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Items: 1 to 50 of 61

1.

Structure-Activity Relationship in Monosaccharide-Based Toll-Like Receptor 4 (TLR4) Antagonists.

Facchini FA, Zaffaroni L, Minotti A, Rapisarda S, Calabrese V, Forcella M, Fusi P, Airoldi C, Ciaramelli C, Billod JM, Schromm AB, Braun H, Palmer C, Beyaert R, Lapenta F, Jerala R, Pirianov G, Martin-Santamaria S, Peri F.

J Med Chem. 2018 Apr 12;61(7):2895-2909. doi: 10.1021/acs.jmedchem.7b01803. Epub 2018 Mar 12.

PMID:
29494148
2.

Probing the Influence of Linker Length and Flexibility in the Design and Synthesis of New Trehalase Inhibitors.

D'Adamio G, Forcella M, Fusi P, Parenti P, Matassini C, Ferhati X, Vanni C, Cardona F.

Molecules. 2018 Feb 16;23(2). pii: E436. doi: 10.3390/molecules23020436.

3.

Toxicogenomics applied to in vitro Cell Transformation Assay reveals mechanisms of early response to cadmium.

Callegaro G, Forcella M, Melchioretto P, Frattini A, Gribaldo L, Fusi P, Fabbri M, Urani C.

Toxicol In Vitro. 2018 Apr;48:232-243. doi: 10.1016/j.tiv.2018.01.025. Epub 2018 Jan 31.

PMID:
29408670
4.

Deregulation of sialidases in human normal and tumor tissues.

Forcella M, Mozzi A, Stefanini FM, Riva A, Epistolio S, Molinari F, Merlo E, Monti E, Fusi P, Frattini M.

Cancer Biomark. 2018 Feb 14;21(3):591-601. doi: 10.3233/CBM-170548.

PMID:
29278877
5.

Non-small cell lung cancer (NSCLC), EGFR downstream pathway activation and TKI targeted therapies sensitivity: Effect of the plasma membrane-associated NEU3.

Forcella M, Oldani M, Epistolio S, Freguia S, Monti E, Fusi P, Frattini M.

PLoS One. 2017 Oct 31;12(10):e0187289. doi: 10.1371/journal.pone.0187289. eCollection 2017.

6.

Cadmium-transformed cells in the in vitro cell transformation assay reveal different proliferative behaviours and activated pathways.

Forcella M, Callegaro G, Melchioretto P, Gribaldo L, Frattini M, Stefanini FM, Fusi P, Urani C.

Toxicol In Vitro. 2016 Oct;36:71-80. doi: 10.1016/j.tiv.2016.07.006. Epub 2016 Jul 16.

PMID:
27432484
7.

NEU3 activity enhances EGFR activation without affecting EGFR expression and acts on its sialylation levels.

Mozzi A, Forcella M, Riva A, Difrancesco C, Molinari F, Martin V, Papini N, Bernasconi B, Nonnis S, Tedeschi G, Mazzucchelli L, Monti E, Fusi P, Frattini M.

Glycobiology. 2015 Aug;25(8):855-68. doi: 10.1093/glycob/cwv026. Epub 2015 Apr 28.

PMID:
25922362
8.

New synthesis and biological evaluation of uniflorine A derivatives: towards specific insect trehalase inhibitors.

D'Adamio G, Sgambato A, Forcella M, Caccia S, Parmeggiani C, Casartelli M, Parenti P, Bini D, Cipolla L, Fusi P, Cardona F.

Org Biomol Chem. 2015 Jan 21;13(3):886-92. doi: 10.1039/c4ob02016b.

9.

A novel AMPK activator reduces glucose uptake and inhibits tumor progression in a mouse xenograft model of colorectal cancer.

Valtorta S, Nicolini G, Tripodi F, Meregalli C, Cavaletti G, Avezza F, Crippa L, Bertoli G, Sanvito F, Fusi P, Pagliarin R, Orsini F, Moresco RM, Coccetti P.

Invest New Drugs. 2014 Dec;32(6):1123-33. doi: 10.1007/s10637-014-0148-8. Epub 2014 Aug 19.

PMID:
25134489
10.

A new bioadhesive material from fish parasite Neobenedenia girellae.

Maffioli E, Nonnis S, Polo NC, Negri A, Forcella M, Fusi P, Galli P, Tedeschi G.

J Proteomics. 2014 Oct 14;110:1-6. doi: 10.1016/j.jprot.2014.07.014. Epub 2014 Jul 22.

PMID:
25058576
11.

Looking at human cytosolic sialidase NEU2 structural features with an interdisciplinary approach.

