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Items: 1 to 50 of 230

1.

Hepatic triglyceride accumulation via endoplasmic reticulum stress-induced SREBP-1 activation is regulated by ceramide synthases.

Kim YR, Lee EJ, Shin KO, Kim MH, Pewzner-Jung Y, Lee YM, Park JW, Futerman AH, Park WJ.

Exp Mol Med. 2019 Nov 1;51(11):129. doi: 10.1038/s12276-019-0340-1.

2.

A Stroll Down the CerS Lane.

Zelnik ID, Rozman B, Rosenfeld-Gur E, Ben-Dor S, Futerman AH.

Adv Exp Med Biol. 2019;1159:49-63. doi: 10.1007/978-3-030-21162-2_4. Review.

PMID:
31502199
3.

The role of ceramide in regulating endoplasmic reticulum function.

Zelnik ID, Ventura AE, Kim JL, Silva LC, Futerman AH.

Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Jan;1865(1). pii: S1388-1981(19)30118-0. doi: 10.1016/j.bbalip.2019.06.015. Epub 2019 Jun 21. Review.

PMID:
31233888
4.

SMPDL3b modulates insulin receptor signaling in diabetic kidney disease.

Mitrofanova A, Mallela SK, Ducasa GM, Yoo TH, Rosenfeld-Gur E, Zelnik ID, Molina J, Varona Santos J, Ge M, Sloan A, Kim JJ, Pedigo C, Bryn J, Volosenco I, Faul C, Zeidan YH, Garcia Hernandez C, Mendez AJ, Leibiger I, Burke GW, Futerman AH, Barisoni L, Ishimoto Y, Inagi R, Merscher S, Fornoni A.

Nat Commun. 2019 Jun 19;10(1):2692. doi: 10.1038/s41467-019-10584-4.

5.

Yeast ceramide synthases, Lag1 and Lac1, have distinct substrate specificity.

Megyeri M, Prasad R, Volpert G, Sliwa-Gonzalez A, Haribowo AG, Aguilera-Romero A, Riezman H, Barral Y, Futerman AH, Schuldiner M.

J Cell Sci. 2019 Jun 24;132(12). pii: jcs228411. doi: 10.1242/jcs.228411.

6.

Ablation of the pro-inflammatory master regulator miR-155 does not mitigate neuroinflammation or neurodegeneration in a vertebrate model of Gaucher's disease.

Watson L, Keatinge M, Gegg M, Bai Q, Sandulescu MC, Vardi A, Futerman AH, Schapira AHV, Burton EA, Bandmann O.

Neurobiol Dis. 2019 Jul;127:563-569. doi: 10.1016/j.nbd.2019.04.008. Epub 2019 Apr 11.

PMID:
30981829
7.

TLR9-mediated dendritic cell activation uncovers mammalian ganglioside species with specific ceramide backbones that activate invariant natural killer T cells.

Paget C, Deng S, Soulard D, Priestman DA, Speca S, von Gerichten J, Speak AO, Saroha A, Pewzner-Jung Y, Futerman AH, Mallevaey T, Faveeuw C, Gu X, Platt FM, Sandhoff R, Trottein F.

PLoS Biol. 2019 Mar 1;17(3):e3000169. doi: 10.1371/journal.pbio.3000169. eCollection 2019 Mar.

8.

In vivo inactivation of glycosidases by conduritol B epoxide and cyclophellitol as revealed by activity-based protein profiling.

Kuo CL, Kallemeijn WW, Lelieveld LT, Mirzaian M, Zoutendijk I, Vardi A, Futerman AH, Meijer AH, Spaink HP, Overkleeft HS, Aerts JMFG, Artola M.

FEBS J. 2019 Feb;286(3):584-600. doi: 10.1111/febs.14744. Epub 2019 Feb 2.

9.

Absence of infiltrating peripheral myeloid cells in the brains of mouse models of lysosomal storage disorders.

Cho SM, Vardi A, Platt N, Futerman AH.

J Neurochem. 2019 Mar;148(5):625-638. doi: 10.1111/jnc.14483. Epub 2018 Aug 9.

PMID:
29900534
10.

Fingolimod phosphate inhibits astrocyte inflammatory activity in mucolipidosis IV.

