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Immunological characterization of HM5023507, an orally active PI3Kδ/γ inhibitor.

Cai Y, Yu J, Ren P, He J, Wu Z, Xiao K, Jia H, Wang J, Sai Y, Dai G, Li X, Su W, Ngo K, Castro G, Acton PD, Fung-Leung WP, Edwards JP, Venable J, Rao TS.

Pharmacol Res Perspect. 2020 Jan 13;8(1):e00559. doi: 10.1002/prp2.559. eCollection 2020 Feb.


Exploiting CD22 To Selectively Tolerize Autoantibody Producing B-Cells in Rheumatoid Arthritis.

Bednar KJ, Nycholat CM, Rao TS, Paulson JC, Fung-Leung WP, Macauley MS.

ACS Chem Biol. 2019 Apr 19;14(4):644-654. doi: 10.1021/acschembio.8b01018. Epub 2019 Mar 20.


T follicular helper cells restricted by IRF8 contribute to T cell-mediated inflammation.

Zhang R, Qi CF, Hu Y, Shan Y, Hsieh YP, Xu F, Lu G, Dai J, Gupta M, Cui M, Peng L, Yang J, Xue Q, Chen-Liang R, Chen K, Zhang Y, Fung-Leung WP, Mora JR, Li L, Morse HC 3rd, Ozato K, Heeger PS, Xiong H.

J Autoimmun. 2019 Jan;96:113-122. doi: 10.1016/j.jaut.2018.09.001. Epub 2018 Sep 19.


Human CD22 Inhibits Murine B Cell Receptor Activation in a Human CD22 Transgenic Mouse Model.

Bednar KJ, Shanina E, Ballet R, Connors EP, Duan S, Juan J, Arlian BM, Kulis MD, Butcher EC, Fung-Leung WP, Rao TS, Paulson JC, Macauley MS.

J Immunol. 2017 Nov 1;199(9):3116-3128. doi: 10.4049/jimmunol.1700898. Epub 2017 Sep 29.


RORγt and RORα signature genes in human Th17 cells.

Castro G, Liu X, Ngo K, De Leon-Tabaldo A, Zhao S, Luna-Roman R, Yu J, Cao T, Kuhn R, Wilkinson P, Herman K, Nelen MI, Blevitt J, Xue X, Fourie A, Fung-Leung WP.

PLoS One. 2017 Aug 1;12(8):e0181868. doi: 10.1371/journal.pone.0181868. eCollection 2017.


T Cell Subset and Stimulation Strength-Dependent Modulation of T Cell Activation by Kv1.3 Blockers.

Fung-Leung WP, Edwards W, Liu Y, Ngo K, Angsana J, Castro G, Wu N, Liu X, Swanson RV, Wickenden AD.

PLoS One. 2017 Jan 20;12(1):e0170102. doi: 10.1371/journal.pone.0170102. eCollection 2017.


Pharmacologic modulation of RORγt translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis.

Xue X, Soroosh P, De Leon-Tabaldo A, Luna-Roman R, Sablad M, Rozenkrants N, Yu J, Castro G, Banie H, Fung-Leung WP, Santamaria-Babi L, Schlueter T, Albers M, Leonard K, Budelsky AL, Fourie AM.

Sci Rep. 2016 Dec 1;6:37977. doi: 10.1038/srep37977.


Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiation.

Soroosh P, Wu J, Xue X, Song J, Sutton SW, Sablad M, Yu J, Nelen MI, Liu X, Castro G, Luna R, Crawford S, Banie H, Dandridge RA, Deng X, Bittner A, Kuei C, Tootoonchi M, Rozenkrants N, Herman K, Gao J, Yang XV, Sachen K, Ngo K, Fung-Leung WP, Nguyen S, de Leon-Tabaldo A, Blevitt J, Zhang Y, Cummings MD, Rao T, Mani NS, Liu C, McKinnon M, Milla ME, Fourie AM, Sun S.

Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12163-8. doi: 10.1073/pnas.1322807111. Epub 2014 Aug 4.


Targeting the ion channel Kv1.3 with scorpion venom peptides engineered for potency, selectivity, and half-life.

