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Items: 21

1.

NIK-IKK complex interaction controls NF-κB-dependent inflammatory activation of endothelium in response to LTβR ligation.

Kucharzewska P, Maracle CX, Jeucken KCM, van Hamburg JP, Israelsson E, Furber M, Tas SW, Olsson HK.

J Cell Sci. 2019 Apr 3;132(7). pii: jcs225615. doi: 10.1242/jcs.225615.

2.

Frank Lloyd-Griffiths.

Furber M, Bower C.

Vet Rec. 2018 May 5;182(18):522. doi: 10.1136/vr.k1983.

PMID:
29728494
3.

Effects of acute or chronic heat exposure, exercise and dehydration on plasma cortisol, IL-6 and CRP levels in trained males.

Costello JT, Rendell RA, Furber M, Massey HC, Tipton MJ, Young JS, Corbett J.

Cytokine. 2018 Oct;110:277-283. doi: 10.1016/j.cyto.2018.01.018. Epub 2018 May 7.

PMID:
29402724
4.

Laryngoscopy during swimming: A novel diagnostic technique to characterize swimming-induced laryngeal obstruction.

Walsted ES, Swanton LL, van van Someren K, Morris TE, Furber M, Backer V, Hull JH.

Laryngoscope. 2017 Oct;127(10):2298-2301. doi: 10.1002/lary.26532. Epub 2017 Feb 25.

PMID:
28236311
5.

Anti-trypanosomal activity of non-peptidic nitrile-based cysteine protease inhibitors.

Burtoloso AC, de Albuquerque S, Furber M, Gomes JC, Gonçalez C, Kenny PW, Leitão A, Montanari CA, Quilles JC Júnior, Ribeiro JF, Rocha JR.

PLoS Negl Trop Dis. 2017 Feb 21;11(2):e0005343. doi: 10.1371/journal.pntd.0005343. eCollection 2017 Feb.

6.

The Physiological Profile of a Multiple Tour de France Winning Cyclist.

Bell PG, Furber MJ, VAN Someren KA, Antón-Solanas A, Swart J.

Med Sci Sports Exerc. 2017 Jan;49(1):115-123.

PMID:
27508883
7.

Cathepsin C inhibitors: property optimization and identification of a clinical candidate.

Furber M, Tiden AK, Gardiner P, Mete A, Ford R, Millichip I, Stein L, Mather A, Kinchin E, Luckhurst C, Barber S, Cage P, Sanganee H, Austin R, Chohan K, Beri R, Thong B, Wallace A, Oreffo V, Hutchinson R, Harper S, Debreczeni J, Breed J, Wissler L, Edman K.

J Med Chem. 2014 Mar 27;57(6):2357-67. doi: 10.1021/jm401705g. Epub 2014 Mar 14.

PMID:
24592859
8.

Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H₁ antagonists. Part I.

Furber M, Alcaraz L, Luckhurst C, Bahl A, Beaton H, Bowers K, Collington J, Denton R, Donald D, Kinchin E, MacDonald C, Rigby A, Riley R, Soars M, Springthorpe B, Webborn P.

Bioorg Med Chem Lett. 2012 Dec 15;22(24):7702-6. doi: 10.1016/j.bmcl.2012.09.113. Epub 2012 Oct 23.

PMID:
23142617
9.

Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H₁ antagonists. Part II: optimising in vivo clearance.

Furber M, Alcaraz L, Luckhurst C, Bahl A, Beaton H, Bowers K, Collington J, Denton R, Donald D, Kinchin E, MacDonald C, Rigby A, Riley R, Soars M, Springthorpe B, Webborn P.

Bioorg Med Chem Lett. 2012 Dec 15;22(24):7707-10. doi: 10.1016/j.bmcl.2012.09.112. Epub 2012 Oct 10.

PMID:
23116889
10.

Organocatalytic enantioselective one-pot four-component ugi-type multicomponent reaction for the synthesis of epoxy-tetrahydropyrrolo[3,4-b]pyridin-5-ones.

Su Y, Bouma MJ, Alcaraz L, Stocks M, Furber M, Masson G, Zhu J.

Chemistry. 2012 Oct 1;18(40):12624-7. doi: 10.1002/chem.201202174. Epub 2012 Aug 28.

PMID:
22930594
11.

The discovery of MMP7 inhibitors exploiting a novel selectivity trigger.

