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Items: 13

1.

Integrated structural variation and point mutation signatures in cancer genomes using correlated topic models.

Funnell T, Zhang AW, Grewal D, McKinney S, Bashashati A, Wang YK, Shah SP.

PLoS Comput Biol. 2019 Feb 22;15(2):e1006799. doi: 10.1371/journal.pcbi.1006799. eCollection 2019 Feb.

2.

Interfaces of Malignant and Immunologic Clonal Dynamics in Ovarian Cancer.

Zhang AW, McPherson A, Milne K, Kroeger DR, Hamilton PT, Miranda A, Funnell T, Little N, de Souza CPE, Laan S, LeDoux S, Cochrane DR, Lim JLP, Yang W, Roth A, Smith MA, Ho J, Tse K, Zeng T, Shlafman I, Mayo MR, Moore R, Failmezger H, Heindl A, Wang YK, Bashashati A, Grewal DS, Brown SD, Lai D, Wan ANC, Nielsen CB, Huebner C, Tessier-Cloutier B, Anglesio MS, Bouchard-Côté A, Yuan Y, Wasserman WW, Gilks CB, Karnezis AN, Aparicio S, McAlpine JN, Huntsman DG, Holt RA, Nelson BH, Shah SP.

Cell. 2018 Jun 14;173(7):1755-1769.e22. doi: 10.1016/j.cell.2018.03.073. Epub 2018 May 10.

3.

CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor.

Funnell T, Tasaki S, Oloumi A, Araki S, Kong E, Yap D, Nakayama Y, Hughes CS, Cheng SG, Tozaki H, Iwatani M, Sasaki S, Ohashi T, Miyazaki T, Morishita N, Morishita D, Ogasawara-Shimizu M, Ohori M, Nakao S, Karashima M, Sano M, Murai A, Nomura T, Uchiyama N, Kawamoto T, Hara R, Nakanishi O, Shumansky K, Rosner J, Wan A, McKinney S, Morin GB, Nakanishi A, Shah S, Toyoshiba H, Aparicio S.

Nat Commun. 2017 Feb 23;8(1):7. doi: 10.1038/s41467-016-0008-7.

4.

Systematic analysis of somatic mutations impacting gene expression in 12 tumour types.

Ding J, McConechy MK, Horlings HM, Ha G, Chun Chan F, Funnell T, Mullaly SC, Reimand J, Bashashati A, Bader GD, Huntsman D, Aparicio S, Condon A, Shah SP.

Nat Commun. 2015 Oct 5;6:8554. doi: 10.1038/ncomms9554.

5.

Synthesis of caged NAADP.

Galione A, Chuang KT, Funnell TM, Davis LC, Morgan AJ, Ruas M, Parrington J, Churchill GC.

Cold Spring Harb Protoc. 2014 Oct 1;2014(10):pdb.prot076943. doi: 10.1101/pdb.prot076943.

PMID:
25275103
6.

Measurement of luminal pH of acidic stores as a readout for NAADP action.

Galione A, Chuang KT, Funnell TM, Davis LC, Morgan AJ, Ruas M, Parrington J, Churchill GC.

Cold Spring Harb Protoc. 2014 Oct 1;2014(10):pdb.prot076935. doi: 10.1101/pdb.prot076935.

PMID:
25275102
7.

Synthesis of NAADP-AM as a membrane-permeant NAADP analog.

Galione A, Chuang KT, Funnell TM, Davis LC, Morgan AJ, Ruas M, Parrington J, Churchill GC.

Cold Spring Harb Protoc. 2014 Oct 1;2014(10):pdb.prot076927. doi: 10.1101/pdb.prot076927.

PMID:
25275101
8.

Synthesis of [³²P]NAADP for the radioreceptor binding assay.

Galione A, Chuang KT, Funnell TM, Davis LC, Morgan AJ, Ruas M, Parrington J, Churchill GC.

Cold Spring Harb Protoc. 2014 Sep 2;2014(9):993-5. doi: 10.1101/pdb.prot076919.

PMID:
25183813
9.

Preparation and use of sea urchin egg homogenates for studying NAADP-mediated Ca²⁺ release.

Galione A, Chuang KT, Funnell TM, Davis LC, Morgan AJ, Ruas M, Parrington J, Churchill GC.

Cold Spring Harb Protoc. 2014 Sep 2;2014(9):988-92. doi: 10.1101/pdb.prot076901.

PMID:
25183812
10.

Two-pore channels form homo- and heterodimers.

Rietdorf K, Funnell TM, Ruas M, Heinemann J, Parrington J, Galione A.

J Biol Chem. 2011 Oct 28;286(43):37058-62. doi: 10.1074/jbc.C111.289835. Epub 2011 Sep 8.

11.

Physiological roles of NAADP-mediated Ca2+ signaling.

Galione A, Parrington J, Funnell T.

Sci China Life Sci. 2011 Aug;54(8):725-32. doi: 10.1007/s11427-011-4207-5. Epub 2011 Jul 24. Review.

PMID:
21786195
12.

TPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+.

Pitt SJ, Funnell TM, Sitsapesan M, Venturi E, Rietdorf K, Ruas M, Ganesan A, Gosain R, Churchill GC, Zhu MX, Parrington J, Galione A, Sitsapesan R.

J Biol Chem. 2010 Nov 5;285(45):35039-46. doi: 10.1074/jbc.M110.156927. Epub 2010 Aug 18.

13.

Purified TPC isoforms form NAADP receptors with distinct roles for Ca(2+) signaling and endolysosomal trafficking.

Ruas M, Rietdorf K, Arredouani A, Davis LC, Lloyd-Evans E, Koegel H, Funnell TM, Morgan AJ, Ward JA, Watanabe K, Cheng X, Churchill GC, Zhu MX, Platt FM, Wessel GM, Parrington J, Galione A.

Curr Biol. 2010 Apr 27;20(8):703-9. doi: 10.1016/j.cub.2010.02.049. Epub 2010 Mar 25.

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