Monti E, Benaglia G, Mozzi A, Fusi P, Longhi G, Gangemi F, Castiglioni E, Woody RW, Fornili SL, Abbate S.

Biochemistry. 2014 Aug 19;53(32):5343-55. doi: 10.1021/bi500249r. Epub 2014 Aug 5.

PMID:
25033330
12.

N-Bridged 1-deoxynojirimycin dimers as selective insect trehalase inhibitors.

Cipolla L, Sgambato A, Forcella M, Fusi P, Parenti P, Cardona F, Bini D.

Carbohydr Res. 2014 May 7;389:46-9. doi: 10.1016/j.carres.2013.12.025. Epub 2014 Jan 30.

PMID:
24680508
13.

A proline-rich loop mediates specific functions of human sialidase NEU4 in SK-N-BE neuronal differentiation.

Bigi A, Tringali C, Forcella M, Mozzi A, Venerando B, Monti E, Fusi P.

Glycobiology. 2013 Dec;23(12):1499-509. doi: 10.1093/glycob/cwt078. Epub 2013 Sep 12.

PMID:
24030392
14.

Functional characterization of a CRH missense mutation identified in an ADNFLE family.

Sansoni V, Forcella M, Mozzi A, Fusi P, Ambrosini R, Ferini-Strambi L, Combi R.

PLoS One. 2013 Apr 11;8(4):e61306. doi: 10.1371/journal.pone.0061306. Print 2013.

15.

Molecular cloning of soluble trehalase from Chironomus riparius larvae, its heterologous expression in Escherichia coli and bioinformatic analysis.

Forcella M, Mozzi A, Bigi A, Parenti P, Fusi P.

Arch Insect Biochem Physiol. 2012 Oct;81(2):77-89. doi: 10.1002/arch.21041. Epub 2012 Jul 31.

PMID:
22851493
16.

Ethidium bromide as a marker of mtDNA replication in living cells.

Villa AM, Fusi P, Pastori V, Amicarelli G, Pozzi C, Adlerstein D, Doglia SM.

J Biomed Opt. 2012 Apr;17(4):046001. doi: 10.1117/1.JBO.17.4.046001.

PMID:
22559680
17.

Synthesis and biological evaluation of 1,4-diaryl-2-azetidinones as specific anticancer agents: activation of adenosine monophosphate activated protein kinase and induction of apoptosis.

Tripodi F, Pagliarin R, Fumagalli G, Bigi A, Fusi P, Orsini F, Frattini M, Coccetti P.

J Med Chem. 2012 Mar 8;55(5):2112-24. doi: 10.1021/jm201344a. Epub 2012 Feb 22.

PMID:
22329561
18.

Molecular insight into substrate recognition by human cytosolic sialidase NEU2.

Mozzi A, Mazzacuva P, Zampella G, Forcella ME, Fusi PA, Monti E.

Proteins. 2012 Apr;80(4):1123-32. doi: 10.1002/prot.24013. Epub 2012 Jan 7.

PMID:
22228546
19.

Hydration studies on the archaeal protein Sso7d using NMR measurements and MD simulations.

Bernini A, Spiga O, Consonni R, Arosio I, Fusi P, Cirri S, Guagliardi A, Niccolai N.

BMC Struct Biol. 2011 Oct 21;11:44. doi: 10.1186/1472-6807-11-44.

20.

Bacteria-induced gap junctions in tumors favor antigen cross-presentation and antitumor immunity.

Saccheri F, Pozzi C, Avogadri F, Barozzi S, Faretta M, Fusi P, Rescigno M.

Sci Transl Med. 2010 Aug 11;2(44):44ra57. doi: 10.1126/scitranslmed.3000739.

21.

A membrane-bound trehalase from Chironomus riparius larvae: purification and sensitivity to inhibition.

Forcella M, Cardona F, Goti A, Parmeggiani C, Cipolla L, Gregori M, Schirone R, Fusi P, Parenti P.

Glycobiology. 2010 Sep;20(9):1186-95. doi: 10.1093/glycob/cwq087. Epub 2010 Jun 11.

PMID:
20542873
22.

Casuarine-6-O-alpha-D-glucoside and its analogues are tight binding inhibitors of insect and bacterial trehalases.

Cardona F, Goti A, Parmeggiani C, Parenti P, Forcella M, Fusi P, Cipolla L, Roberts SM, Davies GJ, Gloster TM.

Chem Commun (Camb). 2010 Apr 21;46(15):2629-31.

PMID:
20461849
23.

CK2 and GSK3 phosphorylation on S29 controls wild-type ATXN3 nuclear uptake.