Edman K, Furber M, Hemsley P, Johansson C, Pairaudeau G, Petersen J, Stocks M, Tervo A, Ward A, Wells E, Wissler L.

ChemMedChem. 2011 May 2;6(5):769-73. doi: 10.1002/cmdc.201000550. Epub 2011 Feb 18. No abstract available.

PMID:
21520417
12.

The effects of P2X7 receptor antagonists on the formation and function of human osteoclasts in vitro.

Agrawal A, Buckley KA, Bowers K, Furber M, Gallagher JA, Gartland A.

Purinergic Signal. 2010 Sep;6(3):307-15. doi: 10.1007/s11302-010-9181-z. Epub 2010 Apr 21.

13.

Discovery of isoindoline and tetrahydroisoquinoline derivatives as potent, selective PPARδ agonists.

Luckhurst CA, Stein LA, Furber M, Webb N, Ratcliffe MJ, Allenby G, Botterell S, Tomlinson W, Martin B, Walding A.

Bioorg Med Chem Lett. 2011 Jan 1;21(1):492-6. doi: 10.1016/j.bmcl.2010.10.117. Epub 2010 Oct 27.

PMID:
21094606
14.

Synthesis and biological evaluation of N-alkylated 8-oxybenz[c]azepine derivatives as selective PPARδ agonists.

Luckhurst CA, Ratcliffe M, Stein L, Furber M, Botterell S, Laughton D, Tomlinson W, Weaver R, Chohan K, Walding A.

Bioorg Med Chem Lett. 2011 Jan 1;21(1):531-6. doi: 10.1016/j.bmcl.2010.10.083. Epub 2010 Oct 23.

PMID:
21075629
15.

Antagonists of the P2X(7) receptor. From lead identification to drug development.

Guile SD, Alcaraz L, Birkinshaw TN, Bowers KC, Ebden MR, Furber M, Stocks MJ.

J Med Chem. 2009 May 28;52(10):3123-41. doi: 10.1021/jm801528x. Review. No abstract available.

PMID:
19191585
16.

Discovery of potent and selective adamantane-based small-molecule P2X(7) receptor antagonists/interleukin-1beta inhibitors.

Furber M, Alcaraz L, Bent JE, Beyerbach A, Bowers K, Braddock M, Caffrey MV, Cladingboel D, Collington J, Donald DK, Fagura M, Ince F, Kinchin EC, Laurent C, Lawson M, Luker TJ, Mortimore MM, Pimm AD, Riley RJ, Roberts N, Robertson M, Theaker J, Thorne PV, Weaver R, Webborn P, Willis P.

J Med Chem. 2007 Nov 29;50(24):5882-5. Epub 2007 Oct 27.

PMID:
17963373
17.

Characterization of a selective and potent antagonist of human P2X(7) receptors, AZ11645373.

Stokes L, Jiang LH, Alcaraz L, Bent J, Bowers K, Fagura M, Furber M, Mortimore M, Lawson M, Theaker J, Laurent C, Braddock M, Surprenant A.

Br J Pharmacol. 2006 Dec;149(7):880-7. Epub 2006 Oct 9.

18.

Synthesis of alpha-iminoimidates by palladium catalysed double isonitrile insertion.

Whitby RJ, Gustaf Saluste C, Furber M.

Org Biomol Chem. 2004 Jul 21;2(14):1974-6. Epub 2004 Jun 18.

PMID:
15254622
19.

Novel P2X7 receptor antagonists.

Alcaraz L, Baxter A, Bent J, Bowers K, Braddock M, Cladingboel D, Donald D, Fagura M, Furber M, Laurent C, Lawson M, Mortimore M, McCormick M, Roberts N, Robertson M.

Bioorg Med Chem Lett. 2003 Nov 17;13(22):4043-6.

PMID:
14592504
20.

A Palladium-Catalyzed Synthesis of Amidines from Aryl Halides This research was supported by AstraZeneca plc.

Saluste CG, Whitby RJ, Furber M.

Angew Chem Int Ed Engl. 2000 Nov 17;39(22):4156-4158. No abstract available.

PMID:
11093238
21.

Identification of Antheridiogens in Lygodium circinnatum and Lygodium flexuosum.

Yamauchi T, Oyama N, Yamane H, Murofushi N, Schraudolf H, Pour M, Furber M, Mander LN.

Plant Physiol. 1996 Jul;111(3):741-745.

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