Weinstock LD, Furness AM, Herron SS, Smith SS, Sankar SB, DeRosa SG, Gao D, Mepyans ME, Scotto Rosato A, Medina DL, Vardi A, Ferreira NS, Cho SM, Futerman AH, Slaugenhaupt SA, Wood LB, Grishchuk Y.

Hum Mol Genet. 2018 Aug 1;27(15):2725-2738. doi: 10.1093/hmg/ddy182.

PMID:
29771310
11.

Eleven residues determine the acyl chain specificity of ceramide synthases.

Tidhar R, Zelnik ID, Volpert G, Ben-Dor S, Kelly S, Merrill AH Jr, Futerman AH.

J Biol Chem. 2018 Jun 22;293(25):9912-9921. doi: 10.1074/jbc.RA118.001936. Epub 2018 Apr 9.

12.

The brain lipidome in neurodegenerative lysosomal storage disorders.

Fuller M, Futerman AH.

Biochem Biophys Res Commun. 2018 Oct 7;504(3):623-628. doi: 10.1016/j.bbrc.2018.03.042. Epub 2018 Mar 12. Review.

PMID:
29524416
13.

Sphingolipid regulation of lung epithelial cell mitophagy and necroptosis during cigarette smoke exposure.

Mizumura K, Justice MJ, Schweitzer KS, Krishnan S, Bronova I, Berdyshev EV, Hubbard WC, Pewzner-Jung Y, Futerman AH, Choi AMK, Petrache I.

FASEB J. 2018 Apr;32(4):1880-1890. doi: 10.1096/fj.201700571R. Epub 2018 Jan 5.

14.

Identification of seipin-linked factors that act as determinants of a lipid droplet subpopulation.

Eisenberg-Bord M, Mari M, Weill U, Rosenfeld-Gur E, Moldavski O, Castro IG, Soni KG, Harpaz N, Levine TP, Futerman AH, Reggiori F, Bankaitis VA, Schuldiner M, Bohnert M.

J Cell Biol. 2018 Jan 2;217(1):269-282. doi: 10.1083/jcb.201704122. Epub 2017 Nov 29.

15.

Critical Role for Very-Long Chain Sphingolipids in Invariant Natural Killer T Cell Development and Homeostasis.

Saroha A, Pewzner-Jung Y, Ferreira NS, Sharma P, Jouan Y, Kelly SL, Feldmesser E, Merrill AH Jr, Trottein F, Paget C, Lang KS, Futerman AH.

Front Immunol. 2017 Nov 1;8:1386. doi: 10.3389/fimmu.2017.01386. eCollection 2017.

16.

Ablation of ceramide synthase 2 exacerbates dextran sodium sulphate-induced colitis in mice due to increased intestinal permeability.

Kim YR, Volpert G, Shin KO, Kim SY, Shin SH, Lee Y, Sung SH, Lee YM, Ahn JH, Pewzner-Jung Y, Park WJ, Futerman AH, Park JW.

J Cell Mol Med. 2017 Dec;21(12):3565-3578. doi: 10.1111/jcmm.13267. Epub 2017 Jul 12.

17.

Signalome-wide RNAi screen identifies GBA1 as a positive mediator of autophagic cell death.

Dasari SK, Bialik S, Levin-Zaidman S, Levin-Salomon V, Merrill AH Jr, Futerman AH, Kimchi A.

Cell Death Differ. 2017 Jul;24(7):1288-1302. doi: 10.1038/cdd.2017.80. Epub 2017 Jun 2.

18.

Jaspine B induces nonapoptotic cell death in gastric cancer cells independently of its inhibition of ceramide synthase.

Cingolani F, Simbari F, Abad JL, Casasampere M, Fabrias G, Futerman AH, Casas J.

J Lipid Res. 2017 Aug;58(8):1500-1513. doi: 10.1194/jlr.M072611. Epub 2017 Jun 1.

19.

Regulation of very-long acyl chain ceramide synthesis by acyl-CoA-binding protein.

Ferreira NS, Engelsby H, Neess D, Kelly SL, Volpert G, Merrill AH, Futerman AH, Færgeman NJ.

J Biol Chem. 2017 May 5;292(18):7588-7597. doi: 10.1074/jbc.M117.785345. Epub 2017 Mar 19.

