doi: 10.1158/0008-5472.CAN-08-1419.


p53 induces distinct epigenetic states at its direct target promoters.

Vrba L, Junk DJ, Novak P, Futscher BW.

BMC Genomics. 2008 Oct 15;9:486. doi: 10.1186/1471-2164-9-486.


DNA methylation changes in ovarian cancer are cumulative with disease progression and identify tumor stage.

Watts GS, Futscher BW, Holtan N, Degeest K, Domann FE, Rose SL.

BMC Med Genomics. 2008 Sep 30;1:47. doi: 10.1186/1755-8794-1-47.


The role of reactive oxygen species in arsenite and monomethylarsonous acid-induced signal transduction in human bladder cells: acute studies.

Eblin KE, Hau AM, Jensen TJ, Futscher BW, Gandolfi AJ.

Toxicology. 2008 Aug 19;250(1):47-54. doi: 10.1016/j.tox.2008.05.018. Epub 2008 Jun 5.


Epigenetic remodeling during arsenical-induced malignant transformation.

Jensen TJ, Novak P, Eblin KE, Gandolfi AJ, Futscher BW.

Carcinogenesis. 2008 Aug;29(8):1500-8. doi: 10.1093/carcin/bgn102. Epub 2008 Apr 30.


Optimal search-based gene subset selection for gene array cancer classification.

Li J, Su H, Chen H, Futscher BW.

IEEE Trans Inf Technol Biomed. 2007 Jul;11(4):398-405.


Pharmacogenomics of the polyamine analog 3,8,13,18-tetraaza-10,11-[(E)-1,2-cyclopropyl]eicosane tetrahydrochloride, CGC-11093, in the colon adenocarcinoma cell line HCT1161.

Ignatenko NA, Yerushalmi HF, Watts GS, Futscher BW, Stringer DE, Marton LJ, Gerner EW.

Technol Cancer Res Treat. 2006 Dec;5(6):553-64.


Epigenetic inactivation of the HOXA gene cluster in breast cancer.

Novak P, Jensen T, Oshiro MM, Wozniak RJ, Nouzova M, Watts GS, Klimecki WT, Kim C, Futscher BW.

Cancer Res. 2006 Nov 15;66(22):10664-70. Epub 2006 Nov 6.


Re-activation of a dormant tumor suppressor gene maspin by designed transcription factors.

Beltran A, Parikh S, Liu Y, Cuevas BD, Johnson GL, Futscher BW, Blancafort P.

Oncogene. 2007 Apr 26;26(19):2791-8. Epub 2006 Oct 23.


5-Aza-2'-deoxycytidine-mediated reductions in G9A histone methyltransferase and histone H3 K9 di-methylation levels are linked to tumor suppressor gene reactivation.

Wozniak RJ, Klimecki WT, Lau SS, Feinstein Y, Futscher BW.

Oncogene. 2007 Jan 4;26(1):77-90. Epub 2006 Jun 26.


Comparisons of PCR-based genome amplification systems using CpG island microarrays.

Pike BL, Groshen S, Hsu YH, Shai RM, Wang X, Holtan N, Futscher BW, Hacia JG.

Hum Mutat. 2006 Jun;27(6):589-96.


AP-2alpha and AP-2gamma are transcriptional targets of p53 in human breast carcinoma cells.

Li H, Watts GS, Oshiro MM, Futscher BW, Domann FE.

Oncogene. 2006 Aug 31;25(39):5405-15. Epub 2006 Apr 24.


Epigenetic regulation of maspin expression in human ovarian carcinoma cells.

Rose SL, Fitzgerald MP, White NO, Hitchler MJ, Futscher BW, De Geest K, Domann FE.

Gynecol Oncol. 2006 Aug;102(2):319-24. Epub 2006 Feb 7.


Epigenetic regulation of the cell type-specific gene 14-3-3sigma.

Oshiro MM, Futscher BW, Lisberg A, Wozniak RJ, Klimecki WT, Domann FE, Cress AE.

Neoplasia. 2005 Sep;7(9):799-808.


Epigenetic silencing of DSC3 is a common event in human breast cancer.

Oshiro MM, Kim CJ, Wozniak RJ, Junk DJ, Muñoz-Rodríguez JL, Burr JA, Fitzgerald M, Pawar SC, Cress AE, Domann FE, Futscher BW.

Breast Cancer Res. 2005;7(5):R669-80. Epub 2005 Jun 16.


Epigenomic changes during leukemia cell differentiation: analysis of histone acetylation and cytosine methylation using CpG island microarrays.

Nouzova M, Holtan N, Oshiro MM, Isett RB, Munoz-Rodriguez JL, List AF, Narro ML, Miller SJ, Merchant NC, Futscher BW.

J Pharmacol Exp Ther. 2004 Dec;311(3):968-81. Epub 2004 Aug 9.


Aberrant methylation of the maspin promoter is an early event in human breast cancer.

Futscher BW, O'Meara MM, Kim CJ, Rennels MA, Lu D, Gruman LM, Seftor RE, Hendrix MJ, Domann FE.

Neoplasia. 2004 Jul-Aug;6(4):380-9.


Flipping the epigenetic switch.

Domann FE, Futscher BW.

Am J Pathol. 2004 Jun;164(6):1883-6. Review. No abstract available.

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