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Items: 23

1.

The γ-Secretase Modulator, BMS-932481, Modulates Aβ Peptides in the Plasma and Cerebrospinal Fluid of Healthy Volunteers.

Soares HD, Gasior M, Toyn JH, Wang JS, Hong Q, Berisha F, Furlong MT, Raybon J, Lentz KA, Sweeney F, Zheng N, Akinsanya B, Berman RM, Thompson LA, Olson RE, Morrison J, Drexler DM, Macor JE, Albright CF, Ahlijanian MK, AbuTarif M.

J Pharmacol Exp Ther. 2016 Jul;358(1):138-50. doi: 10.1124/jpet.116.232256. Epub 2016 Apr 20.

2.

A validated enantioselective LC-MS/MS assay for quantification of a major chiral metabolite of an achiral 11-β-hydroxysteroid-dehydrogenase 1 inhibitor in human plasma: Application to a clinical pharmacokinetic study.

Furlong MT, Ji QC, Iacono L, Dang O, Noren M, Bruce J, Aubry AF, Arnold ME.

J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jun 1;1022:167-172. doi: 10.1016/j.jchromb.2016.03.043. Epub 2016 Mar 29.

PMID:
27100678
3.

Diclofenac and Its Acyl Glucuronide: Determination of In Vivo Exposure in Human Subjects and Characterization as Human Drug Transporter Substrates In Vitro.

Zhang Y, Han YH, Putluru SP, Matta MK, Kole P, Mandlekar S, Furlong MT, Liu T, Iyer RA, Marathe P, Yang Z, Lai Y, Rodrigues AD.

Drug Metab Dispos. 2016 Mar;44(3):320-8. doi: 10.1124/dmd.115.066944. Epub 2015 Dec 29.

PMID:
26714763
4.

An exploratory universal LC-MS/MS assay for bioanalysis of hinge region-stabilized human IgG4 mAbs in clinical studies.

Furlong MT, Titsch C, Xu W, Jiang H, Jemal M, Zeng J.

Bioanalysis. 2014;6(13):1747-58. doi: 10.4155/bio.14.64. Epub 2014 Mar 24.

PMID:
24661028
5.

Innovative use of LC-MS/MS for simultaneous quantitation of neutralizing antibody, residual drug, and human immunoglobulin G in immunogenicity assay development.

Jiang H, Xu W, Titsch CA, Furlong MT, Dodge R, Voronin K, Allentoff A, Zeng J, Aubry AF, DeSilva BS, Arnold ME.

Anal Chem. 2014 Mar 4;86(5):2673-80. doi: 10.1021/ac5001465. Epub 2014 Feb 17.

PMID:
24506335
6.

Dual universal peptide approach to bioanalysis of human monoclonal antibody protein drug candidates in animal studies.

Furlong MT, Zhao S, Mylott W, Jenkins R, Gao M, Hegde V, Tamura J, Tymiak A, Jemal M.

Bioanalysis. 2013 Jun;5(11):1363-76. doi: 10.4155/bio.13.55.

PMID:
23742306
7.

A validated HPLC-MS/MS assay for quantifying unstable pharmacologically active metabolites of clopidogrel in human plasma: application to a clinical pharmacokinetic study.

Furlong MT, Savant I, Yuan M, Scott L, Mylott W, Mariannino T, Kadiyala P, Roongta V, Arnold ME.

J Chromatogr B Analyt Technol Biomed Life Sci. 2013 May 1;926:36-41. doi: 10.1016/j.jchromb.2013.02.031. Epub 2013 Mar 1.

PMID:
23542721
8.

A validated enantioselective LC-MS/MS assay for the simultaneous determination of carvedilol and its pharmacologically active 4'-hydroxyphenyl metabolite in human plasma: application to a clinical pharmacokinetic study.

Furlong MT, He B, Mylott W, Zhao S, Mariannino T, Shen J, Stouffer B.

J Pharm Biomed Anal. 2012 Nov;70:574-9. doi: 10.1016/j.jpba.2012.05.026. Epub 2012 May 30.

PMID:
22709607
9.

A universal surrogate peptide to enable LC-MS/MS bioanalysis of a diversity of human monoclonal antibody and human Fc-fusion protein drug candidates in pre-clinical animal studies.