20.

Oxidative stress elicited by modifying the ceramide acyl chain length reduces the rate of clathrin-mediated endocytosis.

Volpert G, Ben-Dor S, Tarcic O, Duan J, Saada A, Merrill AH Jr, Pewzner-Jung Y, Futerman AH.

J Cell Sci. 2017 Apr 15;130(8):1486-1493. doi: 10.1242/jcs.199968. Epub 2017 Mar 9.

21.

Identification of a feedback loop involving β-glucosidase 2 and its product sphingosine sheds light on the molecular mechanisms in Gaucher disease.

Schonauer S, Körschen HG, Penno A, Rennhack A, Breiden B, Sandhoff K, Gutbrod K, Dörmann P, Raju DN, Haberkant P, Gerl MJ, Brügger B, Zigdon H, Vardi A, Futerman AH, Thiele C, Wachten D.

J Biol Chem. 2017 Apr 14;292(15):6177-6189. doi: 10.1074/jbc.M116.762831. Epub 2017 Mar 3.

22.

Altered lysosome distribution is an early neuropathological event in neurological forms of Gaucher disease.

Zigdon H, Meshcheriakova A, Farfel-Becker T, Volpert G, Sabanay H, Futerman AH.

FEBS Lett. 2017 Mar;591(5):774-783. doi: 10.1002/1873-3468.12591. Epub 2017 Feb 28.

23.

Combining Deep Sequencing, Proteomics, Phosphoproteomics, and Functional Screens To Discover Novel Regulators of Sphingolipid Homeostasis.

Lebesgue N, Megyeri M, Cristobal A, Scholten A, Chuartzman SG, Voichek Y, Scheltema RA, Mohammed S, Futerman AH, Schuldiner M, Heck AJ, Lemeer S.

J Proteome Res. 2017 Feb 3;16(2):571-582. doi: 10.1021/acs.jproteome.6b00691. Epub 2016 Nov 29.

PMID:
28152593
24.

The metabolism of glucocerebrosides - From 1965 to the present.

Futerman AH, Platt FM.

Mol Genet Metab. 2017 Jan - Feb;120(1-2):22-26. doi: 10.1016/j.ymgme.2016.11.390. Epub 2016 Dec 2. Review.

PMID:
27955980
25.

Pathological levels of glucosylceramide change the biophysical properties of artificial and cell membranes.

Varela AR, Ventura AE, Carreira AC, Fedorov A, Futerman AH, Prieto M, Silva LC.

Phys Chem Chem Phys. 2016 Dec 21;19(1):340-346. doi: 10.1039/c6cp07227e.

PMID:
27905603
26.

Sortilin Deficiency Reduces Ductular Reaction, Hepatocyte Apoptosis, and Liver Fibrosis in Cholestatic-Induced Liver Injury.

Hubel E, Saroha A, Park WJ, Pewzner-Jung Y, Lavoie EG, Futerman AH, Bruck R, Fishman S, Dranoff JA, Shibolet O, Zvibel I.

Am J Pathol. 2017 Jan;187(1):122-133. doi: 10.1016/j.ajpath.2016.09.005. Epub 2016 Nov 11.

PMID:
27842214
27.

Clozapine Modulates Glucosylceramide, Clears Aggregated Proteins, and Enhances ATG8/LC3 in Caenorhabditis elegans.

Hao L, Ben-David O, Babb SM, Futerman AH, Cohen BM, Buttner EA.

Neuropsychopharmacology. 2017 Mar;42(4):951-962. doi: 10.1038/npp.2016.230. Epub 2016 Oct 6.

28.

Making Sense of the Yeast Sphingolipid Pathway.

Megyeri M, Riezman H, Schuldiner M, Futerman AH.

J Mol Biol. 2016 Dec 4;428(24 Pt A):4765-4775. doi: 10.1016/j.jmb.2016.09.010. Epub 2016 Sep 21. Review.

PMID:
27664439
29.

Perspective: Finding common ground.

Futerman AH, Hardy J.

Nature. 2016 Sep 22;537(7621):S160-1. doi: 10.1038/537S160a. No abstract available.

PMID:
27652785
30.

Identification of Modifier Genes in a Mouse Model of Gaucher Disease.

