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Items: 20

1.

The GABAA receptor alpha+beta- interface: a novel target for subtype selective drugs.

Ramerstorfer J, Furtmüller R, Sarto-Jackson I, Varagic Z, Sieghart W, Ernst M.

J Neurosci. 2011 Jan 19;31(3):870-7. doi: 10.1523/JNEUROSCI.5012-10.2011.

2.

Anxiolytic-like effects of 8-acetylene imidazobenzodiazepines in a rhesus monkey conflict procedure.

Fischer BD, Licata SC, Edwankar RV, Wang ZJ, Huang S, He X, Yu J, Zhou H, Johnson EM Jr, Cook JM, Furtmüller R, Ramerstorfer J, Sieghart W, Roth BL, Majumder S, Rowlett JK.

Neuropharmacology. 2010 Dec;59(7-8):612-8. doi: 10.1016/j.neuropharm.2010.08.011. Epub 2010 Aug 18.

3.

The point mutation gamma 2F77I changes the potency and efficacy of benzodiazepine site ligands in different GABAA receptor subtypes.

Ramerstorfer J, Furtmüller R, Vogel E, Huck S, Sieghart W.

Eur J Pharmacol. 2010 Jun 25;636(1-3):18-27. doi: 10.1016/j.ejphar.2010.03.015. Epub 2010 Mar 19.

PMID:
20303942
4.

Novel positive allosteric modulators of GABAA receptors: do subtle differences in activity at alpha1 plus alpha5 versus alpha2 plus alpha3 subunits account for dissimilarities in behavioral effects in rats?

Savić MM, Majumder S, Huang S, Edwankar RV, Furtmüller R, Joksimović S, Clayton T Sr, Ramerstorfer J, Milinković MM, Roth BL, Sieghart W, Cook JM.

Prog Neuropsychopharmacol Biol Psychiatry. 2010 Mar 17;34(2):376-86. doi: 10.1016/j.pnpbp.2010.01.004. Epub 2010 Jan 13.

5.

Antiseizure activity of novel gamma-aminobutyric acid (A) receptor subtype-selective benzodiazepine analogues in mice and rat models.

Rivas FM, Stables JP, Murphree L, Edwankar RV, Edwankar CR, Huang S, Jain HD, Zhou H, Majumder S, Sankar S, Roth BL, Ramerstorfer J, Furtmüller R, Sieghart W, Cook JM.

J Med Chem. 2009 Apr 9;52(7):1795-8. doi: 10.1021/jm801652d.

6.

A study of the structure-activity relationship of GABA(A)-benzodiazepine receptor bivalent ligands by conformational analysis with low temperature NMR and X-ray analysis.

Han D, Holger Försterling F, Li X, Deschamps JR, Parrish D, Cao H, Rallapalli S, Clayton T, Teng Y, Majumder S, Sankar S, Roth BL, Sieghart W, Furtmuller R, Rowlett JK, Weed MR, Cook JM.

Bioorg Med Chem. 2008 Oct 1;16(19):8853-62. doi: 10.1016/j.bmc.2008.08.072. Epub 2008 Sep 2.

7.

Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunit.

Harris D, Clayton T, Cook J, Sahbaie P, Halliwell RF, Furtmüller R, Huck S, Sieghart W, DeLorey TM.

J Med Chem. 2008 Jul 10;51(13):3788-803. doi: 10.1021/jm701433b. Epub 2008 Jun 7.

PMID:
18537233
8.

PWZ-029, a compound with moderate inverse agonist functional selectivity at GABA(A) receptors containing alpha5 subunits, improves passive, but not active, avoidance learning in rats.

Savić MM, Clayton T, Furtmüller R, Gavrilović I, Samardzić J, Savić S, Huck S, Sieghart W, Cook JM.

Brain Res. 2008 May 7;1208:150-9. doi: 10.1016/j.brainres.2008.02.020. Epub 2008 Feb 19.

9.

An updated unified pharmacophore model of the benzodiazepine binding site on gamma-aminobutyric acid(a) receptors: correlation with comparative models.

Clayton T, Chen JL, Ernst M, Richter L, Cromer BA, Morton CJ, Ng H, Kaczorowski CC, Helmstetter FJ, Furtmüller R, Ecker G, Parker MW, Sieghart W, Cook JM.