Pastori V, Sangalli E, Coccetti P, Pozzi C, Nonnis S, Tedeschi G, Fusi P.

Biochim Biophys Acta. 2010 Jul-Aug;1802(7-8):583-92. doi: 10.1016/j.bbadis.2010.03.007. Epub 2010 Mar 27.

24.

Complexity in influenza virus targeted drug design: interaction with human sialidases.

Chavas LM, Kato R, Suzuki N, von Itzstein M, Mann MC, Thomson RJ, Dyason JC, McKimm-Breschkin J, Fusi P, Tringali C, Venerando B, Tettamanti G, Monti E, Wakatsuki S.

J Med Chem. 2010 Apr 8;53(7):2998-3002. doi: 10.1021/jm100078r.

PMID:
20222714
25.

Human sialidase NEU4 long and short are extrinsic proteins bound to outer mitochondrial membrane and the endoplasmic reticulum, respectively.

Bigi A, Morosi L, Pozzi C, Forcella M, Tettamanti G, Venerando B, Monti E, Fusi P.

Glycobiology. 2010 Feb;20(2):148-57. doi: 10.1093/glycob/cwp156. Epub 2009 Sep 30.

PMID:
19797320
26.

Proteomic and biochemical analyses unveil tight interaction of ataxin-3 with tubulin.

Mazzucchelli S, De Palma A, Riva M, D'Urzo A, Pozzi C, Pastori V, Comelli F, Fusi P, Vanoni M, Tortora P, Mauri P, Regonesi ME.

Int J Biochem Cell Biol. 2009 Dec;41(12):2485-92. doi: 10.1016/j.biocel.2009.08.003. Epub 2009 Aug 8.

PMID:
19666135
27.

Glycolipids and benzylammonium lipids as novel antisepsis agents: synthesis and biological characterization.

Piazza M, Rossini C, Della Fiorentina S, Pozzi C, Comelli F, Bettoni I, Fusi P, Costa B, Peri F.

J Med Chem. 2009 Feb 26;52(4):1209-13. doi: 10.1021/jm801333m.

PMID:
19161283
28.

NMR studies on the surface accessibility of the archaeal protein Sso7d by using TEMPOL and Gd(III)(DTPA-BMA) as paramagnetic probes.

Bernini A, Venditti V, Spiga O, Ciutti A, Prischi F, Consonni R, Zetta L, Arosio I, Fusi P, Guagliardi A, Niccolai N.

Biophys Chem. 2008 Oct;137(2-3):71-5. doi: 10.1016/j.bpc.2008.07.003. Epub 2008 Jul 16.

PMID:
18678440
29.

Study of subcellular localization and proteolysis of ataxin-3.

Pozzi C, Valtorta M, Tedeschi G, Galbusera E, Pastori V, Bigi A, Nonnis S, Grassi E, Fusi P.

Neurobiol Dis. 2008 May;30(2):190-200. doi: 10.1016/j.nbd.2008.01.011. Epub 2008 Feb 15.

PMID:
18353661
30.

Structural determinants responsible for the thermostability of Sso7d and its single point mutants.

Consonni R, Arosio I, Recca T, Fusi P, Zetta L.

Proteins. 2007 May 15;67(3):766-75. No abstract available.

PMID:
17340638
31.

Destabilization of non-pathological variants of ataxin-3 by metal ions results in aggregation/fibrillogenesis.

Ricchelli F, Fusi P, Tortora P, Valtorta M, Riva M, Tognon G, Chieregato K, Bolognin S, Zatta P.

Int J Biochem Cell Biol. 2007;39(5):966-77. Epub 2007 Jan 20.

PMID:
17300980
32.

Ataxin-3 is subject to autolytic cleavage.

Mauri PL, Riva M, Ambu D, De Palma A, Secundo F, Benazzi L, Valtorta M, Tortora P, Fusi P.

FEBS J. 2006 Sep;273(18):4277-86.

33.

Genomic and antigenic characterization of viruses from the 1993 Italian foot-and-mouth disease outbreak.

Núñez JI, Fusi P, Borrego B, Brocchi E, Pacciarini ML, Sobrino F.

Arch Virol. 2006 Jan;151(1):127-42. Epub 2005 Aug 12.

PMID:
16096711
34.

The powerful high pressure tool for protein conformational studies.

Marchal S, Torrent J, Masson P, Kornblatt JM, Tortora P, Fusi P, Lange R, Balny C.

Braz J Med Biol Res. 2005 Aug;38(8):1175-83. Epub 2005 Jul 30.

35.

Crystal structure of the human cytosolic sialidase Neu2. Evidence for the dynamic nature of substrate recognition.