Klein AD, Ferreira NS, Ben-Dor S, Duan J, Hardy J, Cox TM, Merrill AH Jr, Futerman AH.

Cell Rep. 2016 Sep 6;16(10):2546-2553. doi: 10.1016/j.celrep.2016.07.085. Epub 2016 Aug 25.

31.

KCa 3.1 upregulation preserves endothelium-dependent vasorelaxation during aging and oxidative stress.

Choi S, Kim JA, Li HY, Shin KO, Oh GT, Lee YM, Oh S, Pewzner-Jung Y, Futerman AH, Suh SH.

Aging Cell. 2016 Oct;15(5):801-10. doi: 10.1111/acel.12502. Epub 2016 Jun 30.

32.

Delineating pathological pathways in a chemically induced mouse model of Gaucher disease.

Vardi A, Zigdon H, Meshcheriakova A, Klein AD, Yaacobi C, Eilam R, Kenwood BM, Rahim AA, Massaro G, Merrill AH Jr, Vitner EB, Futerman AH.

J Pathol. 2016 Aug;239(4):496-509. doi: 10.1002/path.4751. Epub 2016 Jul 5.

PMID:
27234572
33.

Induction of the type I interferon response in neurological forms of Gaucher disease.

Vitner EB, Farfel-Becker T, Ferreira NS, Leshkowitz D, Sharma P, Lang KS, Futerman AH.

J Neuroinflammation. 2016 May 12;13(1):104. doi: 10.1186/s12974-016-0570-2.

34.

Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodelling in a hypoxic model of pulmonary arterial hypertension.

MacRitchie N, Volpert G, Al Washih M, Watson DG, Futerman AH, Kennedy S, Pyne S, Pyne NJ.

Cell Signal. 2016 Aug;28(8):946-55. doi: 10.1016/j.cellsig.2016.03.014. Epub 2016 Apr 6.

35.

Glucosylceramide Reorganizes Cholesterol-Containing Domains in a Fluid Phospholipid Membrane.

Varela ARP, Couto AS, Fedorov A, Futerman AH, Prieto M, Silva LC.

Biophys J. 2016 Feb 2;110(3):612-622. doi: 10.1016/j.bpj.2015.12.019.

36.

Altering sphingolipid composition with aging induces contractile dysfunction of gastric smooth muscle via K(Ca) 1.1 upregulation.

Choi S, Kim JA, Kim TH, Li HY, Shin KO, Lee YM, Oh S, Pewzner-Jung Y, Futerman AH, Suh SH.

Aging Cell. 2015 Dec;14(6):982-94. doi: 10.1111/acel.12388. Epub 2015 Aug 20.

37.

Virus-Induced Type I Interferon Deteriorates Control of Systemic Pseudomonas Aeruginosa Infection.

Merches K, Khairnar V, Knuschke T, Shaabani N, Honke N, Duhan V, Recher M, Navarini AA, Hardt C, Häussinger D, Tümmler B, Gulbins E, Futerman AH, Hoffmann D, Lang F, Lang PA, Westendorf AM, Lang KS.

Cell Physiol Biochem. 2015;36(6):2379-92. doi: 10.1159/000430200. Epub 2015 Jul 27.

38.

Ceramide synthases in biomedical research.

Cingolani F, Futerman AH, Casas J.

Chem Phys Lipids. 2016 May;197:25-32. doi: 10.1016/j.chemphyslip.2015.07.026. Epub 2015 Aug 3.

PMID:
26248326
39.

LPS-mediated septic shock is augmented in ceramide synthase 2 null mice due to elevated activity of TNFα-converting enzyme.

Ali M, Saroha A, Pewzner-Jung Y, Futerman AH.

FEBS Lett. 2015 Aug 4;589(17):2213-7. doi: 10.1016/j.febslet.2015.06.045. Epub 2015 Jul 13.

40.

Development of pheochromocytoma in ceramide synthase 2 null mice.

Park WJ, Brenner O, Kogot-Levin A, Saada A, Merrill AH Jr, Pewzner-Jung Y, Futerman AH.

Endocr Relat Cancer. 2015 Aug;22(4):623-32. doi: 10.1530/ERC-15-0058. Epub 2015 Jun 25.

41.

Preface to the Special Issue on brain lipids.