Curr Med Chem. 2007;14(26):2755-75. Review.

PMID:
18045122
10.

Are GABAA receptors containing alpha5 subunits contributing to the sedative properties of benzodiazepine site agonists?

Savić MM, Huang S, Furtmüller R, Clayton T, Huck S, Obradović DI, Ugresić ND, Sieghart W, Bokonjić DR, Cook JM.

Neuropsychopharmacology. 2008 Jan;33(2):332-9. Epub 2007 Mar 28.

11.

N-Substituted 4-amino-3,3-dipropyl-2(3H)-furanones: new positive allosteric modulators of the GABA(A) receptor sharing electrophysiological properties with the anticonvulsant loreclezole.

El Hadri A, Abouabdellah A, Thomet U, Baur R, Furtmüller R, Sigel E, Sieghart W, Dodd RH.

J Med Chem. 2002 Jun 20;45(13):2824-31.

PMID:
12061884
12.

Tranexamic acid, a widely used antifibrinolytic agent, causes convulsions by a gamma-aminobutyric acid(A) receptor antagonistic effect.

Furtmüller R, Schlag MG, Berger M, Hopf R, Huck S, Sieghart W, Redl H.

J Pharmacol Exp Ther. 2002 Apr;301(1):168-73.

PMID:
11907171
13.

Alternate use of distinct intersubunit contacts controls GABAA receptor assembly and stoichiometry.

Klausberger T, Sarto I, Ehya N, Fuchs K, Furtmuller R, Mayer B, Huck S, Sieghart W.

J Neurosci. 2001 Dec 1;21(23):9124-33.

14.

5-[1'-(2'-N-Arylsulfonyl-1',2',3',4'-tetrahydroisoquinolyl)]-4, 5-dihydro-2(3H)-furanones: positive allosteric modulators of the GABA(A) receptor with a new mode of action.

Razet R, Thomet U, Furtmüller R, Chiaroni A, Sigel E, Sieghart W, Dodd RH.

J Med Chem. 2000 Nov 16;43(23):4363-6. No abstract available.

PMID:
11087560
15.

Use of bicuculline, a GABA antagonist, as a template for the development of a new class of ligands showing positive allosteric modulation of the GABA(A) receptor.

Razet R, Thomet U, Furtmüller R, Jursky F, Sigel E, Sieghart W, Dodd RH.

Bioorg Med Chem Lett. 2000 Nov 20;10(22):2579-83.

PMID:
11086734
16.

A novel positive allosteric modulator of the GABA(A) receptor: the action of (+)-ROD188.

Thomet U, Baur R, Razet R, Dodd RH, Furtmüller R, Sieghart W, Sigel E.

Br J Pharmacol. 2000 Oct;131(4):843-50.

17.

Synthesis and GABA(A) receptor activity of 6-oxa-analogs of neurosteroids.

Nicoletti D, Ghini AA, Furtmüller R, Sieghart W, Dodd RH, Burton G.

Steroids. 2000 Jun;65(6):349-56.

PMID:
10802285
18.

Chronic and acute effects of thiazolidinediones BM13.1258 and BM15.2054 on rat skeletal muscle glucose metabolism.

Fürnsinn C, Brunmair B, Meyer M, Neschen S, Furtmüller R, Roden M, Kühnle HF, Nowotny P, Schneider B, Waldhäusl W.

Br J Pharmacol. 1999 Nov;128(6):1141-8.

19.

EDPC: a novel high affinity ligand for the benzodiazepine site on rat GABA(A) receptors.

Thomet U, Furtmüller R, Sieghart W, Le Hyaric-Almeida M, Rousseau JF, Dodd RH, Venault P, Chapouthier G, Sigel E.

Neurosci Lett. 1999 Jul 9;269(2):63-6.

PMID:
10430505
20.

Failure of leptin to affect basal and insulin-stimulated glucose metabolism of rat skeletal muscle in vitro.

Fürnsinn C, Brunmair B, Furtmüller R, Roden M, Englisch R, Waldhäusl W.

Diabetologia. 1998 May;41(5):524-9.

PMID:
9628268

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