Edwards W, Fung-Leung WP, Huang C, Chi E, Wu N, Liu Y, Maher MP, Bonesteel R, Connor J, Fellows R, Garcia E, Lee J, Lu L, Ngo K, Scott B, Zhou H, Swanson RV, Wickenden AD.

J Biol Chem. 2014 Aug 15;289(33):22704-14. doi: 10.1074/jbc.M114.568642. Epub 2014 Jun 17.


Comparison of RNA-Seq and microarray in transcriptome profiling of activated T cells.

Zhao S, Fung-Leung WP, Bittner A, Ngo K, Liu X.

PLoS One. 2014 Jan 16;9(1):e78644. doi: 10.1371/journal.pone.0078644. eCollection 2014.


PI3Kγ kinase activity is required for optimal T-cell activation and differentiation.

Ladygina N, Gottipati S, Ngo K, Castro G, Ma JY, Banie H, Rao TS, Fung-Leung WP.

Eur J Immunol. 2013 Dec;43(12):3183-96. doi: 10.1002/eji.201343812. Epub 2013 Oct 9.


Gender-biased regulation of human IL-17-producing cells in vitro by peptides corresponding to distinct HLA-DRB1 allele-coded sequences.

Blanco LP, Plegue M, Fung-Leung WP, Holoshitz J.

J Immune Based Ther Vaccines Antimicrob. 2013 Jul;2(3):29-38. doi: 10.4236/jibtva.2013.23004. Epub 2013 Jul 1.


Phosphoinositide 3-kinase gamma in T cell biology and disease therapy.

Fung-Leung WP.

Ann N Y Acad Sci. 2013 Mar;1280:40-3. doi: 10.1111/nyas.12029.


Antagonism of the histamine H4 receptor reduces LPS-induced TNF production in vivo.

Cowden JM, Yu F, Challapalli M, Huang JF, Kim S, Fung-Leung WP, Ma JY, Riley JP, Zhang M, Dunford PJ, Thurmond RL.

Inflamm Res. 2013 Jun;62(6):599-607. doi: 10.1007/s00011-013-0612-5. Epub 2013 Mar 27.


Phosphoinositide 3-kinase delta (PI3Kδ) in leukocyte signaling and function.

Fung-Leung WP.

Cell Signal. 2011 Apr;23(4):603-8. doi: 10.1016/j.cellsig.2010.10.002. Epub 2010 Oct 16. Review.


Phosphoinositide 3-kinase gamma (PI3Kgamma) inhibitors for the treatment of inflammation and autoimmune disease.

Venable JD, Ameriks MK, Blevitt JM, Thurmond RL, Fung-Leung WP.

Recent Pat Inflamm Allergy Drug Discov. 2010 Jan;4(1):1-15. Review.


IRAK1: a critical signaling mediator of innate immunity.

Gottipati S, Rao NL, Fung-Leung WP.

Cell Signal. 2008 Feb;20(2):269-76. Epub 2007 Aug 23. Review.


CpG-induced tyrosine phosphorylation occurs via a TLR9-independent mechanism and is required for cytokine secretion.

Sanjuan MA, Rao N, Lai KT, Gu Y, Sun S, Fuchs A, Fung-Leung WP, Colonna M, Karlsson L.

J Cell Biol. 2006 Mar 27;172(7):1057-68.


Histamine H4 receptor antagonists: the new antihistamines?

Fung-Leung WP, Thurmond RL, Ling P, Karlsson L.

Curr Opin Investig Drugs. 2004 Nov;5(11):1174-83. Review.


Histamine H4 receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation.

Ling P, Ngo K, Nguyen S, Thurmond RL, Edwards JP, Karlsson L, Fung-Leung WP.

Br J Pharmacol. 2004 May;142(1):161-71. Erratum in: Br J Pharmacol. 2004 Jul;142(6):1052.


A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties.

Thurmond RL, Desai PJ, Dunford PJ, Fung-Leung WP, Hofstra CL, Jiang W, Nguyen S, Riley JP, Sun S, Williams KN, Edwards JP, Karlsson L.

J Pharmacol Exp Ther. 2004 Apr;309(1):404-13. Epub 2004 Jan 13.