Futerman AH.

Biochim Biophys Acta. 2015 Aug;1851(8):997-8. doi: 10.1016/j.bbalip.2015.04.003. Epub 2015 Apr 11. No abstract available.

PMID:
25869182
42.

Identification of a biomarker in cerebrospinal fluid for neuronopathic forms of Gaucher disease.

Zigdon H, Savidor A, Levin Y, Meshcheriakova A, Schiffmann R, Futerman AH.

PLoS One. 2015 Mar 16;10(3):e0120194. doi: 10.1371/journal.pone.0120194. eCollection 2015.

43.

Innate immune responses in the brain of sphingolipid lysosomal storage diseases.

Vitner EB, Futerman AH, Platt N.

Biol Chem. 2015 Jun;396(6-7):659-67. doi: 10.1515/hsz-2014-0301. Review.

PMID:
25720063
44.

Lack of ceramide synthase 2 suppresses the development of experimental autoimmune encephalomyelitis by impairing the migratory capacity of neutrophils.

Barthelmes J, de Bazo AM, Pewzner-Jung Y, Schmitz K, Mayer CA, Foerch C, Eberle M, Tafferner N, Ferreirós N, Henke M, Geisslinger G, Futerman AH, Grösch S, Schiffmann S.

Brain Behav Immun. 2015 May;46:280-92. doi: 10.1016/j.bbi.2015.02.010. Epub 2015 Feb 16.

PMID:
25697397
45.

Emerging therapeutic targets for Gaucher disease.

Vitner EB, Vardi A, Cox TM, Futerman AH.

Expert Opin Ther Targets. 2015 Mar;19(3):321-34. doi: 10.1517/14728222.2014.981530. Epub 2014 Nov 21. Review.

PMID:
25416676
46.

A rapid ceramide synthase activity using NBD-sphinganine and solid phase extraction.

Tidhar R, Sims K, Rosenfeld-Gur E, Shaw W, Futerman AH.

J Lipid Res. 2015 Jan;56(1):193-9. doi: 10.1194/jlr.D052001. Epub 2014 Nov 3.

47.

CerS2 Haploinsufficiency Inhibits β-Oxidation and Confers Susceptibility to Diet-Induced Steatohepatitis and Insulin Resistance.

Raichur S, Wang ST, Chan PW, Li Y, Ching J, Chaurasia B, Dogra S, Öhman MK, Takeda K, Sugii S, Pewzner-Jung Y, Futerman AH, Summers SA.

Cell Metab. 2014 Nov 4;20(5):919. doi: 10.1016/j.cmet.2014.10.007. Epub 2014 Nov 4. No abstract available.

48.

Reduced ceramide synthase 2 activity causes progressive myoclonic epilepsy.

Mosbech MB, Olsen AS, Neess D, Ben-David O, Klitten LL, Larsen J, Sabers A, Vissing J, Nielsen JE, Hasholt L, Klein AD, Tsoory MM, Hjalgrim H, Tommerup N, Futerman AH, Møller RS, Færgeman NJ.

Ann Clin Transl Neurol. 2014 Feb;1(2):88-98. doi: 10.1002/acn3.28. Epub 2014 Jan 13.

49.

CerS2 haploinsufficiency inhibits β-oxidation and confers susceptibility to diet-induced steatohepatitis and insulin resistance.

Raichur S, Wang ST, Chan PW, Li Y, Ching J, Chaurasia B, Dogra S, Öhman MK, Takeda K, Sugii S, Pewzner-Jung Y, Futerman AH, Summers SA.

Cell Metab. 2014 Oct 7;20(4):687-95. doi: 10.1016/j.cmet.2014.09.015. Erratum in: Cell Metab. 2014 Nov 4;20(5):919. Chaurasia, Bghagirath [corrected to Chaurasia, Bhagirath]. Erratum in: Cell Metab. 2014 Nov 4;20(5):919.

50.

Hepatic fatty acid uptake is regulated by the sphingolipid acyl chain length.

Park WJ, Park JW, Merrill AH, Storch J, Pewzner-Jung Y, Futerman AH.

Biochim Biophys Acta. 2014 Dec;1841(12):1754-66. Erratum in: Biochim Biophys Acta. 2015 Jul;1851(7):996.

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