Furlong MT, Ouyang Z, Wu S, Tamura J, Olah T, Tymiak A, Jemal M.

Biomed Chromatogr. 2012 Aug;26(8):1024-32. doi: 10.1002/bmc.2759. Epub 2012 May 24.

PMID:
22623136
10.

Pellet digestion: a simple and efficient sample preparation technique for LC-MS/MS quantification of large therapeutic proteins in plasma.

Ouyang Z, Furlong MT, Wu S, Sleczka B, Tamura J, Wang H, Suchard S, Suri A, Olah T, Tymiak A, Jemal M.

Bioanalysis. 2012 Jan;4(1):17-28. doi: 10.4155/bio.11.286.

PMID:
22191591
11.

A validated LC-MS/MS assay for the simultaneous determination of the anti-leukemic agent dasatinib and two pharmacologically active metabolites in human plasma: application to a clinical pharmacokinetic study.

Furlong MT, Agrawal S, Hawthorne D, Lago M, Unger S, Krueger L, Stouffer B.

J Pharm Biomed Anal. 2012 Jan 25;58:130-5. doi: 10.1016/j.jpba.2011.09.008. Epub 2011 Sep 16.

PMID:
21982905
12.

Identifying and overcoming bioanalytical challenges associated with chlorine-containing dehydrogenation metabolites.

Furlong MT, Wujcik CE, Ji C, Su Y.

Rapid Commun Mass Spectrom. 2010 Nov 15;24(21):3092-102. doi: 10.1002/rcm.4741.

PMID:
20941755
13.

Quantitative interference by cysteine and N-acetylcysteine metabolites during the LC-MS/MS bioanalysis of a small molecule.

Barricklow J, Ryder TF, Furlong MT.

Drug Metab Lett. 2009 Aug;3(3):181-90. Epub 2009 Aug 1.

PMID:
19702543
14.

Accuracy and predictability of intraocular lens power calculation after photorefractive keratectomy.

Gimbel HV, Sun R, Furlong MT, van Westenbrugge JA, Kassab J.

J Cataract Refract Surg. 2000 Aug;26(8):1147-51.

PMID:
11008040
15.

Rare activation of the TCF/beta-catenin pathway in ovarian cancer.

Furlong MT, Morin PJ.

Gynecol Oncol. 2000 Apr;77(1):97-104.

PMID:
10739697
16.

Evidence for the colonic origin of ovarian cancer cell line SW626.

Furlong MT, Hough CD, Sherman-Baust CA, Pizer ES, Morin PJ.

J Natl Cancer Inst. 1999 Aug 4;91(15):1327-8. No abstract available.

PMID:
10433623
17.

Phosphorylation- and activation-independent association of the tyrosine kinase Syk and the tyrosine kinase substrates Cbl and Vav with tubulin in B-cells.

Fernandez JA, Keshvara LM, Peters JD, Furlong MT, Harrison ML, Geahlen RL.

J Biol Chem. 1999 Jan 15;274(3):1401-6.

18.

Incidence and management of intraoperative and early postoperative complications in 1000 consecutive laser in situ keratomileusis cases.

Gimbel HV, Penno EE, van Westenbrugge JA, Ferensowicz M, Furlong MT.

Ophthalmology. 1998 Oct;105(10):1839-47; discussion 1847-8.

PMID:
9787353
19.

Identification of the major sites of autophosphorylation of the murine protein-tyrosine kinase Syk.

Furlong MT, Mahrenholz AM, Kim KH, Ashendel CL, Harrison ML, Geahlen RL.

Biochim Biophys Acta. 1997 Feb 4;1355(2):177-90.

20.
21.

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk.

Turner M, Mee PJ, Costello PS, Williams O, Price AA, Duddy LP, Furlong MT, Geahlen RL, Tybulewicz VL.

Nature. 1995 Nov 16;378(6554):298-302.

PMID:
7477352
22.

Signaling-induced association of a tyrosine-phosphorylated 36-kDa protein with p50csk.

Ford CE, Furlong MT, Geahlen RL, Harrison ML.

J Biol Chem. 1994 Dec 2;269(48):30378-85.

23.

Interactions of Lyn with the antigen receptor during B cell activation.

Burg DL, Furlong MT, Harrison ML, Geahlen RL.

J Biol Chem. 1994 Nov 11;269(45):28136-42.

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