Histamine H4 receptor mediates chemotaxis and calcium mobilization of mast cells.

Hofstra CL, Desai PJ, Thurmond RL, Fung-Leung WP.

J Pharmacol Exp Ther. 2003 Jun;305(3):1212-21. Epub 2003 Mar 6.


Norepinephrine release from the ischemic heart is greatly enhanced in mice lacking histamine H3 receptors.

Koyama M, Seyedi N, Fung-Leung WP, Lovenberg TW, Levi R.

Mol Pharmacol. 2003 Feb;63(2):378-82.


IgE-dependent mast cell activation potentiates airway responses in murine asthma models.

Mayr SI, Zuberi RI, Zhang M, de Sousa-Hitzler J, Ngo K, Kuwabara Y, Yu L, Fung-Leung WP, Liu FT.

J Immunol. 2002 Aug 15;169(4):2061-8.


Behavioral characterization of mice lacking histamine H(3) receptors.

Toyota H, Dugovic C, Koehl M, Laposky AD, Weber C, Ngo K, Wu Y, Lee DH, Yanai K, Sakurai E, Watanabe T, Liu C, Chen J, Barbier AJ, Turek FW, Fung-Leung WP, Lovenberg TW.

Mol Pharmacol. 2002 Aug;62(2):389-97. Erratum in: Mol Pharmacol 2002 Sep;62(3):763.


Leukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues.

van Eck M, Bos IS, Kaminski WE, Orsó E, Rothe G, Twisk J, Böttcher A, Van Amersfoort ES, Christiansen-Weber TA, Fung-Leung WP, Van Berkel TJ, Schmitz G.

Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):6298-303. Epub 2002 Apr 23.


ATP-binding cassette transporter A1 (ABCA1) affects total body sterol metabolism.

Drobnik W, Lindenthal B, Lieser B, Ritter M, Christiansen Weber T, Liebisch G, Giesa U, Igel M, Borsukova H, Büchler C, Fung-Leung WP, Von Bergmann K, Schmitz G.

Gastroenterology. 2001 Apr;120(5):1203-11.


Functional loss of ABCA1 in mice causes severe placental malformation, aberrant lipid distribution, and kidney glomerulonephritis as well as high-density lipoprotein cholesterol deficiency.

Christiansen-Weber TA, Voland JR, Wu Y, Ngo K, Roland BL, Nguyen S, Peterson PA, Fung-Leung WP.

Am J Pathol. 2000 Sep;157(3):1017-29.


Tbt-1, a new T-box transcription factor induced in activated Th1 and CD8+ T cells.

Shier P, Hofstra CL, Ma XJ, Wu Y, Ngo K, Fung-Leung WP.

Immunogenetics. 2000 Aug;51(10):771-8.


Targeted disruption of the galectin-3 gene results in attenuated peritoneal inflammatory responses.

Hsu DK, Yang RY, Pan Z, Yu L, Salomon DR, Fung-Leung WP, Liu FT.

Am J Pathol. 2000 Mar;156(3):1073-83.


The role of H2-O and HLA-DO in major histocompatibility complex class II-restricted antigen processing and presentation.

Alfonso C, Liljedahl M, Winqvist O, Surh CD, Peterson PA, Fung-Leung WP, Karlsson L.

Immunol Rev. 1999 Dec;172:255-66. Review.


Impaired immunoproteasome assembly and immune responses in PA28-/- mice.

Preckel T, Fung-Leung WP, Cai Z, Vitiello A, Salter-Cid L, Winqvist O, Wolfe TG, Von Herrath M, Angulo A, Ghazal P, Lee JD, Fourie AM, Wu Y, Pang J, Ngo K, Peterson PA, Früh K, Yang Y.

Science. 1999 Dec 10;286(5447):2162-5.


Defective interleukin (IL)-18-mediated natural killer and T helper cell type 1 responses in IL-1 receptor-associated kinase (IRAK)-deficient mice.

Kanakaraj P, Ngo K, Wu Y, Angulo A, Ghazal P, Harris CA, Siekierka JJ, Peterson PA, Fung-Leung WP.

J Exp Med. 1999 Apr 5;189(7):1129-38.