Chavas LM, Tringali C, Fusi P, Venerando B, Tettamanti G, Kato R, Monti E, Wakatsuki S.

J Biol Chem. 2005 Jan 7;280(1):469-75. Epub 2004 Oct 22.

36.

Guanidine-induced unfolding of the Sso7d protein from the hyperthermophilic archaeon Sulfolobus solfataricus.

Granata V, Vecchio PD, Barone G, Shehi E, Fusi P, Tortora P, Graziano G.

Int J Biol Macromol. 2004 Jun;34(3):195-201.

PMID:
15225992
37.

Temperature-dependent, irreversible formation of amyloid fibrils by a soluble human ataxin-3 carrying a moderately expanded polyglutamine stretch (Q36).

Shehi E, Fusi P, Secundo F, Pozzuolo S, Bairati A, Tortora P.

Biochemistry. 2003 Dec 16;42(49):14626-32.

PMID:
14661975
38.

Properties of recombinant human cytosolic sialidase HsNEU2. The enzyme hydrolyzes monomerically dispersed GM1 ganglioside molecules.

Tringali C, Papini N, Fusi P, Croci G, Borsani G, Preti A, Tortora P, Tettamanti G, Venerando B, Monti E.

J Biol Chem. 2004 Jan 30;279(5):3169-79. Epub 2003 Nov 12.

39.

Domain architecture of the polyglutamine protein ataxin-3: a globular domain followed by a flexible tail.

Masino L, Musi V, Menon RP, Fusi P, Kelly G, Frenkiel TA, Trottier Y, Pastore A.

FEBS Lett. 2003 Aug 14;549(1-3):21-5.

40.

Thermal stability and DNA binding activity of a variant form of the Sso7d protein from the archeon Sulfolobus solfataricus truncated at leucine 54.

Shehi E, Granata V, Del Vecchio P, Barone G, Fusi P, Tortora P, Graziano G.

Biochemistry. 2003 Jul 15;42(27):8362-8.

PMID:
12846585
41.

Structural instability and fibrillar aggregation of non-expanded human ataxin-3 revealed under high pressure and temperature.

Marchal S, Shehi E, Harricane MC, Fusi P, Heitz F, Tortora P, Lange R.

J Biol Chem. 2003 Aug 22;278(34):31554-63. Epub 2003 May 23.

42.
43.

Investigations of Sso7d catalytic residues by NMR titration shifts and electrostatic calculations.

Consonni R, Arosio I, Belloni B, Fogolari F, Fusi P, Shehi E, Zetta L.

Biochemistry. 2003 Feb 18;42(6):1421-9.

PMID:
12578354
44.

Exploring hyperthermophilic proteins under pressure: theoretical aspects and experimental findings.

Mombelli E, Shehi E, Fusi P, Tortora P.

Biochim Biophys Acta. 2002 Mar 25;1595(1-2):392-6. Review.

PMID:
11983413
45.

The Sso7d DNA-binding protein from Sulfolobus solfataricus has ribonuclease activity.

Shehi E, Serina S, Fumagalli G, Vanoni M, Consonni R, Zetta L, Dehò G, Tortora P, Fusi P.

FEBS Lett. 2001 May 25;497(2-3):131-6. Erratum in: FEBS Lett 2001 Jul 20;501(2-3):177.

46.
47.

Differential scanning calorimetry study of the thermodynamic stability of some mutants of Sso7d from Sulfolobus solfataricus.

Catanzano F, Graziano G, Fusi P, Tortora P, Barone G.

Biochemistry. 1998 Jul 21;37(29):10493-8.

PMID:
9671520
48.

Isolation of a new phenotypic variant of E coli O157:H7 from food.

Colombo S, Pacciarini ML, Fusi P.

Vet Rec. 1998 Feb 7;142(6):144-5. No abstract available.

PMID:
9507650
49.

Extreme heat- and pressure-resistant 7-kDa protein P2 from the archaeon Sulfolobus solfataricus is dramatically destabilized by a single-point amino acid substitution.

Fusi P, Goossens K, Consonni R, Grisa M, Puricelli P, Vecchio G, Vanoni M, Zetta L, Heremans K, Tortora P.

Proteins. 1997 Nov;29(3):381-90.

PMID:
9365992
50.

The role of phenylalanine 31 in maintaining the conformational stability of ribonuclease P2 from Sulfolobus solfataricus under extreme conditions of temperature and pressure.

Mombelli E, Afshar M, Fusi P, Mariani M, Tortora P, Connelly JP, Lange R.

Biochemistry. 1997 Jul 22;36(29):8733-42.

PMID:
9220960

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