Cardiovascular responses mediated by protease-activated receptor-2 (PAR-2) and thrombin receptor (PAR-1) are distinguished in mice deficient in PAR-2 or PAR-1.

Damiano BP, Cheung WM, Santulli RJ, Fung-Leung WP, Ngo K, Ye RD, Darrow AL, Derian CK, de Garavilla L, Andrade-Gordon P.

J Pharmacol Exp Ther. 1999 Feb;288(2):671-8.


Requirement of the CD8+ or CD4+ T lymphocyte subsets for the rejection of lymphoma and fibrosarcoma grafts studied in gene knockout hosts.

Wen T, Trümper L, Fung-Leung W, Rahemtulla A, Klein E, Klein G, Mak TW.

Immunol Lett. 1998 Apr;61(2-3):187-90.


Interleukin (IL)-1 receptor-associated kinase (IRAK) requirement for optimal induction of multiple IL-1 signaling pathways and IL-6 production.

Kanakaraj P, Schafer PH, Cavender DE, Wu Y, Ngo K, Grealish PF, Wadsworth SA, Peterson PA, Siekierka JJ, Harris CA, Fung-Leung WP.

J Exp Med. 1998 Jun 15;187(12):2073-9.


Altered antigen presentation in mice lacking H2-O.

Liljedahl M, Winqvist O, Surh CD, Wong P, Ngo K, Teyton L, Peterson PA, Brunmark A, Rudensky AY, Fung-Leung WP, Karlsson L.

Immunity. 1998 Feb;8(2):233-43.


Thymic selection by a single MHC/peptide ligand produces a semidiverse repertoire of CD4+ T cells.

Surh CD, Lee DS, Fung-Leung WP, Karlsson L, Sprent J.

Immunity. 1997 Aug;7(2):209-19.


Peptide-induced positive selection of TCR transgenic thymocytes in a coreceptor-independent manner.

Sebzda E, Choi M, Fung-Leung WP, Mak TW, Ohashi PS.

Immunity. 1997 May;6(5):643-53.


Impaired immune responses toward alloantigens and tumor cells but normal thymic selection in mice deficient in the beta2 integrin leukocyte function-associated antigen-1.

Shier P, Otulakowski G, Ngo K, Panakos J, Chourmouzis E, Christjansen L, Lau CY, Fung-Leung WP.

J Immunol. 1996 Dec 15;157(12):5375-86.


Biological consequences of thrombin receptor deficiency in mice.

Darrow AL, Fung-Leung WP, Ye RD, Santulli RJ, Cheung WM, Derian CK, Burns CL, Damiano BP, Zhou L, Keenan CM, Peterson PA, Andrade-Gordon P.

Thromb Haemost. 1996 Dec;76(6):860-6.


HLA-DO is a lysosomal resident which requires association with HLA-DM for efficient intracellular transport.

Liljedahl M, Kuwana T, Fung-Leung WP, Jackson MR, Peterson PA, Karlsson L.

EMBO J. 1996 Sep 16;15(18):4817-24.


Antigen presentation and T cell development in H2-M-deficient mice.

Fung-Leung WP, Surh CD, Liljedahl M, Pang J, Leturcq D, Peterson PA, Webb SR, Karlsson L.

Science. 1996 Mar 1;271(5253):1278-81.


Tepoxalin blocks neutrophil migration into cutaneous inflammatory sites by inhibiting Mac-1 and E-selectin expression.

Zhou L, Pope BL, Chourmouzis E, Fung-Leung WP, Lau CY.

Eur J Immunol. 1996 Jan;26(1):120-9.


Transgenic mice expressing the human high-affinity immunoglobulin (Ig) E receptor alpha chain respond to human IgE in mast cell degranulation and in allergic reactions.

Fung-Leung WP, De Sousa-Hitzler J, Ishaque A, Zhou L, Pang J, Ngo K, Panakos JA, Chourmouzis E, Liu FT, Lau CY.

J Exp Med. 1996 Jan 1;183(1):49-56.


Down-regulation of CD8 on mature antigen-reactive T cells as a mechanism of peripheral tolerance.

Zhang L, Fung-Leung W, Miller RG.

J Immunol. 1995 Oct 1;155(7):3464-71.


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